Targeting Cancer by siRNA; A Review on Current Strategies

Abstract

Recent development in RNA Interference (RNAi) brought enthusiasm in the scientific community and opened the new ways for many therapeutic applications. The RNAi is a phenomenon which is used to targets mRNA and chops them up. The most appealing work of RNAi is observed in cancer inhibition by silencing genome sequences. Ultimate level of specificity can be achieved through siRNA targeted therapeutics. Short interfering RNA(siRNA) belongs to dsRNA molecules that can be produced exogenously and endogenously. This review sums up the recent approaches for cancer inhibition by siRNA. The article also points out the current targets of siRNA in cancer therapy development including expression level of cancerous and non-cancerous cells, their genetic concerns and siRNA drug delivery system like lipid base Nano-vectors. Currently, many of RNA based drugs are in practice at clinical trials level to overcome this deadly disease. In view of the encouraging results of RNAi based therapy, it is obvious that in near future siRNA will prove itself as a major cancer inhibitor and can become a standard cancer treatment.