Radiation Medicine and Protection最新文献

{"title":"RXRα agonist bexarotene attenuates radiation-induced skin injury by relieving oxidative stress","authors":"Sheng Jiang ,&nbsp;Weichao Cai ,&nbsp;Jianhui Chen ,&nbsp;Wenling Tu ,&nbsp;Yulan Liu ,&nbsp;Lixin Gong ,&nbsp;Yahui Feng ,&nbsp;Wei Mo ,&nbsp;Tao Yan ,&nbsp;Shuyu Zhang ,&nbsp;Daojiang Yu","doi":"10.1016/j.radmp.2022.04.004","DOIUrl":"https://doi.org/10.1016/j.radmp.2022.04.004","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the protective effect of bexarotene in radiation-induced skin injury and elucidate underlying mechanism.</p></div><div><h3>Methods</h3><p>Irradiated cellular and animal models were established using an X-ray linear accelerator. Cell viability and apoptosis were evaluated by CCK8 and flow cytometry. <em>In vivo</em> protective effect of bexarotene was measured in irradiated SD rats. The antioxidant capacity of bexarotene was validated by DCF-DA method. The signaling pathways involved in bexarotene-mediated skin repair were enriched by RNA sequencing.</p></div><div><h3>Results</h3><p>Bexarotene could significantly restore the proliferation and inhibit the apoptosis of WS1 cells with radiation damage (<em>P</em> ​&lt; ​0.05). Moreover, bexarotene could effectively shorten the process of skin damage and promote skin repair in a rat model of radiation-induced skin injury (<em>P</em> ​&lt; ​0.05). Mechanistically, bexarotene effectively reduced the expression of RXRα (<em>P</em> ​&lt; ​0.05), thus leading to an early decrease in reactive oxygen species (ROS) after radiation exposure. Furthermore, a transcriptome analysis indicated that bexarotene-mediated recovery of radiation damage involves redox signaling, immune regulation, lipid metabolism and autophagy.</p></div><div><h3>Conclusion</h3><p>Bexarotene is a promising therapeutic agent in the treatment of radiation-induced skin injury.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 2","pages":"Pages 56-63"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000247/pdfft?md5=8b47cf7ab32470f0bb78093675747d92&pid=1-s2.0-S2666555722000247-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137141366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-induced non-targeted effect of immunity provoked by mitochondrial DNA damage triggered cGAS/ AIM2 pathways","authors":"Wen Zhang ,&nbsp;Shi Chen ,&nbsp;Hua Guan ,&nbsp;Ping-Kun Zhou","doi":"10.1016/j.radmp.2022.05.002","DOIUrl":"10.1016/j.radmp.2022.05.002","url":null,"abstract":"<div><p>Non-targeted effect is an important complement to the classical target theory of radiation biology which takes nuclear genomic DNA as the core target. The principle of radiation target theory is to assume that an organism or cell has one or more sensitive points or targets, hit and inactivation of which directly by radiation leads to considerable damage and the death event. Recent findings indicate that not only cell nucleus but also other cellular parts can be considered as possible targets. Mitochondrion is considered as a critical organelle where the non-targeted effect is initiated. A series of recent studies have provided substantial evidence and solid data which profoundly facilitate the understanding of radiation-induced non-targeted effects emitted from mitochondrion in the irradiated cells, such the major apparent performances, signaling pathways and biological significance. Mitochondrial genome is more sensitive to genotoxic than nuclear genome. Ionizing radiation can induce mtDNAs double-strand breaks directly or indirectly via increased mitochondrial ROS. Under stress conditions, mitochondrial DNA (mtDNA) fragments are released into the cytoplasm. The cytosol mtDNAs are sensed by cGAS and AIM2 proteins and they activate the corresponding signaling pathways, generating relevant inflammatory and immune responses. These newly developed mitochondrial DNA-initiating pathways may boost the development of targeted therapies for preventing normal tissue toxicity as well as radio-immunotherapy, an emerging trend for cancer therapies. Here we focus and discuss the mechanisms and biological significance of mtDNA-triggering cGAS/AIM2 signaling pathways of immune response from the aspect of non-targeted effect of radiation.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 2","pages":"Pages 47-55"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000260/pdfft?md5=37a4aa09957dd60e5df5eeaba5e33b66&pid=1-s2.0-S2666555722000260-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41449117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhaled amifostine for the prevention of radiation-induced lung injury","authors":"Ting Chen ,&nbsp;Bo Zhuang ,&nbsp;Yueqi Huang ,&nbsp;Wanmei Wang ,&nbsp;Yiguang Jin","doi":"10.1016/j.radmp.2022.05.001","DOIUrl":"10.1016/j.radmp.2022.05.001","url":null,"abstract":"<div><h3>Objective</h3><p>To alleviate radiation-induced lung injury and prevent the related pneumonitis and pulmonary fibrosis by inhaled amifostine (AMI).</p></div><div><h3>Methods</h3><p>15 ​Gy ⁶⁰Co γ-ray irradiation was performed on the thoracic area of rats once to establish the radiation injury model. AMI was intraperitoneally (i.p.) injected or intratracheally (i.t.) administered to the rats 30 ​min pre-irradiation. The protective effects of the two AMI administration manners were compared in the aspects of hematopoietic system, lung edema, and histopathological examination, and the mechanisms were explored.</p></div><div><h3>Results</h3><p>Compared to i.p. AMI, i.t. AMI remarkably alleviated radiation-induced lung injury and prevented consequent pneumonitis or pulmonary fibrosis. Specifically, i.t. AMI notably protected white blood cells and platelets, reduced the lung wet/dry weight ratio, and decreased collagen volume fractions compared to the model group (<em>P</em> ​&lt; ​0.05), while i.p. AMI showed no significant difference with the model group (<em>P</em> ​&gt; ​0.05). The high therapeutic efficiency of i.t. AMI was related to its high antioxidation and anti-inflammation effects with downregulation of pro-inflammatory cytokines, the enhanced superoxide dismutase activity, the low levels of malondialdehyde and total proteins.</p></div><div><h3>Conclusion</h3><p>Inhaled AMI is a promising medicine for preventing radiation-induced lung injury, including pneumonitis and pulmonary fibrosis.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 2","pages":"Pages 72-80"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000259/pdfft?md5=22aae9696125c2fe061f855672369988&pid=1-s2.0-S2666555722000259-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47834566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in preventing neutropenia during definitive concurrent chemoradiotherapy in patients with esophageal squamous carcinoma","authors":"Xin Dong,&nbsp;Wei Deng,&nbsp;Leilei Jiang,&nbsp;Dan Yang,&nbsp;Huiming Yu,&nbsp;Dongming Li,&nbsp;Anhui Shi,&nbsp;Rong Yu,&nbsp;Weihu Wang","doi":"10.1016/j.radmp.2022.04.002","DOIUrl":"https://doi.org/10.1016/j.radmp.2022.04.002","url":null,"abstract":"<div><h3>Objective</h3><p>To compare the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) for preventive or delayed treatment in neutropenia, completion rate of concurrent chemoradiotherapy and hospitalization rate in patients with esophageal squamous carcinoma during definitive concurrent chemoradiotherapy.</p></div><div><h3>Methods</h3><p>A total of 70 patients with esophageal squamous carcinoma in Peking University Cancer Hospital from January 2019 to December 2020, who received PEG-rhG-CSF during concurrent chemoradiotherapy, were enrolled in this retrospective analysis. There were 32 patients in the preventive group, and 38 patients in the delayed group. The incidence of neutropenia, completion rate of concurrent chemoradiotherapy and neutropenia-related hospitalization rate were compared between PEG-rhG-CSF preventive group and delayed group.</p></div><div><h3>Results</h3><p>The incidence of severe neutropenia (Grades 3–4) in all patients was 31.4%. Comparison between preventive group and delayed group showed that the incidence of severe neutropenia was 6.3% and 39.4% (χ² ​= ​10.428, <em>P</em> ​= ​0.001), respectively. In preventive group, the incidence of severe neutropenia was 3.7% and 20.0%, respectively, for primary prevention and secondary prevention of PEG-rhG-CSF (χ² ​= ​12.321, <em>P</em> ​= ​0.001). The completion rate of concurrent chemoradiotherapy was 93.8% in the preventive group and 63.2% in the delayed group (χ² ​= ​9.220, <em>P</em> ​= ​0.002). The incidence of treatment interruption was 25.7% in the whole group, 12.5% in the preventive group and 36.8% in the delayed group (χ² ​= ​5.389, <em>P</em> ​= ​0.020). Seven patients (7/70, 10.0%) were hospitalized and treated with intravenous antibiotics for neutropenia, including 1 in the preventive group and 6 in the delayed group (<em>P</em> ​= ​0.078).</p></div><div><h3>Conclusions</h3><p>Prophylactic use of PEG-rhG-CSF during concurrent chemoradiotherapy for patients with esophageal squamous carcinoma can effectively reduce the incidence of neutropenia, ensure the safety of treatment, and improve the completion rate of concurrent chemoradiotherapy.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 2","pages":"Pages 81-85"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000223/pdfft?md5=ccac9fa2d2e6fd1826dca57d3f260462&pid=1-s2.0-S2666555722000223-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137141365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary study on effect of carbon ion radiotherapy on bone marrow suppression","authors":"Ying Qi ,&nbsp;Xin Pan ,&nbsp;Caixia Lyu ,&nbsp;Wanguo Li ,&nbsp;Huixiang Lu ,&nbsp;Sha Li ,&nbsp;Yanshan Zhang ,&nbsp;Xiaoli Lu ,&nbsp;Dongji Chen ,&nbsp;Yee-Min Jen","doi":"10.1016/j.radmp.2022.04.001","DOIUrl":"10.1016/j.radmp.2022.04.001","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the effect of carbon ion radiotherapy (CIRT) on the bone marrow adjacent to or within the treatment fields, and to observe the bone marrow toxicities after CIRT alone.</p></div><div><h3>Methods</h3><p>Twenty-one patients with malignant tumors of different body parts and treated with CIRT in Heavy Ion Center, Wuwei Cancer Hospital were analyzed retrospectively. The data of white blood cells, neutrophils, hemoglobin, platelets, lymphocytes and globulin before treatment, 7, 14 and 28 ​d during treatment, and 1 and 3 months after treatment were collected. Hematological toxicities were measured according to the Common Terminology Criteria for Adverse Events (CTCAE, Version 4.03) criteria. Dose-volume histogram parameters were obtained for all patients and analyzed for their correlation with myelosuppression. Univariate analysis was performed for patients’ sex, age group, tumor site, radiation dose, and Karnofsky performance score (KPS) was used as an independent factor to find predictors factors for the risk of myelosuppression.</p></div><div><h3>Results</h3><p>CIRT minimized the dose radiated to the bone marrow. Overall, volume receiving 3 GyE(<em>V</em>_<em>3</em>) or more of the bone marrow were less than 0.5%, especially <em>V</em>₅ less than 0.1%. No patients treated with carbon ion radiotherapy developed grade III or IV myelosuppression. Seven patients (33.3%) developed grade I myelosuppression and one patient (4.8%) developed grade II myelosuppression, and most of them showed reduced white blood cell counts. There were no significant differences in hemoglobin and globulin levels before and after CIRT. Univariate analysis did not find any statistically significant predictors for myelosuppression.</p></div><div><h3>Conclusions</h3><p>CIRT is effective in preserving bone marrow function regardless of tumor site. Patients receiving CIRT alone have a low incidence of grade I−II myelosuppression and a mild effect on globulins. There was no significant correlation between occurrence of myelosuppression and the dose and site irradiated by CIRT.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 2","pages":"Pages 86-90"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000211/pdfft?md5=7b37ee94e42c12856baf04d607bac74e&pid=1-s2.0-S2666555722000211-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45370398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactoferrin improves hepatic pyroptosis in mice after irradiation","authors":"Ru Zhang ,&nbsp;Jia Gu ,&nbsp;Yulu Wei ,&nbsp;Yaxing Guo ,&nbsp;Liqiang Qin ,&nbsp;Jiaying Xu","doi":"10.1016/j.radmp.2022.01.001","DOIUrl":"10.1016/j.radmp.2022.01.001","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the effects of lactoferrin (Lf) on hepatic pyroptosis (an inflammatory form of programmed cell death) in mice exposed to radiation.</p></div><div><h3>Methods</h3><p>A total of thirty-six BALB/c male mice were randomly divided into four groups, namely the control group, 5 ​Gy group, 5 ​Gy ​+ ​2 ​mg Lf group, and 5 ​Gy ​+ ​4 ​mg Lf group. The mice were administered whole-body ionizing radiation using a PRIMUS accelerator, with a single dose of 5 ​Gy and an absorbed dose rate of 2.0 ​Gy/min at a source-skin distance of 100 ​cm. Lf solution was intraperitoneally injected into the mice 2 ​h before and per day after radiation. The mice were sacrificed 1, 3, and 9 ​d after radiation, and their livers were used for histopathologic examination, immunohistochemistry analysis, and Western blot analysis for absent in melanoma 2 (AIM2) inflammasome pathway.</p></div><div><h3>Results</h3><p>Histopathologic examination showed the disorder of the hepatocellular structure and the accumulation of inflammatory cells after radiation. Lf intervention inhibited hepatocellular proliferation and decreased the infiltration of inflammatory cells. Immunohistochemistry analysis indicated that AIM2 overexpression was significantly attenuated by 4 ​mg of Lf (<em>t</em> ​= ​3.065, <em>P</em> ​&lt; ​0.05) 3 ​d after radiation and by 2 ​mg and 4 ​mg of Lf (<em>t</em> ​= ​4.032, <em>t</em> ​= ​2.786, <em>P</em> ​&lt; ​0.05) 9 ​d after radiation. Western blot analysis showed that Lf downregulated the hepatic overexpression of AIM2, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC), IL-1β, and IL-18. 2 ​mg of Lf significantly downregulated the abovementioned protein expression 3 ​d (<em>t</em> ​= ​7.934, 4.092, 5.193, 2.916, <em>P</em> ​&lt; ​0.05) and 9 ​d after radiation (<em>t</em> ​= ​5.016, 3.882, 9.528, <em>P</em> ​&lt; ​0.05 for AIM2, ASC, IL-1β).</p></div><div><h3>Conclusions</h3><p>Lf intervention suppressed the hepatic pyroptosis in mice exposed to ionizing radiation by downregulating the protein expression of AIM2 inflammasome.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 1","pages":"Pages 16-21"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000016/pdfft?md5=5006920187b8e234c61e9bad14b08753&pid=1-s2.0-S2666555722000016-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47292711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on the learning curve for a new radioactive seed template retainer assisted by CT-guided radioactive seed implantation for advanced non-small cell lung cancer","authors":"Xiaodong Huo ,&nbsp;Huixing Wang ,&nbsp;Bin Huo ,&nbsp;Lei Wang ,&nbsp;Shude Chai ,&nbsp;Junjie Wang ,&nbsp;Haitao Wang","doi":"10.1016/j.radmp.2022.01.004","DOIUrl":"10.1016/j.radmp.2022.01.004","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the application of a new radioactive seed template retainer in the learning curve of CT-guided ¹²⁵I seed brachytherapy (CTISBT) for advanced non-small cell lung cancer (NSCLC).</p></div><div><h3>Methods</h3><p>This study retrospectively analyzed the medical records of 60 patients who underwent CTISBT for advanced NSCLC by a single physician between January 2018 and December 2019. The data were sorted in order of admission and divided into three groups according to the order of surgery, group A (cases 1–20), group B (cases 21–40), and group C (cases 41–60). All patients underwent preoperative planning and postoperative dosimetry verification, and the operation time, intraoperative CT scans, postoperative hospital stay, and postoperative complications were compared among the three groups. The quality of life (QOL) score and tumor volume were compared before and 2 months after surgery.</p></div><div><h3>Results</h3><p>There were no statistically significant differences among the three groups in QOL scores, tumor volume, and tumor site before CTISBT assisted by the new radioactive seed template retainer. However, the surgical time differed significantly between the three groups (<em>P</em> ​&lt; ​0.01). The operation time was longer in group A than that in groups B and C (<em>P</em> ​&lt; ​0.01). There was no significant difference between groups B and C. There were no significant differences in the number of CT scans among the three groups and the length of postoperative hospital stay. The follow-up QOL and tumor volume were significantly reduced at 2 months after surgery compared with those before surgery (<em>P</em> ​&lt; ​0.01).</p></div><div><h3>Conclusions</h3><p>The short-term efficacy of the new radioactive seed template retainer-assisted CTISBT was definitive for advanced NSCLC. After the physician had accumulated experience with 20 cases of a new type of radioactive seed template retainer-assisted CTISBT surgery, the follow-up operation time was significantly shortened and the learning curve entered the plateau stage.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 1","pages":"Pages 31-36"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000041/pdfft?md5=c6b36fa1a7993539e477466fc3be5724&pid=1-s2.0-S2666555722000041-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44839641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical dosimetric reconstruction of a case of large area back skin injury due to overexposure in an interventional procedure","authors":"Yuchen Yin ,&nbsp;Xuan Wang ,&nbsp;Xianghui Kong ,&nbsp;Wenyue Zhang ,&nbsp;Yidi Wang ,&nbsp;Yuxuan Mao ,&nbsp;Jianwei Wang ,&nbsp;Tianhe Jia ,&nbsp;Yu Tu ,&nbsp;Bingjie Zhang ,&nbsp;Liang Sun","doi":"10.1016/j.radmp.2022.02.001","DOIUrl":"10.1016/j.radmp.2022.02.001","url":null,"abstract":"<div><p>To estimate the physical dose of skin and key organs in a case of overexposure during a cardiac interventional procedure.</p></div><div><h3>Methods</h3><p>The female patient aged 50 suffered from overexposure during cardiac interventional therapy in a hospital, Xinxiang city, Henan province, China in January 2020. The mesh-type phantom for the patient was constructed based on the adult mesh-type reference computational phantoms (MRCPs) released by the International Commission on Radiological Protection Publication 145 (ICRP145) and phantom deformation technology. Models of exposure scenario were constructed and simulated with particle and heavy ion transport code system (PHITS) according to exposure conditions.</p></div><div><h3>Results</h3><p>The maximum absorbed dose of key organs/tissues under irradiation in posteroanterior (PA) and 30° left anterior oblique directions(LOA) was 632.4 and 305.6 ​mGy, respectively. The left lung, heart, and left mammary gland received a larger dose under both irradiation conditions. The ratio of the absorbed dose with and without shielding was calculated, and the relative difference in most organs was &lt;1% between two directions. The iso-dose curve of the back skin revealed the distribution of the absorbed dose (0.1 −5.2 ​Gy). The dose estimate of key tissues/organs was higher than the conventional level, especially the local skin, up to 5.2 ​Gy.</p></div><div><h3>Conclusions</h3><p>The interventional procedure in this case resulted in a higher dose. Monte Carlo codes combined with the MRCPs can be employed to estimate physical dose to individuals in concrete irradiation scenarios.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 1","pages":"Pages 3-8"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000077/pdfft?md5=8e4092fefa86378c1f65e3ca63de1758&pid=1-s2.0-S2666555722000077-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41797670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memory of Honorary Editor-in-chief Ziqiang Pan (1936–2022)","authors":"Quanfu Sun,&nbsp;Xianhua Guo,&nbsp;Jianzhong Hao","doi":"10.1016/j.radmp.2022.02.002","DOIUrl":"10.1016/j.radmp.2022.02.002","url":null,"abstract":"","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 1","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000089/pdfft?md5=eea75dc119264edc53ed6b5e48cbe9e5&pid=1-s2.0-S2666555722000089-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46030530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salicylic acid sensitizes cervical cancer cells to radiotherapy by activating AMPK/TSC2/mTOR pathway","authors":"Shun Lu ,&nbsp;Wenjing Ye ,&nbsp;Jie Zhou ,&nbsp;Guangming Yi ,&nbsp;Jianming Huang ,&nbsp;Siyao Deng ,&nbsp;Minglun Li ,&nbsp;Yimin Li ,&nbsp;Yanqiong Song ,&nbsp;Jiayu Zhang ,&nbsp;Lichun Wei ,&nbsp;Guiquan Zhu ,&nbsp;Jinyi Lang","doi":"10.1016/j.radmp.2022.01.005","DOIUrl":"https://doi.org/10.1016/j.radmp.2022.01.005","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the radio-sensitizing effect of salicylic acid (SA) on human cervical cancer cells and its potential molecular mechanism.</p></div><div><h3>Methods</h3><p>Cervical cancer cells were treated with SA and ionizing radiation. The expression of γ-H2AX was evaluated by immunofluorescence (IF) assay. Cell cycle and apoptosis were analyzed by flow cytometry. Western blot was performed to detect the protein level of AMPK/TSC2/mTOR pathway.</p></div><div><h3>Results</h3><p>SA inhibited basal proliferation of cervical cancer cells in a dose and time dependent manner. In addition, SA increased radiation-induced DNA damage, promoted apoptosis, triggered a redistribution of cell cycle from G₂-M phase to G₁-S phase of cervical cancer cells, and hence increased cell sensitivity to radiation. Moreover, SA treatment elevated the expression levels of p-AMPKα(<em>t</em> ​= ​3.996, <em>P</em> ​&lt; ​0.05) and p-TSC2(<em>t</em> ​= ​5.308, <em>P</em> ​&lt; ​0.05), whereas the level of p-mTOR (<em>t</em> ​= ​10.160, <em>P</em> ​&lt; ​0.05) was significantly decreased.</p></div><div><h3>Conclusion</h3><p>SA enhances the radiosensitivity of cervical cancer cells by targeting AMPK/TSC2/mTOR signaling pathway, and might serve as a promising therapeutic strategy to improve the efficacy of radiotherapy for cervical cancer.</p></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"3 1","pages":"Pages 9-15"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666555722000053/pdfft?md5=69bdc019a46d70a17e2b4dd2f5d5c2c0&pid=1-s2.0-S2666555722000053-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137158288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}