Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo最新文献_第2页

[Features of clinical and laboratory parameters in elderly patients with acute coronary syndrome.] 老年急性冠状动脉综合征的临床及实验室参数特点

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

A S Markova, O T Bogova, K B Mirzaev, V N Potapov, S S Puzin, S N Puzin, D A Sychev

{"title":"[Features of clinical and laboratory parameters in elderly patients with acute coronary syndrome.]","authors":"A S Markova, O T Bogova, K B Mirzaev, V N Potapov, S S Puzin, S N Puzin, D A Sychev","doi":"","DOIUrl":"","url":null,"abstract":"The inclusion of elderly patients in randomized clinical trials does not reflect the age-related association in coronary heart disease. At the same time, there are few scientific papers devoted to clinical and laboratory factors characteristic of the development of acute coronary syndrome (ACS) in this age category. Timely assessment of clinical and biochemical blood parameters in elderly patients is of great importance in preventing complications that naturally increase in them, significantly affects treatment tactics and the possibility of using generally accepted approaches when choosing drug therapy. From these positions, our study showed the special role of triglycerides and glucose in the development of ACS in elderly patients. A joint assessment of the median serum creatinine (sCr) concentration and the nature of its change during stay in the coronary care unit was carried out, which allowed us to conclude that the stratification risk of mortality was reduced. In patients with ACS, the daily value of sCr and the nature of its change are stronger predictors of hospital mortality than only the initial value of sCr. The results of the study suggest that it is recommended to evaluate serum creatinine to ensure a more accurate and dynamic risk stratification in elderly patients with ACS.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"64-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Inflammaging and metabolic syndrome: molecular mechanisms.] 炎症和代谢综合征：分子机制。

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

I Y Pchelin, K Y Lukianets, E S Mironova, A D Kosova, Y I Belova, S A Ayrapetyan

{"title":"[Inflammaging and metabolic syndrome: molecular mechanisms.]","authors":"I Y Pchelin, K Y Lukianets, E S Mironova, A D Kosova, Y I Belova, S A Ayrapetyan","doi":"","DOIUrl":"","url":null,"abstract":"One of the most pressing medical and social problems in the world is the widespread prevalence of chronic age-associated pathology, which includes metabolic syndrome. Metabolic inflammation accompanying metabolic diseases and aging have a common pathogenesis, the basis of which is the activation of the innate immune system and an increase in the inflammatory background. During the aging process, chronic, asymptomatic, sluggish inflammation develops, called inflamaging, which leads to a cascade of pathological changes that disrupt the functions of adipose tissue and the endocrine system, and thereby contributes to the development of a number of diseases. Inflamaging is supported by various stimuli, including pathogens, endogenous cellular debris and defective molecules, as well as excess nutrients. The review examines the common mechanisms of inflammation, aging and metabolic homeostasis disorders, emphasizing the significant role of inflammaging in the development of metabolic syndrome, as well as biomarkers of age-associated diseases, the use of which as targets for therapeutic treatment can help in the fight against metabolic syndrome.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"118-125"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Patterns of physiological reactions to standardized cardiorespiratory load as markers of age-related changes.] [对标准化心肺负荷的生理反应模式作为年龄相关变化的标志。]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

D S Medvedev, D V Trotsyuk, D V Dobrynin, K L Kozlov, S B Shevchenko, V O Polyakova

引用次数: 0

[Analysis of frailty syndrome in oncology: A review and selection of geriatric assessment tools for oncology inpatient care.] [肿瘤衰弱综合征分析：肿瘤住院治疗老年评估工具综述与选择]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

N K Myrzaliyev, S T Olzhayev, A T Mansharipova, G S Krasnov, B J Adjibayev, A U Gekhaev, E E Shostak, S G Lenkin

引用次数: 0

[Peptide bioregulation in prosthetic stomatitis among the elder people.] 老年人假体口炎的肽生物调控

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

K A Kerimkhanov, M E Malyshev, E A Orlova, L N Soldatova, N N Bedelov, A K Iordanishvili

引用次数: 0

[The effect of physical activity on biomarkers of aging in normal and pathological conditions (analytical review).] [在正常和病理条件下，体育活动对衰老生物标志物的影响[分析性综述]。]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

D S Medvedev, D V Dobrynin, S B Maltsev, V O Polyakova, K L Kozlov, S B Shevchenko

引用次数: 0

[Associations of impaired physical status and visual pathology in the elderly.] [老年人身体状况受损与视觉病理的关系。]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

A A Trofimova, A M Grjibovski, V V Popov, S S Mokeeva

{"title":"[Associations of impaired physical status and visual pathology in the elderly.]","authors":"A A Trofimova, A M Grjibovski, V V Popov, S S Mokeeva","doi":"","DOIUrl":"","url":null,"abstract":"Aging is associated with a decline in the patient's physical, mental, and social domains. The physical condition of the elderly is assessed by measuring walking speed, balance impairment, assessing the risk of falls syndrome and other methods. Sensory deficits are also part of the aging body and can affect physical status. It is necessary to know how the parameters of physical status can change in certain pathologies of sensory organs, in particular the eyes. Objective: to study the relationship between physical status disorders and visual pathology in patients over 60 years of age. The database was compiled on the basis of medical records of 481 patients of the Arkhangelsk War Veterans Hospital JSC from 2019-2023. Impaired characteristics of physical status increased with increasing age group; women were mostly affected by impaired physical status. Associations with decreased walking speed were shown by glaucoma OR=1,74; 95% CI 1,10-2,77, cataract OR=1,83; 95% CI 1,12-2,97, retinopathy OR=2,15; 95% CI 1,09-4,03 and refractive error OR=1,47; 95% CI 1,14-2,53. Worsening of the Time up and go test showed refractive error OR 1,47; 95% CI 1,14-2,53. An increased risk of falls according to the Morse scale was shown by uncorrected vision OR 1,51; 95% CI 1-2,26. The listed diseases can serve as ophthalmic pathology markers when introducing a geriatric approach and constructing an algorithm for providing ophthalmological care to the elderly.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"81-86"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Influence of retroelements on the relationship between aging and neurodegenerative diseases.] [逆转录因子对衰老与神经退行性疾病关系的影响]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

R N Mustafin

{"title":"[Influence of retroelements on the relationship between aging and neurodegenerative diseases.]","authors":"R N Mustafin","doi":"","DOIUrl":"","url":null,"abstract":"During physiological aging, pathological activation of retroelements with accumulation and aggregation of beta-amyloid, tau, alpha-synuclein, and TDP-43 proteins is observed in the brain, which may be the cause of progressive decline in cognitive abilities with age. In neurodegenerative diseases, these processes are enhanced by hereditary predisposition (disease-associated polymorphisms are localized mainly in intronic and intergenic regions where retroelements are located) and specific viral infections. This leads to hyperactivation of retroelements, which is reflected in changes in epigenetic factors involved in the pathogenesis of neurodegenerative diseases, since the same viruses that cause activation and aggregation of beta-amyloid, tau, alpha-synuclein and TDP-43 stimulate transcription of retroelements. The resulting aggregates cause derepression of retroelements, since these proteins normally inhibit transcription of retroelements. The listed processes occur at the epigenetic level, since they do not affect DNA sequences, and the key participants are retroelements, which are drivers of epigenetic regulation. Therefore, for the treatment of neurodegenerative diseases, it may be promising to develop therapeutic interventions aimed at the activity of retroelements, which has already shown its effectiveness in the treatment of multiple sclerosis, an autoimmune disease of the central nervous system, in which persistent inflammation and demyelination processes lead to the onset of neurodegeneration with proven involvement of retroelements in the pathogenesis.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"71-80"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Vasosspastic angina: current concepts about pathogenesis, diagnosis, treatment (literature review).] [血管痉挛性心绞痛：发病、诊断、治疗的最新概念（文献综述）]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

A V Barsukov, E V Borisova, I A Vasilyeva, D V Glukhovskoy, M V Kuznetsov, G B Saraev

{"title":"[Vasosspastic angina: current concepts about pathogenesis, diagnosis, treatment (literature review).]","authors":"A V Barsukov, E V Borisova, I A Vasilyeva, D V Glukhovskoy, M V Kuznetsov, G B Saraev","doi":"","DOIUrl":"","url":null,"abstract":"The review examines risk factors, triggers, diagnostic approaches, treatment and preventive strategies for vasospastic angina (VSA). Transient coronary spasm plays an important role in the pathogenesis of stable angina and acute coronary syndromes. Among the factors in the pathogenesis of VSA, the most relevant are sympatho-vagal imbalance, endothelial dysfunction, hypercontractility of smooth muscle cells of the coronary arteries, intravascular and perivascular inflammation, and genetic predisposition. The review provides diagnostic criteria for VSA based on clinical manifestations, electrocardiographic data and angiographic documentation of coronary spasm. Indications and contraindications for intracoronary administration of vasospasm provoking agents are described. Current ideas about traditional and innovative (including interventional) approaches to the treatment and prevention of VSA are revealed. Insufficient study of the problem of VSA in elderly and senile patients has been noted. The factors that have the most adverse impact on the quality of life and prognosis in patients with recurrent coronary spasm are identified.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"36-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

Y V Nesterov

引用次数: 0