Fujita Medical Journal最新文献

{"title":"Effect of moderation on rubric criteria for inter-rater reliability in an objective structured clinical examination with real patients.","authors":"Tetsuro Watari, Soichiro Koyama, Yusaku Kato, Yonho Paku, Yoshikiyo Kanada, Hiroaki Sakurai","doi":"10.20407/fmj.2021-010","DOIUrl":"10.20407/fmj.2021-010","url":null,"abstract":"<p><p>Objectives: Objective structured clinical examinations (OSCEs) are used to assess clinical competence in medical education. Evaluations using video-recorded OSCEs are effective in reducing costs in terms of time and human resources. To improve inter-rater reliability, these evaluations undergo moderation in the form of a discussion between the raters to obtain consistency in grading according to the rubric criteria. We examined the effect of moderation related to the rubric criteria on the inter-rater reliability of a video-recorded OSCE with real patients.</p><p><strong>Methods: </strong>Forty OSCE videos in which students performed range-of-motion tests at shoulder abduction on real patients were assessed by two raters. The two raters scored videos 1 to 10 without moderation and videos 11 to 40 with moderation each time. The inter-rater reliability of the OSCE was calculated using the weighted kappa coefficient.</p><p><strong>Results: </strong>The mean scores of the weighted kappa coefficients were 0.49 for videos 1 to 10, 0.57 for videos 11 to 20, 0.66 for videos 21 to 30, and 0.82 for videos 31 to 40.</p><p><strong>Conclusions: </strong>An assessment of video-recorded OSCEs was conducted with real patients in a real clinical setting. Repeated moderation improved the inter-rater reliability. This study suggests the effectiveness of moderation in OSCEs with real patients.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 3","pages":"83-87"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of vacuum-assisted closure after stoma closure with purse string suturing: a retrospective trial.","authors":"Koji Masumori,&nbsp;Kotaro Maeda,&nbsp;Tsunekazu Hanai,&nbsp;Harunobu Sato,&nbsp;Yoshikazu Koide,&nbsp;Hiroshi Matsuoka,&nbsp;Hidetoshi Katsuno,&nbsp;Tomoyoshi Endo,&nbsp;Yeongcheol Cheong,&nbsp;Ichiro Uyama","doi":"10.20407/fmj.2021-007","DOIUrl":"https://doi.org/10.20407/fmj.2021-007","url":null,"abstract":"<p><strong>Objectives: </strong>Surgical site infection (SSI) is a problematic complication after stoma closure. The purse string suture (PSS) technique eliminates this problem, but the area takes longer to heal. The present retrospective study was performed to evaluate the usefulness of a vacuum-assisted closure (VAC) system for the promotion of wound healing after stoma closure.</p><p><strong>Methods: </strong>Consecutive patients undergoing stoma closure with the PSS technique were divided into two groups: those treated with and without use of the VAC system. The volume of dead space and the size of the wound were measured after stoma closure in both groups. The same measurements were performed on days 3 and 7 after closure. The time needed for wound closure was also examined in both groups. Outcomes were also evaluated according to age, body mass index, operative time, bleeding volume, wound consistency, patient satisfaction, perioperative inflammatory response, occurrence of SSI, and hospitalization days.</p><p><strong>Results: </strong>The VAC group comprised 31 patients, and the non-VAC group comprised 34 patients. The volume of dead space on days 3 and 7 after closure was significantly smaller in the VAC group than in the non-VAC group (P=0.006 and P<0.001, respectively). The number of SSIs was significantly lower in the VAC group than in the non-VAC group (P=0.014).</p><p><strong>Conclusion: </strong>The dead space volume on days 3 and 7 after stoma closure with PSS significantly decreased by using the VAC system. The incidence of SSI after stoma closure also significantly decreased by using the VAC system.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 3","pages":"67-72"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of the menthol test as a clinical evaluation method for oxaliplatin-induced neuropathy.","authors":"Yeongcheol Cheong,&nbsp;Hidetoshi Katsuno,&nbsp;Hiroshi Matsuoka,&nbsp;Masahiro Mizuno,&nbsp;Tomoyoshi Endo,&nbsp;Tadahiro Kamiya,&nbsp;Yosuke Tajima,&nbsp;Keigo Ashida,&nbsp;Yoshikazu Koide,&nbsp;Koji Masumori,&nbsp;Harunobu Sato,&nbsp;Tsunekazu Hanai,&nbsp;Kotaro Maeda,&nbsp;Ichiro Uyama,&nbsp;Junichiro Hiro,&nbsp;Koichi Suda","doi":"10.20407/fmj.2021-011","DOIUrl":"https://doi.org/10.20407/fmj.2021-011","url":null,"abstract":"<p><strong>Objectives: </strong>To determine whether the tongue menthol test, which measures the cold sensation detection threshold (CDT) of the tongue, used before and after oxaliplatin administration is an objective evaluation method for oxaliplatin-induced peripheral neuropathy (OPN).</p><p><strong>Methods: </strong>The tongue menthol test was administered to patients both before and after undergoing chemotherapy containing oxaliplatin for colorectal cancer. The tongue menthol test was conducted by applying a menthol solution (a selective agonist of transient receptor potential cation channel subfamily M member 8 [TRPM8]) to the tongue and measuring the CDT.</p><p><strong>Results: </strong>The mean CDT before the first dose of oxaliplatin was 0.34% (0.005%-1%; <i>n</i>=38), and the mean CDT after the first dose was 0.32% (0.005%-1%; <i>n</i>=38). The CDT appeared to decrease after the first dose, but this difference was not significant. In patients who received five courses of oxaliplatin, changes in CDT values were compared before and after the five courses. In patients with Neurotoxicity Criteria of Debiopharm (DEB-NTC) grade 2 neuropathy, the pre-oxaliplatin administration CDT was compared between before grade exacerbation and when exacerbation occurred, and was found to decline when grade exacerbation occurred. Moreover, when the CDTs before and after administration were compared before grade exacerbation, there was a significant decrease in CDT after administration (<i>P</i>=0.04).</p><p><strong>Conclusions: </strong>By performing a menthol test in oxaliplatin-treated patients, it may be possible to objectively predict the exacerbation of peripheral neuropathy at an early stage.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 3","pages":"88-95"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse reactions to mRNA coronavirus disease 2019 (COVID-19) vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 576 medical staff.","authors":"Masamichi Hayashi,&nbsp;Sayako Morikawa,&nbsp;Yusuke Goto,&nbsp;Takazumi Yoshida,&nbsp;Yutaro Kimura,&nbsp;Kazuyoshi Imaizumi","doi":"10.20407/fmj.2021-009","DOIUrl":"https://doi.org/10.20407/fmj.2021-009","url":null,"abstract":"<p><strong>Objectives: </strong>Various measures have been taken to curb the COVID-19 epidemic, but their effect has been limited. Vaccines are expected to make a definite improvement. In Japan, vaccination began in February 2021. However, there are very few reports of adverse reactions to mRNA vaccines for the new coronavirus (SARS-CoV-2) in Japanese people. Therefore, adverse reactions in 576 vaccinated medical staff at the author's hospital were investigated.</p><p><strong>Methods: </strong>The subjects were 576 medical staff who wished to receive the new coronavirus (SARS-CoV-2) vaccine. The first vaccination was performed with Pfizer's new coronavirus mRNA vaccine (commercial name: Comirnaty intramuscular injection) from March 8 to March 15, 2021. The second vaccination was performed from March 29 to April 5, 2021, at an interval of more than 21 days from the first vaccination.</p><p><strong>Results: </strong>Adverse reactions were seen in six subjects in the first vaccination. There was dyspnea in one subject, arthralgia in one subject, fever/malaise in three subjects, and left axillary pain and lymphadenopathy in one subject. One subject had a reaction at the vaccination site that needed to be addressed. At the second vaccination, adverse reactions were observed in 64 subjects. There was fever in 58 subjects, malaise in 21 subjects, arthralgia in 12 subjects, aching pain in 11 subjects, headache in six subjects, chills in six subjects, nausea in three subjects, redness in two subjects, dizziness in two subjects, hives in two subjects, swelling in two subjects, cough in one subject, and itching in one subject (some had multiple adverse reactions). Fever was observed in the range of body temperature from 37.4 to 38.9 degrees.</p><p><strong>Conclusions: </strong>Most of the adverse reactions to the COVID-19 vaccine were mild, and no serious anaphylaxis was observed. Vaccination was considered perfectly feasible if attention is paid to adverse reactions.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 3","pages":"79-82"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40684205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal study of the vaginal microbiome in pregnancies involving preterm labor.","authors":"Yoshiko Sakabe,&nbsp;Haruki Nishizawa,&nbsp;Asuka Kato,&nbsp;Yoshiteru Noda,&nbsp;Akiko Ohwaki,&nbsp;Hikari Yoshizawa,&nbsp;Takema Kato,&nbsp;Takao Sekiya,&nbsp;Takuma Fujii,&nbsp;Hiroki Kurahashi","doi":"10.20407/fmj.2021-017","DOIUrl":"https://doi.org/10.20407/fmj.2021-017","url":null,"abstract":"<p><strong>Objectives: </strong>Alterations in the vaginal bacterial flora reflect the status of various obstetric conditions and are associated with mechanisms that underlie certain pregnancy-associated complications. These changes are also a predictive biomarker for clinical outcomes of these adverse events.</p><p><strong>Methods: </strong>We examined the vaginal microbiome in samples from pregnant Japanese women with preterm labor.</p><p><strong>Results: </strong>The microbiota composition in preterm delivery (PD) samples differed from those of control or threatened preterm delivery (TPD) samples in principal component analysis. An increase in Firmicutes and a decrease in Actinobacteria were significantly associated with PD only (both <i>P</i><0.01). In the Firmicutes phylum, <i>Lactobacillus</i> tended to be abundant, and the abundance of <i>L. iners</i> and <i>L. crispatus</i> was especially high, whereas the <i>L. gasseri</i> population was low in PD samples. Longitudinal analysis showed that the abundance of <i>L. iners</i> decreased after commencing tocolytic treatment in TPD samples compared with before treatment, but it remained high in PD samples.</p><p><strong>Conclusions: </strong>The vaginal microbiome may be a useful prognostic indicator of preterm labor and a monitoring tool for tocolytic treatment to prevent preterm birth.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 3","pages":"96-101"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delays in initial workflow cause delayed initiation of mechanical thrombectomy in patients with in-hospital ischemic stroke.","authors":"Kenichiro Suyama,&nbsp;Shoji Matsumoto,&nbsp;Ichiro Nakahara,&nbsp;Yoshio Suyama,&nbsp;Jun Morioka,&nbsp;Akiko Hasebe,&nbsp;Jun Tanabe,&nbsp;Sadayoshi Watanabe,&nbsp;Kiyonori Kuwahara,&nbsp;Yuichi Hirose","doi":"10.20407/fmj.2021-014","DOIUrl":"https://doi.org/10.20407/fmj.2021-014","url":null,"abstract":"<p><strong>Objectives: </strong>The benefit of mechanical thrombectomy for acute ischemic stroke is highly time dependent. However, time to treatment is longer for in-hospital stroke patients than community-onset stroke patients. This study aimed to clarify the cause of this difference.</p><p><strong>Methods: </strong>A retrospective single-center study was performed to analyze patients with large vessel occlusion who underwent mechanical thrombectomy between January 2017 and December 2019. Patients were divided into in-hospital stroke and community-onset stroke groups. Clinical characteristics and treatment time intervals were compared between groups.</p><p><strong>Results: </strong>One hundred four patients were analyzed: 17 with in-hospital stroke and 87 with community-onset stroke. Patient characteristics did not significantly differ between groups. Median door (stroke recognition)-to-computed tomography time (36 min vs. 14 min, P<0.01) and door-to-puncture time (135 min vs. 117 min, P=0.02) were significantly longer in the in-hospital stroke group than the community-onset stroke group. However, median computed tomography-to-puncture time (104 min vs. 104 min, P=0.47) and puncture-to-reperfusion time (53 min vs. 38 min, P=0.17) did not significantly differ.</p><p><strong>Conclusions: </strong>Longer door-to-puncture time in in-hospital stroke patients was mostly caused by longer door-to-computed tomography time, which is the initial part of the workflow. An in-hospital stroke protocol that places importance on early stroke specialist consultation and prompt transportation to the computed tomography scanner might hasten treatment and improve outcomes in patients with in-hospital stroke.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 3","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation in the prevalence of Gram-negative bacilli in sputum and urine specimens from outpatients and inpatients.","authors":"Yusuke Kito,&nbsp;Kazunobu Kuwabara,&nbsp;Kiyotaka Ono,&nbsp;Kenichi Kato,&nbsp;Tatsuyoshi Yokoi,&nbsp;Kohki Horiguchi,&nbsp;Keisuke Kato,&nbsp;Masahiro Hirose,&nbsp;Tomomi Ohara,&nbsp;Kenta Goto,&nbsp;Yumi Nakamura,&nbsp;Yoshikatsu Koike,&nbsp;Takahiko Horiguchi","doi":"10.20407/fmj.2021-003","DOIUrl":"https://doi.org/10.20407/fmj.2021-003","url":null,"abstract":"<p><strong>Objectives: </strong>To determine whether the prevalence of gram-negative bacilli (GNB; <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumoniae</i>, and <i>Escherichia coli</i>) in sputum and urine specimens from outpatients and inpatients differed by season and according to temperature and humidity changes.</p><p><strong>Methods: </strong>In this retrospective study, microbiologic data for adult patients from 2008 to 2019 were retrieved from the electronic database of a hospital in Japan. Data were categorized by specimen type (sputum and urine) and specimen collection (outpatient and inpatient). Associations between variables were assessed using Spearman's rank correlation coefficients. Differences between groups were assessed using Pearson's chi-square test and analysis of discrete variance.</p><p><strong>Results: </strong>Among inpatients, the frequencies of <i>P. aeruginosa</i> and <i>K. pneumoniae</i> isolation from sputum specimens were higher in summer and autumn. The frequency of <i>P. aeruginosa</i> isolation from urine specimens was higher in autumn. These seasonal trends were observed in specimens from both outpatients and inpatients. No seasonal trend was observed in the frequency of <i>E. coli</i> isolation. Mean monthly temperature was positively correlated with the frequency of isolating <i>P. aeruginosa</i> (r=0.2198, p=0.0081) and <i>K. pneumonia</i>e (r=0.3443, p=0.00002) from sputum as well as with the frequency of isolating <i>K. pneumoniae</i> (r=0.1905, p=0.0222) from urine. Mean monthly humidity was positively correlated with the frequency of isolating <i>K. pneumoniae</i> (r=0.2602, p=0.0016) from sputum.</p><p><strong>Conclusions: </strong>GNB were isolated more frequently in summer and autumn than in other seasons. These seasonal trends were observed for both outpatient and inpatient specimens. Seasonality should be considered for optimal infection control of GNB in hospitals.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 2","pages":"46-51"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between serum albumin and serum zinc in malignant lymphoma.","authors":"Misaki Morisaku,&nbsp;Kaori Ito,&nbsp;Anna Ogiso,&nbsp;Misa Imai,&nbsp;Yoshiko Hiraoka,&nbsp;Miho Zennami,&nbsp;Masahiro Tsuge,&nbsp;Maiko Mori,&nbsp;Seira Toyosato,&nbsp;Hidezo Matsuda,&nbsp;Yosuke Ando,&nbsp;Masutaka Tokuda,&nbsp;Akihiro Tomita,&nbsp;Shigeki Yamada","doi":"10.20407/fmj.2021-006","DOIUrl":"https://doi.org/10.20407/fmj.2021-006","url":null,"abstract":"<p><strong>Objectives: </strong>Zinc (Zn) is a cofactor for more than 200 enzymes within the human body. Zn deficiency can result in cell-mediated immune dysfunction. Furthermore, serum Zn levels have been reported to be associated with nutritional status, but this association has not been clarified in malignant lymphoma. This study aimed to examine the deficiency of serum Zn levels and clarify the factors that are correlated with serum Zn in malignant lymphoma.</p><p><strong>Methods: </strong>Initial malignant lymphoma was diagnosed in patients at Fujita Health University Hospital between April 2011 and March 2019. Based on the serum Zn levels, the study population was divided into \"deficient\" and \"low or normal\". For the serum Zn levels of patients undergoing pre-chemotherapy, laboratory parameters and nutritional factors were included. We compared these factors between the abovementioned two groups, and the serum Zn levels with its correlation factors were investigated.</p><p><strong>Results: </strong>A total of 77 patients (Deficient group, n=20 and Low or Normal group, n=57) were enrolled. Histology, hemoglobin, serum albumin levels, Glasgow Prognostic Score (GPS), neutrophile-lymphocyte ratio (NLR), prognostic nutrition index (PNI) and Controlling Nutritional Status (CONUT) were significantly different between the two groups. Of these parameters, only serum albumin level was significantly associated with serum Zn level (p=0.0024; estimated regression coefficient, 9.51; adjusted coefficient of determination, 0.28).</p><p><strong>Conclusions: </strong>Poor nutritional status at the initial diagnosis may have affected Zn deficiency in initial malignant lymphoma.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 2","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10248046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing infection after synthetic expander implantation in patients undergoing breast reconstruction.","authors":"Satoko Onishi,&nbsp;Yoshikazu Inoue,&nbsp;Maki Inukai,&nbsp;Takayuki Okumoto","doi":"10.20407/fmj.2020-029","DOIUrl":"https://doi.org/10.20407/fmj.2020-029","url":null,"abstract":"<p><strong>Objectives: </strong>Breast reconstruction using synthetic materials has increased rapidly in Japan since July 2013, when national health insurance began covering the procedure. Although synthetic material-based reconstruction of other body parts has not resulted in wounds with complications, this significant advantage is overshadowed by a risk of complications, including infection, following breast reconstruction. We therefore reviewed breast-reconstruction patients who experienced infection after implantation of synthetic materials and the countermeasures we used to address the problem.</p><p><strong>Methods: </strong>From July 2013 through December 2019, our department performed primary breast reconstructions using tissue expanders (TEs) in 106 patients and secondary breast reconstructions in 39 patients. We retrospectively reviewed these 145 patients in terms of their age, body mass index, timing of the reconstruction, presence/absence of both chemotherapy and radiation therapy before and after surgery, presence/absence of postoperative wound complications, and presence/absence of atopic dermatitis. We then evaluated whether these factors put patients at risk for postoperative TE infection.</p><p><strong>Results: </strong>Among the 145 patients who underwent reconstruction with TE, 3 (2.0%) were diagnosed with a postoperative TE infection. Our review revealed that necrosis of the skin around the surgical wound (P=0.004) and atopic dermatitis (P=0.041) were risk factors for TE infection.</p><p><strong>Conclusions: </strong>Infection following breast reconstruction with synthetic materials is a serious complication. Thus, patients requiring this surgery deserve optimal perioperative management. For those with known risk factors, a more appropriate surgical approach-e.g., using autologous tissue instead of a synthetic material-could be considered.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 2","pages":"42-45"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10240695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serological examination for clinical cross-reactivity between salmon roe and pollock roe in patients with a salmon roe allergy.","authors":"Kaoru Okamoto,&nbsp;Yoichi Nakajima,&nbsp;Tetsushi Yoshikawa,&nbsp;Yasuto Kondo","doi":"10.20407/fmj.2021-004","DOIUrl":"https://doi.org/10.20407/fmj.2021-004","url":null,"abstract":"<p><strong>Objectives: </strong>Fish roe is a common allergen in Japan. We have previously reported that although immunoglobulin (IgE) from patients with salmon roe (SR) or pollock roe (PR) allergies cross-react, 70% of patients with SR allergy can consume PR without developing any symptoms. However, a correlation between clinical cross-reactivity and serological cross-reactivity remains to be demonstrated.</p><p><strong>Methods: </strong>Serum samples were collected from 15 patients with SR allergy who had consumed cooked PR previously. Among these volunteers, four had experienced immediate symptoms after consuming cooked PR, while the others had exhibited no symptoms of PR allergy. A competitive enzyme-linked immunosorbent assay (ELISA) was performed to analyze the serological cross-reactivity with SR and PR. Immunoblotting inhibition assays were performed using serum samples that had been pre-incubated with SR or PR extracts.</p><p><strong>Results: </strong>In ELISAs, binding to SR was inhibited by >50% when the serum samples from patients with both SR and PR allergies were pre-incubated with PR extract (<i>p</i>=0.0256). In immunoblots, pre-incubation of serum samples with PR extract inhibited detection of the 16-kDa protein, which likely corresponds to the major SR allergen beta' component, significantly more for samples from patients with both SR and PR allergies (100%) than for samples from those with only an SR allergy (18.2%) (<i>p</i>=0.011).</p><p><strong>Conclusions: </strong>The superior competitive binding of the sera from patients with both SR and PR allergies to PR compared with that to SR may induce clinical cross-reactivity between SR and PR.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 2","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}