JOJ Sciences最新文献

{"title":"Assessment of the Difficulty of the Third Molar Surgery in A Sample of the Lebanese Population","authors":"A. Berbéri","doi":"10.19080/jojs.2022.03.555603","DOIUrl":"https://doi.org/10.19080/jojs.2022.03.555603","url":null,"abstract":"","PeriodicalId":345283,"journal":{"name":"JOJ Sciences","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133716135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Cancer by siRNA; A Review on Current Strategies","authors":"Muhammad Irfan","doi":"10.19080/jojs.2018.01.555573","DOIUrl":"https://doi.org/10.19080/jojs.2018.01.555573","url":null,"abstract":"Recent development in RNA Interference (RNAi) brought enthusiasm in the scientific community and opened the new ways for many therapeutic applications. The RNAi is a phenomenon which is used to targets mRNA and chops them up. The most appealing work of RNAi is observed in cancer inhibition by silencing genome sequences. Ultimate level of specificity can be achieved through siRNA targeted therapeutics. Short interfering RNA(siRNA) belongs to dsRNA molecules that can be produced exogenously and endogenously. This review sums up the recent approaches for cancer inhibition by siRNA. The article also points out the current targets of siRNA in cancer therapy development including expression level of cancerous and non-cancerous cells, their genetic concerns and siRNA drug delivery system like lipid base Nano-vectors. Currently, many of RNA based drugs are in practice at clinical trials level to overcome this deadly disease. In view of the encouraging results of RNAi based therapy, it is obvious that in near future siRNA will prove itself as a major cancer inhibitor and can become a standard cancer treatment.","PeriodicalId":345283,"journal":{"name":"JOJ Sciences","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127662187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Impact of Customer Experience in The Hospitality Establishment - A Case Study of Chariot Hotel, Molyko Buea","authors":"Abam Evaristus","doi":"10.19080/jojs.2018.01.555570","DOIUrl":"https://doi.org/10.19080/jojs.2018.01.555570","url":null,"abstract":"It is no coincidence that brand loyalty was stronger then, than today as brand was used by costumers as a proxy for quality, in this era organization that could reliably deliver a product on time, in full; every time earned costumers trust, then loyalty. A company’s relationship with its customers is much more than improving product rating or decreasing wait times. Understanding the customer journey is about learning what customer experience from the moment they begin considering to purchase, and then working to make the journey towards buying a product or service as simple clear and efficient as possible. Therefore, delivering a consistently good costumer experience require the execution of a hierarchy of sequenced requirement and that each level must be satisfied before the next becomes important. Delivering the type of costumer experience that will lead to customer loyalty in a competitive market now requires organization to pay attention to their performance. A company’s abilities to deliver an experience that sets its eye on its customers will increase the amounts of costumers spending with the company and inspire culture. An important factor in costumer experience that Chariot hotel need to lay emphasis on is the relationship between the employee and the costumer so as to deliver better services and thus improve on the customer experience.","PeriodicalId":345283,"journal":{"name":"JOJ Sciences","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124765312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Interactional Behavior of some Biologically Important Compounds by a Quantitative Method","authors":"Khadem Sadigh Mahsa","doi":"10.19080/jojs.2018.01.555568","DOIUrl":"https://doi.org/10.19080/jojs.2018.01.555568","url":null,"abstract":"During the last decades, the community needs for understanding of chemical structure and activity of various groups of drug molecules have been as an important challenge. It is interesting to know that recently scientists have developed the applicable analytical methods such as different types of spectroscopic technique [1-5] to study the unique characteristic of biologically important compounds. There is no doubt that provide of a proper method can give a precise information of complex molecular details. This is vital in disease diagnosis and design of pharmacologically and biological important compounds. In laboratory condition, the experimental researches and naturally occurring phenomena are usually used in solution state. Under this circumstance, solvent molecules have profound effects on the behavior of solute molecules in various biological, chemical and physical phenomena. In general, solvent sensitive processes are acquired from various molecular interactions, these includes general and specific solute-solvent interactions. Solvent induced effects are commonly discussed by their polarity and solvatochromic parameters [6-10]. The nature and strength of various molecular interactions cannot exactly have described by single solvent polarity parameters. Hence, multi-linear solvent polarity parameters known as Catalan equation (equation 1) are used [6]. 0 ' ' ' ' y y a SA b Sdp c SA d SB = + + + + (2)","PeriodicalId":345283,"journal":{"name":"JOJ Sciences","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129231249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case History-The Control of Impurities-A Critical Issue to The Active Pharmaceutical Ingredient","authors":"Krishnasarma Pathy","doi":"10.19080/jojs.2018.01.555566","DOIUrl":"https://doi.org/10.19080/jojs.2018.01.555566","url":null,"abstract":"The ICH guidelines on impurity have clearly defined the levels of toxic impurities and have become benchmark in establishing impurities in pharmaceutical drug products. The present article summarizes the concept of impurity profiling and presents a case study on impurity profiling of quantification of active pharmaceutical ingredient and impurities in sildenafil citrate purchased via internet and its relative outcomes.","PeriodicalId":345283,"journal":{"name":"JOJ Sciences","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115945145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Extended Cohesive Damage Model in Predicting Novel Sandwich Composites with Graded Layered Core","authors":"Jiye Chen","doi":"10.19080/jojs.2018.01.555565","DOIUrl":"https://doi.org/10.19080/jojs.2018.01.555565","url":null,"abstract":"This paper presents a highly efficient approach in predicting Novel Sandwich Composites with Graded Layered Core (NSCGLC) using the extended cohesive damage model (ECDM). Graded sandwich composites have drawn extensive attention from academics and engineers in the composite society in the last twenty years. In traditional sandwich structures, the core between the top and the bottom fibre laminates is single foam material with homogeneous property. This sandwich construction has two interfaces between core and the top and the bottom laminates respectively. At the interfaces miss matched materials may bring interfacial fractures e.g. delamination thus sandwich structures lose loading capacity.","PeriodicalId":345283,"journal":{"name":"JOJ Sciences","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121182612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Diversity Assessment of Japanese persimmon Using Morphological Markers and Its Contribution towards Livelihood in District Gilgit","authors":"T. Khan","doi":"10.19080/jojs.2018.01.555562","DOIUrl":"https://doi.org/10.19080/jojs.2018.01.555562","url":null,"abstract":"Japanese persimmon ( ) is a delicious fruit tree. It is grown relatively warm areas (<1500 m asl) of Gilgit Baltistan. Around four million tons are produced globally. China, being major producer contributes almost 80% followed by Korea and Japan (0.4 and 0.2 million tons) respectively. Asian countries collectively produce 95% of the total worldwide production. There is no record of persimmon production is available from Pakistan. However, Gilgit-Baltistan has the highest production followed by Swat. Study conducted in district Gilgit revealed that it has least contribution into local economy. Fruit is harvested in October to December. Mature plant produces an average of 151.8kg (Std. Dev.103.58749) annually. Sixty-four percent is sold for a mean price of 13.2 (Std. Dev.6.62) Pak rupees per kilogram. Mean household consumption was 25.65kg (Std. Dev.25.52). Mean DBH of 78.59cm (Std. Dev. 54.5136) and 20 ft high. Average life span estimate was 59.3-year (Std. Dev. 27.57198). Contrary to several medicinal uses in the world, people (>98%) in the area never use it as medicine except some rare use for skin fairness and improving blood circulation (<2%). About 80% trees flower as early as in April, fruiting starts in May (82%) and 84% harvested in November. Majority population (78%) is disease free. Around 78% farmers believe that it requires low water and fertilization. Mean leaf size was 257.52cm 2 (length 11.57cm, width 22.2cm). Ten leaves have a mean weight of 0.82g. Mean fruit height recorded was 4.2cm, diameter 6.0cm and weight 121.4g. Three varieties exist in the area. Dendrogram constructed using Hierarchical clustering showed that use of leave and fruit quantitative morphological characters cannot be used towards any discrimination and taxonomic classification. There is no selective breeding nor any value chain development programmes to improve depreciating gene pool in changing climatic conditions. Besides, its promotional efforts, detailed investigations are required to document biochemical, molecular and morphological markers.","PeriodicalId":345283,"journal":{"name":"JOJ Sciences","volume":"174 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133558627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and Indicators of Reduced Welfare of Grazing Dairy Cows from Selected Smallholder Dairy Farms in Midlands Province","authors":"Matore Z","doi":"10.19080/jojs.2018.01.555561","DOIUrl":"https://doi.org/10.19080/jojs.2018.01.555561","url":null,"abstract":"Consumers of animal products in the whole world have become increasingly concerned about food quality, safety and welfare of farm animals. As a result, new approaches, new regulations and new standards have been developed to ensure particular animal welfare levels on farm. Zimbabwe like many African countries is lagging behind and has its Prevention of cruelty to animals act of 1960, which doesn’t effectively address modern day animal welfare realities. On the other hand, rangeland (veld) in Zimbabwe is of good quality only in wet summer (November-February) whereas in winter veld quality drastically drops. Five percent of the smallholder dairy farmers in Zimbabwe own forage pastures while about 10% supplement their cows with urea treated stover and sometimes maize silage in winter. The grazing area is shared by the community with a recommended carrying capacity of 1LU/ 9 hectares and a stocking rate of 1LU/3 hectares.","PeriodicalId":345283,"journal":{"name":"JOJ Sciences","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127948146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Intense Physical Exercise In Rehabilitation of Patients Submitted to Heart Transplant","authors":"G. D. Ferreira","doi":"10.19080/jojs.2018.01.555560","DOIUrl":"https://doi.org/10.19080/jojs.2018.01.555560","url":null,"abstract":"Cardiovascular diseasesaccount for 17.3 milliondeaths per year and it is estimated that by 2030 this number will reach 23.6 million [1]. Despite the constant therapeutic advances of the last decades, heart failures still a reserve dprognosis, and heart transplantation is a widely accepted surgical alternative in cases where drug therapy is not sufficient to maintain the quality of life of patients with the form most severe disease [2]. Post-transplant cardiacre habilitation with physical exercise has proven benefits for thepatienttoreturntodailyactivities, improving fitness, and reduce some complications such as obesity, hypertension and depressio[3,4].","PeriodicalId":345283,"journal":{"name":"JOJ Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115259266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photochemistry Governing Bacteriorhodopsin and Bacterial Reaction Center","authors":"Bernadine G Ang","doi":"10.19080/jojs.2018.01.555559","DOIUrl":"https://doi.org/10.19080/jojs.2018.01.555559","url":null,"abstract":"Bacteriorhodopsin (bR) is an integral membrane protein found in the purple membrane of the Halobacterium halobium. As a light driven proton pump, bRs capture photons in the order of 500nm-650nm. Existing research found that 300mv of electricity generated per purple membrane [1]. Conversely, bacterial reaction center (bRC) is found in Rhodobacter sphaeroides. It generates 800mv of electricity in total, considering the transfer of 4 protons in the membrane. Multiple interventions to denature and modulate the structure of bR should be considered, including pH, temperature, detergent and wavelength of laser light. Bacteriorhodopsin has been known to function between0C to 45C at a pH of 1-11. It tolerates temperature over 80C in water and up to 140C in dry [2]. Conventionally, laser is utilized to precipitate the photoisomerization of bR, consequently shifting all trans-13 to structure. The chromophore which is covalently attached to Lys216 through a Schiff base is modulated through this method. Bacterial Reaction Center (bRC) is a light driven electron transfer reaction that converts solar energy to chemical energy. bRC are integral membrane structured proteins found in the purple membrane of Rhodobacter sphaeroides. It is composed of 3 protein subunits--L, M and H. It has 3 major co-factors composed of 4bacterio-chlorophylls, 2 bacteriopheophytins and 2 quinones [3]. In this interaction, electron transfer occurs through light ejection of electron that passes through them embrane. Conversion of sunlight to chemical energy simultaneously precipitates. Both bR and bRC from Halobacterium halobium and Rhodobacter sphaeroides respectively generate a considerable worth of electricity that can be used in the industry today. Although bRC emits power in a rather limited merit, future research would determine its potential for catalyzing electrically reliant applications such as optics, instrumentation and therapeutic values. bRC can be utilized for solar energy and drive photovoltaic cells. Its usage is ubiquitous at this point and has generated multitude of photovoltaic and solar energy driven applications. Further research will enhance the efficacy of bRC generated solar cells and related interventions.","PeriodicalId":345283,"journal":{"name":"JOJ Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115308013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}