Fujita Medical Journal最新文献

{"title":"The electrophysiological index can effectively predict subsequent coronary artery aneurysm in children with Kawasaki disease.","authors":"Daijiro Suzuki, Takanori Suzuki, Masayuki Fujino, Yumiko Asai, Arisa Kojima, Hidetoshi Uchida, Kazuyoshi Saito, Hirofumi Kusuki, Yuanying Li, Hiroshi Yatsuya, Tsuneaki Sadanaga, Tadayoshi Hata, Tetsushi Yoshikawa","doi":"10.20407/fmj.2023-001","DOIUrl":"https://doi.org/10.20407/fmj.2023-001","url":null,"abstract":"<p><strong>Objectives: </strong>The Gunma score is used to predict the severity of Kawasaki disease (KD), including coronary artery aneurysm (CAA) as a cardiac complication, in Japan. Additionally, the characteristic ratio of ventricular repolarization (T-peak to T-end interval to QT interval [Tp-e/QT]) on a surface electrocardiogram reflects myocardial inflammation. This study aimed to determine whether the Tp-e/QT can be used to predict CAA in children with KD.</p><p><strong>Methods: </strong>We analyzed chest surface electrocardiograms of 112 children with KD before receiving intravenous immunoglobulin therapy using available software (QTD; Fukuda Denshi, Tokyo, Japan).</p><p><strong>Results: </strong>The Tp-e/QT (lead V5) was positively correlated with the Gunma score (r=0.352, p<0.001). The Tp-e/QT was larger in patients with CAA (residual CAA at 1 month after onset) than in those without CAA (0.314±0.026 versus 0.253±0.044, p=0.003). A receiver operating characteristic curve analysis was performed to assess whether the Gunma score and Tp-e/QT could predict subsequent CAA. The area under the curve of the Gunma score was 0.719 with the cutoff set at 5 points. The area under the curve of the Tp-e/QT was 0.892 with a cutoff value of 0.299. The fit of the prediction models to the observed probability was tested by the Hosmer-Lemeshow test with calibration plots using Locally weighted scatterplot smoothing (LOESS) fit. The Gunma score (p=0.95) and Tp-e/QT (p=0.95) showed a good fit.</p><p><strong>Conclusions: </strong>The Tp-e/QT is a useful biomarker in predicting coronary aneurysm complications in KD.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 4","pages":"275-281"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and audiovisual senses in older patients with diabetes: a cross-sectional observational study.","authors":"Sayuri Sable-Morita, Yuko Harasawa, Kiyomi Yamada, Saiko Sugiura, Hideki Fukuoka, Haruhiko Tokuda","doi":"10.20407/fmj.2022-029","DOIUrl":"https://doi.org/10.20407/fmj.2022-029","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the relationship between frailty in older patients with diabetes and audiovisual senses.</p><p><strong>Methods: </strong>The survey included (1) basic attributes, (2) diabetes-related items, (3) frailty, evaluated according to the Obu Study of Health Promotion for the Elderly (OSHPE) standard, and (4) audiovisual function. Participants included 157 diabetes patients aged ≥65 years, divided into three groups: robust health (n=50), pre-frail (n=76), and frail (n=31). A simple regression analysis, in which the total OSHPE score was used as the dependent variable and the most relevant audiovisual items were used as independent variables, was performed to analyze the frailty factor. Next, a multiple regression analysis adjusted for age and sex was performed with total OSHPE score as the dependent variable and the items most relevant for audiovisual senses as independent variables.</p><p><strong>Results: </strong>For the robust health, pre-frail, and frail groups, frequencies of hearing loss were 18.4%, 42.1%, and 35.5%, respectively, and were associated with frailty; visual impairment frequencies were 38%, 63.2%, and 58.1%, respectively. In multiple regression analysis, economic difficulties (B=0.349, β=0.172, p<0.05), absence of dyslipidemia (B=-0.494, β=-0.171, p<0.05), lower MNA score (B=-0.169, β=-0.214, p<0.05), and worsening hearing in the poor hearing ear (B=0.015, β=0.176, p<0.05) were significantly associated with frailty.</p><p><strong>Conclusions: </strong>Hearing but not vision was associated with frailty in older patients with diabetes.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 4","pages":"295-300"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of prophylactic prochlorperazine injections at the initiation of opioid injections in preventing opioid-induced nausea and vomiting among patients with end-stage cancer.","authors":"Kazuki Imai, Akihiko Futamura, Miyo Murai, Akihiro Ito, Norimasa Tsuzuki, Masanobu Usui","doi":"10.20407/fmj.2022-034","DOIUrl":"https://doi.org/10.20407/fmj.2022-034","url":null,"abstract":"<p><strong>Objectives: </strong>Antiemetics have been widely recommended for treating opioid-induced nausea and vomiting (OINV). According to a previous study, the use of prophylactic prochlorperazine at the initiation of treatment with oral oxycodone was ineffective in preventing OINV. This study examined whether prochlorperazine injection prevents OINV and induces drowsiness in patients with end-stage cancer (a different patient population from the previous study).</p><p><strong>Methods: </strong>Patients with end-stage cancer who received opioid injections for more than 5 days between April 2017 and March 2020 were classified into two groups: the opioid and prochlorperazine injection group and opioid alone group. Their systemic conditions were evaluated on the basis of the performance status and the palliative performance scale, a prognostic indicator.</p><p><strong>Results: </strong>Of 325 patients who received opioid treatment during the study period, 156 patients met the inclusion criteria. Of these, 103 patients and 53 patients were classified into the opioid and prochlorperazine injection group (prochlorperazine) and opioid alone groups (placebo) , respectively. There was no significant difference in characteristics, age, gender, performance status, or palliative performance scale results between the 2 groups. OINV developed in 4 patients in the opioid and prochlorperazine injection groups and in 1 patient in the opioid alone group. Given that sleep disturbance develops in many patients with end-stage cancer who had a specific condition, it is difficult to conclude regarding the relationship between prochlorperazine injection and drowsiness, although this study examined this relationship.</p><p><strong>Conclusions: </strong>As with the previous study, prophylactic prochlorperazine injection was ineffective in preventing OINV in patients who received opioid injections.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 4","pages":"270-274"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of the lifestyle of head injury patients using the Frenchay Activities Index.","authors":"Masayuki Yamada, Toshio Teranishi, Megumi Suzuki, Kei Ohtsuka, Mihoko Ito, Akiko Maeda, Yoshikiyo Kanada","doi":"10.20407/fmj.2022-036","DOIUrl":"https://doi.org/10.20407/fmj.2022-036","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to capture the lifestyle characteristics of traumatic brain injury (TBI) patients by administering the Frenchay Activities Index (FAI), a self-assessment questionnaire used for assessing life-related activities, among TBI patients.</p><p><strong>Methods: </strong>This study was conducted using the revised FAI Self-Assessment Form, administering an interview-based questionnaire survey to TBI patients and healthy participants. The target group comprised 60 traumatic brain injury patients who had progressed from at least 1 year since the injury, with a comparison group of 788 healthy participants.</p><p><strong>Results: </strong>A comparison of FAI scores between TBI patients and healthy participants by questionnaire revealed that TBI patients exhibited significantly higher FAI scores than healthy participants for outdoor walking and transportation use (Mann-Whitney U test, <i>P</i><0.01). A comparison by occupation revealed that TBI patients were significantly less among the unemployed and other categories (Mann-Whitney U test, <i>P</i><0.01). For office workers, government employees, high school students, and college students, scores were higher among TBI patients compared with healthy participants, although the differences were not significant.</p><p><strong>Conclusions: </strong>Although TBI patients were less active than healthy participants in life-related activities, their scores for cleaning up after meals and cleaning and putting things in order were close to those of healthy participants, indicating that TBI patients cannot be considered to be inactive. The findings also revealed differences in TBI patients' engagement in life-related activities and frequency of activities depending on their social position.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 4","pages":"282-287"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the health-promoting effects of exercise and the involvement of myokines.","authors":"Kazuhiro Nishii,&nbsp;Naoki Aizu,&nbsp;Kouji Yamada","doi":"10.20407/fmj.2022-020","DOIUrl":"https://doi.org/10.20407/fmj.2022-020","url":null,"abstract":"<p><p>Exercise reduces the risk of obesity-based, lifestyle-related diseases, such as metabolic abnormalities and cardiovascular diseases. The present review covers the health-promoting effects of exercise from the point of view of the physiologically active factor myokine, which is secreted by skeletal muscle, and focuses on the skeletal muscle as a new endocrine organ. Myokines have various effects, such as preventing metabolic syndrome by breaking down fat, preventing diabetes by improving glucose metabolism, and preventing progression of arteriosclerosis, dementia, and osteoporosis by enhancing bone metabolism. These substances also stabilize blood pressure, prevent cancer, increase immunity against infections, and prevent the development of age-associated diseases. Myokines are secreted by skeletal muscle into blood vessels, allowing them to exert systemic endocrine effects in organs throughout the body. Myokines are involved in bodily homeostasis and adaptation to the environment, and function by a mechanism similar to that of the skeletal muscle mass regulatory mechanism. Determining the relationships between multiple organs and their biological significance is important for exercise and health research. Progress in this field is expected to result in the identification of pathological mechanisms of action, development of new drugs, evaluation of the effectiveness of biomarkers over a wide range, and future improvement in healthcare.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"171-178"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9956767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinicopathological analysis of forkhead box A1 (FOXA1) and estrogen receptor alpha expression in extramammary Paget's disease.","authors":"Chiho Sumitomo,&nbsp;Yohei Iwata,&nbsp;Masaru Arima,&nbsp;Kazumitsu Sugiura","doi":"10.20407/fmj.2022-030","DOIUrl":"https://doi.org/10.20407/fmj.2022-030","url":null,"abstract":"<p><strong>Objectives: </strong>Extramammary Paget's disease (EMPD) is a neoplastic skin disease of unknown etiology. EMPD is frequently associated with forkhead box A1 (FOXA1) expression, which correlates with the expression of estrogen receptor alpha (ER). FOXA1 regulates the transcriptional activity of ER and may function cooperatively in the tumorigenesis of breast cancer.</p><p><strong>Methods: </strong>We performed immunohistochemical staining for FOXA1 and ER using tissue samples from 16 patients with EMPD.</p><p><strong>Results: </strong>The nuclei of Paget cells isolated from each of the 16 patients with EMPD (100%) were strongly FOXA1-positive, and the FOXA1 staining intensity was similar across all samples. ER staining was detected in the nuclei of Paget cells originating from seven patients with EMPD (44%), and the ER staining intensity varied between these patients.</p><p><strong>Conclusions: </strong>In the present study, we confirmed that EMPD was frequently associated with FOXA1 expression. However, ER expression varied between patients and did not always coincide with FOXA1 expression. No clear relationship was observed between ER expression, the intensity of ER staining, or EMPD metastasis and prognosis. However, the results indicate that hormone-dependent cancer therapy may be effective in patients with ER-positive EMPD.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"236-239"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9963120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing early obliteration during flow diverter treatment of cerebral aneurysms: Establishment of an early obliteration inhibition score.","authors":"Akiko Hasebe,&nbsp;Ichiro Nakahara,&nbsp;Shoji Matsumoto,&nbsp;Jun Morioka,&nbsp;Jun Tanabe,&nbsp;Sadayoshi Watanabe,&nbsp;Kenichiro Suyama,&nbsp;Takuma Ishihara,&nbsp;Yuichi Hirose","doi":"10.20407/fmj.2022-033","DOIUrl":"https://doi.org/10.20407/fmj.2022-033","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study aimed to investigate factors associated with inhibition of early aneurysm obliteration after flow diverter (FD) treatment. We also created the early obliteration inhibition (EOI) score for pre-operative evaluation.</p><p><strong>Methods: </strong>We examined 110 cerebral aneurysms in 104 patients who underwent FD treatment. The following parameters were investigated: age, sex, symptoms, aneurysm location and type, maximum aneurysm diameter, parent vessel diameter, neck diameter, and dome-neck ratio. We also noted aneurysm location relative to the curvature of the parent artery and any branches arising from the aneurysm dome. Procedural factors such as FD diameter and length, number of FDs placed, type of FD, and use of adjunctive coiling were also investigated. Aneurysm obliteration was evaluated using digital subtraction angiography 3 months after the procedure. Adequate obliteration was defined as grade C or D on the O'Kelly-Marotta scale.</p><p><strong>Results: </strong>The following factors inhibited early obliteration: 1) extradural location, 2) saccular aneurysm, 3) aneurysm neck located at the outer convexity of the parent artery, and 4) arterial branch arising from the aneurysm dome. Odds ratios were used to create an EOI score. Receiver operating characteristic curve analysis showed that the optimal cut-off EOI score for adequate obliteration was 1.5 (area under the curve, 0.81; 95% confidence interval, 0.73-0.9; sensitivity, 0.9; specificity, 0.57).</p><p><strong>Conclusion: </strong>The EOI score, which is based on factors that inhibit early obliteration, may predict early treatment outcomes of FD placement.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"240-245"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9968632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Similarities in rotavirus vaccine viral shedding and immune responses in pairs of twins.","authors":"Yasuko Enya,&nbsp;Hiroyuki Hiramatsu,&nbsp;Masaru Ihira,&nbsp;Ryota Suzuki,&nbsp;Yuki Higashimoto,&nbsp;Yusuke Funato,&nbsp;Kei Kozawa,&nbsp;Hiroki Miura,&nbsp;Masafumi Miyata,&nbsp;Yoshiki Kawamura,&nbsp;Takuma Ishihara,&nbsp;Koki Taniguchi,&nbsp;Satoshi Komoto,&nbsp;Tetsushi Yoshikawa","doi":"10.20407/fmj.2022-039","DOIUrl":"https://doi.org/10.20407/fmj.2022-039","url":null,"abstract":"<p><strong>Objectives: </strong>Intestinal rotavirus (RV) vaccine replication and host immune response are suggested to be affected by several factors, including maternal antibodies, breastfeeding history, and gut microbiome, which are thought to be similar in pairs of twins. The aim of this study was to determine whether viral shedding from the fecal RV vaccine strain Rotarix^® (RV1) and IgG and IgA responses to RV show similarity in pairs of twins.</p><p><strong>Methods: </strong>Quantitative reverse transcription polymerase chain reaction specific to RV vaccine strain RV1 was used to monitor fecal RV1 viral shedding. RV IgG and IgA titers were measured using an in-house enzyme-linked immunosorbent assay. Fecal RV1 viral shedding and immune responses were compared between twins and singletons with mixed effects and fixed effects models.</p><p><strong>Results: </strong>A total of 347 stool and 54 blood samples were collected from four pairs of twins and twelve singletons during the observation period. Although the kinetics of fecal RV1 viral shedding and immune responses differed among vaccinated individuals, they appeared to be similar within twin pairs. RV shedding after the first dose (<i>P</i>=0.049) and RV IgG titers during the entire observation period (<i>P</i>=0.015) had a significantly better fit in the fixed effect model that assumed that twins have the same response versus the model that assumed that twins have a different response.</p><p><strong>Conclusions: </strong>The similarity of RV vaccine viral replication in intestine and host immune responses in twin pairs was demonstrated using statistical analysis.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"253-258"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9956768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective assessment of brexpiprazole in patients with schizophrenia: a prospective observational study.","authors":"Rina Yokoi,&nbsp;Masakazu Hatano,&nbsp;Hiroyuki Kamei,&nbsp;Aoi Morita,&nbsp;Manako Hanya,&nbsp;Nakao Iwata,&nbsp;Shigeki Yamada","doi":"10.20407/fmj.2022-031","DOIUrl":"https://doi.org/10.20407/fmj.2022-031","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the subjective assessments of an antipsychotic treatment with brexpiprazole.</p><p><strong>Methods: </strong>This was a 14-week prospective observational study. Nineteen patients participated in the study between February 2019 and January 2020.</p><p><strong>Results: </strong>Patients had a mean age of 40.6±14.2 years and a Clinical Global Impressions-Severity of Illness scale (CGI-S) score of 4.6±1.2 at the initiation of brexpiprazole treatment. The Subjective Well-being under Neuroleptic drug treatment Short form, Japanese version (SWNS-J) total score significantly improved from 68.1±22.3 in week 2 to 79.5±21.0 in week 14 (p=0.0084). The SWNS-J subscales of self-control and social integration status also significantly improved from 14.0±4.7 and 13.9±6.0 in week 2 to 17.0±4.7 and 16.0±5.1 in week 14, respectively (p=0.0053 and 0.012, respectively). No significant improvements were observed in any other SWNS-J subscales or the Drug Attitude Inventory-10 (DAI-10) in the 14-week observation period. Moreover, the SWNS-J total score did not correlate with the DAI-10 (r=0.31, p=0.19), or CGI-S (r=-0.18, p=0.47) scores.</p><p><strong>Conclusions: </strong>The present results suggest that brexpiprazole might improve subjective well-being, although this may not necessarily reflect psychopathological improvements. To enhance medication adherence, it is important to perform subjective assessments on patients over time.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"231-235"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9963119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative detailed evaluation intracranial artery stenosis using three-dimensional visualization analysis reduces the invasiveness of superficial temporal artery-middle cerebral artery bypass.","authors":"Riki Tanaka,&nbsp;Fuminari Komatsu,&nbsp;Kento Sasaki,&nbsp;Kyosuke Miyatani,&nbsp;Yasuhiro Yamada,&nbsp;Yoko Kato,&nbsp;Yuichi Hirose","doi":"10.20407/fmj.2022-022","DOIUrl":"https://doi.org/10.20407/fmj.2022-022","url":null,"abstract":"<p><strong>Objectives: </strong>Superficial temporal artery (STA) to middle cerebral artery (MCA) bypass surgery is a common treatment for preventing cerebral ischemia in patients with intracranial artery stenosis. The aim of this study was to analyze the surgical outcomes of the STA-MCA bypass procedure, particularly with regard to the invasiveness of targeted bypass (TB) with preoperative planning using Amira^® software.</p><p><strong>Methods: </strong>Consecutive patients with single STA-MCA bypass performed by a single neurosurgeon from January 2019 to May 2022 were included. The clinical parameters of seven TB patients were compared with those of 11 patients treated with the conventional method (CM).</p><p><strong>Results: </strong>Compared with CM patients, TB using Amira^® software patients had a shorter scalp incision (median [interquartile range]=11.2 [9.7-12.7] cm vs. 16.9 [16.0-17.7] cm, respectively; <i>p</i>=0.004], smaller craniotomy size (11.8 [11.5-14.4] cm² vs. 20.9 [17.1-22.2] cm², respectively; <i>p</i>=0.01], shorter surgery duration (201 [195-218] min vs. 277 [229-310] min, respectively; <i>p</i>=0.003], and less intraoperative bleeding (10 [10-20] g vs. 23 [20-50] g, respectively; <i>p</i>=0.033]. However, there were no differences in surgical complications between the two groups.</p><p><strong>Conclusions: </strong>Detailed preoperative evaluation using Amira^® software can reduce the invasiveness of the STA-MCA bypass procedure.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"9 3","pages":"206-210"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9963121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}