[Early measurement of digoxin concentration in blood serum to predict adverse events in older age groups with chronic heart failure and atrial fibrillation.]

Q4 Medicine
A A Yakovlev, G A Ryzhak, A S Pushkin
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引用次数: 0

Abstract

To evaluate the effect of early measurement of serum digoxin concentration (SDC) on therapeutical safety and efficacy in patients with recent-onset atrial fibrillation and heart failure. De novo ventricular arrhythmias, high-grade AV node or sinus node blocks were noted in 22%, this risk was positively associated with endpoint SDC (mean SDC 0,88±0,78 ng/mL vs 0,45±0,71 ng/mL, p=0,039) irrespective of baseline characteristics. Empiric calculators for long-term digoxin monitoring correlated with both SDC (r=0,54...0,58, p=0,008...0,003) and risk of conductivity disturbances. Re-hospitalizations by urgent cardiovascular indications within 10 months were associated with higher endpoint SDC (0,82±0,77 ng/mL in hospitalized patients vs 0,42±0,44 ng/mL in non-hospitalized, p=0,009), with no association between early SDC and deaths. Early SDC monitoring may minimize the risk of adverse events in the treatment of atrial fibrillation. Existing empirical SDC calculators can also be used in clinical practice, but their predictive value for assessing the long-term safety of digoxin therapy remains unclear and requires further study.

[早期测量血清中的地高辛浓度,预测老年慢性心力衰竭和心房颤动患者的不良事件]
目的:评估早期测量血清地高辛浓度(SDC)对近期心房颤动和心力衰竭患者的治疗安全性和有效性的影响。22%的患者出现了新发室性心律失常、高级别房室结或窦房结阻滞,这种风险与终点SDC呈正相关(平均SDC为0.88±0.78纳克/毫升 vs 0.45±0.71 纳克/毫升,p=0.039),与基线特征无关。用于长期地高辛监测的经验计算器与 SDC(r=0,54...0,58,p=0,008...0,003)和传导性障碍风险都有相关性。10 个月内因心血管疾病紧急指征再次住院与终点 SDC 较高有关(住院患者为 0,82±0,77 纳克/毫升,未住院患者为 0,42±0,44 纳克/毫升,p=0,009),早期 SDC 与死亡之间没有关联。在治疗心房颤动的过程中,早期 SDC 监测可将不良事件的风险降至最低。现有的经验性 SDC 计算器也可用于临床实践,但其对评估地高辛治疗长期安全性的预测价值仍不明确,需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
131
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