Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo最新文献_第3页

[Patterns of physiological reactions to standardized cardiorespiratory load as markers of age-related changes.] [对标准化心肺负荷的生理反应模式作为年龄相关变化的标志。]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

D S Medvedev, D V Trotsyuk, D V Dobrynin, K L Kozlov, S B Shevchenko, V O Polyakova

引用次数: 0

[Analysis of frailty syndrome in oncology: A review and selection of geriatric assessment tools for oncology inpatient care.] [肿瘤衰弱综合征分析：肿瘤住院治疗老年评估工具综述与选择]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

N K Myrzaliyev, S T Olzhayev, A T Mansharipova, G S Krasnov, B J Adjibayev, A U Gekhaev, E E Shostak, S G Lenkin

引用次数: 0

[Peptide bioregulation in prosthetic stomatitis among the elder people.] 老年人假体口炎的肽生物调控

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

K A Kerimkhanov, M E Malyshev, E A Orlova, L N Soldatova, N N Bedelov, A K Iordanishvili

引用次数: 0

[The effect of physical activity on biomarkers of aging in normal and pathological conditions (analytical review).] [在正常和病理条件下，体育活动对衰老生物标志物的影响[分析性综述]。]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

D S Medvedev, D V Dobrynin, S B Maltsev, V O Polyakova, K L Kozlov, S B Shevchenko

引用次数: 0

[Strategies for accessing primary health care for older people in urban and rural areas.] [城市和农村地区老年人获得初级保健的战略。]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

K A Galkin

{"title":"[Strategies for accessing primary health care for older people in urban and rural areas.]","authors":"K A Galkin","doi":"","DOIUrl":"","url":null,"abstract":"The article is devoted to the treatment of primary health care among older people living in urban and rural areas. The empirical basis of the research consists of semi-structured interviews conducted with residents of St. Petersburg and villages of the Republic of Karelia. A total of 40 interviews were collected. Using the method of thematic analysis, key strategies for seeking primary health care were identified, as well as the specifics of calling for emergency care and the impact of the place of residence on the subjective experience of seeking primary health care. In the course of the study, three main strategies for seeking primary health care were identified: The strategy of emergency treatment for primary health care involves treatment exclusively in critical situations. The strategy of frequent access to primary health care is characterized by regular interaction with medical institutions. The strategy of therapeutic treatment for primary health care focuses on preventive visits and planned treatment. The results show differences in the frequency and nature of requests depending on the place of residence. Urban residents are more likely to seek primary health care, while in rural areas they apply less regularly. These differences underline the importance of studying the subjective perception of primary health care and the experience of older people in various social and territorial contexts.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 2","pages":"187-196"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Associations of impaired physical status and visual pathology in the elderly.] [老年人身体状况受损与视觉病理的关系。]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

A A Trofimova, A M Grjibovski, V V Popov, S S Mokeeva

{"title":"[Associations of impaired physical status and visual pathology in the elderly.]","authors":"A A Trofimova, A M Grjibovski, V V Popov, S S Mokeeva","doi":"","DOIUrl":"","url":null,"abstract":"Aging is associated with a decline in the patient's physical, mental, and social domains. The physical condition of the elderly is assessed by measuring walking speed, balance impairment, assessing the risk of falls syndrome and other methods. Sensory deficits are also part of the aging body and can affect physical status. It is necessary to know how the parameters of physical status can change in certain pathologies of sensory organs, in particular the eyes. Objective: to study the relationship between physical status disorders and visual pathology in patients over 60 years of age. The database was compiled on the basis of medical records of 481 patients of the Arkhangelsk War Veterans Hospital JSC from 2019-2023. Impaired characteristics of physical status increased with increasing age group; women were mostly affected by impaired physical status. Associations with decreased walking speed were shown by glaucoma OR=1,74; 95% CI 1,10-2,77, cataract OR=1,83; 95% CI 1,12-2,97, retinopathy OR=2,15; 95% CI 1,09-4,03 and refractive error OR=1,47; 95% CI 1,14-2,53. Worsening of the Time up and go test showed refractive error OR 1,47; 95% CI 1,14-2,53. An increased risk of falls according to the Morse scale was shown by uncorrected vision OR 1,51; 95% CI 1-2,26. The listed diseases can serve as ophthalmic pathology markers when introducing a geriatric approach and constructing an algorithm for providing ophthalmological care to the elderly.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"81-86"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prognostic factors in elderly patients with diffuse large B-cell lymphoma and their treatment results.] [老年弥漫性大b细胞淋巴瘤患者预后因素及治疗效果]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

L O Ametova, V B Kaliberdenko, A A Yatsenko, G R Asanova, D A Yakushev, E S Syskova, A S Goncharova, M I Shlapak, P V Nevedomskaya, M V Prutin, A V Tupikin, D A Kerimova

{"title":"[Prognostic factors in elderly patients with diffuse large B-cell lymphoma and their treatment results.]","authors":"L O Ametova, V B Kaliberdenko, A A Yatsenko, G R Asanova, D A Yakushev, E S Syskova, A S Goncharova, M I Shlapak, P V Nevedomskaya, M V Prutin, A V Tupikin, D A Kerimova","doi":"","DOIUrl":"","url":null,"abstract":"Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Treatment of elderly patients with NHL has always been a challenge; however, treatment statistics have begun to show favorable results similar to those of younger patients with DLBCL, thanks to new treatment protocols. The aim of this study is to evaluate the impact of prognostic factors on survival and efficacy of therapy in elderly patients with DLBCL in the Republic of Crimea. This study included 87 patients diagnosed with DLBCL who were treated in the Department of Hematology and Chemotherapy of the N.A. Semashko Republican Clinical Hospital from 2008 to 2024. The mean age was 72 (65-89) years, and 13 (14,9%) patients were over 80 years old. The median follow-up time was 42 months, and 45 patients (51,7%) died during the follow-up period. The median overall survival (OS) was 55 months, and the median progression-free survival was calculated as 27 months. Sixty-three patients (72,4%) received standard therapy R-CHOP. Complete response was achieved in 46 patients (52,9%). The median survival for patients with complete response was 136 months (p<0,001); however, OS was not statistically different between elderly (>80 years) and young patients (p=0,236). According to our results, we believe that the opportunity to undergo standard therapy R-CHOP is vital for the survival of elderly patients with DLBCL.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 2","pages":"236-242"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Tumor necrosis factor in fibroblasts of human dermis in the process of physiological aging.] [生理性衰老过程中真皮成纤维细胞肿瘤坏死因子的研究]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

A G Gunin, N N Golubtzova, T G Denisova, E V Miheeva

{"title":"[Tumor necrosis factor in fibroblasts of human dermis in the process of physiological aging.]","authors":"A G Gunin, N N Golubtzova, T G Denisova, E V Miheeva","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this work was to examine the content of tumor necrosis factor in fibroblasts of human dermis from the development until 85 years old, and defining of a role of this protein age-dependent changes in the number of fibroblasts in the dermis. Tumor necrosis factor, proliferating cells nuclear antigen (PCNA), marker of fibroblasts vimentin were detected with indirect immunohistochemical staining. Results showed that portion of fibroblasts with positive staining for tumor necrosis factor in the dermis is increased from 20 weeks of pregnancy until 60 years old followed by a little decrease in age interval 61-85 years old. Common number and percent of PCNA positive fibroblasts in dermis are decreased with age with more expressed changes until 40 years old. Correlation analysis showed that age dependent decrease in the number of fibroblasts and their proliferative activity is significantly associated with increase in the number of dermal fibroblasts positively stained for tumor necrosis factor. Results obtained allow to suggest that tumor necrosis factor plays a role in age dependent decrease in the number of fibroblasts and their proliferation in human dermis.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 2","pages":"229-235"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Influence of retroelements on the relationship between aging and neurodegenerative diseases.] [逆转录因子对衰老与神经退行性疾病关系的影响]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

R N Mustafin

{"title":"[Influence of retroelements on the relationship between aging and neurodegenerative diseases.]","authors":"R N Mustafin","doi":"","DOIUrl":"","url":null,"abstract":"During physiological aging, pathological activation of retroelements with accumulation and aggregation of beta-amyloid, tau, alpha-synuclein, and TDP-43 proteins is observed in the brain, which may be the cause of progressive decline in cognitive abilities with age. In neurodegenerative diseases, these processes are enhanced by hereditary predisposition (disease-associated polymorphisms are localized mainly in intronic and intergenic regions where retroelements are located) and specific viral infections. This leads to hyperactivation of retroelements, which is reflected in changes in epigenetic factors involved in the pathogenesis of neurodegenerative diseases, since the same viruses that cause activation and aggregation of beta-amyloid, tau, alpha-synuclein and TDP-43 stimulate transcription of retroelements. The resulting aggregates cause derepression of retroelements, since these proteins normally inhibit transcription of retroelements. The listed processes occur at the epigenetic level, since they do not affect DNA sequences, and the key participants are retroelements, which are drivers of epigenetic regulation. Therefore, for the treatment of neurodegenerative diseases, it may be promising to develop therapeutic interventions aimed at the activity of retroelements, which has already shown its effectiveness in the treatment of multiple sclerosis, an autoimmune disease of the central nervous system, in which persistent inflammation and demyelination processes lead to the onset of neurodegeneration with proven involvement of retroelements in the pathogenesis.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"71-80"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Vasosspastic angina: current concepts about pathogenesis, diagnosis, treatment (literature review).] [血管痉挛性心绞痛：发病、诊断、治疗的最新概念（文献综述）]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2025-01-01

A V Barsukov, E V Borisova, I A Vasilyeva, D V Glukhovskoy, M V Kuznetsov, G B Saraev

{"title":"[Vasosspastic angina: current concepts about pathogenesis, diagnosis, treatment (literature review).]","authors":"A V Barsukov, E V Borisova, I A Vasilyeva, D V Glukhovskoy, M V Kuznetsov, G B Saraev","doi":"","DOIUrl":"","url":null,"abstract":"The review examines risk factors, triggers, diagnostic approaches, treatment and preventive strategies for vasospastic angina (VSA). Transient coronary spasm plays an important role in the pathogenesis of stable angina and acute coronary syndromes. Among the factors in the pathogenesis of VSA, the most relevant are sympatho-vagal imbalance, endothelial dysfunction, hypercontractility of smooth muscle cells of the coronary arteries, intravascular and perivascular inflammation, and genetic predisposition. The review provides diagnostic criteria for VSA based on clinical manifestations, electrocardiographic data and angiographic documentation of coronary spasm. Indications and contraindications for intracoronary administration of vasospasm provoking agents are described. Current ideas about traditional and innovative (including interventional) approaches to the treatment and prevention of VSA are revealed. Insufficient study of the problem of VSA in elderly and senile patients has been noted. The factors that have the most adverse impact on the quality of life and prognosis in patients with recurrent coronary spasm are identified.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"38 1","pages":"36-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0