Zhi-Jun Meng , Yan-Ling Yu , Xin-Tong Chen , Tao Pang , Jian He , Chun-Chun Wang , Hong-Lu Zhang , Tian-Liang Wang , Bai-Ren Hu , Hong Peng
{"title":"Controllable fabrication of bioinspired pollen-like microparticles via solvent evaporation of polyvinyl alcohol (PVA)-stabilized microfluidic polymer microdroplets","authors":"Zhi-Jun Meng , Yan-Ling Yu , Xin-Tong Chen , Tao Pang , Jian He , Chun-Chun Wang , Hong-Lu Zhang , Tian-Liang Wang , Bai-Ren Hu , Hong Peng","doi":"10.1016/j.jcis.2026.139926","DOIUrl":"10.1016/j.jcis.2026.139926","url":null,"abstract":"<div><div>Shaping the polymeric materials into pollen-inspired microparticles with unique structural properties represent a promising area in drug delivery, environmental sensing, and biomaterials. This work reports a robust droplet microfluidic method for fabricating bioinspired pollen-like microparticles from polyvinyl alcohol (PVA) stabilized polymer-contained chloroform microdroplets followed by a solvent evaporation induced consolidation process. Monodisperse oil in water droplets containing dissolved polymer(s) in chloroform are initially generated in a glass capillary microfluidic device using an aqueous continuous phase containing PVA. The PVA provides robust droplet stability during the incubation/evaporation process by suppressing droplet coalescence and enabling reproducible interfacial conditions for morphology development. By systematically varying polymer type (homopolymer or copolymer), polymer concentration, PVA concentration (0.5% to 5.0% (<em>w</em>/<em>v</em>)), incubation temperature (5 °C to 30 °C), and the number of polymer components (one to four), we achieved precise control over particle morphology without requiring elaborately synthesized block copolymer or conjugate polymers. By leveraging these variables, comprehensive characterization through optical microimaging and scanning electron microscopy (SEM) are used to reveal distinct structural outcomes: single-component polymer droplets evolved into spherical microparticles with smooth, porous, or concave surfaces, whereas multi-component droplets yielded complex non-spherical and multi-compartment structures mimicking Bougainvillea, Canna, and Pinus pollen. This study elucidates the interplay between fabrication parameters and microparticle morphology properties, providing a versatile, synthesis-light strategy for innovatively designing functional microparticles with tunable bioinspired features from common polymers.</div></div>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"709 ","pages":"Article 139926"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zongmian Wang , Peng Zhao , Huanying Zhao , Zhonghan Li , Liqun Chi , Hao Wang , Wei Gu
{"title":"Disulfiram-enhanced bacterial cuproptosis-like death synergized with chemodynamic therapy for potentiated resistant infection treatment and accelerated wound healing","authors":"Zongmian Wang , Peng Zhao , Huanying Zhao , Zhonghan Li , Liqun Chi , Hao Wang , Wei Gu","doi":"10.1016/j.jcis.2026.139904","DOIUrl":"10.1016/j.jcis.2026.139904","url":null,"abstract":"<div><div>The bacterial cuproptosis-like death presents a promising strategy against antibiotic-resistant infections, yet its efficacy remains constrained by the insufficient influx of copper ions into bacteria. Inspired by the role of disulfiram (DSF) in disrupting copper homeostasis, we herein present an injectable hydrogel-based therapeutic system featuring DSF-enhanced bacterial cuproptosis-like death, synergistically combined with chemodynamic therapy (CDT), which demonstrated enhanced efficacy against methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) in both <em>in vitro</em> and <em>in vivo</em> models. Meanwhile, the underlying mechanism of DSF-enhanced bacterial cuproptosis-like death was explored at the transcriptional level. Moreover, the developed hydrogel fostered a pro-healing microenvironment by promoting angiogenesis, collagen deposition, and fibroblast proliferation in a mouse model of the MRSA-infected wound. This hydrogel-based DSF-enhanced bacterial cuproptosis-like death provides a synergized strategy for treating antibiotic-resistant infected wounds.</div></div>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"709 ","pages":"Article 139904"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xinxing Zhan , Ao Xu , Jiakai Zhang , Xiubin Ren , Yangyang Wang , Xin Tong , Yi Shao , Gang Wang , Xiaojie Liu
{"title":"Bifunctional mechanism of immobilized organic molecule to steer Zn2+ and polyiodides transport kinetics toward ultra-stable aqueous ZnI2 batteries","authors":"Xinxing Zhan , Ao Xu , Jiakai Zhang , Xiubin Ren , Yangyang Wang , Xin Tong , Yi Shao , Gang Wang , Xiaojie Liu","doi":"10.1016/j.jcis.2026.139884","DOIUrl":"10.1016/j.jcis.2026.139884","url":null,"abstract":"<div><div>Aqueous zinc‑iodine batteries (AZIBs) have been considered due to the significant potential for multi-electron transfer reactions and a high theoretical capacity of 211 mAh g<sup>−1</sup> and a considerable output potential. Nevertheless, aqueous Zn<img>I<sub>2</sub> batteries face some formidable challenges in conventional aqueous electrolytes, including catastrophic Zn dendrite hyperplasia and severe parasitic reactions, and terrible shuttle effect of polyiodides. To address these concerns, it has been recognized that hydrogel electrolyte (HE) can effectively block the active water molecules and coordinate with Zn<sup>2+</sup>, thus inhibiting the growth of zinc dendrites and meanwhile can mitigate the shuttle effects. Herein, anionic polyacrylamide (PAM) hydrogel electrolyte with immobilization of organic molecule of amber acid with carboxyl functional groups elaborately designed with bifunctional mechanism to address the adverse reactions simultaneously on both Zn anode and I<sub>2</sub> cathode. The immobilization of organic additives can build suitable ion transport highways for the modulation of Zn<sup>2+</sup> and polyiodides transport kinetics toward ultra-stable aqueous Zn<img>I<sub>2</sub> Batteries. Eventually, as a proof of demonstration, the assembled PAM/AA based aqueous Zn<img>I<sub>2</sub> cell can yield an remarkable rate performance and a high and maintained capacity of 138 mAh g<sup>−1</sup> over 15,000 cycles with a negligible decay rate of 0.005 ‰ per cycle at a high current of 5 Ag<sup>−1</sup>.</div></div>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"709 ","pages":"Article 139884"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to “Construction of hierarchical C/MoS2 nanobelts wrapped by N-doped carbon toward high-performance lithium/sodium storage” [J. Colloid Interface Sci. 700 (2025) 138458]","authors":"Bingqing Ye , Xingke Cai , Ruo Zhao","doi":"10.1016/j.jcis.2026.139905","DOIUrl":"10.1016/j.jcis.2026.139905","url":null,"abstract":"","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"709 ","pages":"Article 139905"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yudong Song , Yang Zou , Xinjian Shi , Shengyan Yin , Song Liang , Zhenning Liu , Qinrong He , Hang Sun
{"title":"Ridge-structured PANI with interfacial stress-concentrating: reversible protonation driven high sensitivity over wide pressures","authors":"Yudong Song , Yang Zou , Xinjian Shi , Shengyan Yin , Song Liang , Zhenning Liu , Qinrong He , Hang Sun","doi":"10.1016/j.jcis.2026.139888","DOIUrl":"10.1016/j.jcis.2026.139888","url":null,"abstract":"<div><div>In research on pressure-sensitive electronic skin (e-skin) for motion and physiological signal monitoring, balancing sensitivity with a broad pressure-sensing range and intelligent sensing capabilities is of critical importance. Inspired by the micro-ridge of human skin, this work integrates a bionic micro-ridge structure with a PANI-based resistivity modulation strategy to develop an e-skin that enables both high sensitivity and a wide pressure-sensing range for motion and physiological signals monitoring. Ridge-structured PANI was grown in-situ on hydrolyzed polyacrylonitrile fibers via chemical oxidative polymerization. By utilizing the reversible protonation-deprotonation mechanism of PANI in combination with a pH modulation strategy, we adjusted the resistivity of the PANI nanofibrous films to investigate the impact on sensing performance. The synergistic effects of ridge-structured PANI, resistivity modulation and micro-deformation effect of the nanofibrous films enabled the e-skin to exhibit a high sensitivity (maximum 1.91 kPa<sup>−1</sup>) and a wide pressure-sensing range (1–600 kPa). The e-skin can accurately and stably monitor a wide range of signals, ranging from subtle throat vibrations during phonation and gentle abdominal undulations caused by breathing, to larger plantar pressure changes during walking or running. Furthermore, we combined the e-skin with a one-dimensional convolutional neural network (1D CNN, PyTorch-based), enabling rapid and accurate classification of four typical respiratory states (Normal breathing, Rapid breathing, Deep breathing, and Apnea). This work, especially the combination of bionic micro-nano structures and resistivity modulation strategy, provides new insights for the development of pressure-sensitive e-skins with excellent sensing performance.</div></div>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"709 ","pages":"Article 139888"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yujuan Guo , Sheng Liu , Jun Du , Yuan Xue , Zushun Xu , Fangfang Du , Qing Li , Qianyuan He
{"title":"Plasmonic bimetallic Au-Ag nanoclusters embedded in covalent organic frameworks as efficient photocatalysts for simultaneous nizatidine degradation and H2O2 evolution","authors":"Yujuan Guo , Sheng Liu , Jun Du , Yuan Xue , Zushun Xu , Fangfang Du , Qing Li , Qianyuan He","doi":"10.1016/j.jcis.2026.139960","DOIUrl":"10.1016/j.jcis.2026.139960","url":null,"abstract":"<div><div>Covalent organic frameworks (COFs) demonstrate great potential as photocatalysts for the remediation of organic pollutants; however, their efficiency is often limited by the factor of rapid electron-hole recombination. In response to this challenge, we anchor ultrasmall (∼2.5 nm) bimetallic Au-Ag nanoclusters within the porous architecture of a nitrogen-rich COFs scaffold. The nitrogenated frameworks not only provide a high surface area and abundant active sites but also facilitate electron transfer. Meanwhile, the ultrafine Au-Ag nanoclusters exhibit strong plasmonic coupling, serving as dual light-harvesting units and electron transfer mediators. This synergistic configuration enhances carrier separation, enabling plasmon-exciton co-driven catalysis. The optimized COF-Au-Ag achieves simultaneous degradation of nizatidine (NZTD) and production of hydrogen peroxide <strong>(</strong>H<sub>2</sub>O<sub>2</sub><strong>)</strong> via a unified photocatalytic mechanism centered on efficient charge separation and directional migration. This photocatalyst illustrates excellent recyclability in five consecutive cycles of use, offering a novel approach for designing multifunctional COF-based photocatalytic systems.</div></div>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"709 ","pages":"Article 139960"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefania Garbujo , Chiara Baioni , Andrea Banfi , Leonardo Bolis , Giulia Bonvini , Elena Del Favero , Paola Gagni , Alessandro Gori , Linda Barbieri , Marco Davide Giustra , Giulia Tomaino , Lucia Morelli , Clizia Chinello , Fulvio Magni , Lucia Salvioni , Miriam Colombo , Davide Prosperi
{"title":"Biomimetic lipid nanoparticles for RNA delivery to breast cancer microenvironment cells by enhanced homotypic and heterotypic adhesion","authors":"Stefania Garbujo , Chiara Baioni , Andrea Banfi , Leonardo Bolis , Giulia Bonvini , Elena Del Favero , Paola Gagni , Alessandro Gori , Linda Barbieri , Marco Davide Giustra , Giulia Tomaino , Lucia Morelli , Clizia Chinello , Fulvio Magni , Lucia Salvioni , Miriam Colombo , Davide Prosperi","doi":"10.1016/j.jcis.2026.139972","DOIUrl":"10.1016/j.jcis.2026.139972","url":null,"abstract":"<div><div>Lipid nanoparticles (LNPs) have emerged as a clinically validated nonviral RNA delivery system. However, their limited tumor targeting remains challenging in oncology. In this work, LNPs were functionally integrated with cancer cell membrane components to enhance their targeting capabilities. The natural composition of tumor membranes was leveraged to promote both homotypic and heterotypic adhesion, exploiting cancer cell self-recognition and interactions with stromal cells in the tumor microenvironment. A biomimetic nanocarrier was developed by cloaking RNA-loaded LNPs with nanoghosts obtained from the membrane of triple negative breast cancer cells. Nanoghosts were dye-labeled and comprehensively characterized in terms of size, surface charge, protein composition, and membrane sidedness. The functional orientation of nanoghost membrane-associated proteins mediated homotypic binding with 4 T1 cells and heterotypic recognition of functionally validated cancer-associated fibroblasts and exhibited higher affinity for the latter, as confirmed through flow cytometry and confocal microscopy. RNA-LNPs were incorporated into nanoghosts using ultrasound-assisted fusion, yielding stable biomimetic LNPs with a multilamellar mRNA-LNP core enveloped by a nanoghost shell, as confirmed by Small-Angle X-ray Scattering. While uncoated LNPs showed negligible interaction with heterotypic cells, biomimetic LNPs displayed strong affinity for cancer-associated fibroblasts, enabling efficient internalization and RNA transfection. Additionally, the biomimetic coating enhanced LNP uptake in homotypic 4 T1 cells, resulting in significantly improved biological activity compared to uncoated LNPs. This work provides proof of concept that RNA-LNPs can be effectively integrated into biomimetic carriers to enable dual targeting of tumor and stromal cells. The enhanced selectivity and delivery performance of biomimetic LNPs highlight their therapeutic potential for overcoming stromal barriers in desmoplastic tumors such as triple negative breast cancer.</div></div>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"709 ","pages":"Article 139972"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shi-Cheng Tian , Xun-Huan Song , Ke-Ke Feng , Cheng-Lei Li , Yi-Fan Tu , Yong-Shan Hu , Jing-Wei Shao
{"title":"Corrigendum to “Self-oxygenating nanoplatform integrating CRISPR/Cas9 gene editing and immune activation for highly efficient photodynamic therapy” [J. Colloid Interface Sci. 693 (2025) 137632]","authors":"Shi-Cheng Tian , Xun-Huan Song , Ke-Ke Feng , Cheng-Lei Li , Yi-Fan Tu , Yong-Shan Hu , Jing-Wei Shao","doi":"10.1016/j.jcis.2026.139906","DOIUrl":"10.1016/j.jcis.2026.139906","url":null,"abstract":"","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"709 ","pages":"Article 139906"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weixiang Chen , Yuxiong Wang , Yaoyu Zhang , Yue Liu , Zhongbiao Wu
{"title":"Mechanistic study on the enhanced N2 selectivity for NH3 selective oxidation over Pt-encapsulated Cu-ZSM-5 catalysts","authors":"Weixiang Chen , Yuxiong Wang , Yaoyu Zhang , Yue Liu , Zhongbiao Wu","doi":"10.1016/j.jcis.2026.139941","DOIUrl":"10.1016/j.jcis.2026.139941","url":null,"abstract":"<div><div>Ammonia (NH<sub>3</sub>) has emerged as a promising zero‑carbon energy source for energy and transportation. However, its utilization leads to the emission of NH<sub>3</sub>, which contributes to PM<sub>2.5</sub> formation and disrupts the global nitrogen cycle. Selective catalytic oxidation (SCO) represents a mainstream technology for NH<sub>3</sub> treatment, yet achieving both sufficient activity and high N<sub>2</sub> selectivity across a broad temperature window remains challenging. Here, a core-shell Pt@Cu-ZSM-5 catalyst was employed for NH<sub>3</sub> catalytic abatement by encapsulating metallic Pt clusters (Pt<sup>0</sup>) inside the channels of Cu ion-exchanged ZSM-5. The optimal sample achieved a complete NH<sub>3</sub> conversion below 250 °C and maintained over 92% N<sub>2</sub> selectivity from 250 to 500 °C due to the synergism between the Pt−Cu dual sites. Mechanistic studies revealed that NH<sub>3</sub> oxidation preferentially occurred on Pt<sup>0</sup> sites with excellent redox capacity to produce N<sub>2</sub>O and NO<sub><em>x</em></sub> at relatively low and high temperatures, respectively. And the presence of Cu ions (Cu<sup>δ+</sup>) could efficiently both inhibit the formation of N<sub>2</sub>O on Pt<sup>0</sup> sites and reduce NO<sub><em>x</em></sub> emission, thereby improving the N<sub>2</sub> selectivity. At relatively low temperatures, NH<sub>3</sub>-solvated Cu<sup>+</sup>(NH<sub>3</sub>)<sub>2</sub> could migrate to the adjacent Pt sites and reduce the adsorbed NO* species from NH<sub>3</sub> oxidation, damping the formation of N<sub>2</sub>O. At high temperatures, the NO and NO<sub>2</sub> emitted from Pt<sup>0</sup> sites could be reduced on Cu<sup>δ+</sup> sites via a typical selective catalytic reduction. This study provides new insights into the rational design of bifunctional SCO catalysts and offers a comprehensive understanding of the synergistic effects in Pt−Cu dual-site systems.</div></div>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"709 ","pages":"Article 139941"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glutathione- responsive Phototheranostic platform for imaging-guided enhanced oxidation photoimmunotherapy-ferroptosis synergistic hepatocellular carcinoma therapy","authors":"Zhuanxia He , Limin Zhang , Xiujun Gao , Jiaxin Zhong , Yanqi Zhang , Feng Gao","doi":"10.1016/j.jcis.2026.139927","DOIUrl":"10.1016/j.jcis.2026.139927","url":null,"abstract":"<div><div>Phototheranostics have emerged as a promising approach in precision medicine. However, the poor tumor selectivity of photosensitizers, insufficient oxidative stress and the intrinsic antioxidant system of tumors compromise the efficacy of phototherapeutic strategies. In this study, we designed a novel phototheranostic platform (ICP@SRF-GPC3 NPs) for active tumor-targeted imaging and oxidation-enhanced photoimmunotherapy-ferroptosis combined therapy. The ICP@SRF-GPC3 NPs were fabricated by conjugating near-infrared photosensitizer IR780 with cystine-polyethylene glycol, modifying it with the Glypican-3 monoclonal antibody and encapsulating of the ferroptosis inducer sorafenib (SRF). ICP@SRF-GPC3 NPs with improved water solubility and liver tumor specificity can produce reactive oxygen species (ROS) upon 808 nm laser irradiation and enable photoimmunotherapy-mediated oxidation treatment. In the tumor microenvironment, the high concentration of glutathione (GSH) cleaved the linkage between the IR780 and the cystine moiety, realizing superior near-infrared fluorescence imaging and synergistic photoimmunotherapy-ferroptosis therapy. The released SRF inhibited cystine/glutamate antiporter, thereby blocking cystine uptake in tumor cells and suppressing GSH synthesis. By depleting existing GSH reserves while simultaneously inhibiting its biosynthetic pathway, ICP@SRF-GPC3 NPs effectively exhausted intracellular GSH, weakening the anti-oxidation ability of tumor cells and amplifying oxidative stress. In a BALB/c nude mouse model bearing GPC3-overexpressing Hepa1–6 allografts, the combination of photoimmunotherapy with ferroptosis not only effectively suppressed primary tumor growth through amplified ROS generation, but also promoted damage-associated molecular patterns release, thereby eliciting a robust immune response that eliminated metastatic and distant tumors. Overall, ICP@SRF-GPC3 NPs offers a promising strategy for regulating GSH and ROS levels in synergistic photoimmunotherapy-ferroptosis antitumor therapy, which has potential clinical applications.</div></div>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"709 ","pages":"Article 139927"},"PeriodicalIF":9.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}