Fujita Medical Journal最新文献

{"title":"Functional outcomes of protocol-based rehabilitation for patients with coronavirus disease 2019 in an acute care setting.","authors":"Yoshitaka Wada, Seiko Shibata, Ayato Shinohara, Koji Mizutani, Masahiko Mukaino, Yohei Otaka","doi":"10.20407/fmj.2023-015","DOIUrl":"10.20407/fmj.2023-015","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the functional outcomes of patients with coronavirus disease 2019 (COVID-19) who underwent a new protocol-based rehabilitation program.</p><p><strong>Methods: </strong>In this retrospective cohort study, we enrolled patients who were hospitalised in a university hospital in Japan because of COVID-19 from 1^st September, 2020-5^th July, 2021. The primary outcome was the Functional Independence Measure (FIM) subtotal score for motor items at discharge. The secondary outcomes included the FIM cognitive subtotal score, length of hospital stay, rehabilitation period, total rehabilitation time, final rehabilitation protocol level, and discharge destination.</p><p><strong>Results: </strong>Of the 78 enrolled patients (49 men; mean age [standard deviation], 70.3 [13.9] years), 24 died (30.8%) during hospitalisation. Disease severity was classified as mild, moderate I, moderate II, and severe in 1, 6, 41, and 30 patients, respectively. The FIM motor subtotal score differed significantly among groups for all participants (p=0.027). Post hoc analysis revealed that the FIM motor subtotal score in the severe group was significantly lower than that in the moderate II group (p=0.030).</p><p><strong>Conclusions: </strong>Disease severity significantly affected patients' functional outcome for COVID-19 at discharge. Our protocol-based program provides a benchmark for COVID-19 rehabilitation in an acute care setting.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 1","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10847633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of early falls using adherence and balance assessments in a convalescent rehabilitation ward.","authors":"Toshio Teranishi, Megumi Suzuki, Masayuki Yamada, Akiko Maeda, Motomi Yokota, Naoki Itoh, Masanori Tanimoto, Aiko Osawa, Izumi Kondo","doi":"10.20407/fmj.2022-037","DOIUrl":"10.20407/fmj.2022-037","url":null,"abstract":"<p><strong>Objectives: </strong>To predict falls by adding an adherence assessment to a static balance ability assessment, and to evaluate fall prediction accuracy.</p><p><strong>Methods: </strong>This study included 416 patients who were admitted to a 45-bed convalescent rehabilitation ward over a 2-year period. The patients were assessed at the time of admission using the Standing Test for Imbalance and Disequilibrium (SIDE) and three additional, newly developed adherence items. Patients were divided into two groups: a group that experienced falls (fall group) and a group that did not experience falls (non-fall group) within 14 days of admission. The sensitivity and specificity of the assessment items for predicting falls were calculated.</p><p><strong>Results: </strong>Sensitivity was 0.86 and specificity was 0.42 when the cutoff was between SIDE levels 0-2a and 2b-4. Combining balance assessment using the SIDE with the memory and instruction adherence items improved fall prediction accuracy such that the sensitivity was 0.75 and the specificity was 0.64.</p><p><strong>Conclusions: </strong>Our analysis suggested that adherence assessment can improve fall risk prediction accuracy.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 1","pages":"30-34"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10847636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taxonomic classification of genus <i>Aeromonas</i> using open reading frame-based binarized structure network analysis.","authors":"Aki Sakurai, Masahiro Suzuki, Kengo Hayashi, Yohei Doi","doi":"10.20407/fmj.2023-007","DOIUrl":"10.20407/fmj.2023-007","url":null,"abstract":"<p><strong>Objectives: </strong>Taxonomic assignment based on whole-genome sequencing data facilitates clear demarcation of species within a complex genus. Here, we applied a unique pan-genome phylogenetic method, open reading frame (ORF)-based binarized structure network analysis (OSNA), for taxonomic inference of <i>Aeromonas</i> spp., a complex taxonomic group consisting of 30 species.</p><p><strong>Methods: </strong>Data from 335 publicly available <i>Aeromonas</i> genomes, including the reference genomes of 30 species, were used to build a phylogenetic tree using OSNA. In OSNA, whole-genome structures are expressed as binary sequences based on the presence or absence of ORFs, and a tree is generated using neighbor-net, a distance-based method for constructing phylogenetic networks from binary sequences. The tree built by OSNA was compared to that constructed by a core-genome single-nucleotide polymorphism (SNP)-based analysis. Furthermore, the orthologous average nucleotide identity (OrthoANI) values of the sequences that clustered in a single clade in the OSNA-based tree were calculated.</p><p><strong>Results: </strong>The phylogenetic tree constructed with OSNA successfully delineated the majority of species of the genus <i>Aeromonas</i> forming conspecific clades for individual species, which was corroborated by OrthoANI values. Moreover, the OSNA-based phylogenetic tree demonstrated high compositional similarity to the core-genome SNP-based phylogenetic tree, supported by the Fowlkes-Mallows index.</p><p><strong>Conclusions: </strong>We propose that OSNA is a useful tool in predicting the taxonomic classification of complex bacterial genera.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 1","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10847635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of urinary tract infections in long-term care facilities in Japan: Insights from physical examination-based diagnosis.","authors":"Makoto Hasegawa, Yasuhiro Osugi, Yoshifumi Moriwaki, Yohei Doi","doi":"10.20407/fmj.2023-012","DOIUrl":"10.20407/fmj.2023-012","url":null,"abstract":"<p><strong>Objectives: </strong>Multidrug-resistant (MDR) bacterial infections are highly prevalent among long-term care facility (LTCF) residents, and are thus important targets for antimicrobial stewardship. Diagnoses of urinary tract infections (UTIs), which are associated with antimicrobial use in these facilities, are not always made by physicians. Past epidemiologic studies have included asymptomatic bacteriuria together with UTIs. The National Healthcare Safety Network has initiated a surveillance program to identify the causative organisms of UTIs in LTCF residents. In Japan, medical care for these residents is provided through in-person physician visits; however, limited related data are available. Therefore, we investigated the organisms causing UTIs and their drug susceptibility among LTCF residents in central Japan, and examined the prevalence of multidrug resistance, its risk factors, and correlations with clinical outcomes.</p><p><strong>Methods: </strong>We retrospectively evaluated clinical and urine culture data of LTCF residents with physician-diagnosed UTIs between April 1, 2019, and April 30, 2022.</p><p><strong>Results: </strong>The detection rate of multidrug-resistant organisms was high, with <i>Escherichia coli</i> being the most prevalent. Ceftriaxone was frequently used for initial therapy. The initial antimicrobial agents were significantly less active against MDR pathogens than non-MDR pathogens. Most residents continued to receive the initial agents regardless of culture results. Nonetheless, differences in the therapy duration, relapse and hospitalization rates, and death rate within 28 days between the multidrug-resistant and non-multidrug-resistant groups were not significant.</p><p><strong>Conclusions: </strong>Antimicrobial stewardship is essential for reducing antimicrobial use and selective pressure in LTCFs in Japan; however, more specific data are needed for its effective implementation.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 1","pages":"24-29"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10847634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outbreak of novel coronavirus infection (COVID-19) in a child and adolescent psychiatric ward: Characteristics and responses.","authors":"Koichi Furuhashi","doi":"10.20407/fmj.2023-003","DOIUrl":"https://doi.org/10.20407/fmj.2023-003","url":null,"abstract":"<p><strong>Background: </strong>The novel coronavirus disease (COVID-19) pandemic has no end in sight. Currently, the emphasis is on policies aimed at easing movement restrictions and maintaining socio-economic activities. However, infection control in psychiatric hospitals has been challenging. There have been reports on the impact on mental health and outpatient/inpatient treatment environments in the field of child psychiatry. An outbreak of COVID-19 was experienced in a child and adolescent psychiatric ward, and considering that there have been few similar reports, it was deemed meaningful to accumulate such experiences.</p><p><strong>Case presentation: </strong>Three COVID-19-positive cases, all 14-year-old girls, were confirmed in a cluster among seven hospitalized patients in a child and adolescent psychiatric ward. Two patients presented symptoms of upper respiratory inflammation and one was asymptomatic. The main psychiatric diagnoses were post-traumatic stress disorder in one patient and autism spectrum disorder in the other two patients. The entire hospital ward was designated as a red zone (contaminated area), and infection control measures were adopted, such as halting group activities, wearing masks, and maintaining distance between patients. Additionally, it was necessary to use the infection control ward as it was difficult to ensure patient compliance.</p><p><strong>Conclusion: </strong>Infection control in COVID-19 clusters at child and adolescent psychiatric wards is difficult due to patient characteristics and symptoms. Restricted activities and care also result in psychobehavioral consequences, regardless of infection status. To achieve both infection control and a better treatment environment, it is necessary to make careful preparations while learning from these experiences.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 4","pages":"301-305"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of online frame-of-reference training on assessment accuracy in the objective structured clinical examination for physical therapy students.","authors":"Tetsuro Watari, Kei Ohtsuka, Yukari Suzuki, Fumihiro Matsuda, Soichiro Koyama, Naoki Aizu, Yoshikiyo Kanada, Hiroaki Sakurai","doi":"10.20407/fmj.2022-032","DOIUrl":"https://doi.org/10.20407/fmj.2022-032","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigates how online frame-of-reference (FOR) training of raters of the objective structured clinical examination (OSCE) for physical therapy students affects assessment accuracy.</p><p><strong>Methods: </strong>The research was conducted in a 1-month-long randomized controlled trial.</p><p><strong>Participants: </strong>The participants were 36 physical therapists without experience assessing clinical skills using the OSCE. The training group completed the FOR training online, which was conducted once a week in two 90-minute sessions. The control group self-studied the rubric rating chart used in the assessment. As a measure of accuracy, weighted kappa coefficients were used to check the agreement between correct score and those assessment by the participant in the OSCE.</p><p><strong>Results: </strong>The scores of the training group were higher than those of the control group in both post- and follow-up assessments, showing significant differences. No significant difference was found based on the assessment time and group for the high-agreement groups. Furthermore, scores of the low-accuracy training group were higher in the post- and follow-up assessments than those in the pre-assessment, showing significant differences.</p><p><strong>Conclusions: </strong>Online FOR training of the raters of the OSCE for physical therapists improved the assessment accuracy of the raters who had low accuracy in the pre-assessment; this improvement was maintained.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 4","pages":"288-294"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting echocardiographic parameters to detect patients with less symptomatic primary mitral regurgitation who require exercise stress echocardiography.","authors":"Yuka Kawada, Akira Yamada, Shinji Jinno, Chihiro Nakashima, Naoki Hoshino, Sayano Ueda, Meiko Hoshino, Sayuri Yamabe, Kayoko Takada, Kunihiko Sugimoto, Hideo Izawa","doi":"10.20407/fmj.2022-038","DOIUrl":"https://doi.org/10.20407/fmj.2022-038","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to identify which resting echocardiographic parameters can detect asymptomatic or mildly symptomatic patients with primary mitral regurgitation (MR) who require exercise stress echocardiography (ESE) to determine their suitability for surgery.</p><p><strong>Methods: </strong>We examined 56 consecutive patients with primary moderate/severe MR who underwent ergometer-based ESE. Patients who met the surgical indications at rest were excluded. Eligible patients were divided into Group I (pulmonary artery systolic pressure [PASP] during exercise >60 mmHg; n=11) and Group II (PASP during exercise ≤60 mmHg; n=30).</p><p><strong>Results: </strong>Forty-one patients were included. Group I was significantly older (65±12 vs. 54±14 years, P=0.042) and had significantly higher serum N-terminal pro-B-type natriuretic peptide concentrations than Group II (351±278 vs. 125±163 pg/mL, P=0.002). The univariate analysis demonstrated that peak E wave velocity (Group I vs. Group II: 125±45 vs. 101±24 cm/sec, P=0.050), left ventricular (LV) end-diastolic diameter index (32±4 vs. 30±3 mm/m², P=0.035), and left atrial volume index (LAVI; 45±14 vs. 30±11 mL/m², P=0.008) were predictors of increased PASP during exercise. In the multivariate analysis, resting LAVI best predicted exercise-induced pulmonary hypertension (hazard ratio 1.081 [95% confidence interval 1.009-1.158], P=0.028), with a cutoff value of 37 mL/m².</p><p><strong>Conclusions: </strong>In asymptomatic or mildly symptomatic patients with primary moderate/severe MR, increased resting LAVI indicates the requirement for ESE, even without LV dilatation.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 4","pages":"265-269"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The electrophysiological index can effectively predict subsequent coronary artery aneurysm in children with Kawasaki disease.","authors":"Daijiro Suzuki, Takanori Suzuki, Masayuki Fujino, Yumiko Asai, Arisa Kojima, Hidetoshi Uchida, Kazuyoshi Saito, Hirofumi Kusuki, Yuanying Li, Hiroshi Yatsuya, Tsuneaki Sadanaga, Tadayoshi Hata, Tetsushi Yoshikawa","doi":"10.20407/fmj.2023-001","DOIUrl":"https://doi.org/10.20407/fmj.2023-001","url":null,"abstract":"<p><strong>Objectives: </strong>The Gunma score is used to predict the severity of Kawasaki disease (KD), including coronary artery aneurysm (CAA) as a cardiac complication, in Japan. Additionally, the characteristic ratio of ventricular repolarization (T-peak to T-end interval to QT interval [Tp-e/QT]) on a surface electrocardiogram reflects myocardial inflammation. This study aimed to determine whether the Tp-e/QT can be used to predict CAA in children with KD.</p><p><strong>Methods: </strong>We analyzed chest surface electrocardiograms of 112 children with KD before receiving intravenous immunoglobulin therapy using available software (QTD; Fukuda Denshi, Tokyo, Japan).</p><p><strong>Results: </strong>The Tp-e/QT (lead V5) was positively correlated with the Gunma score (r=0.352, p<0.001). The Tp-e/QT was larger in patients with CAA (residual CAA at 1 month after onset) than in those without CAA (0.314±0.026 versus 0.253±0.044, p=0.003). A receiver operating characteristic curve analysis was performed to assess whether the Gunma score and Tp-e/QT could predict subsequent CAA. The area under the curve of the Gunma score was 0.719 with the cutoff set at 5 points. The area under the curve of the Tp-e/QT was 0.892 with a cutoff value of 0.299. The fit of the prediction models to the observed probability was tested by the Hosmer-Lemeshow test with calibration plots using Locally weighted scatterplot smoothing (LOESS) fit. The Gunma score (p=0.95) and Tp-e/QT (p=0.95) showed a good fit.</p><p><strong>Conclusions: </strong>The Tp-e/QT is a useful biomarker in predicting coronary aneurysm complications in KD.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 4","pages":"275-281"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and audiovisual senses in older patients with diabetes: a cross-sectional observational study.","authors":"Sayuri Sable-Morita, Yuko Harasawa, Kiyomi Yamada, Saiko Sugiura, Hideki Fukuoka, Haruhiko Tokuda","doi":"10.20407/fmj.2022-029","DOIUrl":"https://doi.org/10.20407/fmj.2022-029","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the relationship between frailty in older patients with diabetes and audiovisual senses.</p><p><strong>Methods: </strong>The survey included (1) basic attributes, (2) diabetes-related items, (3) frailty, evaluated according to the Obu Study of Health Promotion for the Elderly (OSHPE) standard, and (4) audiovisual function. Participants included 157 diabetes patients aged ≥65 years, divided into three groups: robust health (n=50), pre-frail (n=76), and frail (n=31). A simple regression analysis, in which the total OSHPE score was used as the dependent variable and the most relevant audiovisual items were used as independent variables, was performed to analyze the frailty factor. Next, a multiple regression analysis adjusted for age and sex was performed with total OSHPE score as the dependent variable and the items most relevant for audiovisual senses as independent variables.</p><p><strong>Results: </strong>For the robust health, pre-frail, and frail groups, frequencies of hearing loss were 18.4%, 42.1%, and 35.5%, respectively, and were associated with frailty; visual impairment frequencies were 38%, 63.2%, and 58.1%, respectively. In multiple regression analysis, economic difficulties (B=0.349, β=0.172, p<0.05), absence of dyslipidemia (B=-0.494, β=-0.171, p<0.05), lower MNA score (B=-0.169, β=-0.214, p<0.05), and worsening hearing in the poor hearing ear (B=0.015, β=0.176, p<0.05) were significantly associated with frailty.</p><p><strong>Conclusions: </strong>Hearing but not vision was associated with frailty in older patients with diabetes.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 4","pages":"295-300"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of prophylactic prochlorperazine injections at the initiation of opioid injections in preventing opioid-induced nausea and vomiting among patients with end-stage cancer.","authors":"Kazuki Imai, Akihiko Futamura, Miyo Murai, Akihiro Ito, Norimasa Tsuzuki, Masanobu Usui","doi":"10.20407/fmj.2022-034","DOIUrl":"https://doi.org/10.20407/fmj.2022-034","url":null,"abstract":"<p><strong>Objectives: </strong>Antiemetics have been widely recommended for treating opioid-induced nausea and vomiting (OINV). According to a previous study, the use of prophylactic prochlorperazine at the initiation of treatment with oral oxycodone was ineffective in preventing OINV. This study examined whether prochlorperazine injection prevents OINV and induces drowsiness in patients with end-stage cancer (a different patient population from the previous study).</p><p><strong>Methods: </strong>Patients with end-stage cancer who received opioid injections for more than 5 days between April 2017 and March 2020 were classified into two groups: the opioid and prochlorperazine injection group and opioid alone group. Their systemic conditions were evaluated on the basis of the performance status and the palliative performance scale, a prognostic indicator.</p><p><strong>Results: </strong>Of 325 patients who received opioid treatment during the study period, 156 patients met the inclusion criteria. Of these, 103 patients and 53 patients were classified into the opioid and prochlorperazine injection group (prochlorperazine) and opioid alone groups (placebo) , respectively. There was no significant difference in characteristics, age, gender, performance status, or palliative performance scale results between the 2 groups. OINV developed in 4 patients in the opioid and prochlorperazine injection groups and in 1 patient in the opioid alone group. Given that sleep disturbance develops in many patients with end-stage cancer who had a specific condition, it is difficult to conclude regarding the relationship between prochlorperazine injection and drowsiness, although this study examined this relationship.</p><p><strong>Conclusions: </strong>As with the previous study, prophylactic prochlorperazine injection was ineffective in preventing OINV in patients who received opioid injections.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 4","pages":"270-274"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}