Zuzana Mlyncekova, Peter Hutka, Zuzana Visnovcova, Nikola Ferencova, Veronika Kovacova, Andrea Macejova, Ingrid Tonhajzerova, Igor Ondrejka
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引用次数: 0
摘要
抑郁症和失眠之间的关系是双向的,这两种情况都需要得到充分的治疗,特别是在青春期脆弱的神经发育阶段。本研究旨在利用视频多导睡眠图(v-PSG)评价沃替西汀(VOR)抗抑郁药物治疗对抑郁症青少年睡眠结构的影响。对30例接受VOR治疗的青少年住院患者(平均年龄15.0岁±1.5 SD,女孩21例)(剂量为10/15/20 mg/天),在VOR治疗前后每天口服1次,进行v-PSG检测。评价参数为常规睡眠参数、睡眠碎片化参数和选定的光谱功率指标。采用有效可靠的问卷(儿童抑郁量表和雅典失眠症量表)评估治疗前后的抑郁和失眠症状。抑郁症青少年治疗后快速眼动潜伏期高于治疗前,快速眼动睡眠率下降(p = 0.005, p = 0.009)。我们的研究显示快速眼动抑制(增加快速眼动潜伏期和减少快速眼动睡眠百分比),表明睡眠结构的改变是VOR治疗的潜在结果,这似乎是剂量依赖性的。
Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder
The relationship between depression and insomnia is bidirectional and both conditions need to be treated adequately, especially in a vulnerable neurodevelopmental stage of adolescence. This study aimed to evaluate the effects of antidepressant treatment using vortioxetine (VOR) on the sleep architecture of depressed adolescents by using video-polysomnography (v-PSG), which has not been researched before. The v-PSG was performed on 30 adolescent in-patients (mean age of 15.0 years ± 1.5 SD, 21 girls) treated with VOR (dosage of 10/15/20 mg/day) administered orally once a day, before and after VOR treatment. The evaluated parameters were conventional sleep parameters, sleep fragmentation parameters, and selected spectral power indices. Symptoms of depression and insomnia before and after the treatment period were evaluated using valid and reliable questionnaires (the Children´s Depression Inventory and the Athens Insomnia Scale). Depressed adolescents showed higher REM latency and decreased REM sleep percentage after treatment than before the treatment period (p = 0.005, p = 0.009, respectively). Our study revealed REM suppression (increased REM latency and reduced REM sleep percentage), indicating altered sleep architecture as a potential result of VOR treatment, which seems to be dose-dependent.