[Potentiating effect of glutamyl-cysteinyl-glycine disodium in the complex treatment of multidrug-resistant tuberculosis in rabbits of different ages.]

Abstract

The high incidence of tuberculosis and the difficulties of its treatment in older age groups are currently an urgent problem in gerontology. The aim of the study was to evaluate the potentiating effect of glutamyl-cysteinyl-glycine disodium in combination with bedaquiline in patients with multidrug-resistant tuberculosis in animals of different ages. The study was conducted on 75 male rabbits of the Soviet Chinchilla breed. Groups of young, middle-aged and elderly animals were formed. A subgroup of infection control (without treatment) was identified in each age group; the treatment control subgroup (infected animals treated only with bedaquiline); the main subgroup (infected animals treated with bedaquiline + glutamyl-cysteinyl-glycine disodium). Computed tomography of the chest organs of animals in the main subgroups showed a lower severity of low intensity focal infiltrative changes in the lungs than in animals from the comparison subgroups, which may indicate the potentiating effect of the drug glutamyl-cysteinyl-glycine disodium. The results obtained indicate the prospects for further study of the possibility of including glutamyl-cysteinyl-glycine disodium in tuberculosis treatment regimens, including for patients of older age groups.