Nigerian Journal of Physiological Sciences最新文献

{"title":"Experimental Evaluation of Sorbitol's Impact on the Testicular Axis in Male Wistar Rats.","authors":"Adams Omoaghe, Zayyanu Saleh, Tony Ezike, Mayowa Adu, Ibidayo Alebiosu, Kehinde Olaniyi","doi":"10.54548/","DOIUrl":"https://doi.org/10.54548/","url":null,"abstract":"<p><strong>Introduction: </strong>Infertility is a growing public‑health concern with male factors contributing substantially; sorbitol use as a low‑calorie sweetener raises questions about its reproductive effects. This study evaluated regimen‑ and dose‑dependent impacts of oral sorbitol on the male reproductive axis in adult Wistar rats.</p><p><strong>Material and methods: </strong>Thirty‑six animals were assigned to control groups or to acute (4 weeks) and chronic (8 weeks) low‑dose (45 mg/kg) and high‑dose (90 mg/kg) sorbitol groups; ethical approval was obtained. Outcomes included body and testicular weight, sperm count, morphology and vitality; serum GnRH, FSH, LH and testosterone; serum and testicular lipid profiles; oxidative markers (MDA, GSH, SOD, GPX); inflammatory markers (TNF‑α, CRP); and histology (H&E, Masson trichrome).</p><p><strong>Results: </strong>Body weight was unchanged across groups, while chronic high‑dose sorbitol caused significant testicular weight reduction. Acute low‑dose exposure increased sperm count but also raised abnormal forms and altered viability, whereas chronic regimens reduced sperm counts. Hormonal responses were regimen specific: acute high dose transiently elevated testosterone and acute low dose increased LH, but chronic high dose produced marked GnRH suppression with downstream gonadotropin decline. Lipid profiling revealed acute systemic lipid shifts and chronic intratesticular lipid accumulation, paralleling compartmentalised changes in oxidative stress. Acute exposure reduced some systemic oxidative markers and increased testicular GSH, but chronic high dose increased testicular MDA and induced GPX, with reconfigured TNF‑α/CRP signalling. Histology showed early seminiferous epithelial disruption in acute groups and interstitial collagen deposition consistent with evolving fibrosis in chronic groups.</p><p><strong>Conclusion: </strong>These mixed biochemical, hormonal and structural findings indicate potential short‑term metabolic signals yet clear long‑term reproductive risks from chronic high‑dose sorbitol, warranting longitudinal mechanistic and interventional studies.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"113-122"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Exploration of Antimalarial Potential of Ethanolic Leaf Extract of Heliotropium indicum.","authors":"Bolanle Christianah Faleye, Fisayo Abraham Bamisaye, Toluwase Hezekiah Fatoki, Rasaq Olawale Ajuwon","doi":"10.54548/","DOIUrl":"https://doi.org/10.54548/","url":null,"abstract":"<p><p>Heliotropium indicum, commonly known as Indian heliotrope, is a member of the family Boraginaceae, and possessed array of ethnomedicinal usefulness. The objective of this study was to computationally investigate phytochemical constituents, pharmacokinetics and binding dynamics of ethanolic leaf extract of H. indicum with key molecular targets relevant to malaria. The method used are pharmacokinetics prediction, target prediction, and molecular docking. The results showed twenty-nine (29) identified constituents of which some are poorly soluble and have low gastrointestinal absorption (GIA) and others soluble with high GIA and could permeate the blood brain barrier (BBB). The molecular docking results showed that eicosane have the highest binding affinity for Enoyl- acyl-carrier protein (ACP) reductase (-7.363 kcal.mol-1), followed by 3-oxoacyl-ACP reductase (-7.012 kcal.mol-1), and beta-hydroxyacyl-ACP dehydratase (-6.295 kcal.mol-1), while Nonadecane has binding affinity of -5.048 kcal.mol-1 for Heat shock protein 90; 2-(Pentyloxycarbonyl) benzoic acid has binding affinity of -5.375 kcal.mol-1 for cysteine protease falcipain-3, and 4-Methoxyanthranilic acid has binding affinity of -5.667 kcal.mol-1 for M17 leucyl aminopeptidase. Overall, this study showed that nonadecane, 1-chlorononadecane, eicosane, 2-(Pentyloxycarbonyl) benzoic acid, and 4-Methoxyanthranilic acid, are the five most active constituents of ethanolic leaves extract of H. indicum; targeting key proteins in P. falciparum. In conclusion, ethanolic leaves extract of H. indicum plant has potential antimalarial properties. However, further in vivo and in vitro studies are required to validate the claims of this study in order to established therapeutic efficacy of active compounds of ethanolic leaves extract of H. indicum that are directly responsible for its antimalarial properties. Keywords: Heliotropium indicum, phytochemicals, pharmacokinetics, Plasmodium falciparum, Enoyl-ACP reductase, M17 leucyl aminopeptidase, molecular docking.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"83-91"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Vitamin E Against Mobile Phone-Induced Oxidative Stress and Neuronal Injury in Rats.","authors":"Pravallika Pagadala, Vinutha Shankar Ms, Harendra Kumar Ml, Ramesh Babu Murikipudi","doi":"10.54548/","DOIUrl":"https://doi.org/10.54548/","url":null,"abstract":"<p><p>Chronic exposure to radiofrequency electromagnetic radiation (RF-EMR) emitted from mobile phones has raised concerns regarding its potential biological effects on the central nervous system. The present study investigated whether prolonged RF-EMR exposure induces oxidative, neuroendocrine, and neuronal stress in rats, and whether Vitamin E supplementation offers protective effects. Male Sprague Dawley (SD) rats were divided into control, RF-EMR-exposed, RF-EMR plus Vitamin E-treated, and vehicle control groups. Animals were exposed to mobile phone-emitted RF-EMR (0.9/1.8 GHz) for 1 hour/day over 50 days and supplemented with Vitamin E (100 mg/kg body weight, orally through oral gavage needle). Feed intake and body weight were recorded, while serum malondialdehyde (MDA), corticosterone, and neuron-specific enolase (NSE) levels were assessed as markers of oxidative stress, neuroendocrine stress, and neuronal injury, respectively. Hippocampal glial fibrillary acidic protein (GFAP) expression was also evaluated. Compared with control rats, RF-EMR exposure did not significantly alter feed intake or body weight; however, serum MDA, corticosterone, and NSE levels were significantly elevated (p < 0.05). Vitamin E supplementation significantly attenuated these biochemical alterations compared with the RF-EMR group (p < 0.05). GFAP expression in the hippocampal CA3 region showed no significant differences among groups. These findings suggest that chronic RF-EMR exposure induces biochemical and neuronal stress prior to overt behavioral changes, and that Vitamin E provides effective antioxidant and neuroprotective benefits.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"93-99"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effects of Fucoidan and Papain on Biliary Flow Rate and Electrolytes in Wistar Rats.","authors":"Irene Atim, Polycarp Adie, Minafuro Okwejie Chijindu, John Atambell, Sam Uquetan Uquetan, Jessica Nzeadibe, Paulica Obi Muji-Wan, Ememfon Inyang Gabriel, Exploit Chukwuka Ezinne","doi":"10.54548/","DOIUrl":"https://doi.org/10.54548/","url":null,"abstract":"<p><p>Papain and Fucoidan are extracted enzymes that have gained recognition across food industry, pharmaceutical and digestive applications, but their comparative effects on Biliary flow rate and electrolytes are not known. Hence, this study compared the effects of papain and fucoidan on Biliary flow rate and electrolytes. Twenty (20) male albino Wistar rats weighing between 100g and 150g were divided into 4 groups of 5 animals each as follows: Group I (Control group) were administered normal saline and had access to food and water ad libitum. Group II (Papain group) were administered with 800mg/kg body weight of the stock solution of papain and were allowed free access to food and water. Group III (Fucoidan group) was given 800mg/kg body weight of the stock solution of fucoidan plus food and water. Group IV (Metoclopramide group) was administered with 30mg/kg body weight of Metoclopramide stock solution plus food and water ad libitum. The administration lasted for a duration of 28 days. Bile was collected from the liver (hepatic duct) and was analyzed for bile flow rate and its composition. The results showed that papain significantly increased biliary sodium and chloride, reduced bicarbonate levels, and had no significant effect on bile flow rate compared to the control group. Fucoidan significant effect on Biliary sodium, chloride and bile flow rate when compared to the control group. These results conclude that the two compounds have regulatory, but not stimulatory effects on biliary secretion, which proves their hepatoprotective and stabilising effects.  Keywords: fucoidan, Papain, bile flow rate, biliary electrolyte.   Short running title: Modulation of Fucoidan and Papain on Biliary Parameter.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"101-106"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulatory Effects of Sesame Seed Oil on Permethrin-Induced Testicular Dysfunctions in Rats.","authors":"Abubakar Lekan Imam, Rukayat Jaji-Sulaimon, Mubarak Muhammed Yunusa, Gabriel Olaiya Omotoso","doi":"10.54548/","DOIUrl":"https://doi.org/10.54548/","url":null,"abstract":"<p><p>Permethrin (PM) is a synthetic type 1 pyrethroid insecticide, and excessive exposure can cause a wide range of toxicity. This study evaluated the activities of sesame seed oil (SSO) on the testicular histology and male reproductive parameters in permethrin-induced toxicity in adult Wistar rats. Forty (40) adult male Wistar rats were randomly allocated into four (4) groups of 10 animals each. Group A received 0.5 ml of normal saline; Group B was given feed mixed with 1,000 mg/kg of 0.6% permethrin; Group C received 5 ml/kg of sesame seed oil, and Group D received feed mixed with 1,000 mg/kg of 0.6% permethrin and 5 ml/kg of sesame seed oil. All treatment was done daily for 4 weeks using an oral cannula. The animals were anesthetized and transcardially perfused with normal saline and 10% buffered formalin. The testis was processed for tissue histology, superoxide dismutase, glutathione, malondialdehyde, testosterone, luteinizing hormone, and follicle-stimulating hormone were assayed. Furthermore, sperm count, motility, morphology, and viability were evaluated using the caudal epididymis. The result showed reduced body weight and testicular weight in the permethrin (PM) group. There was a reduction in the level of semen parameters due to permethrin exposure. There was also a reduction in the level of testosterone, coupled with a high level of follicle-stimulating hormone and luteinizing hormone in the PM group. Permethrin disrupts endogenous antioxidants, and there were degenerative changes in the testicular histoarchitecture in the PM group. The sesame seed oil protected against oxidative damage in male Wistar rats. It regulated the hormonal profiles and improved the caudal epididymal sperm quality as well as improved testicular histoarchitectural integrity. This study showed that sesame seed oil improved testicular histoarchitecture and enhanced reproductive parameters in permethrin-induced testicular damage. Key words: Permethrin, Sesame seed oil, Glutathione, Testosterone, histoarchitecture.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"107-112"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of (Pre)Hypertension and Correlations between Blood Pressures and Obesity in a Lean Population of Adults from the Old Eastern Region of Nigeria.","authors":"Ifeoma Ijeh, Chidnma Ikewuchi, Chibuzor Okonkwo, Ugochukwu Onyeonoro, Ugochukwu Ezeani, Anthony Nnamudi, Charles Osodeke, Chiamaka Ikechi, Nnaemeka Nwawuba, Okwunna Ikwuazom, Chukwunonso Ejike","doi":"10.54548/","DOIUrl":"https://doi.org/10.54548/","url":null,"abstract":"<p><p>Hypertension is a prevalent disease globally and its prevalence is rising in sub-Saharan Africa. Urban-rural differences in the prevalence of hypertension are under-reported in Nigeria. Though hypertension is known to be related to obesity, the nature of the relationship is still unclear. This study sought to interrogate these and thus enrolled a total of 1,755 subjects (59% females) from five states in the old Eastern Region of Nigeria. Standard protocols and definitions were used to take measurements and diagnose relevant disease states. Appropriate statistical tools were used for data analysis. The results indicate that prehypertension was found in 40.0% of males and 27.5% of females while hypertension was found in 19.1% of males and 18.6% of females. The prevalence of (pre)hypertension among urban and rural males were similar (19%). However, prehypertension was more prevalent among urban females (29.1% Vs 24.3%); while hypertension was more prevalent among rural females (21.9% Vs 17.1%). SBP was found to be positively and significantly correlated with weight, waist circumference, hip circumference, waist-to-height ratio and body mass index in the general population. When disaggregated based on blood pressure phenotypes, the correlations were found to be consistent mostly among normotensive subjects and among females. Among subjects with (pre)hypertension, the correlations varied in strength and direction depending on sex and measure of adiposity used. The urban-rural difference in the prevalence of hypertension and the relationship between hypertension and obesity are not linear.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"17-27"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory Potentials of Anacardium Occidentale L. Nut Methanol Extract in Wistar Rats.","authors":"Gbenga Olayinka, Oyetola Oyebanjo, Mujeedat Olubori, Abayomi Ajayi, Samuel Onasanwo","doi":"10.54548/","DOIUrl":"https://doi.org/10.54548/","url":null,"abstract":"<p><p>The Anacardium occidentale nut is increasingly gaining attention due to its economic, nutritional value and biological properties. This study is aimed at evaluating the anti-inflammatory potential of Anacardium occidentale nut Methanol extract (AOME) in carrageenan-induced paw oedema and the carrageenan-induced air pouch models of inflammation. AOME (200 mg/kg) significantly (p<0.05) inhibited carrageenan-induced increase in paw volume and increase in paw size, respectively, at 5 hours post-carrageenan injection. In the carrageenan induced air pouch inflammation model, 200 mg/kg AOME significantly (P<0.05) reduced exudate volume, Total leucocyte count, Neutrophil cell count, Monocyte count and Lymphocyte count.  200 mg/kg AOME also reduced significantly MDA, Nitrite, TNF-α, IL-6, and significantly increased GSH and catalase levels. Anacardium occidentale nuts showed anti-inflammatory effects through reduction in lipid peroxidation and TNF-α and IL-6 activity, alongside amelioration of oxidative stress.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Narrative: A New Era Begins.","authors":"Bamidele Victor Owoyele","doi":"10.54548/","DOIUrl":"10.54548/","url":null,"abstract":"<p><p>A welcome message from the new Editor-in-Chief, Prof. B.V. Oyewole.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"v"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Correlates of Erectile Dysfunction: A Comparative Study of Adult Hypertensive Patients in an Outpatient Clinic, South East Nigeria.","authors":"Malachy Chigozie Nwafor, Augustine Obiora Ikwudimma, Chijioke Stanley Anyigor-Ogah, Idika Mba Idika, Ifeyinwa Nneka Umezurike, Benjamin Ikechukwu Umezurike, Ikechukwu Henry Amazue, Ikechukwu Aloh Ogah, Chidi Vincent Okeke, Chukwuemeka Mbam Ovuoba, Agatha Nkechinyere Ekechi, Chibueze Ogbodo Nweke","doi":"10.54548/","DOIUrl":"https://doi.org/10.54548/","url":null,"abstract":"<p><strong>Background: </strong>There has been an increase in the prevalence of erectile dysfunction (ED) in the general population especially among hypertensive patients. This seems to be neglected problem in low-income countries especially our environment with huge attendance consequences. Measures to address the risk factors are advocated as to reduce the burden of the disease and its financial impact on the economy. It is an important public health problem by the National Institute of Health Consensus Development Conference Panel. It has been found to be more associated with chronic medical conditions such as hypertension and diabetes mellitus.</p><p><strong>Objectives: </strong>This study assessed erectile dysfunction and its associated risk factors among adult hypertensive patients attending a tertiary care centre, with a view to screening for erectile dysfunction, advocating for lifestyle modification in order to reduce the burden of the disease.</p><p><strong>Methods: </strong>It was a hospital-based cross-sectional comparative design which involved two hundred and thirty-six adult male patients recruited via a systematic random sampling technique. Data collection was done using a semi-structured researcher-administered pretested questionnaire to obtain information on the socio-demographic characteristics, past medical history, behavioural characteristics, clinical assessment and erectile dysfunction assessment using Sexual Health Inventory for Men (SHIM). Data was analyzed with SPSS (version 23). Chi square test, fisher's test and logistic regression were used for analysis.</p><p><strong>Results: </strong>The mean age of respondents was 42.1±15.17 years. Out of the 41.1% young age category; 40.7% and 41.5% were hypertensive and non-hypertensive respectively. An overall prevalence of erectile dysfunction of 44.1% with higher prevalence in hypertensive (54.2%) than non-hypertensive (33.9%) respondents was noted. There was a significant difference when ED was compared in the two groups (hypertensive and non-hypertensive) (p<0.05). The study also revealed that body mass index has a significant association with erectile dysfunction (P<0.05). The logistic regression showed that blood pressure (SBP and DBP) and BMI were predictors of erectile dysfunction (p=0.010), (OR=2.026, 95% CI=1.180-3.479) and (p= 0.048), (OR=0.688, 95% CI= 0.372-1.271).</p><p><strong>Conclusion: </strong>In as much as smoking and the class of anti-hypertensive medications used by the respondents had no significant association with erectile dysfunction, hypertension and obesity were independently associated with erectile dysfunction. Alcohol use was also significantly associated with erectile dysfunction, but such as an associated vanished on elimination of cofounders.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"29-36"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological Differences in Superior Colliculus of Adult and Juvenile African Grasscutter (Thryonomys swinderianus).","authors":"Aisha Nana Ahmad, Abel Nosereme Agbon","doi":"10.54548/","DOIUrl":"https://doi.org/10.54548/","url":null,"abstract":"<p><p>Rodents have provided insight to specific aspects of neural organization including morphology, function, development, and evolution in mammalian species. The superior colliculus (SC) also referred to as rostral colliculus has been studied in several mammals, including nonhuman primates. The SC has been considered a visual motor integration center of the CNS. Under-explored species such as the African Grasscutter (AGC), a semi nocturnal rodent species, exhibits peculiar SC-regulated behaviors in the wild including arrest and freezing abilities in response to predators. This study morphologically assessed differences in the SC of adult and juvenile AGCs. Six AGCs (adult/ juvenile, n= 3) were procured for this study. Brains were harvested and morphologic characteristics including histology, histometry (pyramidal soma size and perimeter) and cell distribution in the SC of AGCs were assessed and quantified. Data obtained were analyzed using GraphPad Prism and computer running imaging software (AmScope and ImageJ, USA). Comparison of morphologic characteristics of SC revealed similarities and variations between the AGCs age groups: SC presented with similar histoarchitectural organization; pyramidal cell soma characteristics and cell distribution showed a significant (p<0.05) difference between the AGCs with higher mean value in the juvenile. This study has demonstrated a basic histoarchitectural organization of the superior colliculus in adult and juvenile African Grasscutter; thus, points to conserved architectural organization across rodent species. Observed differences could be attributed to variations in cellular functionality with response to developmental neurogenesis and synaptic refinement between the rodents. Findings are of potential benefit in understanding neurodevelopmental variations that influence functional capabilities across different age group.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"41 1","pages":"133-139"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}