European Polymer Journal最新文献_第4页

An azide-containing initiator for the cationic ring-opening-polymerization of 2-oxazolines 一种用于2-恶唑啉阳离子开环聚合的含叠氮化物引发剂

IF 6.3 2区化学

European Polymer Journal Pub Date : 2026-03-11 Epub Date: 2026-01-20 DOI: 10.1016/j.eurpolymj.2026.114515

Jakob Meyer , Christine Weber , Phil Köhler , Ulrich S. Schubert

{"title":"An azide-containing initiator for the cationic ring-opening-polymerization of 2-oxazolines","authors":"Jakob Meyer , Christine Weber , Phil Köhler , Ulrich S. Schubert","doi":"10.1016/j.eurpolymj.2026.114515","DOIUrl":"10.1016/j.eurpolymj.2026.114515","url":null,"abstract":"<div><div>Poly(2-oxazoline)s (POx) are a versatile class of polymers synthesized <em>via</em> a living cationic ring-opening polymerization (CROP). This living nature enables the precise control over molar mass, dispersity, and end-group functionality. One common method for end-capping the CROP is through termination with nucleophiles such as sodium azide, which introduces an azide end-group suitable for further click chemistry modifications. However, the functionalization of, in particular, hydrophobic POx with azide end groups for bioconjugation has posed significant synthetic challenges. Herein, we report the development of a novel initiator for the CROP of 2-oxazolines that enables the direct incorporation of an azide functionality at the α-terminus of various POx, including amphiphilic block copolymers. This approach overcomes previous limitations in quenching reactions of hydrophobic POx variants and provides consistently high end group fidelity across a spectrum of POx hydrophilicity. Polymers with an azide end group exhibited excellent reactivity in azide-alkyne cycloaddition reactions. This versatile synthetic platform expands the potential applications of POx in drug delivery systems by providing a reliable method for bioconjugation while maintaining the favorable properties that position POx as a promising PEG alternative in biomedical applications.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"245 ","pages":"Article 114515"},"PeriodicalIF":6.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bispyridinium-phenylene-based cationic porous organic polymers for efficient removal of oxoanions from water 用于有效去除水中氧阴离子的双吡啶-苯基阳离子多孔有机聚合物

IF 6.3 2区化学

European Polymer Journal Pub Date : 2026-03-11 Epub Date: 2026-01-27 DOI: 10.1016/j.eurpolymj.2026.114544

Zhiye Zheng , Ying Gao , Shunfeng Peng, Jialong Li, Shijie Chen, Hongyu Wang

{"title":"Bispyridinium-phenylene-based cationic porous organic polymers for efficient removal of oxoanions from water","authors":"Zhiye Zheng , Ying Gao , Shunfeng Peng, Jialong Li, Shijie Chen, Hongyu Wang","doi":"10.1016/j.eurpolymj.2026.114544","DOIUrl":"10.1016/j.eurpolymj.2026.114544","url":null,"abstract":"<div><div>Heavy-metal-derived oxoanions are major contributors to water contamination, posing serious threats to both the environment and human health. The selective and efficient removal of these oxoanions from water remains a significant scientific and technical challenge. Leveraging the inherent advantages of cationic porous organic polymers (POPs) for anion capture, we report a three-dimensional cationic POP, <strong>TEPM-BPymPh</strong>, constructed from tetraphenylmethane and bispyridinium-phenylene monomers via two synthetic approaches: direct Sonogashira cross-coupling and post-cyclization of the neutral precursor <strong>TEPM-BPyPh</strong>. Owing to its high charge density and ion-exchange properties, <strong>TEPM-BPymPh</strong> effectively adsorbs toxic oxoanions, including MnO<sub>4</sub><sup>−</sup>, ReO<sub>4</sub><sup>−</sup>, CrO<sub>4</sub><sup>2−</sup>, and Cr<sub>2</sub>O<sub>7</sub><sup>2−</sup>, from aqueous solutions. In particular, it exhibits an exceptional adsorption capacity for MnO<sub>4</sub><sup>−</sup> (454 mg g<sup>−1</sup>), along with excellent selectivity against competing anions and broad pH compatibility. Energy-dispersive X-ray spectroscopy (EDS) elemental mapping and X-ray photoelectron spectroscopy (XPS) analyses confirmed that anion exchange governs the adsorption process. Dynamic flow-through adsorption experiments demonstrated nearly quantitative removal of 0.2 mM MnO<sub>4</sub><sup>−</sup> at a flow rate of 1 mL min<sup>−1</sup>, with complete regeneration achieved by washing with HCl solution. Furthermore, both static and dynamic adsorption tests revealed excellent recyclability.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"245 ","pages":"Article 114544"},"PeriodicalIF":6.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of soluble lignin and its application mechanism in aerogel 水溶性木质素的制备及其在气凝胶中的应用机理

IF 6.3 2区化学

European Polymer Journal Pub Date : 2026-03-11 Epub Date: 2026-01-20 DOI: 10.1016/j.eurpolymj.2026.114524

Qian Guo, He-Fei Wan, Xin Zhao, Ce Gao, Run-Cang Sun

{"title":"Preparation of soluble lignin and its application mechanism in aerogel","authors":"Qian Guo, He-Fei Wan, Xin Zhao, Ce Gao, Run-Cang Sun","doi":"10.1016/j.eurpolymj.2026.114524","DOIUrl":"10.1016/j.eurpolymj.2026.114524","url":null,"abstract":"<div><div>The solubility of lignin has long represented a critical bottleneck limiting its broad application. In this study, a novel modified lignin was successfully synthesized using glutamic acid as the modifier viaa Mannichreaction, which exhibits excellent water solubility. The aerogel prepared with this modified lignin as the precursor possesses outstanding ion affinity and selectivity for Pb (II). At 298 K, itsmaximum adsorption capacityfor Pb (II) in aqueous solutions reaches 324.88 mg·g<sup>−1</sup> (fitted by the Langmuir model). After 5 adsorption–desorption cycles, the adsorption capacity remains at 202.4 mg·g<sup>−1</sup> with acapacity retention rate of 62.3%, demonstrating goodreusability. Kinetic and isothermal model analyses confirm that the adsorption process follows a monolayer chemisorption mechanism. Density Functional Theory (DFT) calculations reveal that the adsorption mechanism involves coordination bonds and electrostatic interactions. This modified lignin-based aerogel demonstrates significant potential for practical application in industrial lead-containing wastewater treatment.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"245 ","pages":"Article 114524"},"PeriodicalIF":6.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel vinyl ketone derivative photoinitiators based on different electron-donating groups for LED photopolymerization and 3D printing 基于不同给电子基团的新型乙烯基酮衍生物光引发剂用于LED光聚合和3D打印

IF 6.3 2区化学

European Polymer Journal Pub Date : 2026-03-11 Epub Date: 2026-01-26 DOI: 10.1016/j.eurpolymj.2026.114541

Guanhao Ma , Jiangyu Luo , Chao Jiang , Tianmiao Kang , Shining Li , Jinqing Qu

{"title":"Novel vinyl ketone derivative photoinitiators based on different electron-donating groups for LED photopolymerization and 3D printing","authors":"Guanhao Ma , Jiangyu Luo , Chao Jiang , Tianmiao Kang , Shining Li , Jinqing Qu","doi":"10.1016/j.eurpolymj.2026.114541","DOIUrl":"10.1016/j.eurpolymj.2026.114541","url":null,"abstract":"<div><div>To address the critical limitations of conventional photoinitiators, including complex synthesis, poor LED wavelength matching, and high molecular mobility, this study rationally designed and synthesized ten vinyl ketone derivatives functionalized with diverse electron-donating substituents. Five of these structures, HMPO-4, HMPO-5, HMPO-6, HMPO-7, and HMPO-8 were found to possess excellent photo-initiating activity, with the maximum absorption wavelengths red-shifted to the visible region, with a maximum molar extinction coefficient of more than 24,000 M<sup>−1</sup>cm<sup>−1</sup>. The multi-component HMPO initiation system effectively initiated PEGDA polymerization under 405 nm and 480 nm LED irradiation, with HMPO-6 exhibiting optimal performance, achieving C<img>C double bond conversions of 96% and 91%, respectively. Steady-state photodegradation and ESR spectroscopy analyses revealed favorable photochemical properties, along with excellent solubility and biocompatibility. Notably, HMPO-6 demonstrated superior migration stability, exhibiting a minimal migration rate of 0.9%. Furthermore, this novel photoinitiator enabled efficient 3D printing under low-intensity (5 mW/cm<sup>2</sup>) 405 nm LED irradiation.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"245 ","pages":"Article 114541"},"PeriodicalIF":6.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research advances in alginate fiber-based medical dressings: A review 海藻酸盐纤维医用敷料的研究进展

IF 6.3 2区化学

European Polymer Journal Pub Date : 2026-03-11 Epub Date: 2026-01-26 DOI: 10.1016/j.eurpolymj.2026.114539

Xiaoshun Yue , Shiyi Liu , Bin Lu , Xiantao Zhang , Aixue Dong , Yinjiang Zhang

{"title":"Research advances in alginate fiber-based medical dressings: A review","authors":"Xiaoshun Yue , Shiyi Liu , Bin Lu , Xiantao Zhang , Aixue Dong , Yinjiang Zhang","doi":"10.1016/j.eurpolymj.2026.114539","DOIUrl":"10.1016/j.eurpolymj.2026.114539","url":null,"abstract":"<div><div>Skin trauma compromises the epidermal barrier function, which may cause systemic physiological disturbances in severe cases, thereby elevating the risks of microbial infections and impaired healing processes. Effective wound management and treatment are crucial for improving the healing efficiency of wounds and enhancing the quality of life for patients. Alginate, a polysaccharide-based biomacromolecule, is widely used in the development of medical dressings due to its excellent biocompatibility, outstanding exudate absorption and controllable biodegradation. This article reviews the current research status of alginate-based dressings in wound healing, with a particular focus on the preparation methods of alginate fiber-based dressings and their application advantages in hemostasis, antibacterial activity, and tissue regeneration. Moreover, material compositing, functional integration, structural innovation, and intelligent design are considered key directions for enhancing the performance of alginate fiber-based dressings in the future. This review aims to provide new insights and development directions for the application and innovation of alginate fiber-based dressings in wound care.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"245 ","pages":"Article 114539"},"PeriodicalIF":6.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in molecularly imprinted synthetic polymers: from structural principles to functional technologies 分子印迹合成聚合物的进展：从结构原理到功能技术

IF 6.3 2区化学

European Polymer Journal Pub Date : 2026-03-11 Epub Date: 2026-01-27 DOI: 10.1016/j.eurpolymj.2026.114542

Samir M.M. Morsi , Morsi M. Morsi , Mahmoud E. Abd El-Aziz

{"title":"Advances in molecularly imprinted synthetic polymers: from structural principles to functional technologies","authors":"Samir M.M. Morsi , Morsi M. Morsi , Mahmoud E. Abd El-Aziz","doi":"10.1016/j.eurpolymj.2026.114542","DOIUrl":"10.1016/j.eurpolymj.2026.114542","url":null,"abstract":"<div><div>Synthetic recognition polymers (SRPs) are functional materials engineered to selectively bind target molecules through molecular imprinting, where a template directs the arrangement of monomers to form complementary binding cavities. Their synthesis relies on key components: a template, a functional monomer, a crosslinker, and an initiator, which collectively create a stable network capable of mimicking the recognition behavior of antibodies and enzymes. Depending on template monomer interactions, SRPs can be prepared using covalent, non-covalent, or semi-covalent imprinting strategies. Advances in polymer chemistry and fabrication methods have expanded SRP applications in chromatography, sensing, separation membranes, catalysis, drug delivery, and environmental remediation. Increasing attention is given to smart, stimuli-responsive SRPs that modulate binding in response to temperature, pH, ions, light, magnetic fields, or biomolecules. This review summarizes the principles of molecular imprinting, recent technological progress, and emerging trends, highlighting how modern design approaches enable SRPs with improved selectivity, faster response, and tunable functionality. It also outlines future challenges and opportunities in developing next-generation adaptive SRP materials.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"245 ","pages":"Article 114542"},"PeriodicalIF":6.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, polymerization and properties of monoacrylamidotriazine 单丙烯酰胺三嗪的合成、聚合及性能研究

IF 6.3 2区化学

European Polymer Journal Pub Date : 2026-03-11 Epub Date: 2026-02-01 DOI: 10.1016/j.eurpolymj.2026.114545

Lijiu Cao , Zongxing Yu , Xu Ma , Danrui Wei , Yue Hu , Yunpeng Gong , Shuai Wang , Jian Huang , Yufang Chen

{"title":"Synthesis, polymerization and properties of monoacrylamidotriazine","authors":"Lijiu Cao , Zongxing Yu , Xu Ma , Danrui Wei , Yue Hu , Yunpeng Gong , Shuai Wang , Jian Huang , Yufang Chen","doi":"10.1016/j.eurpolymj.2026.114545","DOIUrl":"10.1016/j.eurpolymj.2026.114545","url":null,"abstract":"<div><div>Melamine (M) is a nitrogen-rich triazine heterocyclic organic compound. Currently, it is primarily utilized in the preparation of melamine–formaldehyde resin (MF), which is widely used in adhesives, molding compounds, coating additives and other fields. However, some problems are associated with MF, such as the release of free formaldehyde in its use, which is hazardous to safety production and human health. In this study, melamine (M) and acrylic acid (AA) are used as raw materials to synthesize the monoacrylamidotriazine (MAT) through dehydration reaction. Subsequently, MAT is polymerized through free radical polymerization to prepare polyacrylamide triazine polymer (P<sub>MAT</sub>) and the structure and properties of P<sub>MAT</sub> are characterized and tested. The results show that P<sub>MAT</sub> was successfully polymerized at 100℃ for 8.0 h, with ethylene glycol used as the solvent and 2,2-azobisisobutyronitrile (AIBN) as the initiator. The chemical structure and morphological characteristics of P<sub>MAT</sub> were systematically verified by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), thermogravimetry (TG), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Additionally, the adhesion of the P<sub>MAT</sub> −based coating reached 13.09 MPa, and exhibited resistance to chemical corrosion and wear. This research has preliminarily established a technical route for the synthesis of melamine-based polymers through free radical polymerization. It holds important practical significance for promoting the technological development of novel functional melamine-based polymers and facilitating the technical iteration, optimization, and upgrading of the melamine industry chain.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"245 ","pages":"Article 114545"},"PeriodicalIF":6.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146185364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green and facile synthesis of tetrahydrogeraniol-initiated lactide oligomers for plasticizing polylactide 绿色简便合成四氢香叶醇引发的聚丙交酯低聚物

IF 6.3 2区化学

European Polymer Journal Pub Date : 2026-03-11 Epub Date: 2026-01-28 DOI: 10.1016/j.eurpolymj.2026.114519

Xu Hu , Kok Hoong Wong , Nai Yeen Gavin Lai , Juan Li , Haibin Yu , Long Wang

{"title":"Green and facile synthesis of tetrahydrogeraniol-initiated lactide oligomers for plasticizing polylactide","authors":"Xu Hu , Kok Hoong Wong , Nai Yeen Gavin Lai , Juan Li , Haibin Yu , Long Wang","doi":"10.1016/j.eurpolymj.2026.114519","DOIUrl":"10.1016/j.eurpolymj.2026.114519","url":null,"abstract":"<div><div>To develop a sustainable and compatible plasticizer for polylactide (PLA), lactide oligomers (LOs) with full biocarbon were synthesized through bulk ring-opening polymerization, initiated by tetrahydrogeraniol. The effects of lactic acid chain length (4, 12, 24 theoretical repeating units) and terminal group (tetrahydrogeranyl and ethyl) on plasticization efficiency were studied. It was determined that the plasticization efficiency decreased with the increase in repeating units and the decrease in terminal alkyl chain length, which could be explained by the strengthened interactions. The LOs have good compatibility with PLA, which can be seen from the high transparent appearance of PLA blends, no phase separation in morphology, one glass transition temperature, low migration rate (<1 % in water, n-hexane and 70 °C) and good durability (performance can be maintained more than 90 days). Tetrahydrogeraniol-initiated lactide oligomer with 4 repeating lactic acid units (TLO4) exhibits higher plasticization efficiency and better durability than commercial acetyl-tri-n-butyl citrate. The elongation at break of the PLA blend is remarkably increased by adding 10 wt% TLO4 (323.9 %) and can further reach 453.1 % (20 wt% loading), with a low glass transition temperature at 32 °C. The crystallization ability of PLA was enhanced by a small amount of LOs, without a noticeable increase in crystallization rate. The molecular dynamics simulation was used to help understand the plasticization mechanism of LOs. This study adds a new choice to the environmentally friendly plasticizers for PLA and may be helpful for the further development of sustainable additives for PLA.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"245 ","pages":"Article 114519"},"PeriodicalIF":6.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Roles of polymeric nanoparticles in cancer Therapy: Design, Targeting, and clinical integration 聚合纳米颗粒在癌症治疗中的新作用：设计、靶向和临床整合

IF 6.3 2区化学

European Polymer Journal Pub Date : 2026-02-20 Epub Date: 2025-12-12 DOI: 10.1016/j.eurpolymj.2025.114447

Seyedeh Elaheh Sheykholeslami , Saba Halimi , Fatemeh Ahangari , Azadeh Mohammadgholi , Afsoun Mansouri , Hamed Mirzaei Dehaghi , Maliheh Khaleghi Eynakchi , Sara Hosseini , Seyed Kasra Sadr Tahouri , Zahra Shahbazi , Hassan Noorbazargan

{"title":"Emerging Roles of polymeric nanoparticles in cancer Therapy: Design, Targeting, and clinical integration","authors":"Seyedeh Elaheh Sheykholeslami , Saba Halimi , Fatemeh Ahangari , Azadeh Mohammadgholi , Afsoun Mansouri , Hamed Mirzaei Dehaghi , Maliheh Khaleghi Eynakchi , Sara Hosseini , Seyed Kasra Sadr Tahouri , Zahra Shahbazi , Hassan Noorbazargan","doi":"10.1016/j.eurpolymj.2025.114447","DOIUrl":"10.1016/j.eurpolymj.2025.114447","url":null,"abstract":"<div><div>Polymeric nanoparticles (PNPs) are recognized as a potent platform for cancer therapy and provide hope for personalized medicine and targeted therapy. Many polymers are used in PNPs, including polycaprolactone (PCL), polyethylene glycol–polycaprolactone (PEG-PCL), poly(n-butyl cyanoacrylate) (PBCA), poly(ethylene oxide)-poly(butylene oxide), pullulan, poly(lactic-co-glycolic acid) (PLGA), poly(lactic acid) (PLA), methoxypoly(ethylene glycol)-poly(l-lactic acid) (MPEG-PLA), D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactic acid) (TPGS-PLA), and chitosan. PNPs have gained attention, owing to their biocompatibility, tunable properties, and value in drug formulation, to improve drug delivery. This technology was originally developed to increase drug effectiveness, improve stability, and reduce systemic exposure. PNPs can take advantage of two different types of targeting: passive targeting using enhanced permeability and, or active targeting via functionalizing ligands that enable drug delivery of components. Furthermore, recent studies also show PNPs can provide solutions to drug resistance, improve patient survival, and enable highly effective drug delivery to solid tumors. It is important to note that PNPs are a transformative innovation in oncology, as they improve drug delivery and therapeutics. Furthermore, PNPs are changing the way we can administer cancer therapy through multidimensional therapeutic approaches since they possess the selectivity, versatility, and biocompatibility potential to make them more powerful enablers of future cancer nanomedicine.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"244 ","pages":"Article 114447"},"PeriodicalIF":6.3,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of single-chain polymer nanoparticles by light-induced inverse electron demand diels-alder (Photo-IEDDA) reaction 利用光诱导逆电子需求didies -alder （photoedda）反应制备单链聚合物纳米颗粒

IF 6.3 2区化学

European Polymer Journal Pub Date : 2026-02-20 Epub Date: 2026-01-16 DOI: 10.1016/j.eurpolymj.2026.114509

Adalet Nur Altunkaya , Binnur Aydogan Temel , Muhammet U. Kahveci

{"title":"Fabrication of single-chain polymer nanoparticles by light-induced inverse electron demand diels-alder (Photo-IEDDA) reaction","authors":"Adalet Nur Altunkaya , Binnur Aydogan Temel , Muhammet U. Kahveci","doi":"10.1016/j.eurpolymj.2026.114509","DOIUrl":"10.1016/j.eurpolymj.2026.114509","url":null,"abstract":"<div><div>Single-chain polymer nanoparticles (SCNPs) have garnered significant attention due to their ability to mimic the folding behavior of proteins and their potential in applications such as drug delivery, catalysis, and sensing. Herein, we present a novel approach for preparation of SCNPs using a photo-induced inverse electron-demand Diels-Alder (photo-IEDDA) reaction. The base polymer, P(MMA-<em>co</em>-HEMA), synthesized <em>via</em> reversible addition-fragmentation chain transfer (RAFT) polymerization, was functionalized with dihydrotetrazine (dHTz) and norbornene (Nb) moieties through esterification over HEMA units. Upon irradiation of a dilute solution of the modified polymer, P(MMA-<em>co</em>-HEMA)-<em>M</em>−PPA−dHTz/Nb, in the presence of a photosensitizer, dihydrotetrazine groups were <em>in situ</em> converted to reactive tetrazine moieties, enabling intramolecular crosslinking <em>via</em> the photo-IEDDA reaction. This process yielded sub-10 nm SCNPs with high precision and control. The integration of light-triggered reactivity with efficient click chemistry highlights the potential of this method for the scalable production of well-defined SCNPs with tailored properties for advanced applications in nanotechnology and materials science.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"244 ","pages":"Article 114509"},"PeriodicalIF":6.3,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0