[Assessment of the severity of oxidative stress and inflamaging in elderly patients with copd who have suffered an ischemic stroke.]

Abstract

The study assessed the severity of inflamaging, lipid peroxidation, as well as the state of antioxidant protection in elderly patients with chronic obstructive pulmonary disease (COPD), depending on the ischemic stroke (IS). A prospective cohort study included 138 elderly patients (mean age 68±4 years). Of these, the 1st (control) group consisted of 30 people who did not have established COPD and cardiovascular diseases comparable in gender and age to the patients of the main group. The main group included 108 patients, of which 53 people [42 (79,2%) men and 11 (20,8%) women] had COPD outside the exacerbation (2nd group), and 55 people [41 (74,5%) men and 14 (25,5%) women] with COPD outside the exacerbation who underwent IS (3rd group). It was found that elderly patients with COPD who underwent IS have more pronounced dysproteinemia, high insulin resistance index (40,4%, p<0,001), NLR (23,2%, p<0,01), MLR (22,9%, p<0,01), CRP (18,4%, p<0,01), MCP-1 (25,9%, p<0,01) compared to the COPD group. An increase in the processes of lipid peroxidation was revealed - the total oxidative capacity (15,9%, p<0,05), oxidized LDL (18,2%, p<0,01), malondialdehyde (17,4%, p<0,01) and a decrease in the body's antioxidant system - vitamin E (34,4%, p<0,01), superoxide dismutase (21,1%, p<0,01), with an increase in the homocysteine content in blood plasma by 28,3% (p<0,01). Thus, the data obtained indicate the maximum severity of inflamaging and imbalance of pro- and antioxidants in the pathogenesis of COPD comorbidity and ischemic stroke in the elderly.