Radiation Medicine and Protection最新文献

{"title":"Expert consensus on radiotherapy for oligometastatic esophageal cancer (2025 edition)","authors":"Radiation Oncology Physician Branch, Chinese Medical Doctor Association ,&nbsp;Radiation Oncology Branch, Chinese Medical Association,&nbsp;Professional Commitee of Radiation Oncology, China Anti-Cancer Association,&nbsp;Expert Committee of Esophageal Cancer, Chinese Cancer Radiotherapy Alliance,&nbsp;Radiotherapy Sub-Committee, Professional Commitee of Elderly Oncology, Gerontological Society of China","doi":"10.1016/j.radmp.2025.05.001","DOIUrl":"10.1016/j.radmp.2025.05.001","url":null,"abstract":"<div><div>Approximately 40% of esophageal cancer patients have metastatic disease at the time of initial diagnosis. Although immunotherapy has changed the treatment pattern of advanced, recurrent, or metastatic esophageal cancer, the options for systemic treatment for these patients are still limited, and the prognosis is poor. Oligometastasis is an intermediate stage between locoregional and widespread systemic metastasis. Some studies have shown that combining systemic treatment with local treatment, such as radiotherapy, may improve the survival of patients with oligometastasis in various solid tumors, including esophageal cancer. At present, there is still a lack of data support from large randomized clinical trials on the timing, dose, and technique of radiotherapy for oligometastatic esophageal cancer. Based on recent studies on oligometastatic esophageal cancer, this consensus was jointly developed after in-depth discussions and multiple revisions by experts from the following organizations: Radiation Oncology Treatment Physician Branch, Chinese Medical Doctor Association; Branch of Radiation Oncology Therapy, Chinese Medical Association; Professional Committee of Radiotherapy for Cancer, Chinese Anti-cancer Association; Expert Committee of Esophageal Cancer, Chinese Cancer Radiotherapy Alliance. This consensus provides a relatively clear definition and classification of oligometastatic esophageal cancer. It summarizes common problems in radiotherapy based on current medical evidence to provide reference and academic guidance for the clinical practice of radiotherapy for oligometastatic esophageal cancer.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 119-131"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of dihydromyricetin against radiation-induced injury to the hematopoietic system","authors":"Xiao Sun ,&nbsp;Feifei Xu ,&nbsp;Zhiyun Wang ,&nbsp;Wenfeng Gou ,&nbsp;Yanli Li ,&nbsp;Hongying Wu ,&nbsp;Yiliang Li ,&nbsp;Wenbin Hou","doi":"10.1016/j.radmp.2025.04.004","DOIUrl":"10.1016/j.radmp.2025.04.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To investigate the potential protective effects of dihydromyricetin (DHM), a primary bioactive compound derived from &lt;em&gt;Ampelopsis grossedentata&lt;/em&gt;, against radiation-induced hematopoietic damage.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The &lt;em&gt;in virto&lt;/em&gt; antioxidant capacity of DHM was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2ʹ-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) assays. Survival rate and hematopoietic damage experiments were conducted on 130 mice. To assess the protective effects of DHM, a lethal dose of 7.5 ​Gy was delivered to 60 mice, and their 30-d survival rates were assessed and survival time were recorded. The mice were divided into 6 groups in survival analysis: DHM-only (200 ​mg/kg), IR, IR ​+ ​low-dose DHM (50 ​mg/kg), IR ​+ ​moderate-dose DHM (100 ​mg/kg), IR ​+ ​high-dose DHM (200 ​mg/kg), and IR ​+ ​amifostine (200 ​mg/kg). Subsequently, a hematopoietic injury model was established by subjecting 70 mice to whole-body irradiation (WBI) at a dose of 4 ​Gy. The mice were divided into 7 groups in the hematopoietic damage experiment: control, DHM-only (200 ​mg/kg), IR, IR ​+ ​low-dose DHM (50 ​mg/kg), IR ​+ ​moderate-dose DHM (100 ​mg/kg), IR ​+ ​high-dose DHM (200 ​mg/kg), and IR ​+ ​amifostine (200 ​mg/kg), with 10 mice in each group. The effects of DHM on body weights, blood routine indices, femoral nucleated cell counts, organ indices, and splenic nodules were analyzed. Using hematoxylin and eosin (H&amp;E) staining, the effects of DHM on the spleen and bone marrow were examined. Furthermore, the antioxidant effects of DHM were evaluated by measuring biochemical markers including glutathione (GSH) and superoxide dismutase (SOD).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;DHM exhibited strong &lt;em&gt;in vitro&lt;/em&gt; antioxidant activity (92.17 ​% in the ABTS assay and 90.75% in the DPPH assay). It significantly improved both the survival time and rates of mice exposed to irradiation at a lethal dose (20% for the IR ​+ ​low-dose DHM group, 40% for the IR ​+ ​moderate-dose DHM group, and 50% for the IR ​+ ​high-dose DHM group; &lt;em&gt;P&lt;/em&gt; ​&lt; ​0.05). In the hematopoietic injury experiment, DHM greatly improved blood routine indices, including the white blood cell count and the lymphocyte percentage (&lt;em&gt;P&lt;/em&gt; ​&lt; ​0.01). Moreover, DHM considerably increased organ indices, the number of splenic nodules, and the nucleated cell count in the femoral bone marrow. H&amp;E staining revealed that DHM significantly alleviated radiation-induced damage to the spleen and bone marrow. Additionally, DHM treatment greatly enhanced the hepatic GSH and SOD levels of the irradiated mice, reaching 219.01 μmol/g prot and 199.53 U/mg prot, respectively (&lt;em&gt;P&lt;/em&gt; ​&lt; ​0.05).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Owing to its free radical scavenging potential, DHM can enhance the survival rates of mice exposed to radiation at a lethal dose and mitigate radiation-induced damage to the he","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 147-155"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric performance of HyperArc and VMAT techniques using full or ipsilateral arcs for unilateral temporal lobe tumor radiotherapy","authors":"Hongtao Chen,&nbsp;Lijun Wang,&nbsp;Zhuangling Li,&nbsp;Shihai Wu,&nbsp;Zihuang Li","doi":"10.1016/j.radmp.2025.04.002","DOIUrl":"10.1016/j.radmp.2025.04.002","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the dosimetric performance of HyperArc and volumetric modulated arc radiotherapy (VMAT) techniques, using either full or ipsilateral arcs, for the radiotherapy of unilateral temporal lobe tumor, in order to quantify and analyze differences among these planning approaches using various dosimetric parameters.</div></div><div><h3>Methods</h3><div>This retrospective study reviewed 30 patients with unilateral temporal lobe tumors treated with radiotherapy in the Department of Radiation Oncology, Shenzhen People's Hospital from August 2020 to December 2023. Using the Eclipse treatment plan system with the Truebeam machine model, HyperArc and VMAT plans were designed with full or ipsilateral arcs, respectively Dosimetric parameters for the planning target volume (PTV) and organs at risk (OARs) were computed and analyzed. Additionally, the monitor units (MU) of four types of plans were calculated for consideration of rays utilization and delivery efficiency.</div></div><div><h3>Results</h3><div>HyperArc demonstrated superior dosimetric performance for PTV and OARs compared to VMAT (<em>P</em> ​&lt; ​0.05), with exceptions noted for the low dose volume (<em>V</em>_{5 Gy}) of the healthy brain and mean dose of ipsilateral cochlea. Ipsilateral arcs and full arcs showed similar efficacy in sparing OARs adjacent to PTV. Furthermore, full arcs improved PTV conformity compared with ipsilateral arcs (<em>P</em> ​&lt; ​0.05), while ipsilateral arcs reduced the dose to contralateral OARs, mean dose and the middle-to-low dose volume of the healthy brain (<em>P</em> ​&lt; ​0.05). Regarding MU, HyperArc (full) plans exhibited the minimum values among the four plan types, with overall MU for HyperArc plans being less than those for VMAT.</div></div><div><h3>Conclusions</h3><div>This study not only highlights the outstanding performance of the HyperArc technique with respect to VMAT but also underscores the advantages of employing ipsilateral arcs over full arcs in the radiotherapy of unilateral temporal lobe tumor. Additionally, the HyperArc technique demonstrated higher efficiency of ray utilization and delivery. The findings of this study can aid in selecting appropriate techniques and guiding arcs arrangements for the radiotherapy of unilateral temporal lobe tumor.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 163-168"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis of the diverse invasion and migration responses of lung cancer cells to photon irradiation","authors":"Yan Zhang ,&nbsp;Qibin Fu ,&nbsp;Xiaorui Huang ,&nbsp;Tuchen Huang","doi":"10.1016/j.radmp.2025.04.006","DOIUrl":"10.1016/j.radmp.2025.04.006","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically review the relevant literature on the effects of photons on the invasion and migration of lung cancer cells through a meta-analysis, in order to quantitatively evaluate the effects of radiation-related factors and cellular biological factors on the invasion and migration responses.</div></div><div><h3>Methods</h3><div>The type of radiation, energy, dose, and subtype of lung cancer cells were recorded, as well as biological endpoints, such as invasion and migration. Quantitative comparisons of various studies were conducted through the inclusion of effect size (ES) indicators. The influence of various physical and biological factors on the response to radiation-induced metastasis was clarified by subgroup analysis and One-way analysis of variance.</div></div><div><h3>Results</h3><div>In terms of radiation types, the promotion effect induced by γ-rays can reach as high as 90%, while X-rays exhibited both promotion (33%) and inhibition effects (55%). For X-rays, the probability of inhibition gradually increased with the increase in dose, ranging from 10% at low doses (0&lt; <em>D</em> ​≤ ​0.5 ​Gy), to 52​% at medium doses (0.5 ​Gy ​&lt; ​<em>D</em> ​≤ ​6 ​Gy), and to 70% at high doses (6 ​Gy ​&lt; ​<em>D</em> ​&lt; ​20 ​Gy). Additionally, from low energy (100–250 ​kV) to high energy (4–10 ​MV), the inhibition rate decreased from 58% to 48%, while the probability of promotion slightly increased from 27% to 31%. Low-energy X-rays with high linear energy transfer (LET) and high relative biological effectiveness (RBE) exhibited a higher proportion of their inhibitory effect than high-energy X-rays.</div></div><div><h3>Conclusion</h3><div>The γ-rays exhibited more consistent effects than X-rays, especially the promoting effects. However, X-rays showed diverse effects, such as inhibitory effects and promoting effects. Furthermore, for X-rays, the probability of inhibition was related to the dose and energy. These research findings indicated that the quantities related to radiation type, energy and dose, such as LET and RBE, may play a significant role in influencing the different responses of lung cancer cells to photons. This work can enhance the understanding of the impact of photons on cancer metastasis.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 156-162"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-induced cellular senescence and adaptive response: mechanistic interplay and implications","authors":"Haiying Wang,&nbsp;Weijin Zou,&nbsp;Yi Cao","doi":"10.1016/j.radmp.2025.05.002","DOIUrl":"10.1016/j.radmp.2025.05.002","url":null,"abstract":"<div><div>Cellular responses to radiation exposure involve complex and dynamic signaling networks that coordinately regulate cell fate. Senescent cells exhibit irreversible growth arrest and functional alterations, while adaptive response confers cellular protection against subsequent radiation insults. The intricate interplay between the two processes influences radiation resistance and genomic stability, with implications for understanding molecular mechanisms of radiotherapy and cellular stress responses. This review systematically investigates the molecular triggers and signaling pathways underlying radiation-induced cellular senescence and adaptive response, and elucidates the molecular interactions between these phenomena. The findings have significant implications for understanding of cellular stress responses, optimizing radiotherapy protocols, and mitigating radiation-induced cellular dysfunction.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 132-139"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of recurrence risk of cervical cancer after radiotherapy using multi-sequence MRI radiomics","authors":"Jie Chen ,&nbsp;Lou Liu ,&nbsp;Yi Fu,&nbsp;Lu Zhang,&nbsp;Shuyue Li,&nbsp;Juying Zhou,&nbsp;Chenying Ma","doi":"10.1016/j.radmp.2025.04.001","DOIUrl":"10.1016/j.radmp.2025.04.001","url":null,"abstract":"<div><h3>Objective</h3><div>To predict the recurrence risk of cervical cancer after radiotherapy using multi-sequence magnetic resonance imaging (MRI) radiomics.</div></div><div><h3>Methods</h3><div>A total of 90 cervical cancer patients treated in the First Affiliated Hospital of Soochow University from January 2018 to January 2023 were enrolled in this retrospective study, comprising 29 cases with recurrence and 61 cases without recurrence. The cohort was divided into a training set of 60 cases and a test set of 30 cases. Tumor regions of interest (ROI) were delineated using MRI radiomics scans before and after treatment, and image features were extracted to build predictive models. Ten models were used to predict recurrence risk in the test set, named as combined model T1-weighted imaging (T1WI) sequence, combined model fast gradient-recalled echo (FGRE) sequence, combined model T2 fat suppression sequence, combined model-epi sequence, FGRE sequence-T1WI sequence model, FGRE sequence-T2 fat suppression sequence, FGRE sequence-epi sequence model, T2 fat suppression sequence-T1WI sequence model, T2 fat suppression sequence-epi sequence model and the combined multi-sequence model.</div></div><div><h3>Results</h3><div>In the training set, compared with the combined multi-sequence model, the receiver operating characteristic (ROC) curves of the T1WI sequence, FGRE sequence, and T2 fat suppression sequence combined with the T1WI sequence model were significantly different (<em>Z</em> ​= ​2.25, 2.66,2.54, <em>P</em> ​&lt; ​0.05). In the test set, the ROC curve of the T1WI sequence model also showed a statistically significant difference from the combined model (<em>Z</em> ​= ​2.21, <em>P</em> &lt; ​0.05). The T1WI sequence, FGRE sequence, T2 fat suppression sequence, EPI sequence, and the combined model were all effective in predicting post-radiotherapy cervical cancer recurrence [area under curve (AUC) ​= ​0.731, 0.705, 0.823, 0.754, 0.871, <em>P</em> ​&lt; ​0.05]. Compared with the single-sequence models, the combined multi-sequence model showed the highest AUC value, accuracy, and precision in the ROC curve (AUC ​= ​0.854, <em>P</em> ​&lt; ​0.05).</div></div><div><h3>Conclusion</h3><div>Multi-sequence MRI radiomics could effectively predict the risk of cervical cancer recurrence after radiotherapy, and the combined multi-sequence model demonstrates enhanced predictive performance.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 169-174"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive physical evaluation of potential CT contrast agents: Integrating Monte Carlo transport simulation and radiation shielding Analysis","authors":"Yadong Zhang,&nbsp;Jinjia Cao,&nbsp;Yulong Zhang,&nbsp;Xiaochang Zheng,&nbsp;Wei Chen,&nbsp;Yanjun Wang","doi":"10.1016/j.radmp.2025.04.005","DOIUrl":"10.1016/j.radmp.2025.04.005","url":null,"abstract":"<div><h3>Objective</h3><div>To perform a comprehensive physical-level assessment of 13 contrast agents, including those with potential applications in CT imaging, focusing on their radiation shielding characteristics and transport behaviors—such as energy deposition, collision frequency, and attenuation performance—under low-energy X-ray conditions.</div></div><div><h3>Methods</h3><div>A dual-method framework was adopted. Geant4 Monte Carlo simulations were used to construct an X-ray tube model and simulate contrast agent interactions in a breast-equivalent water phantom, enabling analysis of microscopic radiation transport parameters including energy deposition, track length, and collision frequency. In parallel, Phy-X/PSD software was used to calculate macroscopic attenuation indices, including the linear attenuation coefficient (LAC), mass attenuation coefficient (MAC), mean free path (MFP), half-value layer (HVL), and exposure buildup factor (EBF), over a wide photon energy range.</div></div><div><h3>Results</h3><div>The study revealed a strong consistency between radiation shielding metrics and transport characteristics across the same energy ranges. For instance, iothalamate meglumine exhibited the highest energy deposition (0.085 60 ​MeV), shortest MFP (1.13 ​cm), and highest collision frequency (5.24 ​× ​10⁸), indicating excellent attenuation potential in the low-energy CT range. Gadolinium- and iron-based agents, while traditionally used in MR imaging, showed distinctive and stable transport behavior at medium-to-high energies, suggesting promising utility in CT or dual-modality applications.</div></div><div><h3>Conclusions</h3><div>These findings highlight the importance of integrating microscopic transport analysis with macroscopic shielding evaluation to fully characterize contrast agent performance. The study provides a validated theoretical foundation for contrast agent screening and optimization in X-ray imaging, and supports future research into clinical applicability and biological safety of emerging contrast materials.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 175-182"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-induced vascular damage and aging: a review of potential therapeutic targets and key signaling pathways","authors":"Chen Li ,&nbsp;Liqiu Ma","doi":"10.1016/j.radmp.2025.04.003","DOIUrl":"10.1016/j.radmp.2025.04.003","url":null,"abstract":"<div><div>Radiation-induced vascular damage has attracted significant attention in various fields, including healthcare (radiotherapy), the nuclear industry (nuclear facilities and devices), and space exploration. Recent studies have indicated a close relationship between such damage and aging, involving multiple signaling pathways and biological targets. This review aims to summarize the potential mechanisms underlying radiation-induced vascular damage, explore key molecular targets and related signaling pathways during the aging process, and provide a theoretical foundation for developing future therapeutic strategies. The review discusses direct mechanisms of radiation-induced vascular damage, such as apoptosis, necrosis, endothelial dysfunction, and alterations in the extracellular matrix. It also delves into the biological links between vascular damage and aging, including changes in the expression of aging markers, telomere shortening, and immune responses. Key molecular targets, such as the p53 pathway, nuclear factor-kappa B (NF-κB) signaling pathway, and silent information regulator 2-related enzyme 1 (SIRT1), are examined for their roles in mediating vascular damage and aging. Additionally, major signaling pathways such as MAPK, PI3K/Akt, and Wnt/β-catenin are analyzed for their involvement in cellular stress responses and vascular repair mechanisms. The review also summarizes the evaluation of current clinical treatments, discusses the potential therapeutic value of new targets, and outlines future research directions and challenges in the field.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 3","pages":"Pages 140-146"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on occupational exposure associated cancer risk in medical X-ray diagnostic workers in Jiangsu province, China, 2011–2021: A cohort study","authors":"Xindi Wei ,&nbsp;Wei Chen ,&nbsp;Jin Wang ,&nbsp;Zihao Zhang ,&nbsp;Yuji Miao ,&nbsp;Yuanyuan Zhou ,&nbsp;Xiangyong Fan ,&nbsp;Jinhan Wang ,&nbsp;Yeqing Gu","doi":"10.1016/j.radmp.2025.03.001","DOIUrl":"10.1016/j.radmp.2025.03.001","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the relationship between occupational X-ray exposure and cancer risk in medical X-ray diagnostic workers, a cohort study was conducted in medical X-ray diagnostic workers in Jiangsu province, China, based on Chinese Medical X-ray Workers Cohort, in order to provide scientific evidence for the improvement of occupational radiation protection in medical X-ray diagnostic workers.</div></div><div><h3>Methods</h3><div>From 2011 to 2021, a retrospective cohort study was conducted in 2,984 medical X-ray diagnostic workers who worked in the radiology departments of all hospitals in Jiangsu during 1950–1980 and were alive by June 30, 2011 (radiation group) and 2,601 medical workers who worked in other departments of the same hospitals during the same period and were alive by June 30, 2011 (control group). Basic information and cancer incidence were collected from the study participants. The person-years of observation in the study participants during 2011–2021 was calculated. Cox regression model was used to calculate the relative risk for cancers such as solid cancer, lung cancer, and lymphomas in the radiation group after adjustment for sex, age, year of birth, and year to start working, and stratified analyses on the risks for total cancer and solid cancer in the radiation group were performed for confounders such as sex.</div></div><div><h3>Results</h3><div>The total number of person-years of follow-up was 52,327, and the loss to follow-up rate was 3.15%. A total of 544 cancer cases were detected in follow-up during this period. Compared with the control group, the hazard ratio (<em>HR)</em> of total cancer was 1.13 (95% <em>CI</em>: 0.93–1.37), and the <em>HR</em> of solid cancer was 1.11 (95% <em>CI</em>: 0.91–1.36) in the radiation group. Compared with the control group, the radiation group had significantly higher risk for lymphoma (<em>HR</em> ​= ​10.36, 95% <em>CI</em>:1.27–84.27). Stratified analyses showed that the medical X-ray workers who started to working before 1970 had higher risks for solid cancer (<em>HR</em> ​= ​1.26, 95% <em>CI</em>:1.01–1.59) and total cancer (<em>HR</em> ​= ​1.29, 95% <em>CI</em>:1.04–1.62) compared with those who started working after 1970.</div></div><div><h3>Conclusion</h3><div>The risk for lymphoma was high in the medical X-ray workers in Jiangsu, suggesting that it is necessaryt to strengthen the occupational radiation protection for medical X-ray workers.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 69-74"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of non-preconditioning allogeneic hematopoietic stem cell transplantation on acute radiation injury","authors":"Liren Qian,&nbsp;Yu Liu,&nbsp;Xiaoxuan Lu,&nbsp;Jiaxin Liu","doi":"10.1016/j.radmp.2025.01.001","DOIUrl":"10.1016/j.radmp.2025.01.001","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the therapeutic effects of non-preconditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT) on acute radiation injury.</div></div><div><h3>Methods</h3><div>Irradiated mice were randomly divided into six groups, i.e., the control group, the irradiation group, and groups treated with transplantation at 0, 4, 8, and 12 ​d post-irradiation, with 10 mice in each group. The survival rates, graft versus host disease (GvHD), and chimerism of the mice in various groups were assessed.</div></div><div><h3>Results</h3><div>The maximum 60 ​d survival rate of mice treated with non-preconditioning allo-HSCT at 0, 4, and 8 ​d after 6.5 ​Gy radiation increased to 70% and 80%, respectively, significantly higher than that of mice that did not undergo non-preconditioning allo-HSCT (50%; <em>P &lt;</em> 0.05). The survival rate of mice undergoing non-preconditioning allo-HSCT at 12 ​d after radiation no longer significantly decreased. No pronounced GvHD was observed in the mice. The mice treated with non-preconditioning allo-HSCT at 0, 4, 8, and 12 ​d post-radiation exhibited chimerism rates of 80.53%, 92.75%, 80.46%, and 80.87%, respectively, at 56 ​d post-transplantation. At 28 ​d after non-preconditioning allo-HSCT, the donor-derived fluorescent cells in recipient mice increased significantly (<em>P</em> ​&lt; ​0.05).</div></div><div><h3>Conclusions</h3><div>This study will fill the gap in the field of radiation medicine and hematopoietic stem cell transplantation (HSCT) by addressing challenges that hinder the application of traditional HSCT, such as donor shortage, toxicity of preconditioning chemotherapy, the occurrence of GvHD, and the administration of post-transplantation immunosuppressants. The results would provide theoretical value and application prospects for research on radiation medicine and HSCT.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 103-106"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}