Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo最新文献

{"title":"[The role of physical activity in the transition from pre‑frailty to frailty.]","authors":"A S Rukavishnikov, O M Kuzminov, S G Gorelik, D P Piskunov","doi":"10.34922/AE.2026.39.1.014","DOIUrl":"10.34922/AE.2026.39.1.014","url":null,"abstract":"<p><p>The aim of the study was to assess the role of physical activity in the transition from pre-frailty to frailty in older adults under hypomobility conditions. The study included 143 elderly patients aged 65-74 years. A comprehensive geriatric assessment was performed using specialized software at baseline, after 1 month, and after 6 months. A decrease in physical activity, both short-term and prolonged, was associated with deterioration of muscle function in patients with pre-frailty. Significant positive correlations were found between handgrip strength dynamics and changes in the maximal torque of lower limb muscles (r from +0,763 to +0,902; p<0,05), indicating a systemic decline in muscle function. Patients with an unfavorable course demonstrated progressive worsening in SARC-F scores and the six-minute walk test. The heterogeneity of pre-frailty progression was established, with two main variants identified: stable and progressive, the latter leading to frailty development. Reduced physical activity was the most significant factor associated with progression, contributing to dynapenia and sarcopenia. The findings confirm the key role of physical activity in preventing the progression of pre-frailty and support the need for targeted interventions aimed at maintaining mobility in older adults.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 1","pages":"124-127"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Psychological predictors of generativity in socially active elderly women.]","authors":"V A Kapustina, A S Melnikova","doi":"10.34922/AE.2026.39.2.006","DOIUrl":"https://doi.org/10.34922/AE.2026.39.2.006","url":null,"abstract":"<p><p>The article examines the transformations in intergenerational transmission of experience in the context of digitalization, globalization, and increased life expectancy. Modern sociological and psychological research demonstrates that the traditional monological model of knowledge transfer is giving way to intergenerational dialogue based on mutual exchange of experience and values. Special attention is paid to the concept of generativity as the ability of older generations to pass on knowledge and maintain connections with younger ones. An empirical study conducted on a sample of socially active elderly women (n=88, women aged 57-79) revealed significant correlations between generativity, healthy lifestyle, and self-compassion. It was found that the key predictor of generativity is the pursuit of personal growth (β=1,23, p<0,001), highlighting the importance of self-development for successful intergenerational communication. The results underscore the need for programs that foster intergenerational dialogue by promoting active aging, psychological well-being, and value continuity.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 2","pages":"213-218"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[State computer literacy courses for the older in Russia and the Republic of Belarus: A comparative analysis.]","authors":"K A Galkin","doi":"10.34922/AE.2026.39.2.007","DOIUrl":"10.34922/AE.2026.39.2.007","url":null,"abstract":"<p><p>The article examines the features of the development of computer literacy courses for the older in Russia and the Republic of Belarus, as well as barriers to the development of such courses and possible ways and prospects for the development of digital technology and knowledge education for the older. The empirical basis of the study is an analysis of similar course programs implemented in Russia and the Republic of Belarus over the past five years and scientific publications on the topic of information and communication technologies education for the older in the two countries. As part of our analysis, we identified the main common features of the development of information and communication technologies courses for the older in Russia and Belarus, and also identified a number of differences in the development of such courses. The main prospects for the development of such courses were highlighted and the importance and significance of the digital socialization of the older and the development of programs for the integration of the older into the digital environment in Russia and Belarus, as well as opportunities for such integration, were noted. The study also noted the development of such courses and key trends in the development of such courses in the two countries.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 2","pages":"219-228"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Regional clinical and epidemiological features of chronic obstructive pulmonary disease in elderly and senile patients of the Rostov region.]","authors":"T V Tayutina, D D Shender, N Y Klimenko, A V Lysenko","doi":"10.34922/AE.2026.39.2.002","DOIUrl":"10.34922/AE.2026.39.2.002","url":null,"abstract":"<p><p>The aim of the study was to evaluate the regional clinical and epidemiological features of COPD in elderly and senile patients living in the Rostov region. A retrospective analysis of 1337 outpatient records and medical records of elderly and senile COPD patients was conducted. The following were analyzed: gender, level of education, the influence of risk factors on the development of the disease, anamnestic data, the severity of dyspnea according to the mMRc scale, quality of life according to the CAT scale, the number and severity of exacerbations, functional changes in the bronchopulmonary system and the presence of concomitant diseases. An increase in the prevalence of COPD with age in male smokers and a relationship between the development of the pathology in women and residence in a regional center have been established. Significant features of COPD in the Rostov region were severe course with frequent exacerbations, high prevalence of comorbid cardiovascular pathology and concomitant malignant neoplasms of the bronchopulmonary system. The analysis of the obtained data indicates the need to take into account the regional characteristics of the course of COPD in elderly and senile patients in order to increase the effectiveness of measures to prevent the development and progression of the disease.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 2","pages":"183-189"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnostic value of molecular biomarkers in evaluating dental implantation results in middle-aged and elderly patients.]","authors":"A A Polyakova, S B Maltsev, I B Oleksyuk, P V Pankratiev, I R Siraev, K L Kozlov","doi":"10.34922/AE.2026.39.1.012","DOIUrl":"10.34922/AE.2026.39.1.012","url":null,"abstract":"<p><p>In the context of an aging population, there is an increasing need for dental implantation in middle-aged and elderly patients with partial tooth loss. Despite the high clinical effectiveness of dental implantation, which is reflected in the high frequency of implant survival in long-term follow-up, the development of periimplant inflammatory complications remains a relevant clinical issue. This problem is particularly relevant for elderly patients, who are characterized by age-related changes in inflammatory regulation, angiogenesis, and the epithelial barrier, which can negatively affect the processes of implant osteointegration and the condition of periimplant tissues. The aim of the study is to evaluate the diagnostic significance of molecular markers of inflammation (COX-1, COX-2, COX-3), angiogenesis (VEGF, VEGFR) and epithelial adhesion (claudin-1, E-cadherin) as tools for early diagnosis and prediction of clinical outcomes of dental implantation in middle-aged and elderly patients. The study included 184 patients divided into two groups - middle-aged and elderly. The biomaterial was buccal epithelium, the expression of molecules was determined before implantation and 6 months later by immunocytochemistry. In middle-aged patients, 6 months after implantation, there was a decrease in COX-1 expression by 33,6%, COX-2 by 47% and COX-3 by 40%, as well as a more than twofold increase in the levels of VEGF and VEGFR (p<0,05). In elderly patients, the decrease in COX-2 and COX-3 expression was less pronounced (17 and 14%, respectively), with insufficient angiogenic response and a significant decrease in claudin-1 and E-cadherin (p<0,01). Age is an independent modifying factor for the outcomes of implantation. A panel of biomarkers, including COX-1,2,3, VEGF, VEGFR, claudin-1 and E-cadherin, can be used for early stratification of the risk of complications and formation of personalized clinical and preventive approaches in dental implantation.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 1","pages":"106-112"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147975931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Some determinants of modern gerontology.]","authors":"U S Moskvitina, O A Osipova, O A Polyakova, N I Klyushnikov, N A Brezhneva, A A Stepanyants, Y A Mezentsev","doi":"10.34922/AE.2026.39.1.017","DOIUrl":"10.34922/AE.2026.39.1.017","url":null,"abstract":"<p><p>This paper aims to update, systematize, and describe data on the most important gerontological determinants - social status, health status, physical functioning, and mental state - as they significantly influence the well-being and duration of active life in older adults. Based on a review of available english-language literature from international and Russian scientific databases, the authors elucidate the meaning of each determinant in its traditional conception and from the perspectives of various disciplines and approaches. They examine the specifics of its gerontological context and highlight the latest methodologies aimed at maintaining these components. The research proposes a framework for a four-component model of gerontological determinants, which presents these factors as elements of a single, interdependent system. The work is structured as an analytical narrative review and is intended to form a holistic view of the current state of gerontological theory and practice. It emphasizes the necessity of a comprehensive approach that integrates the development of the healthcare system, the adaptation of digital technologies, and the formation of a supportive environment to ensure active longevity in the context of global trend to aging of the population.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 1","pages":"144-153"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147975995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of the medical and social status of hundred-year centenarians in the Chelyabinsk region.]","authors":"T A Bezuglyy, A I Kuzin, O V Camerer, R N Mnatsakanyan, S V Derkach, E R Khakimova","doi":"10.34922/AE.2026.39.1.018","DOIUrl":"10.34922/AE.2026.39.1.018","url":null,"abstract":"<p><p>The analysis of demographic trends reveals a sustained pattern of population aging. This process is associated with both declining fertility rates and increasing life expectancy. Despite these well-documented global demographic shifts, the health status of centenarians remains understudied. The aim of this research is to assess the medical and social status of centenarians in the Chelyabinsk Region. To investigate the health of centenarians, data extraction was performed for patients aged 100 years and older. The final database comprises 72 records detailing the health status and parameters of hundred-year centenarians in the Chelyabinsk Region. Each entry includes age, sex, diagnosis upon presentation, anthropometric measurements (height, weight, BMI), and a range of laboratory indicators from complete blood count and biochemical panels. The most prevalent conditions among the centenarian population of the Chelyabinsk Region belong to the following nosological groups: «I.67 Other cerebrovascular diseases» - recorded as either a primary or concomitant diagnosis in 65,27% of patients; «I.11 Hypertensive heart disease» - 51,39%; and «I.20 Angina pectoris» - 22,22%. These conditions were found in both the group of centenarians with disability and the group without this social status. In the group of patients without disability, the diagnosis «I.11 Hypertensive heart disease» as a primary diagnosis (46,5%) upon presentation to a healthcare facility is established statistically significantly more often than in the group of centenarians with the aforementioned social status (disability) (17,24%), p<0,05. A statistically significant difference exists in the number of clinical diagnoses between individuals with disability - 5 (4-6) and those without this status - 3 (2-3,5). This supports the assertion of a link between permanent loss of working capacity and polymorbidity (p<0,001). Venous blood glucose levels are statistically significantly higher in the group of hundred-year centenarians without disability (p<0,05).</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 1","pages":"154-159"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prognostic model of the course of pulmonary tuberculosis in the elderly: The role of signaling molecules.]","authors":"Y S Krylova, M A Dokhov, T S Zubareva, Y I Startseva, A S Panfilova, Y I Belova, I A Zaytsev, P K Yablonskiy","doi":"10.34922/AE.2026.39.1.007","DOIUrl":"10.34922/AE.2026.39.1.007","url":null,"abstract":"<p><p>The most important socially significant disease is pulmonary tuberculosis, which is based on the development of granulomatous inflammation with the formation of fibrosis. In the elderly, it occurs with the features of pathomorphosis, due to the presence of comorbid pathology. The processes of development of coarse-fibrous connective tissue, sclerosis-fibrosis occur according to the general patterns with the involvement of the organ stroma, vessels and remodeling of the connective-tissue matrix, the study of which is impossible without the study of the relevant molecular markers. On the other hand, diagnosis and treatment are impossible without understanding the dynamics of the pathological process. Therefore, research aimed at predicting the development of pulmonary tuberculosis (especially in elderly patients) is undoubtedly relevant. The aim of the study - to create a prognostic model of the severity of the course of pulmonary tuberculosis in elderly patients. In the course of the study, the outcomes of treatment of 45 patients treated in Saint-Petersburg Research Institute of Phthisiopulmonology were analyzed. Based on the degree of activity of the tuberculous process by B.M.Ariel (1998), groups with pulmonary tuberculosis without progression and active inflammatory changes with progression were allocated. Quantitative assessment of the expression of signaling molecules (TIMP-1, NGF, CD44, CD51, CD68, CD83, Vit D) was performed using immunohistochemical morphometry and computer analysis of microscopic images. The prediction model was constructed using logistic regression. In the course of the study, the activity of monoclonal antibodies for the corresponding signaling molecules was studied: TIMP-1, NGF, CD44, CD51, CD68, CD83, Vit D, statistically significant differences in the relative area of expression of the following biological markers were established: NGF, CD68, CD83 depending on the degree of tuberculosis activity. Logistic regression was used to create a model for predicting the course of the tuberculosis process. Based on the numerical values of molecular markers (NGF, CD-68, and CD-83), a logistic regression equation was obtained that allows for the association of the severity of the disease with the levels of the markers. The sensitivity of the model was 85,7%, and the specificity was 87,5%. Thus, the obtained regression model based on the expression of molecular markers NGF, CD-68, and CD-83 allows for the prediction of the severity of pulmonary tuberculosis in elderly patients, which will enable the control of treatment in these patients.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 1","pages":"69-73"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The relationship between resilience and magical ideation in the elderly.]","authors":"V A Kapustina, N S Zakharova","doi":"10.34922/AE.2026.39.1.019","DOIUrl":"10.34922/AE.2026.39.1.019","url":null,"abstract":"<p><p>The article examines the relationship between magical thinking and resilience in elderly individuals. Magical thinking is considered as a psychological mechanism serving a protective function under conditions of stress and age-related crises associated with aging. An empirical study conducted on a sample of 92 elderly people (aged 59-74) revealed positive correlations between magical thinking indicators (measured by the MIS scale) and overall resilience (Rs=0,22, p<0,02), with resilience components such as self-efficacy (Rs=0,21, p<0,001), internal locus of control (Rs=0,20, p<0,001), and spirituality (Rs=0,32, p<0,001). The results suggest that belief in the supernatural and rituals may serve as a resource for maintaining psychological resilience in old age, complementing self-confidence and moral-ethical values. However, no correlation was found with adaptive strategies, indicating potential passivity in stress management. Special attention is given to the study's limitations related to sample characteristics (active, educated elderly individuals). The work emphasizes the need for further research on the role of magical thinking in self-regulation and stress coping within this age group.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 1","pages":"160-165"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Aortic valve defects as a risk factor for delelopment and complications of coronary artery disease in the elderly.]","authors":"E Y Leonov, E I Shabaeva, N V Popova, O A Кozyrev","doi":"10.34922/AE.2026.39.3.004","DOIUrl":"https://doi.org/10.34922/AE.2026.39.3.004","url":null,"abstract":"<p><p>The presence of aortic valve defects in patients is associated with a more severe course of coronary heart disease and heart failure. This article examines the impact of aortic valve defects on the risk of developing and progressing coronary heart disease. The study was conducted based on a retrospective statistical assessment of own clinical experience (a sample of 193 patients in whom the most significant indicators of cardiac function and hemodynamics were determined) and literature data. A significant decrease in the heart's ability to relax and, consequently, greater severity of diastolic dysfunction, manifested by an increase in the size of the left atrium and the diastolic diameter of the LV, were found in patients with aortic valve defects. A relationship between aortic valve defects and the presence of multivessel atherosclerotic lesions was established. For all parameters, p<0,05. The presence of aortic valve defects negatively impacts the course of coronary artery disease, leading to disruption of myocardial structure and function. This fact must be taken into account when assessing the severity of the disease, choosing treatment strategies, and determining the patient's prognosis.</p>","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"39 3","pages":"365-370"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}