Effect of Aqueous Extract of Hibiscus Sabdariffa on Cadmium Chloride-Induced Neurotoxicity in Male Wistar Rats.

Q4 Medicine
Ogadinma Ilochi, Arthur N Chuemere
{"title":"Effect of Aqueous Extract of Hibiscus Sabdariffa on Cadmium Chloride-Induced Neurotoxicity in Male Wistar Rats.","authors":"Ogadinma Ilochi, Arthur N Chuemere","doi":"10.54548/njps.v39i1.14","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigated the neurologic effect of aqueous extract of Hibiscus sabdariffa on cadmium chloride-induced neurotoxicity in wistar rats. Thirty male wistar rats were grouped accordingly; Group A: control, Group B-F: CdCl2 0.3ml; H. sabdariffa 1.5ml; CdCl2 + H. sabdariffa 1.0ml; CdCl2 + H. sabdariffa 1.5ml; CdCl2 + H. sabdariffa 2ml, respectively. Gas chromatography coupled to flame ionization detector (GC-FID), total antioxidant capacity (TAC) and mineral analysis of H. sabdariffa was done to reveal the bioactive agents in the plant sample. Oxidative stress, muscle function markers and plasma electrolytes were assayed. Phytochemical screening revealed alkaloids, phytate, anthraquinone and flavonoids. The mineral analysis revealed predominantly, Mn, Ca, K and Fe. The biochemical results were in comparison with control and statistically significant at 95% confidence interval. There was an increase in SOD, CAT, GSH, GR and GPx in groups C-F, MDA decreased in group C, E and F while PC decreased in group C and F. There was a decrease in plasma creatine kinase in groups C to F and increase in AChE in group C. Ca and K levels had no significant change (P<0.05). Nitric oxide level had no significant change in group C, E and F, but increased in group D. This study demonstrated that H. sabdariffa has the potential to ameliorate the neurotoxicity caused by CdCl2 in wistar rats.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"39 1","pages":"111-118"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Journal of Physiological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54548/njps.v39i1.14","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

This study investigated the neurologic effect of aqueous extract of Hibiscus sabdariffa on cadmium chloride-induced neurotoxicity in wistar rats. Thirty male wistar rats were grouped accordingly; Group A: control, Group B-F: CdCl2 0.3ml; H. sabdariffa 1.5ml; CdCl2 + H. sabdariffa 1.0ml; CdCl2 + H. sabdariffa 1.5ml; CdCl2 + H. sabdariffa 2ml, respectively. Gas chromatography coupled to flame ionization detector (GC-FID), total antioxidant capacity (TAC) and mineral analysis of H. sabdariffa was done to reveal the bioactive agents in the plant sample. Oxidative stress, muscle function markers and plasma electrolytes were assayed. Phytochemical screening revealed alkaloids, phytate, anthraquinone and flavonoids. The mineral analysis revealed predominantly, Mn, Ca, K and Fe. The biochemical results were in comparison with control and statistically significant at 95% confidence interval. There was an increase in SOD, CAT, GSH, GR and GPx in groups C-F, MDA decreased in group C, E and F while PC decreased in group C and F. There was a decrease in plasma creatine kinase in groups C to F and increase in AChE in group C. Ca and K levels had no significant change (P<0.05). Nitric oxide level had no significant change in group C, E and F, but increased in group D. This study demonstrated that H. sabdariffa has the potential to ameliorate the neurotoxicity caused by CdCl2 in wistar rats.

求助全文
约1分钟内获得全文 求助全文
来源期刊
Nigerian Journal of Physiological Sciences
Nigerian Journal of Physiological Sciences Medicine-Physiology (medical)
CiteScore
0.80
自引率
0.00%
发文量
23
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信