休息-活动节律和肝功能测试之间的关系:美国国家健康和营养检查调查,2011-2014

IF 2.1 Q3 CLINICAL NEUROLOGY
Chris Ho Ching Yeung, Cici Bauer, Qian Xiao
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引用次数: 0

摘要

肝功能受昼夜节律调节;然而,昼夜节律减弱是否与肝功能受损有关尚不清楚。本研究旨在探讨休息-活动节律特征与肝功能生物标志物异常水平的关系。数据来源于2011-2014年全国健康与营养检查调查。采用扩展余弦模型和非参数方法,从24 h活动记录仪数据中得到7个休息-活动节律参数。采用多元logistic回归和多元线性回归模型评估静息-活动节律参数与丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、γ -谷氨酰转氨酶(GGT)、白蛋白和胆红素的关系。以较低F统计值为特征的整体节律性减弱与ALP (ORQ1vs)异常升高的几率较高相关。Q5: 2.16;95% CI 1.19, 3.90)和GGT (ORQ1vs。Q5: 2.04;95% CI 1.30, 3.20)和异常降低的白蛋白(ORQ1vs)。Q5: 5.15;95% ci 2.14, 12.38)。在较低的振幅、振幅:中介率、日间稳定性和日内变异性方面也发现了类似的结果。结果对混杂因素的调整是稳健的,不能完全用个人的休息-活动行为来解释,包括睡眠和身体活动。通过多种生物标志物测量,休息-活动节律减弱与肝功能恶化相关,支持昼夜节律在肝脏健康中的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between Rest–Activity Rhythms and Liver Function Tests: The US National Health and Nutrition Examination Survey, 2011–2014
Liver functions are regulated by the circadian rhythm; however, whether a weakened circadian rhythm is associated with impaired liver function is unclear. This study aims to investigate the association of characteristics of rest–activity rhythms with abnormal levels of biomarkers of liver function. Data were obtained from the National Health and Nutrition Examination Survey 2011–2014. Seven rest–activity rhythm parameters were derived from 24 h actigraphy data using the extended cosine model and non-parametric methods. Multiple logistic regression and multiple linear regression models were used to assess the associations between rest–activity rhythm parameters and alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transaminase (GGT), albumin and bilirubin. Weakened overall rhythmicity characterized by a lower F statistic was associated with higher odds of abnormally elevated ALP (ORQ1vs.Q5: 2.16; 95% CI 1.19, 3.90) and GGT (ORQ1vs.Q5: 2.04; 95% CI 1.30, 3.20) and abnormally lowered albumin (ORQ1vs.Q5: 5.15; 95% CI 2.14, 12.38). Similar results were found for a lower amplitude, amplitude:mesor ratio, interdaily stability and intradaily variability. Results were robust to the adjustment of confounders and cannot be fully explained by individual rest–activity behaviors, including sleep and physical activity. Weakened rest–activity rhythms were associated with worse liver function as measured by multiple biomarkers, supporting a potential role of circadian rhythms in liver health.
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来源期刊
Clocks & Sleep
Clocks & Sleep Multiple-
CiteScore
4.40
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7 weeks
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