Folia Medica Indonesiana最新文献

{"title":"Characteristics of Aphasia in Ischemic Stroke Patients at Dr. Mahar Mardjono National Brain Center Hospital Indonesia in 2021","authors":"Rasya Hapsari Danardhono, Arman Yurisaldi Saleh, Ria Maria Theresa, Riezky Valentina Astari","doi":"10.20473/fmi.v59i4.42746","DOIUrl":"https://doi.org/10.20473/fmi.v59i4.42746","url":null,"abstract":"Highlights:\u00001. To author’s knowledge, this study is the first study done in National Brain Center Hospital In Jakarta2. No similar studies have been done during the pandemic era3. This study can add additional data to further studies about aphasia in comparison with post pandemic era\u0000 \u0000Abstract\u0000Global aphasia, sensory transcortical aphasia, motor transcortical aphasia, motor aphasia, sensory aphasia, conduction aphasia and anomic aphasia can occur in ischemic stroke. There are different locations of lesions in each type of aphasia. There has been an increase in incidence and mortality of stroke patients during the COVID-19 pandemic. Before the pandemic, global aphasia was the most common type of aphasia. This study was conducted to determine the type of aphasia, clinical and radiological features, and also management of aphasia in ischemic stroke during the pandemic. This research is a descriptive study with a cross sectional approach. Sampling was done by total sampling technique. The research sample was ischemic stroke subjects with aphasia diagnosed from January 1, 2021 - December 31, 2021 at the National Brain Center Hospital Prof. Dr. dr. Mahar Mardjono Jakarta. Statistical analysis was done using IBM SPSS Statistics for Mac, Version 25.0 (IBM Corp., Armonk, N.Y., USA). There were 162 aphasic subjects with ischemic stroke. Age range was 34 – 87 years. Most subjects were male (59.9%), aged 55-65 years (37.0%). Hypertension (90.1%), diabetes mellitus (50.0%), and dyslipidemia (75.9%) were the dominant risk factors. The most common type of aphasia is global aphasia (43.8%) and motoric aphasia. (33,3%). The parietal lobe was the dominant location of global aphasia (38 subjects) and motoric aphasia (47 subjects). The therapy given to aphasic subjects with a history of ischemic stroke includes speech therapy (85.2%), antiplatelet therapy (98.1%), anticoagulants (19.1%), rTPA (1.2%), and neuroprotectors (3.0 %). In conclusion, in ischemic stroke subjects with aphasia at the National Brain Center Hospital during the pandemic, global aphasia was found to be the most common with the dominant global aphasia lesion location in the parietal lobe.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ascorbate and Alpha-Tocopherol Mitigate Toxic Pathological Changes in Adult Wistar Rats Exposed to Cypermethrin","authors":"Temidayo Daniel Adeniyi, Akinpelu Moronkeji, Osetohanmen Flourish Ralph-Okhiria","doi":"10.20473/fmi.v59i4.49611","DOIUrl":"https://doi.org/10.20473/fmi.v59i4.49611","url":null,"abstract":"Excessive and uncontrolled use of pyrethroids such as cypermethrin (CYP) for pest control in Nigeria can adversely affect humans. This study investigated the oxidative stress response to cypermethrin exposure as well as the therapeutic effect of ascorbate and alpha-tocopherol when administered singly or co-administered. Additionally, the lungs and heart of the exposed animals were histologically assessed for cypermethrin-induced cytopathic changes. Twenty-five adult male Wistar rats weighing between 180 – 200g were randomly assigned to five groups of five animals each. Group I was the unexposed control group, while Group II was the exposed untreated group that was orally administered Cypermethrin at a dose of 10mg/kg/bw. Group III – V was given cypermethrin at standard doses of 10mg/kg/bw, and orally administered with ascorbate (5000mg/kg/bw), alpha-tocopherol (3000mg/kg/bw) and co-administration of ascorbate and alpha-tocopherol (5000mg/kg/bw and 3000mg/kg/bw) respectively. Animals were euthanized after 28 days, and samples were processed for histological and biochemical studies. The results showed elevated malondialdehyde (MDA) levels with a concurrent marked decrease in superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities (p<0.05) in the cypermethrin-exposed untreated rats, while histopathological findings revealed inflammation and congestion in the organs studied. The co-administrative treatment with ascorbate and alpha-tocopherol better restores biochemical parameters than their single administration. Conclusively, co-administration of ascorbic acid and alpha-tocopherol ameliorates cypermethrin-induced oxidative damage better than single administration, which may be due to their synergistic antioxidant properties.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":"57 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of SYNTAX Score with Longterm Outcomes of Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention for Left Main Coronary Artery Disease: A Systematic Review","authors":"Faiq Murteza, Chabib Fachry Albab, Almas Talida Habibah, Achmad Fayyad Mas’udi, Vemaniarti Lian Pravitasari, Arya Satya Rajanagara, Zaha El-Ma’i","doi":"10.20473/fmi.v59i4.46514","DOIUrl":"https://doi.org/10.20473/fmi.v59i4.46514","url":null,"abstract":"The SYNTAX  score was designed to predict the postprocedural risk associated with PCI or surgical revascularization. This study aims to evaluate long term (>5 years) outcome of PCI with CABG by comparing several existing studies. A systematic search was conducted through PubMed/MEDLINE and ScienceDirect databases. This systematic review used all studies in the field of differences in outcome of PCI and CABG intervention in left main coronary artery stenosis. This study used cross sectional study design with a systematic review method based on several cohort studies. The search was conducted until February 10th, 2023. Assessment of the study quality was carried out using the criteria of the Newcastle-Ottawa Scale (NOS). Based on the final assessment, all included studies had a mean NOS score of 8 which could be interpreted as excellent quality. Our search yielded 1675 studies of which we included 5 studies for the final analysis. A total of 5.494 patients were treated with PCI and CABG. In this study, there were differences outcome in low, medium and high syntax scores on long term major adverse cardiac or cerebrovascular events (MACCE) and long term mortality. However, the similar outcome was obtained in long term revascularization, long term stroke and long term Miokard Infark (MI). Left main coronary artery (LMCA) stenosis patients with low to high SS may result various long-term outcomes. CABG is associated with lower incidence of mortality, repeat revascularization, myocardial infarction, and MACCE than PCI. Meanwhile, PCI gives lower incidence of stroke.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":"1123 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocyte Cell Expressions and SARS-COV-2 Antibody Titers in Healthy Donors’ Blood at an Indonesian Blood Transfusion Center (UTD PMI Surabaya)","authors":"Adelia Gita Prasasti, Evy Diah Woelansari, Anita Dwi Suhariyadi, Anggraini","doi":"10.20473/fmi.v59i4.38954","DOIUrl":"https://doi.org/10.20473/fmi.v59i4.38954","url":null,"abstract":"Highlights:\u00001. There was no relationship between total lymphocyte count and antibody titers against SARS-CoV-2.2. This original research report offers information on the several blood test result after getting COVID-19vaccines and provides data that the public may use as scientific evidence to the further research.\u0000 \u0000Abstract\u0000 SARS-CoV-2 is a virus that infects the respiratory tract and attacks the respiratory mucosa and epithelial cells.Lymphocytes are a subset of agranulocyte leukocytes that have a role in the immune response to pathogenicmicroorganisms' attacks. The number of lymphocytes will increase if a virus causes an infection. An antibody is aprotective protein produced by the body's immune system in response to the presence of an antigen. Antibodies bind and inactivate foreign substances so that the replication of pathogens can be prevented and destroyed. This mechanism can be expressed through the total number of lymphocyte cells. The objective of this study was to define the relationship between the number of lymphocytes and antibody titers against SARS-CoV-2. The type of research used was analytic observational with a cross-sectional approach using quantitative analysis methods and a purposive sampling method for sampling. The samples used were 30 donor blood samples from UTD PMI Surabaya. This research was conducted in May 2022 at the Hematology Laboratory, Department of Medical Laboratory Technology, Poltekkes, Ministry of Health, Surabaya, to examine the number of lymphocyte cells using the flowcytometry method and the Immunoserology Laboratory of the Surabaya Health Laboratory Center for antibody titer examination using the ELISA (Enzyme-Linked Immuno Sorbent Assay) method. The study showed an average lymphocyte level of 2.2633 x 103/µl and an average antibody titer value expressed in OD of 0.2197. Data analysis using Spearman's rank correlation statistical test revealed p = 0.262 0.005. It showed no relationship between total lymphocyte count and antibody titers against SARS-CoV-2","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138981996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the Development of Language and Social Independence in Children with Speech Delay and Sensorineural Hearing Loss based on Age of Early Intervention and Duration of Auditory Verbal Therapy","authors":"Zamrotu Iva Purwanti, Achmad Chusnu Romdhoni, Ahmad Suryawan, Nyilo Purnami, Ninuk Dwi Ariningtyas","doi":"10.20473/fmi.v59i4.51495","DOIUrl":"https://doi.org/10.20473/fmi.v59i4.51495","url":null,"abstract":"Highlights :1. This original research report provides information to the public about the importance of early detection, the use of hearing technology and the advantages of Auditory Verbal Therapy in delayed speech children with sensorineural hearing loss, where this therapy makes it easier for children to achieve language development on par with other children their age.2. Auditory Verbal Therapy as part of the process of learning to speak and hear deaf children is still quite new and unfamiliar among the community, so based on this study it can be seen that AVT has a positive impact on child development.\u0000AbstractSpeech delay with sensorineural hearing loss is a delay in a child's speech process compared to normal children of the same age, mostly caused by hearing loss. It can give may affect the development of language and social independence of children. Auditory Verbal Therapy (AVT) as early intervention maximizes the use of residual hearing with hearing aids or a cochlear implant for sound detection. Therapy that is routinely and periodically conducted may affect language development to support children's independence. This study aims to analyze differences in the development of language and social independence of children with delayed speech and sensorineural hearing loss based on the age of early intervention and duration of auditory verbal therapy. This study used an analytical-observational study design with a cross-sectional approach. The samples were obtained by total sampling from all children who underwent routine AVT once a week at the Aurica Surabaya Foundation, with a total sample of 29 children. The instrument used Developmental Pre-Screening Questionnaire. Method of data analysis was bivariate analysis with the Chi-Square (p-value) proportions different test using SPSS . The results regarding language development based on the age of early intervention and the duration of AVT obtained p = value 0.013 (p < 0.05) and p = 0.019 (p < 0.05), while the results of the chi-square test analysis of the development of social independence based on the age of early intervention and duration of AVT obtained p value = 0.229 (p > 0.05) and p-value = 0.111 (p > 0.05). In conclusion, there was a difference between language development based on the age of early intervention and the duration of AVT, but no difference was found between the development of social independence based on the age of early intervention and the duration of AVT.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":"2 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Discharge Planning for Stroke Patients","authors":"Muhammad Imron Rosadi Mujib, Fitri Arofiati","doi":"10.20473/fmi.v59i4.42819","DOIUrl":"https://doi.org/10.20473/fmi.v59i4.42819","url":null,"abstract":"Highlights:\u00001. Given the frequent long-term complications of stroke, this study identified the ideal approach to discharge planning to improve the quality of life of patients and hospital care.2. This study provides evidence supporting the effectiveness of a conventional discharge planning approach that incorporates specific educational intervention with interactive learning through audiovisual media.3. The approaches presented in this study may offer valuable perspectives on enhancing health service provisions, particularly regarding the discharge planning process for nurses.\u0000 \u0000Abstract\u0000The quality improvement of discharge planning is essential throughout the development of discharge planning, which guarantees a seamless transition of care for stroke patients and family preparedness. This systematic review aimed to analyze the development of discharge planning and its impact on stroke patients and their families. The research was conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible pieces of literature were compiled from seven electronic databases, i.e., ScienceDirect, Scopus, PubMed, EBSCOhost, ProQuest, SAGE Journals, and Google Scholar. The literature search was performed using predetermined search terms, with specific criteria that included papers exclusively published in English and studies conducted in 2018–2022. The development of discharge planning showed a significant impact on stroke patients, as it could influence various aspects of their quality of life. This included improvements in physiological function, enhanced cognitive knowledge, increased satisfaction and self-efficacy, reduced stress levels and care burden, and the opportunity for families to adequately prepare for home-based patient care. This study concluded that integrating conventional with technology-based media is effective for developing discharge plans for stroke patients. The implementation of this novel approach in a health system can improve patient outcomes, family preparedness when providing care, and the quality of hospital care.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":"534 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Melanoma Antigen Genes A11 and A12 in Non-Small Cell Lung Cancer","authors":"Gondo Mastutik, Alphania Rahniayu, Isnin Anang Marhana, Mochamad Amin, Heru Fajar Trianto, Reny I’tishom","doi":"10.20473/fmi.v59i4.50477","DOIUrl":"https://doi.org/10.20473/fmi.v59i4.50477","url":null,"abstract":"Highlights:1. In this study, new primers designed using the semi-nested polymerase chain reaction (PCR) method were utilized to identify MAGE-A11 and MAGE-A12 expressions in specimens collected from core biopsy, forcep biopsy, and bronchoalveolar lavage.2. The histopathological analysis revealed positive expressions of MAGE-A11 and MAGE-A12 in specimens diagnosed with non-small cell lung cancer (NSCLC) as well as in specimens with no malignant cells.\u0000AbstractThe melanoma antigen gene (MAGE) belongs to the group of cancer testis antigens that are exclusively expressed in germ cells but may be re-expressed in cancer cells. The highly expressed MAGE-A subfamily in lung cancer may potentially be a diagnostic and prognostic biomarker. This study aimed to identify MAGE-A11 and MAGE-A12 expressions in lung tumors obtained from core biopsy, forceps biopsy, and bronchoalveolar lavage specimens. A cross-sectional observational study was conducted on 90 patients clinically diagnosed with lung tumors. These patients received core biopsy, forceps biopsy, and bronchoalveolar lavage interventions after ethical approval was obtained. The complementary deoxyribonucleic acid (cDNA) quality was assessed by the polymerase chain reaction (PCR) of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The assessment was performed to ascertain if all specimens exhibited positive PCR amplification of the GAPDH gene. MAGE-A11 and MAGE-A12 were identified through a semi-nested reverse transcription PCR. The positive results were detected by measuring the PCR products, with MAGE-A11 and MAGE-A12 measuring at base pairs (bp) of 858 and 496 in the first and second rounds, respectively. The expressions of MAGE-A11 and MAGE-A12 were observed in 3 (3.33%) and 40 (44.44%) out of 90 specimens, respectively. The prevalence rate of non-small cell lung cancer (NSCLC) was 31.11% (28/90). Among these cases, 3.57% (1/28) showed the expression of MAGE-A11, while 32.14% (9/28) exhibited the expression of MAGE-A12. Sixty-two (68.89%) out of 90 patients were diagnosed with no tumor cell malignancy. Out of 62 cases, 2 (3.23%) exhibited the expression of MAGE-A11, while 31 (50%) demonstrated the expression of MAGE-A12. MAGE-A11 and MAGE-A12 were detected in NSCLC and in certain specimens with a pathological diagnosis that indicated the absence of malignant cells. In conclusion, MAGE A11 and MAGE A12 have potential markers that can improve the pathological diagnosis of lung cancer. Further investigation is necessary to explore the expression of MAGE-A in correlation with lung cancer progression.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":"513 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Aging Properties of Temulawak Extract (Curcuma xanthorrhiza L.) by In Vitro Assay","authors":"Teresa Liliana Wargasetia, Wahyu Widowati, Anis Syabani Muthmainnah, Rizal","doi":"10.20473/fmi.v59i4.44944","DOIUrl":"https://doi.org/10.20473/fmi.v59i4.44944","url":null,"abstract":"Highlights:1. Elastase, hyaluronidase, and tyrosinase can all be inhibited by temulawak extract.2. Temulawak extract has strong anti-aging ability and can be used as a candidate for cosmetic applications.\u0000 \u0000AbstractThe process of aging is the gradual loss of a tissue's capacity to heal and maintain normal or physiological form and function. Elastase, hyaluronidase, and tyrosinase are the enzymes that contribute to skin aging. The anti-aging effect is connected to the inhibition of these enzymes' activity. Many medicinal plants with active metabolite have been utilized extensively to treat aging. Active compounds of temulawak (Curcuma xanthorrhiza L.) such as phenolic, curcuminoid and xanthorrhizol have potential as antiaging. This study aims to determine whether temulawak extract (TE), a potential candidate for cosmeceutical agent, has anti-aging characteristics by inhibiting the elastase, hyaluronidase, and tyrosinase enzymes. TE was processedxby PT FAST. Stock solution of TE was made by dissolving 20 mg of extract with 1 ml of DMSO 100%, the stock solution was then diluted to achieve the concentrations level 31.25 - 1000 μg/ml working solution of TE. The antiaging activity assays were carried out at PT Aretha Medika Utama. In vitro antiaging assay of TE includes elastase, hyaluronidase, and tyrosinase enzyme inhibition at 7 level of various concentrations of 2.08-66.67 μg/ml for anti-elastase assay, 5.21-166.67 μg/ml for anti-hyaluronidase assay, and 3.125-100 μg/ml for anti-tyrosinase assay with three replications. SPSS software was used to conduct the statistical analysis (p<0,05 is considered significant). TE exhibited highest inhibition percentage of 82.72%, 89.41%, and 94.17% for anti-tyrosinase, anti-elastase, and anti-hyaluronidase, respectively. The median inhibitory concentration (IC50) for elastase inhibitory activity was 10.66 μg/ml, hyaluronidase 70.39 μg/ml, and tyrosinase 55.87 μg/ml. According to this study, TE can be used as cosmeceu\u0000 ","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":"56 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Mid-Upper Arm Circumference as a Screening Tool to Predict Infant Birth Weight","authors":"Muhammad Rais Fathurrachman, Sri Umijati, Eighty Mardiyan Kurniawati, Bagus Setyoboedi","doi":"10.20473/fmi.v59i4.50422","DOIUrl":"https://doi.org/10.20473/fmi.v59i4.50422","url":null,"abstract":"\u0000\u0000\u0000Highlights:1. This study investigated previous research that stated there is no significant correlation between a maternal’s mid-upper arm circumference and an infant's birth weight.2. This study’s findings show that mid-upper arm circumference can be used as a screening tool to predict infant birth weight.\u0000AbstractMid-upper arm circumference (MUAC) was commonly used in assessing chronic energy deficiency in women of childbearing age. In pregnancy, the mother's MUAC was mainly used for early detection of the possibility of low birth weight babies. However, some studies showed that maternal MUAC did not have a significant correlation with birth weight. Therefore, this study aimed to determine the relationship between nutritional status of pregnant women and birth weight. This study was conducted using an analytical observation method with a cross-sectional approach with 86 samples of mothers who gave birth at Jagir Public Health Centre, Surabaya, Indonesia, from July 2019 to December 2019 who met the inclusion and exclusion criteria. Data were obtained through secondary data from the medical records of Jagir Public Health Centre. They were analysed by Spearman test with a 95% confidence interval and 5% margin of error. Mostly (86.05%) mothers had good nutritional status (MUAC  23.5 cm). Only a few (3.49%) babies were born with low birth weight (< 2,500g) and as many as 1.16% of babies were born with large birth weight (> 4,000g). Based on the research conducted, mothers with low MUAC did not give birth to babies with low birth weights and instead gave birth to babies with normal birth weights. The results of the analysis related to the relationship of MUAC of pregnant women at Jagir Health Centre in the period July 2019-December 2019 had a significant relation to the birth weight of the baby they gave birth to. MUAC described the condition of muscle tissue and fat under the skin of the mother's arm, which was the storage of the energy for the mother. However, other factors affected the birth weight of the baby, such as the nutrient intake of the mother.\u0000\u0000\u0000","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":"655 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138983025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Characterizations of Poly(Ethylene Glycol) Dimethacrylate)-Nanofibrillated Cellulose as an Injectable Biomaterial Substitute for Herniated Nucleus Pulposus","authors":"P. Widiyanti, Yurituna Firda, Aminatun, Herry Wibowo","doi":"10.20473/fmi.v59i4.50084","DOIUrl":"https://doi.org/10.20473/fmi.v59i4.50084","url":null,"abstract":"Highlights:\u0000\u0000Novel synthetic biopolymer hydrogels were successfully prepared using photopolymerization method based on pristine PEGDMA and pristine NFC.\u0000Biocomposite hydrogel based on pristine PEGDMA: pristine NFC can be developed as a substitute biomaterial for the nucleus pulposus in cases of herniated nucleus pulposus which can afford for clinical application standards\u0000\u0000 \u0000Abstract\u0000As many as 30-80% of cases low back pain (LBP) is frequently attributed to herniated nucleus pulposus (HNP) with 18-29% of instances reported in Indonesia. HNP can cause in motor weakness, sensory disturbances and decreased physiological reflexes. HNP occurs due to protrusion of the intervertebral disc through the annulus fibrosus which can be caused by the rupture of the annulus fibrosus or decreased proteoglycans (PGs). Hydrogel implant material is injected into the disc space, which can restore disc thickness caused by disc degeneration with minimal invasive. This study utilizes  poly(ethylene glycol) dimethacrylate (PEGDMA):nanofibrillated cellulose (NFC) used to treat first-degree HNP using photopolymerization method. PEGDMA is very hydrophilic and is able to produce hydrogel. The addition of NFC to the PEGDMA precursor that forms a hydrogel was able to show mechanical properties as a hydrogel biocomposite candidate. This research to characterize of PEGDMA:NFC for biomaterial substitute of HNP. Characterizations involves Fourier Transform Infrared (FTIR) test, viscosity assessment and in vitro injection model test.  PEGDMA:NFC concentrations explored include 1:0 (control), 1:0.5 (K1 sample), 1:0.75 (K2 sample) and 1:1 (K3 sample). FTIR test can indicating each functional group for hydrogel biomaterial of PEGDMA:NFC. Based on characterization results, the K3 sample has the best results with a concentration of 1:1. The viscosity value was 74,67 dPa.s and in vitro injection model test showed the addition of NFC indicates the hydrogel state when released from the mold will be not ruptured. Hydrogels can be injected with syringe 18 gauge. Consequently, the study concludes that the PEGDMA:NFC biocomposite hydrogel can be effectively applied in cases of  herniated nucleus pulposus.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":"126 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}