Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo最新文献_第6页

[Gender-specific differences in postural balance among non-working retirees aged 65-69 years.] [65-69岁非在职退休人员在姿势平衡方面的性别差异]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

A V Dyomin, N V Blokhina, A N Ilnitski, A A Spitsina, O M Ivko, A U Gekhaev

{"title":"[Gender-specific differences in postural balance among non-working retirees aged 65-69 years.]","authors":"A V Dyomin, N V Blokhina, A N Ilnitski, A A Spitsina, O M Ivko, A U Gekhaev","doi":"","DOIUrl":"","url":null,"abstract":"The study was aimed at obtaining new knowledge about the balance function of non-working retirees, including data on the gender-specific characteristics of postural balance (PB) after retirement. The participants comprised 30 men and 30 women within the age range of 65-69 years, retired and unemployed. The subjective age (SA) of the examined individuals was determined by asking them how old they actually felt. For a comprehensive assessment of the components of PB, the Sensory Organization Test (SOT) and the Motor Control Test (MCT) were carried out using the computer posturography complex «Smart Equitest Balance Manager». Comparative analysis of SA did not reveal any gender-specific differences in ageing perception among retirees aged 65-69 years. It has been established that retirement does not lead to a deterioration in age-related self-esteem in older people. Analysis of the resulting MCT assessment also did not reveal any gender-related differences in coordinated motor reactions and sensorimotor support of postural control in retired people between 65 and 69 years of age. However, a comparative assessment of SOT indicators showed that retired women have a decrease in static-dynamic balance and automatic postural control, as well as a decrease in the degree of participation of vestibular information in the control of balance. The findings of the study suggest that it is precisely these functional changes that are the root causes that increase the risk of falls in women after 64 years of age. Thus, we have established gender-specific differences in the components of PB among non-working retirees, which indicates the need to take into account gender characteristics when developing preventive measures aimed primarily at reducing the risk of falls.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 6","pages":"714-721"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Epigenetic mechanisms of the interrelations of osteoarthritis with aging.] [骨关节炎与衰老相互关系的表观遗传学机制]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

R N Mustafin

引用次数: 0

[Early measurement of digoxin concentration in blood serum to predict adverse events in older age groups with chronic heart failure and atrial fibrillation.] [早期测量血清中的地高辛浓度，预测老年慢性心力衰竭和心房颤动患者的不良事件]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

A A Yakovlev, G A Ryzhak, A S Pushkin

{"title":"[Early measurement of digoxin concentration in blood serum to predict adverse events in older age groups with chronic heart failure and atrial fibrillation.]","authors":"A A Yakovlev, G A Ryzhak, A S Pushkin","doi":"","DOIUrl":"","url":null,"abstract":"To evaluate the effect of early measurement of serum digoxin concentration (SDC) on therapeutical safety and efficacy in patients with recent-onset atrial fibrillation and heart failure. De novo ventricular arrhythmias, high-grade AV node or sinus node blocks were noted in 22%, this risk was positively associated with endpoint SDC (mean SDC 0,88±0,78 ng/mL vs 0,45±0,71 ng/mL, p=0,039) irrespective of baseline characteristics. Empiric calculators for long-term digoxin monitoring correlated with both SDC (r=0,54...0,58, p=0,008...0,003) and risk of conductivity disturbances. Re-hospitalizations by urgent cardiovascular indications within 10 months were associated with higher endpoint SDC (0,82±0,77 ng/mL in hospitalized patients vs 0,42±0,44 ng/mL in non-hospitalized, p=0,009), with no association between early SDC and deaths. Early SDC monitoring may minimize the risk of adverse events in the treatment of atrial fibrillation. Existing empirical SDC calculators can also be used in clinical practice, but their predictive value for assessing the long-term safety of digoxin therapy remains unclear and requires further study.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 4","pages":"344-351"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Assessment of the severity of oxidative stress and inflamaging in elderly patients with copd who have suffered an ischemic stroke.] [评估缺血性脑卒中老年患者氧化应激和炎症的严重程度]。

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

O A Osipova, Y A Lykov, L V Vasilyeva, E V Gosteva, V V Andreeva, R N Shepel, M S Litvinov

{"title":"[Assessment of the severity of oxidative stress and inflamaging in elderly patients with copd who have suffered an ischemic stroke.]","authors":"O A Osipova, Y A Lykov, L V Vasilyeva, E V Gosteva, V V Andreeva, R N Shepel, M S Litvinov","doi":"","DOIUrl":"","url":null,"abstract":"The study assessed the severity of inflamaging, lipid peroxidation, as well as the state of antioxidant protection in elderly patients with chronic obstructive pulmonary disease (COPD), depending on the ischemic stroke (IS). A prospective cohort study included 138 elderly patients (mean age 68±4 years). Of these, the 1st (control) group consisted of 30 people who did not have established COPD and cardiovascular diseases comparable in gender and age to the patients of the main group. The main group included 108 patients, of which 53 people [42 (79,2%) men and 11 (20,8%) women] had COPD outside the exacerbation (2nd group), and 55 people [41 (74,5%) men and 14 (25,5%) women] with COPD outside the exacerbation who underwent IS (3rd group). It was found that elderly patients with COPD who underwent IS have more pronounced dysproteinemia, high insulin resistance index (40,4%, p<0,001), NLR (23,2%, p<0,01), MLR (22,9%, p<0,01), CRP (18,4%, p<0,01), MCP-1 (25,9%, p<0,01) compared to the COPD group. An increase in the processes of lipid peroxidation was revealed - the total oxidative capacity (15,9%, p<0,05), oxidized LDL (18,2%, p<0,01), malondialdehyde (17,4%, p<0,01) and a decrease in the body's antioxidant system - vitamin E (34,4%, p<0,01), superoxide dismutase (21,1%, p<0,01), with an increase in the homocysteine content in blood plasma by 28,3% (p<0,01). Thus, the data obtained indicate the maximum severity of inflamaging and imbalance of pro- and antioxidants in the pathogenesis of COPD comorbidity and ischemic stroke in the elderly.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 4","pages":"404-409"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Efficiency of computerized cognitive training for prevention of cognitive impairments and stimulation of neuroplasticity.] [计算机化认知训练在预防认知障碍和刺激神经可塑性方面的效率]。

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

I V Shirolapov, A V Zakharov, A A Shishkina, M S Sergeeva, Y S Komarova, N P Romanchuk, V M Bannov, O G Kuznetsova, E V Khivintseva

{"title":"[Efficiency of computerized cognitive training for prevention of cognitive impairments and stimulation of neuroplasticity.]","authors":"I V Shirolapov, A V Zakharov, A A Shishkina, M S Sergeeva, Y S Komarova, N P Romanchuk, V M Bannov, O G Kuznetsova, E V Khivintseva","doi":"","DOIUrl":"","url":null,"abstract":"Computerized cognitive training (CCT) is a rapidly developing area of cognitive rehabilitation at the intersection of information technology and healthcare, the constantly updated results of which can be successfully translated into practical application in clinical medicine and in particular in gerontology. The basis of CCT, as a non-invasive method of influencing the functional activity of the brain and the processes of neuroplasticity, is software for stimulating cognitive functions in order to improve their productivity. The level of scientific and practical interest in CCP technology is growing rapidly. The article reports on the current state of research on the use of CCT aimed at correcting cognitive impairment. The purpose of this work is to systematize the available scientific data in this area, as well as to promote further integration of research in the field of information technology into clinical practice, in particular, to study the potential of CCT as a promising therapeutic tool in the paradigm of successful aging and prevention of the progression of cognitive impairment. This noninvasive intervention may improve global cognitive function in patients with clinically defined impairments and during normal aging in cognitively healthy older adults. However, new studies with fully comparable protocols are needed to evaluate in more detail the duration of the effect and the effectiveness of CCT in preventing cognitive decline in the long term.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 3","pages":"221-229"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Association between emotional disorders and ophthalmopathology in residents of the Arkhangelsk region at the age of 60-74 years.] [阿尔汉格尔斯克州60-74岁居民情绪失调与眼科病理学之间的关系]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

A A Trofimova, A V Kudryavtsev, V A Postoev, R N Zelentsov, I A Novikova, A L Sannikov

{"title":"[Association between emotional disorders and ophthalmopathology in residents of the Arkhangelsk region at the age of 60-74 years.]","authors":"A A Trofimova, A V Kudryavtsev, V A Postoev, R N Zelentsov, I A Novikova, A L Sannikov","doi":"","DOIUrl":"","url":null,"abstract":"A study was conducted to investigate the associations of the diseases of the organ of vision and its accessory apparatus with anxiety and depression in the elderly people. The study included 678 participants of the ESSE-RF3 population study in the Arkhangelsk region in the age of 60-74 years. We used a questionnaire, including the hospital scale of anxiety and depression score (HADS), and the assessment of the ophthalmological status. It was found that all the study participants had diseases of the visual organ. Elevated depression scores were associated with sex, age, marital status (being single), and disability, elevated anxiety scores - with sex. The scores on the anxiety scale were on average 25% higher in participants whose visual acuity decreased to 0,5 units, and showed no independent associations with diagnosed ophthalmological diseases. The scores on the depression scale were on average 33% higher in participants with visual acuity 0,5 units, and 22% higher in the presence of retinopathy. In conclusion, anxiety and depression in the elderly people were more associated with visual deficits rather than with the presence of ophthalmological diseases underlying a decrease in functional status.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 1-2","pages":"72-79"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Novel integrative multi-omics strategies of human's biological age computation.] [人类生物年龄计算的多组学综合新策略]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

I A Solovev

{"title":"[Novel integrative multi-omics strategies of human's biological age computation.]","authors":"I A Solovev","doi":"","DOIUrl":"","url":null,"abstract":"Multi-omics methods for analysing postgenomic data have become firmly established in the tools of molecular gerontology only in recent years, since previously there were no comprehensive integrative approaches adequate to the task of calculating biological age. This paper provides an overview of existing papers on multi-omics integrative approaches in calculating the biological age of a human. An analysis of the most common options for integrating methylomic, transcriptomic, proteomic, microbiomic and metabolomic datasets was carried out. We defined (1) concatenation (machine learning), in which models are developed using a concatenated data matrix, formed by combining multiple omics data sets; (2) fusion model approaches that create multiple intermediate submodels for different omics data to then build a final integrated model from the various intermediate submodels; and (3) transformation methods (via artificial intelligence) that first transform each of the single omics data sets into core plots or matrices, and then combine them all into one graph before building an integral complex model. It is unlikely that multi-omics approaches will find application in anti-aging personalized medicine, but they will undoubtedly deepen and expand the understanding of the fundamental processes standing behind the phenomenon of the biological aging clocks.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 1-2","pages":"21-25"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Using of the film therapy in psychocorrective work with the elderly.] [在老年人心理矫正工作中使用电影疗法]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

L V Tokarskaya, O I Dorogina, M F Borisenkov

引用次数: 0

[Prospects for use of short peptides in pharmacotherapeutic correction of Alzheimer's disease.] [利用短肽对阿尔茨海默病进行药物治疗的前景]

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

A R Ilina, I G Popovich, G A Ryzhak, V K Khavinson

引用次数: 0

[Analysis of age-related incidence (by circulation) of age-associated pathology in 2018-2023 on the example of the municipal polyclinic of Saint-Petersburg.] [以圣彼得堡市综合医院为例，分析 2018-2023 年与年龄相关的老年病发病率（按循环）]。

Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo Pub Date : 2024-01-01

U R Saginbaev, S A Rukavishnikova, T A Akhmedov, E P Davydova, I V Merkulova

{"title":"[Analysis of age-related incidence (by circulation) of age-associated pathology in 2018-2023 on the example of the municipal polyclinic of Saint-Petersburg.]","authors":"U R Saginbaev, S A Rukavishnikova, T A Akhmedov, E P Davydova, I V Merkulova","doi":"","DOIUrl":"","url":null,"abstract":"From the age of 25-30, the likelihood of developing pathological processes associated with aging begins to increase. Age-associated diseases (AAD) are a heterogeneous group of pathologies that are more likely to develop as they age. Clinically, the early development of AAD is identical to premature aging with all the ensuing consequences. Timely targeted detection of AAD will slow down age-related processes. In order to study the peculiarities of age-related morbidity (by circulation), age-associated pathology, the study included 5 600 people with a newly diagnosed diagnosis who applied to the municipal polyclinic of St. Petersburg in 2017-2023. During the study, heterogeneity of the timing of the manifestation of AAD at the population level was found. In addition, the median age of patients was comparable to the value of the developed age-specific incidence index, which serves as a basis for continuing research in order to comprehensively assess the properties and limitations of the considered indicator.","PeriodicalId":35293,"journal":{"name":"Advances in gerontology = Uspekhi gerontologii / Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo","volume":"37 1-2","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0