Radiation Medicine and Protection最新文献

{"title":"Nomogram for predicting the overall survival of patients after D2/R0 resection and chemoradiotherapy for stage III gastric cancer or gastroesophageal junction cancer","authors":"Jinming Shi ,&nbsp;Wenzhe Kang ,&nbsp;Songlin Gao ,&nbsp;Wenyang Liu ,&nbsp;Yuan Tang ,&nbsp;Ning Li ,&nbsp;Qiang Zeng ,&nbsp;Huiying Ma ,&nbsp;Haoyue Li ,&nbsp;Yantao Tian ,&nbsp;Jing Jin","doi":"10.1016/j.radmp.2023.07.002","DOIUrl":"10.1016/j.radmp.2023.07.002","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the independent factors associated with the overall survival (OS) after D2/R0 resection and adjuvant chemoradiotherapy(CRT) for stage III gastric cancer (GC) and gastroesophageal junction (GEJ) cancer, and establish and validate a nomogram model to predict the OS in this patient population.</p></div><div><h3>Methods</h3><p>A total of 569 stage III GC or GEJ cancer patients who underwent D2/R0 resection and adjuvant CRT at our center from January 2013 to May 2018 were retrospectively enrolled in this study. The patients were randomly divided into training and validation cohorts in a 3:1 ratio. In the training cohort, univariate and multivariate analysis were conducted to identify clinical factors associated with OS, and a nomogram model was established on the basis of the independent factors. The concordance index (C-index) and the calibration curve were used to validate the prediction power of the nomogram.</p></div><div><h3>Results</h3><p>Overall, 427 and 142 patients were enrolled in the training and validation cohorts, respectively. In the univariate and multivariate analyses, age, Lauren's classification, TNM stage, and administration of adjuvant CRT were independent factors for OS to construct the nomogram. The C-index values were 0.654 and 0.613 in the training and validation cohorts, respectively. The calibration curves were identical to the actual OS. Risk stratification based on the nomogram model showed good risk stratification for OS in both groups.</p></div><div><h3>Conclusion</h3><p>Our study included adjuvant CRT as a predictive factor and established a nomogram model for predicting the OS in patients with stage III GC or GEJ after D2/R0 resection and adjuvant therapy. This nomogram could facilitate more individualized prediction of OS in clinical practice.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 3","pages":"Pages 130-135"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49255080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation on the radioactivity levels of seawater, sediments, and biota in Daya Bay, China","authors":"Fan Cui ,&nbsp;Honghui Huang ,&nbsp;Yi Shen ,&nbsp;Zhan Tan ,&nbsp;Pengxiang Qu ,&nbsp;Ming Dai ,&nbsp;Hongwei Yu ,&nbsp;Weixu Huang ,&nbsp;Zixiang Wu ,&nbsp;Huifeng Chen ,&nbsp;Weizhen Guo ,&nbsp;Yuxin Jia ,&nbsp;Yanbing Liu","doi":"10.1016/j.radmp.2023.07.004","DOIUrl":"10.1016/j.radmp.2023.07.004","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the radioactivity levels of seawater, sediments, and biota in the Daya Bay sea area, China, in order to establish the radioactivity baseline values, and provide basic data for the assessment of potential radiological risks that might result from the application of nuclear technology or human activities.</p></div><div><h3>Methods</h3><p>Samples of seawater, sediments, and biota were collected from the Daya Bay sea area and analyzed. Their radioactivity baseline data were then compared with information from other regions in China and around the world reported in related literature.</p></div><div><h3>Results</h3><p>For the seawater samples, the activity concentrations of natural radionuclide ⁴⁰K were 9.9–10.4 Bq/L, while ²³⁸U, ²²⁶Ra, ²¹⁰Pb, ¹³⁷Cs, and ¹¹⁰Ag^m were below the minimum detectable activity (MDA). Regarding the sediment samples, the activity concentrations of ²³⁸U, ²²⁸Ra, ²²⁶Ra, ²¹⁰Pb, ⁴⁰K, and ¹³⁷Cs were 38.1–40.4, 49.1−53.7, 32.6−38.6, 59−95, 590−650, and 0.48–0.88 Bq/(kg dry weight), respectively, while ¹¹⁰Ag^m was below the MDA. For the marine shrimps in the biota samples, the activity concentrations of ²²⁸Ra, ²²⁶Ra, ⁴⁰K, and ¹³⁷Cs were 1.14–2.75, 0.17−0.43, 63–76, and 0.038–0.045 Bq/(kg wet weight), respectively, while ²³⁸U, ²¹⁰Pb, and ¹¹⁰Ag^m were all below the MDA. Furthermore, for the marine fishes in the biota samples, the activity concentrations of ²²⁸Ra, ²²⁶Ra, ²¹⁰Pb, ⁴⁰K, and ¹³⁷Cs were 2.1–19.7, 0.32–3.78, &lt;2.2–2.8, 59–70, and &lt;0.007–0.026 Bq/(kg wet weight), respectively, while ²³⁸U and ¹¹⁰Ag^m were all below the MDA. ²²⁸Ra was found to be concentrated in <em>Osteomugil ophuyseni</em> with 19.7 Bq/(kg wet weight).</p></div><div><h3>Conclusions</h3><p>The radioactivity levels of seawater and marine sediments in the Daya Bay sea area are within the range of the normal background values. <em>Osteomugil ophuyseni</em> exhibited higher concentrations of ²²⁸Ra than other species in this study, while the other species in the biota show no significant difference in the radioactivity levels from data in relevant literature.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 3","pages":"Pages 165-169"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49222176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of 4D dynamic dose for thoracic tumor stereotactic body radiation therapy with variable parameters","authors":"Yiling Zeng ,&nbsp;Yu Chang ,&nbsp;Sheng Zhang ,&nbsp;Jun Han ,&nbsp;Hongyuan Liu ,&nbsp;Feng Xiao ,&nbsp;Bo Pang ,&nbsp;Bin Hu ,&nbsp;Junping Cheng ,&nbsp;Hong Quan ,&nbsp;Zhiyong Yang","doi":"10.1016/j.radmp.2023.07.003","DOIUrl":"10.1016/j.radmp.2023.07.003","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the dose uncertainty in stereotactic body radiation therapy induced by respiratory motion using a 4D dynamic dose (4DDD) reconstruction method.</p></div><div><h3>Methods</h3><p>A retrospective analysis was conducted on five lung cancer patients who received static intensity-modulated radiation therapy. The 4DDD was constructed using beam delivery log files, four-dimensional computed tomography (4DCT) scans, and treatment plans. To evaluate the impact of respiratory motion, 4DDD calculations were performed with 10 starting phases for each field. A total of 270 field doses were simulated and calculated. The differences between the cumulative volume histogram in whole-course treatment and the field doses' gamma passing rate (GPR) were compared. The correlations between plan complexity metrics and the dose deviation caused by respiratory motion were evaluated independently. The phase distributions of 398 subfields were calculated and evaluated for the influence of dose rate and breathing frequency.</p></div><div><h3>Results</h3><p>The GPRs of all fields were different among various starting phases, with the highest range from 62.20% to 76.87% for 2 mm/3% GPR. The deviation of mean point dose was (5.42 ​± ​5.21) %, and the deviation in the mean dose and <span><math><mrow><msub><mi>D</mi><mrow><mn>98</mn><mo>%</mo></mrow></msub></mrow></math></span> within the internal gross tumor volume were (0.97 ​± ​0.71) % and (0.77 ​± ​0.53) %, respectively. There was a significant correlation between the beam aperture-to-volume (BA2V) ratio and the average 2 mm/2% GPR (<em>R ​=</em> 0.601, <em>P</em> ​&lt; ​0.01). Lower dose rates led to a more homogeneous distribution of phases among subfields (<em>t</em> ​= ​44.100, <em>P</em> ​&lt; ​0.001).</p></div><div><h3>Conclusions</h3><p>Different beam starting phases had a limited impact on the overall treatment evaluation. However, the respiratory motion could be observed to induce dose deviations using the 4DDD reconstruction model, particularly for fields with small BA2V.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 3","pages":"Pages 150-158"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47689090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation properties of 3D-printed materials for an Ir-192 high dose rate source using Valencia skin applicators","authors":"Jie Zhang ,&nbsp;Wenjun Zhang ,&nbsp;Bo Yang ,&nbsp;Zhequn Liu ,&nbsp;Lang Yu ,&nbsp;Jie Qiu ,&nbsp;Fuquan Zhang","doi":"10.1016/j.radmp.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.radmp.2023.07.001","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the physical properties of commonly used 3D-printed materials and the dose attenuation around a high-dose-rate ¹⁹²Ir source, in order to provide a reference for selecting appropriate 3D-printed materials for brachytherapy.</p></div><div><h3>Methods</h3><p>Fifteen 3D-printed materials (12 non-metallic material and 3 metallic material) were assessed. Each material was fabricated into a wafer with a diameter of 30 ​mm and thickness of 3 ​mm using 3D printing. The CT number of each material was measured, and attenuation measurements were conducted with a Valencia skin applicator and well-type ionization chamber. ¹⁹²Ir was used as the radioactive source, and the attenuated ionization charges were normalized against that obtained in the presence of a solid water phantom at the same depth.</p></div><div><h3>Results</h3><p>The CT number of nylon was (−7.78 ​± ​3.36) HU, closest to water among all materials. The CT numbers of the other 11 non-metallic materials were below 300 HU. Moreover, the CT number of the Al alloy was (1,350.89 ​± ​374.55) HU, while the CT numbers of the Ti alloy and stainless steel exceeded 2,976 HU, reaching the upper limit of the CT number range. The results of the attenuation measurements were normalized with the solid water phantom. The average attenuation coefficients of a polyamide, epoxy resin, photosensitive resin, carbon fiber, silica gel, Al alloy, Ti alloy, and stainless steel were 1.003, 0.994, 0.992, 0.995, 0.995, 0.967, 0.939, and 0.866, respectively.</p></div><div><h3>Conclusions</h3><p>Among the common 3D-printed materials with a density similar to that of water, nylon exhibited the best performance, while the metallic materials caused significant dose attenuation and exhibited CT number distortion. As a result, care should be taken when metallic materials are used as 3D-printed materials for brachytherapy.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 3","pages":"Pages 145-149"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49705862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic analysis of acute radiation-induced rectal injury in rats","authors":"Yue Zhu ,&nbsp;Jun Dai ,&nbsp;Xiaopeng Xu ,&nbsp;Yi Gao ,&nbsp;Weidong Shen ,&nbsp;Shuyu Zhang ,&nbsp;Pengfei Liu","doi":"10.1016/j.radmp.2023.08.003","DOIUrl":"10.1016/j.radmp.2023.08.003","url":null,"abstract":"<div><h3>Objective</h3><p>To comprehensively elucidate overall protein alterations associated with acute radiation-induced rectal injury in rats.</p></div><div><h3>Methods</h3><p>A rat model of acute radiation-induced rectal injury was established by irradiating rectal segments with a single dose of 17.5 ​Gy X-rays. These segments were then collected at 7 d and 10 ​d post-irradiation. Tandem mass tag-based quantitative proteomic analysis was then performed.</p></div><div><h3>Results</h3><p>65,526 peptides were identified, corresponding to 8,088 proteins. Hematoxylin-eosin staining revealed characteristic epithelial cell degeneration and necrosis, intestinal gland atrophy and dilatation, and interstitial inflammatory cell infiltration. Inflammation was more pronounced in the 10 d irradiation group than in the 7 d irradiation group. Overall, 127 up- and 108 downregulated proteins were identified at 7 d post-irradiation, and 122 up- and 44 downregulated proteins were identified at 10 d post-irradiation. Notably, 17 up- and 6 downregulated proteins were consistently co-expressed at both time points. The expression of three of these proteins was validated via real-time quantitative PCR: polypeptide YY (Pyy), thymidylate synthase (Tyms), and tetraspanin (CD9). Tyms transcript levels were significantly higher in irradiated rectal tissues (<em>P</em> ​&lt; ​0.05). Pyy transcript levels were significantly higher at both time points (<em>P</em> ​&lt; ​0.05). Finally, CD9 mRNA expression was significantly lower in both the 7 d and 10 d irradiation groups (<em>P</em> ​&lt; ​0.05).</p></div><div><h3>Conclusions</h3><p>The potential targets were found to prevent and treat acute radiation-induced rectal injury in clinical practice.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 3","pages":"Pages 117-124"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43059927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between IDEAL-IQ MRI fat fraction quantification and pelvic bone marrow reserve function in concurrent chemoradiotherapy for cervical cancer","authors":"Xiaomin Wen ,&nbsp;Qinghua Qin ,&nbsp;Yanling Wu ,&nbsp;Zhouyu Li ,&nbsp;Xinglong Yang ,&nbsp;Jinquan Liu ,&nbsp;Ling Lin ,&nbsp;Mingyi Li","doi":"10.1016/j.radmp.2023.08.002","DOIUrl":"10.1016/j.radmp.2023.08.002","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze the association between iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantification sequence (IDEAL-IQ) magnetic resonance imaging (MRI) of bone marrow fat fraction and bone marrow reserve function during concurrent chemoradiotherapy for cervical cancer.</p></div><div><h3>Methods</h3><p>The study retrospectively analyzed twenty-six patients with stage IB1 to IVA cervical cancer treated between February 2020 and November 2020. All patients received concurrent chemoradiotherapy that included platinum alone or combined paclitaxel and platinum. Pelvic IDEAL-IQ MRI (plain and enhanced) was performed before and after treatment. Regions of interest, including the fifth lumbar vertebra, sacrum, ilium, ischium, and femoral neck, were manually delineated, and the bone marrow fat fraction was measured. Peripheral blood cell counts were recorded during treatment, and the relationship between the fat fraction values and changes in the blood cell counts was explored.</p></div><div><h3>Results</h3><p>IDEAL-IQ MRI bone marrow fat fraction was associated with platelet nadir and platelet decline during treatment. The average pelvic bone marrow fat fraction before chemoradiotherapy was moderately negatively correlated with platelet count nadir during concurrent chemoradiotherapy (<em>r</em> ​= ​−0.450, <em>P</em> ​= ​0.021). The change in average pelvic bone marrow fat fraction through chemoradiotherapy was moderately positively correlated with the degree of thrombocytopenia (<em>r</em> ​= ​0.399, <em>P</em> ​= ​0.044).</p></div><div><h3>Conclusion</h3><p>Bone marrow fat content quantified by IDEAL-IQ was associated with platelet count nadir and the degree of thrombocytopenia in patients with cervical cancer undergoing concurrent chemoradiotherapy.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 3","pages":"Pages 136-144"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46217785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuation properties of 3D-printed materials for an Ir-192 HDR source using Valencia skin applicators","authors":"Jie Zhang, Wenjun Zhang, Bo Yang, Zhequn Liu, Lang Yu, J. Qiu, Fuquan Zhang","doi":"10.1016/j.radmp.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.radmp.2023.07.001","url":null,"abstract":"","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47858775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The radioresistant and survival mechanisms of Deinococcus radiodurans","authors":"Feng Liu ,&nbsp;Nuomin Li ,&nbsp;Yongqian Zhang","doi":"10.1016/j.radmp.2023.03.001","DOIUrl":"10.1016/j.radmp.2023.03.001","url":null,"abstract":"<div><p><em>Deinococcus radiodurans</em> (<em>D. radiodurans</em>) is distinguished by the most radioresistant organism ever known, and can tolerate extreme environments such as ionizing radiation, ultraviolet radiation, oxidation, and desiccation. <em>D. radiodurans</em> is an important model for studying DNA damage/repair and redox regulation upon high dose ionizing radiation. How <em>D. radiodurans</em> response and repair ROS-induced oxidative damage remains a subject of ongoing investigation. This review provides an overview of the radioresistance characteristics of <em>D. radiodurans</em>. Among them, the DNA damage repair pathway and high-efficiency antioxidant defense system are summarized in detail. Furthermore, a novel model that protects the cell against the ionizing radiation is proposed. This review also discusses the potential application , future challenges and directions in advancing towards <em>D. radiodurans</em> studies.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 2","pages":"Pages 70-79"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49585363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of occupational exposure in medical practice in Gabon during 2013–2020","authors":"P. Ondo Meye ,&nbsp;S.Y. Loemba Mouandza ,&nbsp;G.B. Dallou ,&nbsp;Y. Omon ,&nbsp;B.C. Mabika Ndjembidouma ,&nbsp;C. Chaley ,&nbsp;G.H. Ben-Bolie","doi":"10.1016/j.radmp.2023.03.004","DOIUrl":"10.1016/j.radmp.2023.03.004","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate whole-body, extremity and eye-lens occupational dose equivalents of ionizing radiation to Occupationally Exposed Workers (OEWs) in Gabon, monitored by the national Individual Monitoring Service (IMS), in the medical practice.</p></div><div><h3>Methods</h3><p>A total of 816 dose records for 205 OEWs were evaluated. Doses were collected for an eight-year period, from 2013 to 2020. Twelve public and private hospitals were involved, including a cancer centre where radiotherapy (RT) and nuclear medicine (NM) procedures are regularly performed. OEWs were monitored, on a monthly or quarterly basis, for whole-body dose and extremity dose using an optically stimulated luminescence (OSL) dosimeter worn on the torso or the wrist, as appropriate. Eye-lens dose was estimated from whole-body dose results.</p></div><div><h3>Results</h3><p>The whole-body dose distribution was skewed and the zero dose was associated with a probability of 47%. Some recorded doses were associated with estimated X-ray energies above those typically encountered in diagnostic radiology, thus suggesting that some doses attributed to workers and believed to be due to X-rays may in fact be due to background radiation (false positive dose records). For the period 2013–2020, annual doses to OEWs in diagnostic radiology (DR), NM and RT departments were 0.40 ​mSv, 0.38 ​mSv and 0.09 ​mSv, respectively. For the same period, the mean annual extremity and eye-lens doses were 0.78 ​mSv (range: 0–5.24 ​mSv) and 0.35 ​mSv (range: 0–3.74 ​mSv), respectively.</p></div><div><h3>Conclusion</h3><p>With little effort by the national IMS and the regulatory body, annual whole-body doses to workers can be kept well below 6 ​mSv, thus efficiently contributing to the optimization of worker's protection. However, extremity doses may in fact be greater than those reported for OEWs in the NM department. Finally, eye-lens doses were well below the new annual dose limit of 20 ​mSv, thus demonstrating that, in the current situation, OEWs in the NM department do not require routine eye lens dose monitoring. Rather, whole-body dose may be used as an indicator of eye-lens dose.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 2","pages":"Pages 109-115"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44456913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inorganic imaging nanoprobes for breast cancer diagnosis","authors":"Qi Guo ,&nbsp;Maosen Hong ,&nbsp;Tong Wu ,&nbsp;Lei Chen ,&nbsp;Guangxin Duan ,&nbsp;Jianfeng Zeng ,&nbsp;Ximing Wang ,&nbsp;Ling Wen ,&nbsp;Chunhong Hu","doi":"10.1016/j.radmp.2023.05.004","DOIUrl":"10.1016/j.radmp.2023.05.004","url":null,"abstract":"<div><p>Breast cancer is one of the most prevalent cancers worldwide, and early diagnosis and screening are vital to its successful treatment. Although medical imaging methods can assist in the early detection of breast cancer, imaging methods that are currently used for clinical diagnosis have drawbacks, such as low sensitivity and accuracy. Contrast agents are often used in diagnostic imaging to address these drawbacks. Nanocontrast agents have attracted considerable attention in recent years due to their unique physicochemical characteristics. Among these agents, inorganic nanoprobes have been substantially developed through improvements in synthesis techniques and pairings with other organic molecules. This paper mainly summarizes the specific applications of inorganic nanoprobes in the magnetic resonance imaging, fluorescence imaging, radionuclide imaging, and bimodal/multimodal imaging of breast cancer.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"4 2","pages":"Pages 80-85"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46814974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}