食用熟豆和5 -羟色胺前体对东莨菪碱损伤小鼠记忆和运动协调的影响。

Q4 Medicine
Johnbull Uket, F B Nyor, Eme E Osim
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引用次数: 0

摘要

阿尔茨海默病(记忆障碍)和运动协调障碍在世界范围内呈上升趋势。5-羟色胺(5-羟色胺)参与短期记忆和运动协调(Buhot et al., 2000)。, Cabaj et al., 2017)。含有5 -羟色胺前体(色氨酸)的豆类是否能改善记忆和运动协调障碍,此前尚未确定。因此,本研究旨在研究食用熟豆(Phaseolus vulgaris)和5 -羟色胺前体饮食对东莨菪碱损伤小鼠记忆和运动协调的影响。60只小鼠随机分为6组,每组10只;对照组,仅东莨菪碱,东莨菪碱与50%熟豆饲粮,东莨菪碱与5 -羟色胺前体饲粮,50%熟豆饲粮和5 -羟色胺前体饲粮。在学习/记忆和运动协调研究之前,对植物化学分析进行了初步研究。采用标准方法研究学习/记忆和运动协调。结果表明,经初步植物化学筛选,熟豆类中含有色氨酸、类黄酮、生物碱和多酚(抗氧化剂)。与对照组和其他试验组相比,东莨菪碱组的学习能力受损(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Consumption of Cooked Beans (Phaseolus vulgaris) and Serotonin Precursor Diets on Scopolamine-Impaired Memory and Motor Co-ordination in Mice.

Alzheimer's disease (memory impairment disorder) and motor co-ordination disorders are on the increase worldwide. 5-Hydroxytryphamine (serotonin) is involved in short term memory and motor co-ordination (Buhot et al., 2000., Cabaj et al., 2017).  Whether beans that contain serotonin precursor (tryptophan) can ameliorate memory and motor co-ordination impairment has not been previously ascertained. Therefore, this research was to study the effects of consumption of cooked beans (Phaseolus vulgaris) and serotonin precursor diets on scopolamine-impaired memory and motor co-ordination in mice. Sixty mice were randomly assigned into 6 groups (10 mice per group) namely; Control, Scopolamine only, Scopolamine with 50% cooked beans diet, Scopolamine with serotonin precursor diet, 50% cooked beans diet only and serotonin precursor diet only. Preliminary studies on phytochemical analyses were done before learning/memory and motor co-ordination were also studied. Standard methods were used to study learning/memory and motor coordination. The results showed that preliminary phytochemical screening of cooked beans indicated the presence of tryptophan, flavonoids, alkaloids, and polyphenols (antioxidants). Learning was impaired in Scopolamine only group compared to control and other test groups (p<0.05). Memory was also impaired in scopolamine only group compared to all other experimental groups (p<0.05). Motor co-ordination was also impaired in scopolamine only group compared to all other groups (p<0.05). In conclusion, consumption of beans and serotonin precursor diets improved memory and motor coordination in scopolamine impaired memory and motor co-ordination in mice. The memory and motor co-ordination enhancement observed may be attributed to serotonin synthesized from tryptophan in beans.

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来源期刊
Nigerian Journal of Physiological Sciences
Nigerian Journal of Physiological Sciences Medicine-Physiology (medical)
CiteScore
0.80
自引率
0.00%
发文量
23
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