Clocks & Sleep最新文献

{"title":"Recovery Sleep Immediately after Prolonged Sleep Deprivation Stimulates the Transcription of Integrated Stress Response-Related Genes in the Liver of Male Rats.","authors":"Keisuke Fukuoka,&nbsp;Yusuke Murata,&nbsp;Tomomi Otomaru,&nbsp;Masayoshi Mori,&nbsp;Kenji Ohe,&nbsp;Kazunori Mine,&nbsp;Munechika Enjoji","doi":"10.3390/clockssleep4040048","DOIUrl":"https://doi.org/10.3390/clockssleep4040048","url":null,"abstract":"<p><p>Sleep loss induces performance impairment and fatigue. The reactivation of human herpesvirus-6, which is related to the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), is one candidate for use as an objective biomarker of fatigue. Phosphorylated eIF2α is a key regulator in integrated stress response (ISR), an intracellular stress response system. However, the relation between sleep/sleep loss and ISR is unclear. The purpose of the current study was to evaluate the effect of prolonged sleep deprivation and recovery sleep on ISR-related gene expression in rat liver. Eight-week-old male Sprague-Dawley rats were subjected to a 96-hour sleep deprivation using a flowerpot technique. The rats were sacrificed, and the liver was collected immediately or 6 or 72 h after the end of the sleep deprivation. RT-qPCR was used to analyze the expression levels of ISR-related gene transcripts in the rat liver. The transcript levels of the <i>Atf3</i>, <i>Ddit3</i>, <i>Hmox-1</i>, and <i>Ppp15a1r</i> genes were markedly increased early in the recovery sleep period after the termination of sleep deprivation. These results indicate that both activation and inactivation of ISRs in the rat liver occur simultaneously in the early phase of recovery sleep.</p>","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"4 4","pages":"623-632"},"PeriodicalIF":3.1,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10322666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Evening Light Exposures with Different Solid Angles on Circadian Melatonin Rhythms, Alertness, and Visual Comfort in an Automotive Setting.","authors":"Michael Weng,&nbsp;Isabel Schöllhorn,&nbsp;Maryia Kazhura,&nbsp;Brian B Cardini,&nbsp;Oliver Stefani","doi":"10.3390/clockssleep4040047","DOIUrl":"https://doi.org/10.3390/clockssleep4040047","url":null,"abstract":"<p><p>Future automotive interior lighting might have the potential to go beyond decorative purposes by influencing alertness, circadian physiology, and sleep. As the available space in the interior of an automobile for lighting applications is limited, understanding the impact of various luminous surface sizes on non-image-forming effects is fundamental in this field. In a laboratory study using a within-subject design, 18 participants were exposed to two bright light conditions with different solid angles and one dim light condition in a balanced, randomized order during the course of the evening. Our results demonstrate that both light conditions significantly increased subjective alertness and reduced salivary melatonin concentration but not cognitive performance compared to dim light. The solid angle of light exposure at constant corneal illuminance only affected visual comfort. While subjective alertness can be increased and melatonin can be attenuated with rather small luminaires, larger solid angles should be considered if visual comfort is a priority.</p>","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"4 4","pages":"607-622"},"PeriodicalIF":3.1,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10322663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations among Alcohol Drinking, Smoking, and Nonrestorative Sleep: A Population-Based Study in Japan.","authors":"Yuichiro Otsuka,&nbsp;Ohki Takeshima,&nbsp;Osamu Itani,&nbsp;Yuuki Matsumoto,&nbsp;Yoshitaka Kaneita","doi":"10.3390/clockssleep4040046","DOIUrl":"https://doi.org/10.3390/clockssleep4040046","url":null,"abstract":"<p><p>Nonrestorative sleep (NRS) is a common sleep disorder. It is associated with several unhealthy lifestyle factors, such as skipping breakfast and lack of exercise. However, the associations between alcohol drinking, smoking, and NRS are unclear. This study examined the prevalence of NRS within the Japanese general population and the relationships among alcohol drinking, smoking, and NRS. We analyzed an anonymized dataset from a 2013 nationwide population survey (35,717 men and 39,911 women). NRS was assessed through a single-item question, and socio-demographic and lifestyle factors were assessed through self-reports. Multivariable logistic regression analyses were used to examine the associations between alcohol drinking, smoking, and NRS. The total prevalence of NRS was 22.2% (95% CI 21.8-22.7) in men and 23.4% (95% CI 23.0-23.8) in women. Further, we found that sleep duration and prevalence of NRS shared an inverse J-shaped relationship. Heavy alcohol drinking was significantly associated with NRS in both sexes. Short sleep duration and certain socioeconomic factors modified the effect of smoking on NRS in men. These results could be useful in the development of more effective sleep health policies to establish better sleep hygiene.</p>","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"4 4","pages":"595-606"},"PeriodicalIF":3.1,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10322664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NREM Sleep Parasomnias Commencing in Childhood: Trauma and Atopy as Perpetuating Factors.","authors":"Cara Walsh, Lee Mitchell, Maria Hrozanova, Serafeim-Chrysovalantis Kotoulas, Christopher Derry, Ian Morrison, Renata L Riha","doi":"10.3390/clockssleep4040043","DOIUrl":"10.3390/clockssleep4040043","url":null,"abstract":"<p><p>Objective/Background: Phenotyping of non-rapid-eye-movement (NREM) parasomnias is currently poorly undertaken. This study aimed to determine whether there are differences phenotypically among childhood-, adolescent-, and adult-onset NREM parasomnias continuing into and presenting in adulthood. Patients/Methods: A retrospective, cohort study of patients presenting with NREM parasomnia between 2008 and 2019 (n = 307) was conducted. Disorders included sleepwalking (n = 231), night terrors (n = 150), sexualised behaviour in sleep (n = 50), and sleep-related eating disorder (n = 28). Results: Compared to the adult-onset NREM behaviours group, the childhood- and adolescent-onset groups were more likely to have a family history of NREM behaviours (p < 0.001), experience a greater spectrum of NREM disorders (p = 0.001), and report a history of sleep-talking significantly more frequently (p = 0.014). Atopy was most prevalent in the childhood-onset group (p = 0.001). Those with childhood-onset NREM parasomnias were significantly more likely to arouse from N3 sleep on video polysomnography (p = 0.0003). Psychiatric disorders were more likely to be comorbid in the adult-onset group (p = 0.012). A history of trauma coinciding with onset of NREM behaviours was significantly more common in the childhood- and adolescent-onset groups (p < 0.001). Conclusions: Significant differences exist across childhood-, adolescent-, and adult-onset NREM parasomnia presenting in adulthood. This study suggests that adult-onset slow-wave sleep disorders may be confounded by psychiatric disorders resulting in nocturnal sleep disruption and that unresolved traumatic life experiences perpetuate NREM disorders arising in childhood and comprise one of the strongest external risk factors for triggering and perpetuating these disorders in adolescence.</p>","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"4 4","pages":"549-560"},"PeriodicalIF":2.1,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9624320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10875194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Habits in Pairs of Japanese High School Students and Their Mothers in Summer and Autumn.","authors":"Koh Mizuno,&nbsp;Kazue Okamoto-Mizuno,&nbsp;Akiko Maeda","doi":"10.3390/clockssleep4040041","DOIUrl":"https://doi.org/10.3390/clockssleep4040041","url":null,"abstract":"<p><p>This study aimed to examine the sleep habits in pairs of Japanese high school students and their mothers in the summer and autumn. Nineteen pairs of high school students and their mothers participated in this study. Wrist actigraphy, subjective sleep evaluations, and bedroom environmental measurements (temperature, humidity, and light) were performed for a duration of one week. The results of a split-plot analysis of variance revealed no significant difference in the actigraphically evaluated time spent in bed (TIB) between the seasons and between the mothers and students. The TIB was approximately 6 h on weekdays, and significantly lengthened to approximately 7 h on weekends (p < 0.05). The average sleep efficiency values recorded were higher than 90%. The mothers showed significantly advanced sleep phases compared to those of the students (p < 0.05). In addition, the waking time on Monday morning was significantly correlated between the mothers and students in the summer and autumn (p < 0.05). A perceived sleep loss “almost every day” or “several times per week” was reported by approximately half of the mothers and students in each season. The students occasionally fell into nocturnal sleep with the room light turned on. These results suggest that sleep hygiene education considering life habit characteristics is required to ensure sufficient sleep time.</p>","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"4 4","pages":"520-534"},"PeriodicalIF":3.1,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10875193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Missing Data and Imputation Methods on the Analysis of 24-Hour Activity Patterns.","authors":"Lara Weed,&nbsp;Renske Lok,&nbsp;Dwijen Chawra,&nbsp;Jamie Zeitzer","doi":"10.3390/clockssleep4040039","DOIUrl":"https://doi.org/10.3390/clockssleep4040039","url":null,"abstract":"<p><p>The purpose of this study is to characterize the impact of the timing and duration of missing actigraphy data on interdaily stability (IS) and intradaily variability (IV) calculation. The performance of three missing data imputation methods (linear interpolation, mean time of day (ToD), and median ToD imputation) for estimating IV and IS was also tested. Week-long actigraphy records with no non-wear or missing timeseries data were masked with zeros or 'Not a Number' (NaN) across a range of timings and durations for single and multiple missing data bouts. IV and IS were calculated for true, masked, and imputed (i.e., linear interpolation, mean ToD and, median ToD imputation) timeseries data and used to generate Bland-Alman plots for each condition. Heatmaps were used to analyze the impact of timings and durations of and between bouts. Simulated missing data produced deviations in IV and IS for longer durations, midday crossings, and during similar timing on consecutive days. Median ToD imputation produced the least deviation among the imputation methods. Median ToD imputation is recommended to recapitulate IV and IS under missing data conditions for less than 24 h.</p>","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"4 4","pages":"497-507"},"PeriodicalIF":3.1,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10853263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of One Night of Forced Wakefulness on Morning Resting Blood Pressure in Humans: The Role of Biological Sex and Weight Status.","authors":"Lieve T van Egmond,&nbsp;Pei Xue,&nbsp;Elisa M S Meth,&nbsp;Maria Ilemosoglou,&nbsp;Joachim Engström,&nbsp;Christian Benedict","doi":"10.3390/clockssleep4030036","DOIUrl":"https://doi.org/10.3390/clockssleep4030036","url":null,"abstract":"<p><p>Permanent night shift work is associated with adverse health effects, including elevated blood pressure (BP) and hypertension. Here, we examined the BP response to one night of forced wakefulness in a sitting position in a cohort without night shift work experience. According to a counterbalanced crossover design, 47 young adults with either obesity (N = 22; 10 women) or normal weight (N = 25; 11 women) participated in one night of sleep and one night of forced wakefulness under in-laboratory conditions. Resting ankle and brachial arterial BP were assessed in the morning, i.e., the time of the day when adverse cardiovascular events peak. After forced wakefulness, diastolic and mean arterial BP were ~4 mmHg higher at the ankle site and ~3 mmHg higher at the brachial site than after regular sleep (p < 0.05). The increase in BP following overnight forced wakefulness was more pronounced among men vs. women and more significant for diastolic BP at both sites among participants with normal weight vs. those with obesity. If confirmed in larger cohorts, including 24 h BP monitoring, people with occupations involving night shifts might benefit from regular BP monitoring. Particular attention should be paid to possible sex- and weight-specific effects of night shift work on BP.</p>","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"4 3","pages":"458-465"},"PeriodicalIF":3.1,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9124895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Light Therapy on Electroencephalographic Sleep in Sleep and Circadian Rhythm Disorders: A Scoping Review.","authors":"Teha B Pun,&nbsp;Craig L Phillips,&nbsp;Nathaniel S Marshall,&nbsp;Maria Comas,&nbsp;Camilla M Hoyos,&nbsp;Angela L D'Rozario,&nbsp;Delwyn J Bartlett,&nbsp;Wendy Davis,&nbsp;Wenye Hu,&nbsp;Sharon L Naismith,&nbsp;Sean Cain,&nbsp;Svetlana Postnova,&nbsp;Ron R Grunstein,&nbsp;Christopher J Gordon","doi":"10.3390/clockssleep4030030","DOIUrl":"https://doi.org/10.3390/clockssleep4030030","url":null,"abstract":"<p><p>Light therapy is used to treat sleep and circadian rhythm disorders, yet there are limited studies on whether light therapy impacts electroencephalographic (EEG) activity during sleep. Therefore, we aimed to provide an overview of research studies that examined the effects of light therapy on sleep macro- and micro-architecture in populations with sleep and circadian rhythm disorders. We searched for randomized controlled trials that used light therapy and included EEG sleep measures using MEDLINE, PubMed, CINAHL, PsycINFO and Cochrane Central Register of Controlled Trials databases. Five articles met the inclusion criteria of patients with either insomnia or delayed sleep−wake phase disorder (DSWPD). These trials reported sleep macro-architecture outcomes using EEG or polysomnography. Three insomnia trials showed no effect of the timing or intensity of light therapy on total sleep time, wake after sleep onset, sleep efficiency and sleep stage duration compared to controls. Only one insomnia trial reported significantly higher sleep efficiency after evening light therapy (>4000 lx between 21:00−23:00 h) compared with afternoon light therapy (>4000 lx between 15:00−17:00 h). In the only DSWPD trial, six multiple sleep latency tests were conducted across the day (09:00 and 19:00 h) and bright light (2500 lx) significantly lengthened sleep latency in the morning (09:00 and 11:00 h) compared to control light (300 lx). None of the five trials reported any sleep micro-architecture measures. Overall, there was limited research about the effect of light therapy on EEG sleep measures, and studies were confined to patients with insomnia and DSWPD only. More research is needed to better understand whether lighting interventions in clinical populations affect sleep macro- and micro-architecture and objective sleep timing and quality.</p>","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"4 3","pages":"358-373"},"PeriodicalIF":3.1,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10872887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noradrenergic Signaling in Astrocytes Influences Mammalian Sleep Homeostasis.","authors":"Ashley M Ingiosi, Marcos G Frank","doi":"10.3390/clockssleep4030028","DOIUrl":"10.3390/clockssleep4030028","url":null,"abstract":"<p><p>Astrocytes influence sleep expression and regulation, but the cellular signaling pathways involved in these processes are poorly defined. We proposed that astrocytes detect and integrate a neuronal signal that accumulates during wakefulness, thereby leading to increased sleep drive. Noradrenaline (NA) satisfies several criteria for a waking signal integrated by astrocytes. We therefore investigated the role of NA signaling in astrocytes in mammalian sleep. We conditionally knocked out (cKO) β2-adrenergic receptors (β2-AR) selectively in astrocytes in mice and recorded electroencephalographic and electromyographic activity under baseline conditions and in response to sleep deprivation (SDep). cKO of astroglial β2-ARs increased active phase siesta duration under baseline conditions and reduced homeostatic compensatory changes in sleep consolidation and non-rapid eye movement slow-wave activity (SWA) after SDep. Overall, astroglial NA β2-ARs influence mammalian sleep homeostasis in a manner consistent with our proposed model of neuronal-astroglial interactions.</p>","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"4 3","pages":"332-345"},"PeriodicalIF":3.1,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10636054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Position and Excessive Daytime Sleepiness: A Systematic Review of Social Epidemiological Studies","authors":"Imene Bendaoud, F. Etindele Sosso","doi":"10.3390/clockssleep4020022","DOIUrl":"https://doi.org/10.3390/clockssleep4020022","url":null,"abstract":"The objectives of this empirical study are to describe and discuss the current literature available on the relationship between excessive daytime sleepiness (EDS) and the socioeconomic position (SEP) as well as to provide recommendations for consideration of SEP in sleep medicine and biomedical research. Databases Medline/PubMed, Web of Science, Google scholar and Scopus were screened from January 1990 to December 2020 using PRISMA guidelines and 20 articles were included in the final synthesis. Nineteen studies were cross-sectional and one study was longitudinal. Among these studies, 25.00% (n = 5) are focused on children and adolescent and the remaining 75.00% (n = 15) focused on adults and seniors. Ages ranged from 8 to 18 years old for children/adolescent and ranged from 18 to 102 years old for adults. Main SEP measures presented in these studies were education, income, perceived socioeconomic status and employment. The sample size in these studies varied from N = 90 participants to N = 33,865 participants. Overall, a lower educational level, a lower income and full-time employment were associated with EDS. Symptoms of EDS are prevalent in women, especially those with a low income or no job; and children and adolescents with difficult living conditions or working part time reported more sleep disturbances. SEP is already considered as an important determinant for many health outcomes, but if SEP is embedded in the experimental design in psychosomatic research, biomedical research and clinical practice as a constant variable regardless of outcome; it will move forward future investigations.","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":"4 1","pages":"240 - 259"},"PeriodicalIF":3.1,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49010875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}