European Polymer Journal最新文献

The potential of cellulose nanocrystal-modified polyhydroxybutyrate/chitosan scaffolds in cartilage regeneration 纤维素纳米晶改性聚羟基丁酸酯/壳聚糖支架在软骨再生中的潜力

IF 6.3 2区化学

European Polymer Journal Pub Date : 2025-10-07 DOI: 10.1016/j.eurpolymj.2025.114333

Mohammad Mohammadalipour , Farzaneh Alihosseini , Zahra Mohammadalipour , Elahe Bahremandi Toloue

{"title":"The potential of cellulose nanocrystal-modified polyhydroxybutyrate/chitosan scaffolds in cartilage regeneration","authors":"Mohammad Mohammadalipour , Farzaneh Alihosseini , Zahra Mohammadalipour , Elahe Bahremandi Toloue","doi":"10.1016/j.eurpolymj.2025.114333","DOIUrl":"10.1016/j.eurpolymj.2025.114333","url":null,"abstract":"<div><div>Electrospun scaffolds are widely used in tissue engineering due to their ability to replicate the extracellular matrix (ECM) architecture, featuring a highly porous fibrous network similar to open-cell foams. This study presents an innovative modeling approach to predict the mechanical properties of nanocomposite electrospun scaffolds prior to their 3D network formation, aimed at cartilage tissue engineering applications. Scaffolds were fabricated from polyhydroxybutyrate (PHB) and chitosan (CHT) reinforced with 1, 3, and 5 wt% cellulose nanocrystals (CNCs). The modulus of the matrix and dispersed phases were first measured via AFM nanoindentation. Using these inputs, the Halpin-Tsai model predicted the modulus of individual composite nanofibers with over 90 % accuracy, which was then integrated into foam mechanical models to estimate 3D-scaffold properties. The outputs indicated that the predicted modulus values are within the physiological range suitable for skeletal tissues. Moreover, incorporation of CNCs influenced network density and bulk porosity, yielding finer fibers and enhancing scaffold characteristics, including an increase in surface roughness (300.2 to 350.1 nm), decreased water contact angle (62.64° to 55.12°), improved thermal stability (245 °C to 252 °C), and increased tensile strength (up to 4.52 MPa). Ultimately, biological evaluations demonstrated that the nanocomposite scaffolds significantly promoted cell adhesion and proliferation, as evidenced by SEM observations and a 41.04 % increase in chondrocyte viability compared to unmodified scaffolds. These findings suggest that the developed nanocomposite electrospun scaffolds offer a mechanically and biologically favorable 3D ECM-like environment, making them promising candidates for cartilage tissue regeneration.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"240 ","pages":"Article 114333"},"PeriodicalIF":6.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bio-based adhesive based on soy protein-gelatin with high cold compression strength, toughness, and water resistance 一种基于大豆蛋白明胶的生物基粘合剂，具有高冷压强度、韧性和耐水性

IF 6.3 2区化学

European Polymer Journal Pub Date : 2025-09-28 DOI: 10.1016/j.eurpolymj.2025.114324

Xiaochun Zhang, Yangsheng Zhang, Wenwu Yang, Jianxing Ren, Bangke Xu, Anbo Pan, Yantao Xu

{"title":"A bio-based adhesive based on soy protein-gelatin with high cold compression strength, toughness, and water resistance","authors":"Xiaochun Zhang, Yangsheng Zhang, Wenwu Yang, Jianxing Ren, Bangke Xu, Anbo Pan, Yantao Xu","doi":"10.1016/j.eurpolymj.2025.114324","DOIUrl":"10.1016/j.eurpolymj.2025.114324","url":null,"abstract":"<div><div>In order to reduce the harm of formaldehyde-based adhesives and solve the problem of petroleum resource shortage, green and formaldehyde free bio-based adhesives have great market development potential. Soy protein adhesive is expected to solve these problems, but it has disadvantages such as low cold compression strength and high bonding brittleness, making it difficult to carry out large-scale industrial applications. This study introduced gelatin and triglycerides (TGA) into soy protein (SM) adhesive to construct a double bond composite system. TGA undergoes cross-linking reaction with soy protein to form a cross-linked structure as the skeleton structure, which endows the adhesive with strength and water resistance; and gelatin (Gel) forms hydrogen bonds with soy protein as sacrificial bonds, improving the toughness and cold compression performance of the adhesive. Compared with pure SM adhesive, the dry/wet shear strength of modified SM/2-Gel/TGA adhesive increased by 27.8 % and 400 %, respectively, reaching 2.3 MPa and 1.4 MPa. The moisture absorption rate of the modified adhesive decreased by 16.5 %, the residual rate increased by 10.0 %, and the fracture strain increased by 52.2 % to 14 %. In addition, in the adhesive treated with cold pressing, the lap strength increased by 25.1 % to 4.23 MPa, indicating that the cold pressing strength, bonding toughness, and water resistance of the modified adhesive were effectively improved. This study provides a new way for preparing green, formaldehyde free high-performance bio-based adhesives.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"239 ","pages":"Article 114324"},"PeriodicalIF":6.3,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogels with TA/Cu2+ release and NIR-II photothermal synergistic antibacterial and antioxidant properties for healing of bacterial-infected wounds 具有TA/Cu2+释放和NIR-II光热协同抗菌和抗氧化性能的水凝胶用于细菌感染伤口愈合

IF 6.3 2区化学

European Polymer Journal Pub Date : 2025-09-27 DOI: 10.1016/j.eurpolymj.2025.114322

Junqi Zhao, Zicheng Chen, Aijian Cao, Jiahao Huang, Suiping Deng, Jingxian Zhang, Langhuan Huang, Shaozao Tan

{"title":"Hydrogels with TA/Cu2+ release and NIR-II photothermal synergistic antibacterial and antioxidant properties for healing of bacterial-infected wounds","authors":"Junqi Zhao, Zicheng Chen, Aijian Cao, Jiahao Huang, Suiping Deng, Jingxian Zhang, Langhuan Huang, Shaozao Tan","doi":"10.1016/j.eurpolymj.2025.114322","DOIUrl":"10.1016/j.eurpolymj.2025.114322","url":null,"abstract":"<div><div>Bacterial infections pose a significant threat to the healing of human skin wounds, as the reactive oxygen species (ROS) they produce can significantly delay the wound healing process, ultimately leading to the formation of chronic wounds and even endangering human life. Therefore, this study successfully constructed a dynamically reversible hydrogel network through dual crosslinking of Schiff base bonds and hydrogen bonds using oxidized hyaluronic acid (OHA), carboxymethyl chitosan (CMCS), and tannic acid (TA). By loading Cu@PDA, the OCTC2 hydrogel wound dressing was prepared, exhibiting synergistic antibacterial and antioxidant properties through TA/Cu<sup>2+</sup> release and NIR-II photothermal effects. We used FTIR, XRD, SEM, and TEM to thoroughly analyse the specific composition and morphology of the Cu@PDA and hydrogel. We measured the injectability, adhesion, NIR-II photothermal, and antibacterial properties of each group of hydrogels. The results showed that TA and Cu@PDA endowed the hydrogel with excellent antioxidant properties, enabling effective scavenging of various free radicals. Additionally, OCTC2, which possesses sustained-release TA/Cu<sup>2+</sup> capability, achieves antibacterial rates of over 94 % against <em>S. aureus</em> and <em>E. coli</em>. Under the combined effect of NIR-II photothermal therapy, it can achieve highly efficient bacterial killing (99.8 %), effectively promoting the healing of bacterial infection wounds. OCTC2 holds promise as a potential ideal hydrogel dressing for treating bacterial-infected wounds.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"239 ","pages":"Article 114322"},"PeriodicalIF":6.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic investigation of photoinduced ATRP in deep eutectic solvent for highly efficient synthesis of poly(methyl methacrylate) 高效合成聚甲基丙烯酸甲酯的深共晶溶剂光诱导ATRP机理研究

IF 6.3 2区化学

European Polymer Journal Pub Date : 2025-09-26 DOI: 10.1016/j.eurpolymj.2025.114323

Wei-Ru Lee , Shih-Ching Wang , Sheng-Sheng Yu

{"title":"Mechanistic investigation of photoinduced ATRP in deep eutectic solvent for highly efficient synthesis of poly(methyl methacrylate)","authors":"Wei-Ru Lee , Shih-Ching Wang , Sheng-Sheng Yu","doi":"10.1016/j.eurpolymj.2025.114323","DOIUrl":"10.1016/j.eurpolymj.2025.114323","url":null,"abstract":"<div><div>This work investigates the behavior of photoinduced atom transfer radical polymerization (ATRP) of methyl methacrylate in deep eutectic solvents (DES). Recently, several works have found that eosin Y (EY) is a highly efficient organic photocatalyst to reduce X-Cu<sup>II</sup>/L complex under green light irradiation for photoinduced ATRP. Nevertheless, the effect of solvents on this dual photoredox/Cu ATRP has not been systematically explored before. This study compares the photoinduced ATRP mediated by EY in dimethyl sulfoxide (DMSO) and a DES composed of tetrabutylammonium chloride (TBACl) and ethylene glycol. The polymerization rate in DES is significantly faster than that in DMSO. Nearly full monomer conversion was achieved within 3 h in DES, but 24 h was required for the polymerization in DMSO. More intriguingly, the initiation mechanism in DES is similar to that of initiators for continuous activator regeneration (ICAR) ATRP. EY mainly acts as a type II photoinitiator in DES to gradually provide radicals that regenerate the Cu<sup>I</sup>/L activator. On the other hand, the photoredox efficiency between excited EY and X-Cu<sup>II</sup>/L is higher in DMSO than in DES. As a result, EY behaves as a photocatalyst in the conventional solvent, DMSO. Finally, we also demonstrate that the fast photoinduced ATRP in DES exhibits high oxygen tolerance and proceeds smoothly in an open-to-air environment. In short, our results reveal that DES enhances the polymerization rate and governs the initiation mechanism of photoinduced ATRP with EY.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"239 ","pages":"Article 114323"},"PeriodicalIF":6.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating advanced engineering strategies and multifunctional applications of sustainable lignin-based polyurethanes: A comprehensive review 综合先进的工程策略和可持续木质素基聚氨酯的多功能应用：综述

IF 6.3 2区化学

European Polymer Journal Pub Date : 2025-09-26 DOI: 10.1016/j.eurpolymj.2025.114321

Xinyue Wang , Wei Ding , Yifan Wang , Zekun Wang , Gonghua Hong , Junling Guo , Yushun Jin , Ruofan Liu , Yibo Wu

{"title":"Integrating advanced engineering strategies and multifunctional applications of sustainable lignin-based polyurethanes: A comprehensive review","authors":"Xinyue Wang , Wei Ding , Yifan Wang , Zekun Wang , Gonghua Hong , Junling Guo , Yushun Jin , Ruofan Liu , Yibo Wu","doi":"10.1016/j.eurpolymj.2025.114321","DOIUrl":"10.1016/j.eurpolymj.2025.114321","url":null,"abstract":"<div><div>Polyurethane (PU) is an important material widely used in numerous industrial products. Currently, the urgent need to mitigate petroleum dependency and environmental impacts has propelled lignin-based PU (LPU) as a sustainable alternative, capitalizing on lignin’s renewability, biodegradability, and non-competitive nature with food or fossil resources. This review critically evaluates engineering strategies for LPU synthesis, focusing on lignin modification (e.g., hydroxylation, fragmentation) and hybrid nanocomposite designs to optimize compatibility and reactivity. The tailored properties of LPU, including enhanced thermal stability, mechanical strength, and biodegradability, are systematically analyzed across diverse applications such as films, foams, adhesives, coatings, and biomedical materials. The discussions extends to the performances of LPU in UV-shielding, self-healing, and inflaming retarding, highlighting its industrial adaptability. Challenges in lignin heterogeneity, scalable processing, and interfacial compatibility are addressed, with future directions emphasizing lignin depolymerization, catalytic functionalization, and circular economy integration. By consolidating these insights, this review is expected to provide a strategic framework to advance the rational design and scalable production of high-performance LPU materials, paving the way for sustainable PU innovations.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"239 ","pages":"Article 114321"},"PeriodicalIF":6.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-assembled polyelectrolyte drug conjugates with minimal hemolytic activity for precision oncology 具有最小溶血活性的自组装多电解质药物偶联物用于精确肿瘤学

IF 6.3 2区化学

European Polymer Journal Pub Date : 2025-09-25 DOI: 10.1016/j.eurpolymj.2025.114319

Dimitra Toumpa , Valentini Vasileiou , Athina Angelopoulou , Konstantinos Avgoustakis , George Pasparakis

{"title":"Self-assembled polyelectrolyte drug conjugates with minimal hemolytic activity for precision oncology","authors":"Dimitra Toumpa , Valentini Vasileiou , Athina Angelopoulou , Konstantinos Avgoustakis , George Pasparakis","doi":"10.1016/j.eurpolymj.2025.114319","DOIUrl":"10.1016/j.eurpolymj.2025.114319","url":null,"abstract":"<div><div>We report the synthesis of well-defined, self-assembled polyelectrolyte drug conjugates (PDCs) for precision pancreatic cancer therapy with minimal hemolytic activity. Block copolymers of poly(ethylene glycol) (PEG) with cationic poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) or anionic HPMA-succinate (HPMA-Suc) were complexed with counterion polymethacrylate–drug copolymers of gemcitabine (GEM) or camptothecin (CPT) to form PEG-shielded polyelectrolyte complexes (PECs). The resulting nanoparticles (40–220 nm) displayed tunable surface charge, high colloidal stability, and controlled release profiles governed by linker chemistry and particle size. <em>In vitro</em> assays against PANC-1 cells showed that several PDCs and PECs—particularly CPT-loaded systems—achieved IC<sub>50</sub> values up to six orders of magnitude lower than the free drugs. Hemolysis assays confirmed excellent biocompatibility, with <5 % red blood cell lysis at the highest tested concentrations. These results highlight a versatile and safe platform for the development of polyelectrolyte-based nanomedicines with strong potential for targeted cancer therapy.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"239 ","pages":"Article 114319"},"PeriodicalIF":6.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laser-processed polymers for humidity sensors and the application 湿度传感器用激光加工聚合物及其应用

IF 6.3 2区化学

European Polymer Journal Pub Date : 2025-09-25 DOI: 10.1016/j.eurpolymj.2025.114318

Hairuo Rao , Pei Zuo , Fang Li , Guoyan Wang , Kaihu Zhang , Hong Tian , Weina Han , Yifan Yuan , Long Lv , Sijia Liu , Yizhuo Huo , Rongrong Xu

{"title":"Laser-processed polymers for humidity sensors and the application","authors":"Hairuo Rao , Pei Zuo , Fang Li , Guoyan Wang , Kaihu Zhang , Hong Tian , Weina Han , Yifan Yuan , Long Lv , Sijia Liu , Yizhuo Huo , Rongrong Xu","doi":"10.1016/j.eurpolymj.2025.114318","DOIUrl":"10.1016/j.eurpolymj.2025.114318","url":null,"abstract":"<div><div>Humidity sensors are widely used in fields such as environmental monitoring, healthcare, agriculture, and industry. Their performance improvement relies on innovations in materials and preparation technologies. Traditional humidity sensors have problems such as slow response, mechanical brittleness, and limited sensitivity, while polymer materials have become ideal alternatives due to their flexibility and processability. In recent years, laser processing technology has brought revolutionary progress to polymer humidity sensors through high-precision, mask-free, green and efficient micro-nano structure preparation methods. This review systematically elaborates on the material systems, preparation processes, sensing mechanisms, and performance optimization strategies of laser-processed polymer humidity sensors, with a focus on analyzing the enhancing effects of laser-induced porous structures, functional modification, and process parameter regulation on the sensitivity, response speed, and stability of the sensors. In addition, the review discusses the practical applications of such sensors in fields such as wearable health monitoring, smart agriculture, and food quality monitoring, and looks forward to future research directions such as self-powered, multi-modal integration, and degradable materials. By comprehensively sorting out the intrinsic connections between “materials − processes − performance − applications”, this review aims to provide theoretical references and application guidance for the design and industrialization of high-performance, flexible, green and sustainable humidity sensors.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"239 ","pages":"Article 114318"},"PeriodicalIF":6.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature-controlled sequence engineering of polar cyclic olefin copolymers 极性环烯烃共聚物的温控序列工程

IF 6.3 2区化学

European Polymer Journal Pub Date : 2025-09-24 DOI: 10.1016/j.eurpolymj.2025.114314

Hyewon Jung , Kang Hee Ku , Jin Young Seo , Sang-Ho Lee

{"title":"Temperature-controlled sequence engineering of polar cyclic olefin copolymers","authors":"Hyewon Jung , Kang Hee Ku , Jin Young Seo , Sang-Ho Lee","doi":"10.1016/j.eurpolymj.2025.114314","DOIUrl":"10.1016/j.eurpolymj.2025.114314","url":null,"abstract":"<div><div>Sequence regulation in polymeric materials plays a critical role in tailoring their macroscopic properties, yet achieving precise sequence control in polar cyclic olefin copolymers (COCs) remains a significant challenge. In this study, we report a temperature-programmed Pd-catalyzed terpolymerization of norbornene (NB), butyl-norbornene (BuNB), and methyl vinyl ketone (MVK), enabling the formation of distinct copolymer sequences from a single monomer feed. By modulating polymerization temperature, we access either gradient-type (NBM5-G) or gradient-block-like (NBM5-GB) architectures, reflecting a shift in monomer incorporation kinetics. These sequence modulation translates into markedly different thermomechanical and optical properties: NBM5-G exhibits superior transparency and flexibility, whereas NBM5-GB displays higher stiffness and reduced transparency due to increased polar-polar interactions. Our findings establish temperature-directed sequence programming as an effective tool for tailoring functional COCs, opening avenues for advanced applications in flexible optics and electronics.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"239 ","pages":"Article 114314"},"PeriodicalIF":6.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid GelMA-HAMA hydrogels incorporating dexamethasone-loaded PLGA nanoparticles for controlled release and osteogenic differentiation for bone tissue regeneration 混合GelMA-HAMA水凝胶，含有地塞米松负载的PLGA纳米颗粒，用于控释和成骨分化，用于骨组织再生

IF 6.3 2区化学

European Polymer Journal Pub Date : 2025-09-24 DOI: 10.1016/j.eurpolymj.2025.114311

Brenda Velasco , Luis Diaz-Gómez , L.C. Rosales-Rivera , Alberto Pardo , S. Barbosa , J.F.A. Soltero Martínez , P. Taboada

{"title":"Hybrid GelMA-HAMA hydrogels incorporating dexamethasone-loaded PLGA nanoparticles for controlled release and osteogenic differentiation for bone tissue regeneration","authors":"Brenda Velasco , Luis Diaz-Gómez , L.C. Rosales-Rivera , Alberto Pardo , S. Barbosa , J.F.A. Soltero Martínez , P. Taboada","doi":"10.1016/j.eurpolymj.2025.114311","DOIUrl":"10.1016/j.eurpolymj.2025.114311","url":null,"abstract":"<div><div>The development of novel approaches to bone regeneration remains a challenge in medicine. For such, the control release of biochemical factors appears key to successfully regulate the regeneration process. In this work, the characterization of methacrylated gelatin (GelMA)-hyaluronic acid (HAMA) hydrogels that incorporated dexamethasone-loaded poly(lactic-co-glycolic acid) nanoparticles (DEX-PLGA NPs) was explored as potential scaffolds for bone tissue regeneration. The DEX-PLGA NPs were synthesized and incorporated into the polymeric hydrogels to achieve a controlled and sustained release of the drug in order to ensure the progressive osteogenic differentiation of adipose-derived mesenchymal stem cells (adMSC) within the scaffold. The physicochemical properties of the NP-loaded hydrogels were not affected by the incorporation of DEX-PLGA NPs. <em>In vitro</em> studies demonstrated that these hybrid hydrogels are biocompatible and presented excellent cell adhesion, proliferation, and differentiation properties promoted by the sustained release of dexamethasone as observed, for example, by the alkaline phosphatase (ALP) assay, which confirmed large concentrations of phosphate ions after the first 14 days of incubation. Furthermore, Alizarin Red S staining corroborated a good mineralization, indicative of effective bone matrix formation.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"239 ","pages":"Article 114311"},"PeriodicalIF":6.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modification of poly(propylene 2,5-furandicarboxylate) with 2,5-thiophenedicarboxylic acid with enhanced mechanical and barrier performance 2,5-噻吩二羧酸改性聚（2,5-呋喃二羧酸丙烯）增强机械性能和阻隔性能

IF 6.3 2区化学

European Polymer Journal Pub Date : 2025-09-23 DOI: 10.1016/j.eurpolymj.2025.114307

Xiaoqin Jiang , Meiling Chen , Jiyang Zuo , Tao Yang , Caiqi Liu , Kangpeng Liu , Siqi Yu , Fei Liu , Jinggang Wang , Jin Zhu

{"title":"Modification of poly(propylene 2,5-furandicarboxylate) with 2,5-thiophenedicarboxylic acid with enhanced mechanical and barrier performance","authors":"Xiaoqin Jiang , Meiling Chen , Jiyang Zuo , Tao Yang , Caiqi Liu , Kangpeng Liu , Siqi Yu , Fei Liu , Jinggang Wang , Jin Zhu","doi":"10.1016/j.eurpolymj.2025.114307","DOIUrl":"10.1016/j.eurpolymj.2025.114307","url":null,"abstract":"<div><div>Bio-based materials provide solutions with both ecological benefits and technical feasibility for replacing traditional petroleum-based materials. This study focused on poly(propylene 2,5-furandicarboxylate) (PPF), a fully bio-based polyester with promising gas barrier properties. However, the lack of mechanical properties has become a key bottleneck in its packaging applications. Aiming at the problems of low molecular weight of PPF, Poly (propylene 2,5-thiophenedicarboxylate) (PPTh) oligomer prepared from 2,5-thiophenedicarboxylic acid and 1,3-propanediol was used to modify PPF, and high molecular weight poly(propylene 2,5-thiophenedicarboxylate-co-2,5-furandicarboxylate) (PPThF) copolyesters were prepared by melt polycondensation. The experimental results exhibited excellent CO<sub>2</sub> and O<sub>2</sub> barrier properties of up to 29.0 and 9.3 times compared with those of PET, respectively. Crucially, a brittle-ductile transition occurs without sacrificing barrier properties (elongation at break increases from 4.6% to 29%). These findings indicate that the material has the potential for packaging materials.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"239 ","pages":"Article 114307"},"PeriodicalIF":6.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0