Radiation Medicine and Protection最新文献

{"title":"Assessment of knowledge, attitudes, and practices about radiation protection and safety among radiology and operating room personnel","authors":"Abdullah Taher Naji,&nbsp;Marwah Abdullah Alhelali,&nbsp;Thana M. Abu-hadi","doi":"10.1016/j.radmp.2026.03.005","DOIUrl":"10.1016/j.radmp.2026.03.005","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the knowledge, attitudes, and practices (KAP) of radiology and operating room personnel regarding radiation protection and safety.</div></div><div><h3>Methods</h3><div>An institution-based cross-sectional study was conducted to assess the KAP of Yemeni staff members in radiology departments and operating rooms representing various public and private institutions throughout Yemeni cities, the data collection was carried out via a Google form-based questionnaire disseminated to 315 individuals. A total of 256 valid responses were received with response rate of 81.27%.</div></div><div><h3>Results</h3><div>The results indicated inadequate knowledge with an overall mean score of (3.547/10). On the other hand, the respondents had positive attitudes (3.895/5), and moderate adherence to practice (3.406/5) toward radiation protection and safety. There were no significant differences in knowledge and practices scores by sex, however, while the attitude dimension score exhibited statistically significant differences (<em>U</em> = 6878, <em>P&lt;</em>0.05). Additionally, significant differences were observed between the occupations (<em>H</em> = 28.949, <em>P&lt;</em>0.05) and education levels of the respondents (<em>H</em> = 11.137, <em>P&lt;</em>0.05). Furthermore, the findings highlighted the positive impact of educational interventions (radiation safety training/lectures) on the total knowledge, attitude and practice scores (all <em>P&lt;</em>0.05) regarding radiation protection. The respondents' attitudes score correlated moderately with their practice compliance score connected to radiation protection (<em>r</em> = 0.48, <em>P&lt;</em>0.05). Moreover, the respondents addressed the shortage of radiation protection equipment (66.02%), and policies/management support (64.45%), as the most common barriers that limit their compliance with radiation protection and safety practices. In addition, they recommended providing sufficient resources (81.25%), establishing a radiation safety culture (76.95%), and providing periodic training programs to improve radiation protection practices (69.92%). These outcomes emphasize the necessity of specific educational intervention and organizational dedication to enhance radiation safety culture in Yemen.</div></div><div><h3>Conclusion</h3><div>The findings highlight the critical need for effective management support, sustained institutional commitment, and targeted educational actions at the university level and through ongoing training to improve radiation protection awareness and behaviours among healthcare workers in medical radiation environments.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 106-113"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessment of radon-induced lung cancer risk with decreasing smoking prevalence in Canada","authors":"Jing Chen","doi":"10.1016/j.radmp.2026.02.002","DOIUrl":"10.1016/j.radmp.2026.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>To re-assess the risk of radon-induced lung cancer with more recent and significantly reduced tobacco smoking rates in Canada.</div></div><div><h3>Methods</h3><div>Based on the radon distribution characteristics obtained from the cross-Canada radon survey and with the EPA/BEIR VI risk model as well as the same model parameters used in previous study, Canadian population risk for radon-induced lung cancer was re-assessed with Canadian age-specific smoking prevalence data of ever smokers in 2022 and Canadian age-specific mortality rates averaged over five years from 2019 to 2022.</div></div><div><h3>Results</h3><div>In the past 20 years from 2002 to 2022, the rates of ever-smokers among Canadians aged 15 and older dropped by 44% for males and by 42% for females. As a result, the baseline risks of lung cancer decreased by 14% for males and 10% for females. The re-evaluation indicates that 12% of lung cancer deaths among Canadian males and 13% of lung cancer deaths among Canadian females are attributable to indoor radon exposure, significantly lower than 16% of radon-induced lung cancer deaths among Canadians as estimated previously.</div></div><div><h3>Conclusions</h3><div>This re-assessment updated the estimates of radon-induced lung cancer in Canada. The study estimated that the success of tobacco control program over time (more than 40% reduction in percentage of ever-smokers in Canadian population in the past two decades) could result in 4% less radon-induced lung cancer deaths in males and 3% less in females.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 95-99"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescription tradeoff decision support for pancreas stereotactic body radiation therapy: From templates to artificial intelligence models","authors":"Yibo Xie ,&nbsp;Manisha Palta ,&nbsp;Ruilin Li ,&nbsp;Wentao Wang ,&nbsp;Qiuwen Wu ,&nbsp;Yaorong Ge ,&nbsp;Q. Jackie Wu ,&nbsp;Yang Sheng","doi":"10.1016/j.radmp.2026.03.004","DOIUrl":"10.1016/j.radmp.2026.03.004","url":null,"abstract":"<div><h3>Objective</h3><div>To develop an artificial intelligence (AI) driven plan tradeoff decision making assistant for radiation oncologists<strong>.</strong></div></div><div><h3>Methods</h3><div>A user interface (UI) was developed to integrate the assistant with the treatment planning system to facilitate prescription decision process. The assistant is powered by a machine learning core which was trained to learn the balance between planning target volume (PTV) coverage and organs-at-risk (OAR) sparing. A group of 98 pancreatic stereotactic body radiation therapy (SBRT) cases were retrospectively included for this study. The clinical plan's PTV coverage was compared against the model predicted value. A 10-fold cross validation was performed for all cases. The comparison was further analyzed in detail for three attending physicians. Cases with large discrepancy were identified and analyzed, and a replan was created to evaluate the achievability of the prediction.</div></div><div><h3>Results</h3><div>The clinical plan PTV <em>V</em>_100% was (87.7 ± 14.5)% while the model predicted value was (90.5 ± 9.6)%. Model agreement discrepancy was observed between attending physicians. Among all 98 cases, 9 were identified with large variation from the model prediction. For the replans, an average of 15.3% improvement was achieved over the original clinical plan, while OARs constrains were met.</div></div><div><h3>Conclusions</h3><div>The assistant's decision provides decent plan quality guidance for prescription drafting. It could provide valuable input prior to treatment planning and save valuable dosimetrist team and radiation oncologist effort. It could further provide valuable insight for resident education and training.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 88-94"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranial radiation-induced abscopal effects drive time-dependent testicular injury in mice","authors":"Ling Guo ,&nbsp;Liyuan Liu ,&nbsp;Tongzhou Qin ,&nbsp;Guiqiang Zhou ,&nbsp;Jiangyi Li ,&nbsp;Yuxin Wang ,&nbsp;Yan Zhou ,&nbsp;Xixi Yang ,&nbsp;Jing Li ,&nbsp;Guirong Ding","doi":"10.1016/j.radmp.2026.02.001","DOIUrl":"10.1016/j.radmp.2026.02.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To investigate the time-dependent progression of cranial radiation-induced testicular injury in mice, focusing on apoptotic pathways and brain-testis axis involvement.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Male mice were randomly divided into sham irradiation group (sham) and cranial irradiation group (IR) with 36 mice in each group. The IR group received a single dose of 20 Gy cranial X-ray irradiation, while peripheral organs were shielded. Assessments of body weight, testis weight, and sperm parameters were conducted at 1, 2, and 4 weeks post-irradiation. Histological changes and apoptosis were evaluated via H&amp;E staining and TUNEL assay, respectively. Cell-specific markers SOX9, WT1, SYCP3 and PRND were quantified by qRT-PCR, while apoptotic proteins Bcl-2, Bax and Cleaved-caspase 3 were examined by Western blot. Serum levels of brain injury biomarkers NSE and S100B were measured using ELISA.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Compared with sham group, IR mice displayed distinct, time-dependent testicular and systemic alterations. At 1 week post-irradiation, no obvious testicular structural damage was observed, but significant reductions in body and testis weight were accompanied by elevated serum NSE (142.1 ± 16.5 &lt;em&gt;vs.&lt;/em&gt; 102.1 ± 3.6&lt;em&gt;, t =&lt;/em&gt; 7.1&lt;em&gt;, P &lt; 0.05&lt;/em&gt;) and S100B ( 178.2 ± 23.8 &lt;em&gt;vs&lt;/em&gt;. 123.9 ± 11.5, &lt;em&gt;t&lt;/em&gt; = 6.2, &lt;em&gt;P &lt;&lt;/em&gt; 0.05). At 2 weeks post-irradiation, disorganized spermatogonial stem cells (SSCs), downregulated SYCP3 and PRND expression, and a marked increase in sperm abnormalities were evident (52.45 ± 3.35 &lt;em&gt;vs&lt;/em&gt;. 33.46±6.05, &lt;em&gt;t&lt;/em&gt; = 7.77, &lt;em&gt;P &lt;&lt;/em&gt; 0.05), alongside sustained weight loss and persistent elevation of NSE (128.6±3.2 &lt;em&gt;vs.&lt;/em&gt;110.6 ± 2.8&lt;em&gt;, t =&lt;/em&gt;12.8 &lt;em&gt;, P &lt; 0.05&lt;/em&gt;) and S100B levels (163.1 ± 5.9 &lt;em&gt;vs.&lt;/em&gt; 131.5 ± 10.9, &lt;em&gt;t&lt;/em&gt; = 7.8, &lt;em&gt;P &lt;&lt;/em&gt; 0.05). At 4 weeks post-irradiation, severe testicular atrophy manifested, characterized by reduced seminiferous tubule diameter, further increased sperm abnormalities (64.61 ± 8.18 &lt;em&gt;vs.&lt;/em&gt; 42.64 ± 3.13 , &lt;em&gt;t&lt;/em&gt; = 7.10, &lt;em&gt;P &lt;&lt;/em&gt; 0.05), decreased sperm counts (&lt;em&gt;vs.&lt;/em&gt; 3.08 ± 1.36 &lt;em&gt;vs.&lt;/em&gt; 8.55 ± 2.05, &lt;em&gt;t&lt;/em&gt; = 6.30, &lt;em&gt;P &lt;&lt;/em&gt; 0.05), upregulated Cleaved-caspase 3 protein expression (1.75 ± 0.15 &lt;em&gt;vs.&lt;/em&gt; 1.00 ± 0.21, &lt;em&gt;t&lt;/em&gt; = 7.10, &lt;em&gt;P &lt;&lt;/em&gt; 0.05), TUNEL-positive cells localized to spermatogonial stem cells (SSCs) niches. Concurrently, SOX9 (2.12 ± 0.96 &lt;em&gt;vs&lt;/em&gt;. 1.00 ± 0.31) and WT1 (2.51 ± 1.34 &lt;em&gt;vs&lt;/em&gt;. 1.00 ± 0.57) mRNA levels were significantly upregulated (&lt;em&gt;t&lt;/em&gt; = 2.72, 2.55, &lt;em&gt;P &lt;&lt;/em&gt; 0.05). Persistent reductions in body and testis weight, as well as sustained elevations in NSE and S100B, were observed throughout the study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Cranial radiation induces progressive, time-dependent testicular injury in mice via mechanisms mediated by the brain-testis axis, primari","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 55-62"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of 238U and 232Th in commonly consumed foods in East China","authors":"Ning Guo ,&nbsp;Maomao Guo ,&nbsp;Yuhan Xie ,&nbsp;Fuyou Fan ,&nbsp;Yanqin Ji","doi":"10.1016/j.radmp.2026.04.003","DOIUrl":"10.1016/j.radmp.2026.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the activity concentrations of naturally occurring radionuclides ²³⁸U and ²³²Th in commonly consumed foods from East China and to evaluate the associated dietary exposure and potential radiological health risk to the general population.</div></div><div><h3>Methods</h3><div>A total of 61 food items belonging to 10 major dietary categories were collected from local markets in a region of East China, pretreated by drying, homogenization, and acid digestion, and analyzed for ²³⁸U and ²³²Th using inductively coupled plasma mass spectrometry (ICP-MS). Activity concentrations were calculated and used to assess distribution patterns and inter-element correlations across food groups. The annual committed effective dose from dietary intake was estimated based on measured concentrations and regional consumption data.</div></div><div><h3>Results</h3><div>Both ²³⁸U and ²³²Th were widely detected in the analyzed food samples, with activity concentrations ranging from 11 to 4514 and 7 to 1649 mBq/kg (dry weight), respectively. A significant positive correlation between the two radionuclides indicates a common natural origin. Clear food-type dependence was observed, with vegetables and legumes showing relatively higher ²³⁸U levels and elevated ²³⁸U/²³²Th ratios, while aquatic products and fruits exhibited lower ratios. The annual committed effective doses from dietary intake were estimated at 0.54 μSv/year for ²³⁸U and 1.90 μSv/year for ²³²Th, which are several orders of magnitude below the recommended public exposure limit of 1 mSv/year.</div></div><div><h3>Conclusion</h3><div>The results provide baseline information on the occurrence of naturally occurring radionuclides in commonly consumed foods and indicate that current dietary intake levels pose negligible radiological risk to the general population. These findings support the continued monitoring of natural radionuclides in food to ensure food safety and public health protection.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 100-105"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrin beta-1 as a critical gene in radiation-induced injury: Bioinformatic and experimental verification","authors":"Rongbing Yu ,&nbsp;Ruling Liu ,&nbsp;Ning Xiao ,&nbsp;Xinyu Min ,&nbsp;Keer Jiang ,&nbsp;Xiangyu Meng ,&nbsp;Xiaoying Li ,&nbsp;Jinlei Zhu ,&nbsp;Hu Liu ,&nbsp;Cheng Zhang ,&nbsp;Xuefei Yuan ,&nbsp;Bailong Li","doi":"10.1016/j.radmp.2026.04.002","DOIUrl":"10.1016/j.radmp.2026.04.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To investigate the role of integrin beta-1 (Itgb1) in radiation-induced tissue injury and elucidate its underlying molecular mechanisms.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Differentially expressed genes associated with radiation injury were identified from the Gene Expression Omnibus (GEO) microarray database through bioinformatics analysis, followed by enrichment analysis to determine core hub genes. &lt;em&gt;In vitro&lt;/em&gt;, Itgb1 was silenced using siRNA transfection in human chronic myeloid leukemia K562 and mouse alveolar epithelial MLE-12 cells. Protein expression was assessed by Western blot, while cell proliferation, apoptosis, and reactive oxygen species (ROS) levels were quantified by flow cytometry following Itgb1 inhibition. &lt;em&gt;In vivo&lt;/em&gt;, C57BL/6 mice were divided into 4 experimental groups (&lt;em&gt;n&lt;/em&gt; = 5 per group): Control (intraperitoneal injection of PBS without irradiation), RGD (intraperitoneal injection of RGD 10 mg/kg without irradiation), IR + PBS (8 Gy &lt;sup&gt;60&lt;/sup&gt;Co γ-ray total body irradiation with PBS), and IR + RGD (intraperitoneal injection of RGD 10 mg/kg, 2 h prior to 8 Gy &lt;sup&gt;60&lt;/sup&gt;Co γ-ray total body irradiation). Bronchoalveolar lavage fluid (BALF) was collected for macrophage analysis. Lung and intestine tissues were subjected to hematoxylin-eosin (H&amp;E) staining and immunofluorescence (IF) examination. Peripheral blood samples were analyzed to evaluate hematopoietic function.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Bioinformatics analysis identified Itgb1 as a hub gene in radiation-induced injury. Western blot analysis demonstrated significant upregulation of Itgb1 protein following irradiation. In K562 cells, Itgb1 expression peaked at 12 h post-irradiation (&lt;em&gt;t =&lt;/em&gt; 3.07, &lt;em&gt;P&lt;/em&gt; &lt; 0.01) and declined by 24 h, whereas MLE-12 cells exhibited sustained elevation at both time points (&lt;em&gt;t&lt;/em&gt; = 10.44, &lt;em&gt;P&lt;/em&gt; &lt; 0.0001). Itgb1 silencing significantly exacerbated radiation-induced cellular damage. In K562 cells, knockdown reduced S-phase proliferation from 52.49% to 36.41% (&lt;em&gt;t&lt;/em&gt; = 9.64, &lt;em&gt;P&lt;/em&gt; &lt; 0.01), increased apoptosis (&lt;em&gt;t&lt;/em&gt; = 11.36, &lt;em&gt;P&lt;/em&gt; &lt; 0.001), and elevated ROS levels (&lt;em&gt;t&lt;/em&gt; = 3.62, &lt;em&gt;P&lt;/em&gt; &lt; 0.05). Comparable effects were observed in MLE-12 cells: reduced proliferation (46.82% to 37.98%, &lt;em&gt;t&lt;/em&gt; = 12.78, &lt;em&gt;P&lt;/em&gt; &lt; 0.0001), enhanced apoptosis (&lt;em&gt;t&lt;/em&gt; = 10.16, &lt;em&gt;P&lt;/em&gt; &lt; 0.0001), and increased ROS (&lt;em&gt;t&lt;/em&gt; = 5.58, &lt;em&gt;P&lt;/em&gt; &lt; 0.0001). &lt;em&gt;In vivo&lt;/em&gt;, Itgb1 inhibition aggravated radiation-induced pulmonary, intestinal and hematopoietic injuries, characterized by increased inflammatory infiltration, alveolar septal thickening, and decreased peripheral blood cell counts (&lt;em&gt;t&lt;/em&gt; = 2.34, &lt;em&gt;P&lt;/em&gt; &lt; 0.01). These findings indicate that Itgb1 functions as a protective factor against radiation injury.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;This study elucidates Itgb1 critical radioprotective rol","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 63-72"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomic analysis of pre-treatment prostate-specific membrane antigen (PSMA) PET/CT for prognostic stratification in patients with oligometastatic castration-sensitive prostate cancer","authors":"Yufeng Cao ,&nbsp;Philip Sutera ,&nbsp;William Silva Mendes ,&nbsp;Zhuoran Jiang ,&nbsp;Amit Sawant ,&nbsp;Luigi Marchionni ,&nbsp;Nicole L. Simone ,&nbsp;Ozan Cem Guler ,&nbsp;Phuoc T. Tran ,&nbsp;Cem Onal ,&nbsp;Lei Ren","doi":"10.1016/j.radmp.2026.03.002","DOIUrl":"10.1016/j.radmp.2026.03.002","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the imaging biomarkers obtained from baseline multi-modality imaging PET/CT before metastasis-directed therapy (MDT), which could offer early response prediction before MDT treatment, optimizing patient management and improving outcomes.</div></div><div><h3>Methods</h3><div>The study analyzed a multi-institutional cohort of 118 patients with oligometastatic castration-sensitive prostate cancer (omCSPC), including 34 from Johns Hopkins Hospital (JHH) and 84 from Baskent University (BU), USA, all treated with stereotactic ablative radiation therapy SABR-MDT. Before MDT, all patients underwent PSMA PET and CT imaging. For radiomics analysis, the gross tumor volume (GTV) was defined as zone 1, with an additional 5 mm peritumoral expansion designated as zone 2. From these regions, 1308 radiomics features were extracted. Feature selection was performed using a mutual information function, identifying the five most informative radiomics features from prostate-specific membrane antigen (PSMA) PET and CT. These were combined with five key clinical parameters—age, Gleason score, total number of lesions, number of untreated lesions, ADT, and pre-MDT prostate-specific antigen (PSA)—as model inputs. Multiple machine-learning algorithms, including random forest, decision tree, support vector machine, and naïve Bayes, were applied to predict 2-year metastasis-free survival (MFS). Model performance was evaluated using both leave-one-out and cross-institution validation.</div></div><div><h3>Results</h3><div>In a leave-one-out test with 93 patients, random forest achieved 78% accuracy and an AUC of 0.80 in predicting 2-year MFS. In cross-institution validation with 61 BU and 32 JHH patients, random forest correctly predicted 2-year MFS for 69% and 71% of patients, with AUC values of 0.71 and 0.73, respectively. Kaplan Meier curve comparison shows statistically significant separation between “rapid progressors” and “non-rapid progressors” patients stratified by the model in both leave one out and cross-institution validation tests.</div></div><div><h3>Conclusion</h3><div>This study provides evidence that pre-treatment multi-modality imaging biomarkers derived from PSMA PET and CT can serve as valuable predictors of metastasis-free survival (MFS) in patients with omCSPC.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 81-87"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of irradiation dose and increased incidence of xerostomia inpatients with nasopharyngeal carcinoma","authors":"Dongling You ,&nbsp;Jie Zhou ,&nbsp;Guiquan Zhu ,&nbsp;En Long ,&nbsp;Peng Xu ,&nbsp;Yiming Li ,&nbsp;Quan Yao ,&nbsp;Jinyi Lang ,&nbsp;Shun Lu","doi":"10.1016/j.radmp.2026.02.003","DOIUrl":"10.1016/j.radmp.2026.02.003","url":null,"abstract":"<div><h3>Objective</h3><div>To identify risk factors for post-radiation xerostomia and to evaluate the tolerance to doses administered to the parotid gland in patients with nasopharyngeal carcinoma (NPC).</div></div><div><h3>Methods</h3><div>A total of 462 patients with NPC who received radiotherapy at Nanfang Hospital of Southern Medical University and Sichuan Cancer Hospital from 2012 to 2016 were retrospectively analyzed. Xerostomia was diagnosed according to the Radiation Therapy and Oncology Group (RTOG) grade. Medcalc software and SPSS software were used for statistical analysis, and MATLAB and R software was used for modeling.</div></div><div><h3>Results</h3><div>The cut-off values for <em>D</em>_mean (the average dose of parotid), <em>D</em>_mean-L (the average dose of left parotid) and <em>D</em>_50-R (dose received at 50% volume of right parotid) were 26.00, 28.30 and 23.93 Gy, above which the risk of long-time xerostomia occurs is increased (<em>P</em> &lt; 0.05). <em>D</em>₅₀, <em>D</em>_50-L, <em>D</em>_50-R, <em>D</em>_mean, <em>D</em>_mean-L and <em>D</em>_mean-R were 28.66, 23.12, 29.04, 28.00, 28.30 and 35.55 Gy, respectively, but the results showed that this dose was not associated with highest xerostomia grade (HXG) (<em>P</em> &gt; 0.05). The relevant factors were independent risk factors for the development of xerostomia, the same was true for age, T stage, and <em>D</em>-PTV (dose of PTV). Using patient's gender, radiation treatment, number of radiotherapy sessions, T stage, TNM stage, <em>D</em>_mean and <em>D</em>₅₀ (dose received at 50% volume of the parotid glands) to established a prediction model to predict HXG and long-term xerostomia grading (LTG), the results indicated that Training showed <em>R</em> = 0.82. The independent risk factors were included to establish the nomogram prediction model. The results showed that the <em>C</em>-index was 0.671.</div></div><div><h3>Conclusion</h3><div>It is feasible to establish a neural network model or a nomogram prediction model using parotid dose parameters to predict the incidence of radiation-induced xerostomia.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 73-80"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Hexyl-pentynoic acid serves as a novel radiosensitizer for breast cancer by inhibiting UCHL3-dependent Rad51 deubiquitination” [Radiat. Med. Protect. (2023) 204–213]","authors":"Zuchao Cai ,&nbsp;David Lim ,&nbsp;Beidi Jia ,&nbsp;Guochao Liu ,&nbsp;Wenwen Ding ,&nbsp;Zhendong Wang ,&nbsp;Zhujun Tian ,&nbsp;Junxuan Peng ,&nbsp;Fengmei Zhang ,&nbsp;Chao Dong ,&nbsp;Zhihui Feng","doi":"10.1016/j.radmp.2025.12.006","DOIUrl":"10.1016/j.radmp.2025.12.006","url":null,"abstract":"","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Page 118"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation medicine and sustainable networks for global health and safety: Institutional progress and perspectives from KIRAMS","authors":"Jin Kyung Lee,&nbsp;Kyeong Min Kim,&nbsp;Dong Ho Kim,&nbsp;Minsu Cho,&nbsp;Yong Jin Lee,&nbsp;Jung Young Kim","doi":"10.1016/j.radmp.2026.03.001","DOIUrl":"10.1016/j.radmp.2026.03.001","url":null,"abstract":"<div><div>Within the United Nations Sustainable Development Goals (UN SDGs), health and well-being are one of the most important goals. This perspective highlights recent institutional progress at Korea Institute of Radiological and Medical Sciences (KIRAMS) that bridges scientific innovation, clinical application, and sustainability, which are aligned with the global vision of the UN SDGs. The key activities include long-term research on second primary cancers to strengthen survivorship care, the clinical application of targeted alpha-particle therapy using Actinium-225 for advanced neuroendocrine and prostate cancers, and the expansion of radiopharmaceutical research and development. These activities demonstrate how advanced radiation technologies can be translated into tangible clinical benefits while enhancing patient safety and long-term outcomes. In addition, KIRAMS has leveraged its expertise in radiation emergency medicine to contribute to broader public health responses. Collectively, these efforts illustrate how a mission-driven medical institution can align specialized radiation medicine with global sustainability agendas and strengthen international networks.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"7 2","pages":"Pages 114-117"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}