Folia Medica Indonesiana最新文献

{"title":"Excision of Recurrent Hemangioma in Hand with Reconstruction Using Abdominal Flap","authors":"Ivan Joalsen Mangara Tua, A. Ardan, H. D. Pagehgiri, Amy Rosalie Sukamto, M. Dwipayana","doi":"10.20473/fmi.v58i2.25869","DOIUrl":"https://doi.org/10.20473/fmi.v58i2.25869","url":null,"abstract":"Highlights:\u0000\u0000Hemangioma of the hand is a challenging case due to the need to maximize eradication of the mass while minimizing damage to the healthy tissue to preserve the physiologic function of the hand.\u0000The reconstruction of the defect also needs to be taken into account to maintain the cosmetical appearance.\u0000Collaborative multidisciplinary work is essential to achieve these demands and maintain the patient’s quality of life.\u0000\u0000 \u0000Abstract:\u0000Hemangiomas are known for their typical involution with age. However, around 40% of cases require intervention. Hemangioma in hand is challenging because the hand function and the aesthetic appearance need to be preserved. Hereby we reported a 21-year-old woman with a recurrent hemangioma on the left hand in Abdul Wahab Sjahranie Hospital, Samarinda, Indonesia. The patient’s previous surgery was ineffective since the mass reappeared in the same area. We performed surgical excision and reconstruction with an abdominal flap. One-month and one-year postoperative follow-up indicated good flap viability and preserved hand functions without the need for amputation. This report also emphasizes the importance of collaboration from multiple surgical and medical fields to allow favorable outcomes in this case.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46894565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A First Step to Novel Approach for Treating Alkali Injury of the Cornea: Effect of Platelet Rich Fibrin Lysates on Cultured Rabbit (Oryctolagus cuniculus) Limbal Stem Cell Proliferation Exposed by Sodium Hydroxide","authors":"Wahyu Endah Prabawati, Gatut Suhendro, E. Retnowati","doi":"10.20473/fmi.v58i2.36321","DOIUrl":"https://doi.org/10.20473/fmi.v58i2.36321","url":null,"abstract":"Highlights:\u0000\u0000Sodium hydroxide causing platelet rich fibrin stimulates limbal stem cell proliferation in chemical trauma.\u0000Limbal stem cell niche and influences limbal stemness was repaired by Platelet Rich Fibrin.\u0000\u0000 \u0000Abstract:\u0000Chemical injuries of the eye produce extensive damage to the ocular surface and limbal stem cells, resulting in permanent unilateral or bilateral visual impairment. Alkali injuries occur more frequently than acid injuries. Platelets are a rich source of potential wound healing, promoting polypeptide growth factors. This study aimed to investigate the effect of platelet-rich fibrin (PRF) lysates on limbal stem cell proliferation, which was exposed to sodium hydroxide that resembled limbal stem cell deficiency due to chemical trauma. Confluent rabbit (Oryctolagus cuniculus) limbal stem cells wounded using 20µL of 0.00625 M sodium hydroxide (pH 13) were treated with platelet-rich fibrin lysates (PRF) (0, 5, and 10%). PRF lysates were prepared from peripheral rabbit blood according to Choukroun's method without using anticoagulant and foreign factors for platelet activation. The proliferation of limbal stem cells was measured by a 3-(4,5-dimethylthiazol-2-yl)-2.50 diphenyl tetrazolium bromide (MTT) colorimetric assay at 24, 48, and 72 hours after exposure to sodium hydroxide. Proliferation significantly increased limbal stem cells with PRF lysates 5% (p<0.01) and 10% (p<0.01) group compared with the control (PRF 0%). There was no significant difference between PRF lysates of 5% and 10% (p>0.01). The highest proliferation of limbal stem cells was found in the PRF lysates 5% group after 48 hours (100.24%). PRF stimulated limbal stem cell proliferation in chemical trauma caused by the sodium hydroxide model. PRF repaired the limbal stem cell niche and influenced the limbal stemness. The present findings warrant further research on PRF as a novel alternative treatment for limbal stem cell deficiency.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44005913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Timeliness of Hepatitis B Birth Dose: A Cross-sectional Study in North-Western Nigeria","authors":"Olayinka Rasheed Ibrahim, R. Ibraheem, Rasaki Aliu, Ibrahim Magaji Lawal","doi":"10.20473/fmi.v58i2.31344","DOIUrl":"https://doi.org/10.20473/fmi.v58i2.31344","url":null,"abstract":"Highlights:\u0000\u0000\u0000Uptake of hepatitis B birth dose vaccine within 24 hours of birth is low in Katsina, north-western Nigeria.\u0000The most common reason for delay presentation for hepatitis B birth dose vaccine is maternal illness.\u0000\u0000\u0000 \u0000Abstract:\u0000No studies focused on the hepatitis B birth dose (HepB-BD) vaccine since Nigeria adopted the strategy to reduce hepatitis B viral infection. Hence, we determined the uptake of HepB-BD, factors associated with timeliness, and those that contributed to delay. This study was a cross-sectional descriptive study carried out at an immunization post in north-western Nigeria. We recruited 400 mother-infant pairs that presented for the first immunization and obtained relevant information, including socio-demographics and reasons for the delays. Of the 400 infants, 44 (11.0%) received HepB-BD within 24 hours (timeliness), 105 (26.3%) and 274 (68.5%) by day 7 and 14, respectively. Multivariate analysis showed that mothers' education (primary adjusted odds (AOR) 17, 95% CI 1.404, 204.611), secondary AOR 5.9, 95% CI 1.148, 29.895), and tertiary AOR 7.7, 95% CI 1.228, 48.545), and third born AOR 8.2, 1.625, 41.018) were associated with HepB-BD timeliness. Maternal-related factors were the commonest (129; 46.6%) for delayed HepB-BD, with maternal illness the most commonly cited reason (37; 28.7%). This study showed a deficient level of uptake of HepB-BD vaccines among infants. Factors that were associated with timeliness included maternal education and higher birth order. The commonest reason for delayed HepB-BD was maternal illness.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46038393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycemia Prevalence Among Artisans and Workers in Selected Factories In Lagos, Southwest, Nigeria","authors":"T. Yahaya, M. Sifau, E. Oladele, Danlami M Bashar, A. Abubakar, N. Salisu, B. Usman, Jamilu D Koko","doi":"10.20473/fmi.v58i2.33988","DOIUrl":"https://doi.org/10.20473/fmi.v58i2.33988","url":null,"abstract":"Highlights:\u0000\u0000Workplace pollutants predispose people to hyperglycemia through beta cell dysfunction and insulin resistance.\u0000The risk is increased by unhealthy lifestyles such as smoking and drinking.\u0000 Aging, due to mitochondrial function decline, also promotes hyperglycemia.\u0000\u0000 \u0000Abstract:\u0000The increased global prevalence of hyperglycemia is linked partly to increasing industrial emission exposure, necessitating risk evaluations of various categories of workers worldwide. This study measured the blood glucose levels of selected non-obese artisans and workers from three companies (Imperio International, Mouka Foam, and Continental Iron) in Lagos, Nigeria. The participants’ demographic data were collected using structured questionnaires, after which their blood glucose levels were measured using a glucometer. The results were compared with the World Health Organization (WHO) standards (88–126 mg/dL). On average, Imperio International participants were 32 years old, Mouka Foam and Continental Iron were 28 years old, and the artisans were 32 years old. Most of the participants were male secondary school graduates who worked an average of nine hours per day, six days a week. Artisans had the highest hyperglycemic population (46.15%), followed by Imperio International and Continental Iron (33% each), and Mouka Foam (29.41%). Smokers accounted for 10.53% of the hyperglycemic population, followed by alcoholics (36.84%), those who drank and smoked (42.11%), and those who did not drink or smoke (10.53%). Age class ≥41 accounted for 36.84% of the hyperglycemic population, class 31-40 (34.21%), and class 21-30 (28.95%). Participants with secondary school education constituted 63.16% of the hyperglycemic population, primary education (18.42%), individuals having no education (13.16%), and tertiary education (5.26%). The findings indicate that workplace pollutants predispose workers to hyperglycemia and that smoking and alcohol increase the risks. The findings necessitate exposure reduction and healthy lifestyles in the workplace.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47268919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Neuroendocrine Tumor Following Radical Nephrectomy","authors":"Muhammad Rozaqy Ishaq, N.A. Febriansyah, Soetojo Soetojo","doi":"10.20473/fmi.v58i2.33283","DOIUrl":"https://doi.org/10.20473/fmi.v58i2.33283","url":null,"abstract":"Highlights:\u0000\u0000Rare occurrence of a large, well-differentiated primary renal neuroendocrine tumor in a young man.\u0000Identifying primary renal NET from the workup and histological examination of renal tumors needs to be done to understand more of this infrequent type of tumor.\u0000\u0000 \u0000Abstract:\u0000Neuroendocrine Tumors (NETs) are a diverse range of neoplasms with various biological and histologic features and therapeutic responses. The prevalence of primary renal carcinoids is scarce worldwide. At the moment, complete surgical resection is the primary treatment against primary neuroendocrine tumors of the kidney. Nephrectomy followed by the lymph node dissection is a standard procedure for localized primary renal NETs. Since renal carcinoid tumor is extremely rare, we decided to present a unique case of a 25-years-old male with neuroendocrine renal carcinoid tumor following radical nephrectomy. The results indicated a solid, solitary tumor verified on the frozen section because a postoperative CT–scan showed a recurring mass in the renal fossa following radical nephrectomy. The case emphasized the need to investigate primary renal NET in the workup and histological examination of renal tumors and also contributed to our understanding of this infrequent clinical entity.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47951653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"8-Hydroxydeoxyguanosine Urine and Total Nitric Oxide Serum in Chronic Kidney Disease","authors":"Putri Aliya Ahadini, M. Thaha, Arifa Mustika","doi":"10.20473/fmi.v58i2.31814","DOIUrl":"https://doi.org/10.20473/fmi.v58i2.31814","url":null,"abstract":"Highlights:\u0000\u0000Oxidative markers 8-Hydroxydeoxyguanosine and Nitric Oxide was found high in hemodialysis and non-hemodialysis chronic kidney disease patients.\u0000There is no correlation between 8-Hydroxydeoxyguanosine and Nitric Oxide in hemodialysis and non-hemodialysis chronic kidney disease patients.\u0000\u0000 \u0000Abstract:\u0000Oxidative stress is essential to chronic kidney disease (CKD). Several markers include 8-Hydroxydeoxyguanosine (8-OHdG) and Nitric Oxide (NO). Reactive oxygen species (ROS) and Reactive Nitrogen Species (RNS) increased in CKD and had a role in renal impairment progressivity. There are some controversies regarding oxidative markers in CKD patients in several studies. This study aimed to understand oxidative markers 8-OHdG and NO and explained the correlation of both markers in hemodialysis and non-hemodialysis CKD patients. Twenty hemodialysis patients and forty-nine non-hemodialysis patients were enrolled in this cross-sectional study. Urine patients were collected to measure 8-OHdG using the enzyme-linked immunoassay (ELISA) method, and NO was measured from serum patients using the Griss Saltzman method. Based on Bivariate Pearson analysis, there was no significant correlation between 8-OHdG urine and total NO serum in the hemodialysis group (p= 0,510, p>0.05) and in the non-hemodialysis group (p= 0.801, p>0,05). In this study, DNA oxidative marker, 8-OHdG, was not correlated with NO in CKD patients.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46543507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Human Resources for Surge Capacity in Referral Hospitals Based on WHO Hospital Readiness Checklist for Covid-19","authors":"Fitri Dinia, L. Trisnantoro, M. Helmi","doi":"10.20473/fmi.v58i2.32579","DOIUrl":"https://doi.org/10.20473/fmi.v58i2.32579","url":null,"abstract":"Highlights:\u0000\u0000Managing human resources for surge capacity in three referral hospital at West Kalimantan was evaluated.\u0000Availability, mobilization and recruitment, duties division, and hospital staff welfare are the reasons for referral hospitals in West Kalimantan are not optimal to face surge capacity during the Covid-19 pandemic.\u0000Provincial Health Office role had not been optimal in the HR management at referral hospitals during the Covid-19 pandemic.\u0000\u0000 \u0000Abstract:\u0000One of the components of effective disaster response management to deal with surge capacity in referral hospitals in West Kalimantan, Indonesia, was to ensure the adequacy of the number of human resources (health workers). This study was conducted to evaluate three referral hospitals and identify the role of the West Kalimantan Provincial Health Office in managing human resources for health workers facing surge capacity due to the Covid-19 pandemic. This study used Rapid Assessment Procedures with qualitative and quantitative methods. Data were collected through observation and interview by using instruments adopted from the Checklist of WHO Hospital Readiness for Covid-19. Based on the checklist, 51.1% of referral hospitals had implemented HR management regarding staff availability. However, the readiness of referral hospitals in West Kalimantan to face surge capacity had not been optimal in several key components, such as staff availability, staff mobilization and recruitment, division of staff duties, and hospital staff welfare during the Covid-19 pandemic. The role of the Provincial Health Office had not been optimal in managing HR at referral hospitals. The Provincial Health Office only played an active role at the beginning of the Covid-19 pandemic, especially for the provision of volunteers. Meanwhile, in the second year of the Covid-19 pandemic, the role of the Provincial Health Office had decreased, especially in the staff availability and training at the referral hospitals. Therefore, the role of the West Kalimantan Provincial Health Office in HR management at the referral hospitals was highly not dominant (17.78%). The central government should regulate the authority of the Provincial Health Office as the leading sector in all types of referral hospitals to integrate all potencies and human resources of local governments to maximize HR management in referral hospitals to face surge capacity due to the increased cases of Covid-19.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42162884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of Women's Exposure to Birth in the Forest – A Cross-Sectional Study on Yei Tribe, Merauke Regency, Indonesia","authors":"Fenita Purnama Sari Indah, Riris Andriati, Ika Rohmawati, Rina Kartikasari, Dini Rachmaniah, A. Andiyan","doi":"10.20473/fmi.v58i2.29457","DOIUrl":"https://doi.org/10.20473/fmi.v58i2.29457","url":null,"abstract":"Highlights:\u0000\u0000The maternal mortality for women's exposed birth in the foreston Tribe Kampung Poo, Merauke Regency is higher.\u0000Mother's knowledge perceptions of women’s exposure to birth in the forest were dominant then community leader’s roles, husband or family roles and respondent characteristics.\u0000\u0000Abstract:\u0000In one of the districts in Papua, namely the Merauke Regency, the maternal mortality number in 2016 reached 17 cases, 13 cases in 2017, 6 cases in 2018, 9 cases in 2019, and 7 cases in 2020. Data in 2020 showed that 4,163 of the 5,377 deliveries by health workers assistance in Merauke Regency had not been fully achieved. There were 4,098 deliveries carried out in health care facilities. This study analyzed determinant factors on perceptions of the exile women giving birth in the forest from women of Yei Tribe, Poo Village, Merauke Regency, Indonesia. This study used analytic design methods with a cross-sectional approach. The sampling was non-probability with a total sample method of 57 mothers with toddlers. Univariate analysis was used to describe the characteristics of each research variable, including respondent characteristics, mother's knowledge, the role of community leaders, and the role of husband or family, while the dependent variable was the perception of women giving birth in the forest. This study found that there was a correlation between education (p-value 0.000; OR=13.33), knowledge (p-value 0.000; OR=133.00), the community leaders’ role (p-value 0.009; OR=5.00), and husband’s role (p-value 0.000; OR=28.00) with perceptions of the exile women giving birth in the forest at women of Yei Tribe, Poo Village, Merauke Regency, Indonesia. Therefore, knowledge is dominant in the perceptions of exiled women giving birth in the forest.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44195948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respirable Dust Levels, Years of Service, and Pulmonary Physiological Disorders in Marble Home Industry Workers","authors":"Siti Arum Alia, N. Widajati, T. Martiana, Firda Qurba Sari, A. R. Tualeka","doi":"10.20473/fmi.v58i2.27435","DOIUrl":"https://doi.org/10.20473/fmi.v58i2.27435","url":null,"abstract":"Highlights:\u0000\u0000The strength of the relationship between respiratory dust levels and pulmonary function disorders could not be obtained.\u0000The weakness level of correlation between years of service and pulmonary function disorders.\u0000\u0000 \u0000Abstract:\u0000Environmental dust in the workplace exposes the workers as they are breathing. The dust is inhaled into the respiratory tract and causes occupational diseases in the form of pulmonary function disorders. Workers in the marble industry are also prone to dust exposure. This study aimed to analyze the correlation between years of service, respiratory dust levels, and pulmonary function disorders in marble home industry workers in Tulungagung Regency, Indonesia. This study was a descriptive observational study with data from a cross-sectional technique. The population was 18 workers taken as respondents. The independent variables in this study were years of service and the level of respirable dust, while the dependent variable was the pulmonary function disorders experienced by the workers. The data were analyzed using the Correlation Contingency test. There was a close correlation between years of service and pulmonary function disorders by 0.196, indicating that the relationship between those variables was weak. The strength of the relationship between respiratory dust levels and pulmonary function disorders could not be obtained because the constant results met the threshold value. The correlation between years of service and pulmonary function disorders was weak, and the relationship between respiratory dust level and pulmonary function disorders could not be obtained.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49060180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing","authors":"H. Wibowo, P. Widiyanti","doi":"10.20473/fmi.v58i2.25212","DOIUrl":"https://doi.org/10.20473/fmi.v58i2.25212","url":null,"abstract":"Highlights:\u0000\u0000Sodium diclofenac is one of NSAID a common treatment to relieve pain associated with bone fractures.\u0000Sodium diclofenac with a some dose of body weight could decrease the callus quality on fracture healing.\u0000\u0000 \u0000Abstract:\u0000Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac sodium, are standard treatments to relieve pain associated with bone fractures. The bone healing process consists of four stages: inflammation, soft callus formation, complex callus formation, and bone remodeling. Previous studies mentioned that intake of NSAIDs (sodium diclofenac) could inhibit the bone healing process. This study examined the effect of diclofenac sodium intake on callus formation in fracture healing. In this study, thirty-six rats (Rattus Norvegicus) with fractures were used and divided into two groups, namely 18 rats for the control and 18 rats for the treatment group. In the treatment group, each rat was given 1.8 mg sodium diclofenac/150 grams of body weight per day. In the control group, each rat was given CMC-Na 0.5% with equal volume as diclofenac sodium in the treatment group. After 28 days, all the rats were stunned until dead, and the diameter and strength of their calluses were measured. In the treatment group with diclofenac sodium1.8 mg/ 150 grams BW/ 28 days after the tibia bone callus was pressed using the Shimadzu tool, the lowest callus strength was found to be 56.500 N, and the highest callus strength was 59.000 N. The lowest callus diameter in the treatment group was 4 mm, the highest was 5 mm. In the control group, the lowest callus strength was 76 N, and the highest callus strength was 77 N. The lowest callus diameter in the control group was 6 mm, and the highest was 8 mm. The strongest callus in the treatment group was found in the sixth observation, with a value of 59 N and a diameter of 4 mm. In the control group, the highest callus strength was 77 N, with a diameter of 7-8 mm. These measurements were found on the 5th, 7th, 8th, 9th, 16th, and 17th observations. Diclofenac sodium with a dose of 1.8 mg/150 grams of body weight could decrease the callus quality parameters, such as callus strength and diameter on fracture healing.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45850796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}