Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo最新文献_第2页

[Medical and hygienic training of the population in the issues of gerontology as a way of ensuring resilience.] [对人口进行老年学方面的医疗和卫生培训，作为确保复原力的一种方式。]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

N I Shvarckopf, E V Fesenko, E V Vaevskaia, V V Stepchenkova

引用次数: 0

[Chronic heart failure in elderly and senile patients with postinfarction left ventricular aneurysm: issues of epidemiology, etiology, surgical treatment.] 老年慢性心力衰竭和老年梗死后左心室动脉瘤患者：流行病学、病因学、手术治疗问题。

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

V V Mishagin, N G Lukyanov, K L Kozlov

引用次数: 0

[Sirtuins: molecular-cellular mechanisms of chondrocyte aging.] [Sirtuins：软骨细胞老化的分子细胞机制]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

V N Khabarov, E S Mironova, D Ngoc Hop

{"title":"[Sirtuins: molecular-cellular mechanisms of chondrocyte aging.]","authors":"V N Khabarov, E S Mironova, D Ngoc Hop","doi":"","DOIUrl":"","url":null,"abstract":"More and more studies are focused on the functions of sirtuin proteins in the pathogenesis of joint diseases. Numerous experimental data illustrate the biological functions of sirtuins in the pathogenesis of osteoarthritis in terms of inflammation and cellular aging. The literature also mentions the role of sirtuins in the regulation of circadian rhythms, which have recently been recognized as one of the key aspects in the development of joint pathologies. Some representatives of the sirtuin protein family can participate in the regulation of mitochondrial functions. Over the past three decades, evidence has been obtained that sirtuins are not only important energy sensors, but also have protective properties against metabolic stress and premature aging of cells. Sirtuins regulate metabolism, inhibit apoptosis and autophagy of chondrocytes, and prevent aging of cartilage tissue by exhibiting their deacetylating function. This review shows the role and participation of sirtuins in various molecular signaling events that are associated with the suppression of the functional activity of chondrocytes with increasing age. Modern studies demonstrate the positive effect of sirtuins on the functional activity of chondrocytes and cartilage anabolism. The development of possible ways to regulate sirtuin activity is of considerable interest, which can lead to progress in the treatment of joint pathology.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 2","pages":"213-221"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Implementation of the gerontological approach to informational and educational support of senior citizens.] [实施老年学方法，为老年人提供信息和教育支持。]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

S V Tarasov, A V Shabrov, G A Bordovsky, A V Finagentov

{"title":"[Implementation of the gerontological approach to informational and educational support of senior citizens.]","authors":"S V Tarasov, A V Shabrov, G A Bordovsky, A V Finagentov","doi":"","DOIUrl":"","url":null,"abstract":"The publication substantiates the use of the gerontological approach in the process of information and educational support for the provision of comprehensive assistance to senior citizens within the framework of the formation of the national project 'Long and Active Life' and the regional program of Saint-Petersburg «Silver Age». Suggestions to the development of an interdepartmental program of information and educational support for senior citizens, which would contribute to increasing the information accessibility, demand and effectiveness of social services through active cooperation between senior citizens - recipients of services with the staff of government agencies providing them, the introduction of innovative information, educational and geronto-technologies, and the involvement of public organizations, commercial structures and volunteer centers in supporting senior citizens. The structure and plot of the program are considered, as well as, the algorithm for its implementation, the organization of a pilot project in the territory of Saint-Petersburg, using the experience, developments and creative potential of social institutions, scientific and educational centers of the region.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"10-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The role of glomerular filtration rate in assessing the risk of hypoglycemia in elderly patients with type 2 diabetes mellitus.] [肾小球滤过率在评估老年2型糖尿病患者低血糖风险中的作用]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

P Y Merzlova, S V Bulgakova, D P Kurmaev, Y A Dolgikh, L A Sharonova, E V Treneva, O V Kosareva

{"title":"[The role of glomerular filtration rate in assessing the risk of hypoglycemia in elderly patients with type 2 diabetes mellitus.]","authors":"P Y Merzlova, S V Bulgakova, D P Kurmaev, Y A Dolgikh, L A Sharonova, E V Treneva, O V Kosareva","doi":"","DOIUrl":"","url":null,"abstract":"Type 2 Diabetes Mellitus (T2DM) is highly prevalent among elderly patients. One of the primary target organs for T2DM is the kidneys. The aim of this study was to investigate the relationship between reduced kidney function and the risk of hypoglycemia in elderly female patients with T2DM and to develop a predictive model for this risk. The study included 150 female patients aged 60-74 years with T2DM, among whom hypoglycemia was observed in 58 (38,7%) patients. The medical history of T2DM, dynamic blood glucose levels, glycated hemoglobin (HbA1c), serum creatinine, and estimated glomerular filtration rate (eGFR) using the CKD-EPI formula were analyzed. Statistically significant differences were found between the study groups in terms of T2DM duration, eGFR, minimum and final blood glucose levels (all p<0,001), as well as maximum glucose levels and HbA1c (p=0,005). Patients with hypoglycemia more frequently had chronic kidney disease. A direct correlation was observed between eGFR and minimum (p<0,001) and last (p=0,041) blood glucose levels. Multivariate logistic regression analysis confirmed that decreased eGFR and duration of T2DM are significant risk factors for hypoglycemia. Based on this method, a diagnostic model for assessing hypoglycemia risk was developed. A ROC curve was constructed (AUC=0,884, p<0,001), with a logistic function cutoff value of 0,38 (indicating a 38% hypoglycemia risk) selected as the threshold. Thus, decreased eGFR and duration of T2DM are predictors of hypoglycemia in elderly patients with T2DM.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 2","pages":"256-263"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Chronical obstructive pulmonary disease: principles of treatment in elderly patients.] 慢性阻塞性肺疾病：老年患者的治疗原则

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

V A Sergeeva, S V Bulgakova

{"title":"[Chronical obstructive pulmonary disease: principles of treatment in elderly patients.]","authors":"V A Sergeeva, S V Bulgakova","doi":"","DOIUrl":"","url":null,"abstract":"Due to the high prevalence of chronic obstructive pulmonary disease (COPD) among elderly patients, the relevance and importance of developing therapeutic concepts to improve the quality and longevity of life expectancy of this demographic group is increasing, taking into account the diverse factors that accompany the aging process. The aim of this review was to analyze the accumulated information from current literature sources on the use of various drugs for the treatment and control of COPD in elderly patients. Taking into account the characteristics of this cohort, various therapeutic approaches are discussed from the standpoint of efficacy and safety, and prospects for improving the delivery of inhaled drugs in order to increase their bioavailability, which is one of the most important factors in improving disease control, are assessed. More than 100 sources of relevant topics were processed; the most significant information in the light of the discussed problem is given in the article. The literature review focuses on the problem of drug management of COPD among elderly and senile people, which requires special attention and approach. The standards of COPD therapy applied to younger patients are not always optimal for geriatric patients. Awareness of physicians in this direction will allow personalizing medication prescriptions and improving the effectiveness in treatment of elderly patients with this pathology.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"87-95"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Experience of applying updated STOPP/START criteria in gerontopsychiatric practice.] [在老年精神病学实践中应用最新STOPP/START标准的经验]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

E G Korneeva, O O Kirilochev, A G Soloviev, E Y Golubeva

{"title":"[Experience of applying updated STOPP/START criteria in gerontopsychiatric practice.]","authors":"E G Korneeva, O O Kirilochev, A G Soloviev, E Y Golubeva","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this study was to assess the frequency of polypharmacy, prescribing of potentially inappropriate medication (STOPP criteria), and potential prescribing omissions (START criteria) in 56 elderly psychiatric inpatients. The analysis of prevalence was conducted using the STOPP/START version 3 criteria, and the degree of anticholinergic burden was assessed using the Anticholinergic Cognitive Burden Scale. Polypharmacy was observed in 67.86% of patients, 75 prescriptions of potentially inappropriate medications and 156 cases of potential prescribing omissions were identified. The highest frequency was observed for STOPP criteria related to the use of medications with anticholinergic properties. The median anticholinergic burden score was 2.5 [0.0; 6.0]. The START criteria with the highest frequency were related to recommendations for pharmacotherapy of comorbid somatic conditions, mainly the prescription of statins and antiplatelet agents in patients with vascular diseases. The study demonstrated a moderate frequency of STOPP criteria and a high frequency of START criteria. The application of the updated STOPP/START criteria in psychiatric care should contribute to improving the effectiveness and safety of pharmacotherapy.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"46-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Experience of using grape polyphenol concentrate in elderly patients with bronchial asthma in the post-COVID period.] 葡萄多酚浓缩液在老年支气管哮喘患者新冠肺炎后治疗中的应用体会

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

V A Beloglazov, I A Yatskov, E D Kumelsky, M A Teslenko

{"title":"[Experience of using grape polyphenol concentrate in elderly patients with bronchial asthma in the post-COVID period.]","authors":"V A Beloglazov, I A Yatskov, E D Kumelsky, M A Teslenko","doi":"","DOIUrl":"","url":null,"abstract":"The state of long-COVID and post-COVID syndrome is associated with the presence of low-grade inflammation (LGI) in patients, associated, among other things, with impaired permeability of natural barriers for lipopolysaccharide (LPS) of gram-negative flora. Objective - to study the effect of adding polyphenolic grape concentrate to the course of spa treatment in patients with bronchial asthma and post-covid syndrome on the state of LGI, intestinal permeability and edotoxemia. The study included 70 patients with a verified diagnosis of Bronchial asthma who had suffered from infection caused by SARS-CoV-2. Patients were divided into two groups. The intervention group (n=40) received grape polyphenol concentrate in addition to standard spa treatment. Subsequent enzyme-linked immunosorbent assay (ELISA) performed for determination of the levels of C-RP, zonulin, LPS, lipopolysaccharide-binding protein (LBP), and bactericidal/permeability-increasing protein (BPI). In patients of the 1st group a reliable decrease in the level of C-RP (p<0,039) and the concentration of circulating LPS (p=0,008) was revealed. In both groups, a statistically significant increase in the concentration of BPI and zonulin was registered (p<0,05). The use of polyphenolic grape concentrate in elderly patients in the post-covid period reduces the level of C-RP and circulating blood endotoxin, which in the future should reduce the likelihood of long-term consequences associated with NCI, including cardiovascular, in patients who have undergone NCI.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"145-149"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Features of clinical and laboratory parameters in elderly patients with acute coronary syndrome.] 老年急性冠状动脉综合征的临床及实验室参数特点

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

A S Markova, O T Bogova, K B Mirzaev, V N Potapov, S S Puzin, S N Puzin, D A Sychev

{"title":"[Features of clinical and laboratory parameters in elderly patients with acute coronary syndrome.]","authors":"A S Markova, O T Bogova, K B Mirzaev, V N Potapov, S S Puzin, S N Puzin, D A Sychev","doi":"","DOIUrl":"","url":null,"abstract":"The inclusion of elderly patients in randomized clinical trials does not reflect the age-related association in coronary heart disease. At the same time, there are few scientific papers devoted to clinical and laboratory factors characteristic of the development of acute coronary syndrome (ACS) in this age category. Timely assessment of clinical and biochemical blood parameters in elderly patients is of great importance in preventing complications that naturally increase in them, significantly affects treatment tactics and the possibility of using generally accepted approaches when choosing drug therapy. From these positions, our study showed the special role of triglycerides and glucose in the development of ACS in elderly patients. A joint assessment of the median serum creatinine (sCr) concentration and the nature of its change during stay in the coronary care unit was carried out, which allowed us to conclude that the stratification risk of mortality was reduced. In patients with ACS, the daily value of sCr and the nature of its change are stronger predictors of hospital mortality than only the initial value of sCr. The results of the study suggest that it is recommended to evaluate serum creatinine to ensure a more accurate and dynamic risk stratification in elderly patients with ACS.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"64-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Inflammaging and metabolic syndrome: molecular mechanisms.] 炎症和代谢综合征：分子机制。

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

I Y Pchelin, K Y Lukianets, E S Mironova, A D Kosova, Y I Belova, S A Ayrapetyan

{"title":"[Inflammaging and metabolic syndrome: molecular mechanisms.]","authors":"I Y Pchelin, K Y Lukianets, E S Mironova, A D Kosova, Y I Belova, S A Ayrapetyan","doi":"","DOIUrl":"","url":null,"abstract":"One of the most pressing medical and social problems in the world is the widespread prevalence of chronic age-associated pathology, which includes metabolic syndrome. Metabolic inflammation accompanying metabolic diseases and aging have a common pathogenesis, the basis of which is the activation of the innate immune system and an increase in the inflammatory background. During the aging process, chronic, asymptomatic, sluggish inflammation develops, called inflamaging, which leads to a cascade of pathological changes that disrupt the functions of adipose tissue and the endocrine system, and thereby contributes to the development of a number of diseases. Inflamaging is supported by various stimuli, including pathogens, endogenous cellular debris and defective molecules, as well as excess nutrients. The review examines the common mechanisms of inflammation, aging and metabolic homeostasis disorders, emphasizing the significant role of inflammaging in the development of metabolic syndrome, as well as biomarkers of age-associated diseases, the use of which as targets for therapeutic treatment can help in the fight against metabolic syndrome.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"118-125"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0