Fujita Medical Journal最新文献

{"title":"Correlation between serum albumin and serum zinc in malignant lymphoma.","authors":"Misaki Morisaku,&nbsp;Kaori Ito,&nbsp;Anna Ogiso,&nbsp;Misa Imai,&nbsp;Yoshiko Hiraoka,&nbsp;Miho Zennami,&nbsp;Masahiro Tsuge,&nbsp;Maiko Mori,&nbsp;Seira Toyosato,&nbsp;Hidezo Matsuda,&nbsp;Yosuke Ando,&nbsp;Masutaka Tokuda,&nbsp;Akihiro Tomita,&nbsp;Shigeki Yamada","doi":"10.20407/fmj.2021-006","DOIUrl":"https://doi.org/10.20407/fmj.2021-006","url":null,"abstract":"<p><strong>Objectives: </strong>Zinc (Zn) is a cofactor for more than 200 enzymes within the human body. Zn deficiency can result in cell-mediated immune dysfunction. Furthermore, serum Zn levels have been reported to be associated with nutritional status, but this association has not been clarified in malignant lymphoma. This study aimed to examine the deficiency of serum Zn levels and clarify the factors that are correlated with serum Zn in malignant lymphoma.</p><p><strong>Methods: </strong>Initial malignant lymphoma was diagnosed in patients at Fujita Health University Hospital between April 2011 and March 2019. Based on the serum Zn levels, the study population was divided into \"deficient\" and \"low or normal\". For the serum Zn levels of patients undergoing pre-chemotherapy, laboratory parameters and nutritional factors were included. We compared these factors between the abovementioned two groups, and the serum Zn levels with its correlation factors were investigated.</p><p><strong>Results: </strong>A total of 77 patients (Deficient group, n=20 and Low or Normal group, n=57) were enrolled. Histology, hemoglobin, serum albumin levels, Glasgow Prognostic Score (GPS), neutrophile-lymphocyte ratio (NLR), prognostic nutrition index (PNI) and Controlling Nutritional Status (CONUT) were significantly different between the two groups. Of these parameters, only serum albumin level was significantly associated with serum Zn level (p=0.0024; estimated regression coefficient, 9.51; adjusted coefficient of determination, 0.28).</p><p><strong>Conclusions: </strong>Poor nutritional status at the initial diagnosis may have affected Zn deficiency in initial malignant lymphoma.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 2","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10248046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing infection after synthetic expander implantation in patients undergoing breast reconstruction.","authors":"Satoko Onishi,&nbsp;Yoshikazu Inoue,&nbsp;Maki Inukai,&nbsp;Takayuki Okumoto","doi":"10.20407/fmj.2020-029","DOIUrl":"https://doi.org/10.20407/fmj.2020-029","url":null,"abstract":"<p><strong>Objectives: </strong>Breast reconstruction using synthetic materials has increased rapidly in Japan since July 2013, when national health insurance began covering the procedure. Although synthetic material-based reconstruction of other body parts has not resulted in wounds with complications, this significant advantage is overshadowed by a risk of complications, including infection, following breast reconstruction. We therefore reviewed breast-reconstruction patients who experienced infection after implantation of synthetic materials and the countermeasures we used to address the problem.</p><p><strong>Methods: </strong>From July 2013 through December 2019, our department performed primary breast reconstructions using tissue expanders (TEs) in 106 patients and secondary breast reconstructions in 39 patients. We retrospectively reviewed these 145 patients in terms of their age, body mass index, timing of the reconstruction, presence/absence of both chemotherapy and radiation therapy before and after surgery, presence/absence of postoperative wound complications, and presence/absence of atopic dermatitis. We then evaluated whether these factors put patients at risk for postoperative TE infection.</p><p><strong>Results: </strong>Among the 145 patients who underwent reconstruction with TE, 3 (2.0%) were diagnosed with a postoperative TE infection. Our review revealed that necrosis of the skin around the surgical wound (P=0.004) and atopic dermatitis (P=0.041) were risk factors for TE infection.</p><p><strong>Conclusions: </strong>Infection following breast reconstruction with synthetic materials is a serious complication. Thus, patients requiring this surgery deserve optimal perioperative management. For those with known risk factors, a more appropriate surgical approach-e.g., using autologous tissue instead of a synthetic material-could be considered.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 2","pages":"42-45"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10240695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serological examination for clinical cross-reactivity between salmon roe and pollock roe in patients with a salmon roe allergy.","authors":"Kaoru Okamoto,&nbsp;Yoichi Nakajima,&nbsp;Tetsushi Yoshikawa,&nbsp;Yasuto Kondo","doi":"10.20407/fmj.2021-004","DOIUrl":"https://doi.org/10.20407/fmj.2021-004","url":null,"abstract":"<p><strong>Objectives: </strong>Fish roe is a common allergen in Japan. We have previously reported that although immunoglobulin (IgE) from patients with salmon roe (SR) or pollock roe (PR) allergies cross-react, 70% of patients with SR allergy can consume PR without developing any symptoms. However, a correlation between clinical cross-reactivity and serological cross-reactivity remains to be demonstrated.</p><p><strong>Methods: </strong>Serum samples were collected from 15 patients with SR allergy who had consumed cooked PR previously. Among these volunteers, four had experienced immediate symptoms after consuming cooked PR, while the others had exhibited no symptoms of PR allergy. A competitive enzyme-linked immunosorbent assay (ELISA) was performed to analyze the serological cross-reactivity with SR and PR. Immunoblotting inhibition assays were performed using serum samples that had been pre-incubated with SR or PR extracts.</p><p><strong>Results: </strong>In ELISAs, binding to SR was inhibited by >50% when the serum samples from patients with both SR and PR allergies were pre-incubated with PR extract (<i>p</i>=0.0256). In immunoblots, pre-incubation of serum samples with PR extract inhibited detection of the 16-kDa protein, which likely corresponds to the major SR allergen beta' component, significantly more for samples from patients with both SR and PR allergies (100%) than for samples from those with only an SR allergy (18.2%) (<i>p</i>=0.011).</p><p><strong>Conclusions: </strong>The superior competitive binding of the sera from patients with both SR and PR allergies to PR compared with that to SR may induce clinical cross-reactivity between SR and PR.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 2","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9069270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remembering Keisuke Fujita, MD, PhD, President and Founder of Fujita Health University.","authors":"Shosuke Ito","doi":"10.20407/fmj.2021-001","DOIUrl":"10.20407/fmj.2021-001","url":null,"abstract":"","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47282041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of diabetes mellitus and hypertension with adherence to continuous positive airway pressure therapy in male patients with obstructive sleep apnea","authors":"S. Kojima, Ayako Saito, F. Sasaki, Masamichi Hayashi, Yuki Mieno, H. Sakakibara, S. Hashimoto","doi":"10.20407/fmj.2020-028","DOIUrl":"https://doi.org/10.20407/fmj.2020-028","url":null,"abstract":"Objectives: Continuous positive airway pressure (CPAP) is the first line of therapy for obstructive sleep apnea (OSA). Adherence to CPAP, however, is known to be problematic, and its associations with the comorbidities of hypertension and diabetes mellitus have not been sufficiently evaluated. Thus, we investigated the associations of CPAP therapy adherence with comorbidities of hypertension and diabetes mellitus. Methods: We conducted a retrospective study among 497 male patients with OSA on CPAP therapy. Participants with pretreatment Apnea–Hypopnea Index (AHI) data based on overnight polysomnographic recordings completed a questionnaire. Adherence data for CPAP therapy were collected using a smart card system. We classified CPAP use of ≥4 hours per night and ≥70% of nights as good adherence; other CPAP use was categorized as poor adherence. Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for poor adherence to CPAP therapy in the hypertension and diabetes mellitus groups, compared with the no comorbidity group, adjusting for body mass index, duration of CPAP therapy, AHI, and Epworth Sleepiness Scale score. Results: In the no comorbidity, hypertension, and diabetes mellitus groups, 43.4%, 44.7%, and 56.0%, respectively, had poor adherence to CPAP therapy. Being in the diabetes mellitus group was significantly associated with poor adherence to CPAP therapy (OR=1.86, 95% CI: 1.18–2.92, p=0.007); there was no association for the hypertension group. Conclusion: Our results indicate that comorbidity of diabetes mellitus is associated with poor adherence to CPAP therapy in male patients with OSA.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 1","pages":"37 - 41"},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41781006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody testing for COVID-19 in patients with acute coronary syndrome in Aichi Prefecture","authors":"Masataka Yoshinaga, T. Muramatsu, H. Fujigaki, Kuniaki Saito, H. Izawa","doi":"10.20407/fmj.2020-032","DOIUrl":"https://doi.org/10.20407/fmj.2020-032","url":null,"abstract":"The currently ongoing coronavirus disease 2019 (COVID-19) pandemic was officially recognized as a worldwide pandemic by the World Health Organization (WHO) on March 11, 2020. On April 16, 2020, the Japanese government declared a state of emergency throughout Japan. Previous work has suggested that COVID-19 may be associated with an elevated risk of systemic thrombotic diseases owing to the inflammatory responses, endothelial dysfunction, and hypercoagulability associated with this disease.1 Evidence of myocardial injury (i.e., an elevated level of cardiac troponin) is often observed among hospitalized patients with COVID-19; however, the COVID-19 prevalence among patients with acute coronary syndrome (ACS) has not yet been investigated. Current clinical practice guidelines strongly recommend diagnostic catheterization and early revascularization (e.g., percutaneous coronary intervention [PCI]) if a patient is considered to have either ST-segment elevation myocardial infarction or high-risk non-ST-segment elevation ACS. Given the potential risk of infectious disease transmission among healthcare providers in the setting of ACS, which potentially requires intensive care and/or emergent catheterization procedures, quick and reliable screening tests are desirable. A Japanese nationwide survey reported that the majority of COVID-19 screening measures applied to such patients included physical examination only (~50%–80%), followed by chest computed tomography (CT) (~10%–50%), and polymerase chain reaction (PCR) (<10%).2 Notably, because PCR testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is performed less frequently in Japan than in other countries, a considerably larger number of patients undergoing COVID-19 screening have an available CT scan. However, the Centers for Disease Control (CDC) guidelines recommend against using chest CT alone for the diagnosis of COVID-19. The level of serum antiviral antibodies in patients who have recovered from SARS-CoV-2 infection does not reduce until 4 months after the initial diagnosis.3 The fully automated immunoassay system VITROS® (Ortho Clinical Diagnostics, Raritan, NJ, USA) is a novel approach for qualitative serologic testing for antibodies against SARS-CoV-2, the causative pathogen of COVID-19. The precision of the VITROS® antiSARS-CoV-2 total assay and its cross-reactivity with other acute respiratory virus infections were clinically validated in previous work.4 Using the PCR method as a standard, the sensitivity, specificity, positive predictive value, negative","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 1","pages":"65 - 66"},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49041413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remembering Keisuke Fujita, M.D., Ph.D., President and Founder of Fujita Health University, and his contributions to medical science and education","authors":"T. Nagatsu","doi":"10.20407/fmj.2020-031","DOIUrl":"https://doi.org/10.20407/fmj.2020-031","url":null,"abstract":"Keisuke Fujita, M.D., Ph.D. (1925–1995), founded and was President of Fujita Gakuen (academy) in 1964, Fujita Health University in 1968, and Fujita Health University (FHU) School of Medicine in 1972. He also established the Institute for Comprehensive Medical Science (ICMS) at FHU in 1972, at the same time as the founding of FHU School of Medicine, to promote the institutional development of FHU School of Medicine by providing a strong foundation for science. I collaborated with Dr. Fujita from 1965. Returning from the study abroad at the NIH in the USA in 1965, I joined Professor Fujita’s Department of Biochemistry at the Aichi Gakuin University School of Dentistry, as an Associate Professor. Dr. Fujita’s major research interest was in the biochemistry of diseases, namely, cancer, neuropsychiatric diseases, and various intractable diseases, which he investigated by applying analytical chemistry and molecular/cellular biochemistry. He was also interested in the pharmacognosy of aloe plants and established “Syoyaku Kenkyu Juku (Center for Pharmacognosy),” and where he studied by himself and trained many FHU graduates. I herein present an overview of the research carried out by Dr. Fujita to share his legacy and praise his memoir and contributions to medical science and education for all faculty members, staffs and students of FHU. It is assumed that individuals at FHU have already made significant contributions to medical science. I hope that his vision of FHU producing a Nobel Prize laureate will be realized someday.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 1","pages":"3 - 12"},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47994218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive rib resection followed by thoracic wall reconstruction using polytetrafluoroethylene mesh and titanium plates for refractory intercostal artery bleeding induced by severe blunt thoracic injury: report of a case","authors":"Yosuke Kobayashi, S. Matsumoto, K. Tajima","doi":"10.20407/fmj.2020-026","DOIUrl":"https://doi.org/10.20407/fmj.2020-026","url":null,"abstract":"Massive hemothorax due to multiple rib fractures and intercostal artery (ICA) injuries is one of the most lethal forms of chest trauma. Urgent thoracotomy is required; however, suturing is sometimes difficult owing to the limited operative field in the thoracic cavity and because the transected ICA retracts between the surrounding intercostal muscles. We present a patient with refractory ICA bleeding induced by severe blunt thoracic injury successfully treated with extensive rib resection followed by thoracic wall reconstruction using GORE® DUALMESH® and titanium plates. A 66-year-old woman attempted suicide by diving into the path of a train. She incurred massive left hemothorax associated with multiple rib fractures and severe trauma to her extremities; both upper limbs and left leg at the thigh were nearly disconnected. Initially, she underwent urgent left anterolateral thoracotomy followed by partial lung resection and suture hemostasis of the thoracic wall. Subsequently, interventional radiology was performed for the ICA bleeding, and her extremities except her right leg were amputated. However, because hemothorax persisted, and because of the comminuted fractures, we removed the fifth to eighth ribs, and the ICA vascular sheath was ligated. Resecting multiple ribs caused deformities and lung herniations, although hemostasis was achieved. On the third postoperative day, thoracic reconstruction using Gore-Tex® Dual Mesh and titanium plates was performed. Although a small empyema occurred, it was controlled with antibiotics and drainage. Paradoxical respiration and atelectasis did not occur, and the patient was moved to the hospital for continued care in a lucid state.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 1","pages":"31 - 33"},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45774920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for epiretinal membrane surgery after initial pars plana vitrectomy for rhegmatogenous retinal detachment","authors":"Y. Takamidou, Tadashi Mizuguchi, Ryouta Sakurai, Mitsuo Sugimoto, A. Tanikawa, M. Horiguchi","doi":"10.20407/fmj.2020-027","DOIUrl":"https://doi.org/10.20407/fmj.2020-027","url":null,"abstract":"Objectives: The purpose of this study was to examine the incidence of, and risk factors for, epiretinal membrane (ERM) surgery after an initial pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD). Methods: The records of consecutive patients (3,495 eyes of 3,387 patients) who underwent RRD repair at Fujita Health University Hospital between January 1, 2008, and February 28, 2019, were retrospectively reviewed. A total of 1,736 eyes without an ERM in preoperative optical coherence tomography were included in this study. Results: The incidence of ERM surgery after RRD repair was 2.4%. The mean time from RRD repair to ERM surgery was 19.5±27.2 months. The odds ratios after adjusting for age and sex were as follows: the preoperative visual acuity (logarithm of the minimum angle of resolution, logMAR), 2.17 (p=0.02; 95% confidence interval [CI], 1.11–5.16); axial length, 1.38 (p=0.002; 95% CI, 1.12–1.72); 20-gauge vitreous surgery instruments, 3.82 (p<0.0001; 95% CI, 2.02–7.16); internal limiting membrane (ILM) peeling, 0.28 (p=0.033; 95% CI, 0.05–0.92). ERM surgery improved visual acuity from 0.36 to 0.01 logMAR, even at ≥1.5 years after RRD repair. Conclusions: Careful follow-up is required in the following cases: long axial length before RRD repair, low visual acuity, use of 20-gauge vitreous surgery instruments, and a lack of ILM peeling.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 1","pages":"25 - 30"},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43957137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Availability of Home sleep apnea test equipment LS-140 on a comparison with Polysomnography","authors":"Yuki Mieno, Masamichi Hayashi, Mariko Hirochi, A. Ikeda, Hisashi Kako, Takuma Ina, Yuri Maeda, Shingo Maeda, Takahiro Inoue, Tomohide Souma, Toshikazu Watanabe, Tomoya Horiguchi, Y. Gotoh, Yoshikazu Niwa, Kumiko Yamatsuta, S. Morikawa, Y. Sakakibara, Takuya Okamura, S. Uozu, Yasuhiro Goto, S. Isogai, S. Fujita, J. Fukumoto, Nami Hosoda, K. Imaizumi","doi":"10.20407/fmj.2020-014","DOIUrl":"https://doi.org/10.20407/fmj.2020-014","url":null,"abstract":"Objective: The prevalence of obstructive sleep apnea (OSA) in Japan is 9% among males and 3% among females. Up to 2.5 million patients are estimated to suffer from the disease, but limited number of facilities are capable of carrying out polysomnography (PSG), leaving more than 80% of these individuals are undiagnosed. In recent years, the development of new portable sleep monitoring (PMs) devices has been remarkable. We evaluate the correlation between the results of the LS-140 PMs device (Fukuda Denshi Tech Co. Ltd.), released in 2017, and those of PSG. Methods: We obtained contemporaneous data from the same patients by equipping 58 patients with PMs (LS-140) devices while they underwent PSG. Our primary outcome was Case 2 of the intraclass correlation coefficient (ICC), i.e., the ICC (2.1). And we used a Bland-Altman analysis to compare the apnea-hypopnea index (AHI) given by PSG and the respiratory event index (REI) given by LS-140 and examined the sensitivity and specificity of the REI relative to the AHI in the diagnosis of OSA. We also carried out the same comparison but in terms of the presence or absence of periodic limb movements (PLMs). Results: The ICC (2.1) between The REI and the AHI was 0.944, a rather high value (p<0.0001). The mean difference between AHI and REI values was –3.6 (p<0.0001), indicating a negative fixed bias. Sensitivity may decrease in groups with PLMs. Conclusion: The REI and the AHI are highly correlated, giving LS-140 sufficient diagnostic sensitivity and specificity to screen for OSA.","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"8 1","pages":"17 - 24"},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42863511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}