Investigation of Interactional Behavior of some Biologically Important Compounds by a Quantitative Method

Abstract

During the last decades, the community needs for understanding of chemical structure and activity of various groups of drug molecules have been as an important challenge. It is interesting to know that recently scientists have developed the applicable analytical methods such as different types of spectroscopic technique [1-5] to study the unique characteristic of biologically important compounds. There is no doubt that provide of a proper method can give a precise information of complex molecular details. This is vital in disease diagnosis and design of pharmacologically and biological important compounds. In laboratory condition, the experimental researches and naturally occurring phenomena are usually used in solution state. Under this circumstance, solvent molecules have profound effects on the behavior of solute molecules in various biological, chemical and physical phenomena. In general, solvent sensitive processes are acquired from various molecular interactions, these includes general and specific solute-solvent interactions. Solvent induced effects are commonly discussed by their polarity and solvatochromic parameters [6-10]. The nature and strength of various molecular interactions cannot exactly have described by single solvent polarity parameters. Hence, multi-linear solvent polarity parameters known as Catalan equation (equation 1) are used [6]. 0 ' ' ' ' y y a SA b Sdp c SA d SB = + + + + (2)