European Polymer Journal最新文献

{"title":"Biobased and biodegradable polyester amides based on nylon 6,6 and polybutylene adipate via straightforward bulk polymerization","authors":"Cornelis Post ,&nbsp;Jeroen van der Vlist ,&nbsp;Jesse A. Jongstra ,&nbsp;Rudy Folkersma ,&nbsp;Vincent S.D. Voet ,&nbsp;Katja Loos","doi":"10.1016/j.eurpolymj.2024.113594","DOIUrl":"10.1016/j.eurpolymj.2024.113594","url":null,"abstract":"<div><div>Aliphatic polyesters are generally known for their limited thermal and mechanical properties, but are prone to biodegradation. On the other hand, aliphatic polyamides, mainly represented by nylons, feature high thermal transition points and enhanced mechanical strength, but are usually classified as nonbiodegradable. In this work, the properties of the aliphatic polyester polybutylene adipate and nylon 6,6 were combined by synthesizing polyester amides. Relatively low- and high-molecular weight series, <span><math><mrow><mover><mrow><msub><mi>M</mi><mi>n</mi></msub></mrow><mrow><mo>¯</mo></mrow></mover></mrow></math></span> 7000 and 14400 g/mol, respectively, were synthesized via a straightforward bulk polymerization process by utilizing biobased starting materials: butanediol, adipic acid and nylon 6,6 salt. The amide-to-ester ratio was varied to analyze the influence of the amide content on the molecular structure, thermal properties, mechanical properties, hydrophilicity and biodegradability. Strong relationships between the amide content and the T_g, T_m, degree of crystallinity, and mechanical properties were observed. Water contact angle measurements revealed that all the polyester amides were hydrophilic. Finally, the biodegradation experiments demonstrated that all polyester amides are prone to biodegradation in activated sludge and that the amide content had a major influence on the biodegradation rate. This work supports the high potential of biobased polyester amides for applications in numerous fields due to their versatility in terms of polymeric properties and sustainable character.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"222 ","pages":"Article 113594"},"PeriodicalIF":5.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strong and conductive gelatin hydrogels enhanced by Hofmeister effect and genipin crosslinking for sensing applications","authors":"Jie Liu ,&nbsp;Zhilu Rao ,&nbsp;Yitong Dong ,&nbsp;Xuejing Zheng ,&nbsp;Keyong Tang","doi":"10.1016/j.eurpolymj.2024.113583","DOIUrl":"10.1016/j.eurpolymj.2024.113583","url":null,"abstract":"<div><div>There is a growing interest in the development of conductive hydrogels based on natural polymers for sensing applications due to their flexibility, versatility and environmental friendliness. However, achieving strong hydrogels capable of withstanding mechanical stress while maintaining their desirable characteristics remains a challenge. This study proposed a strategy to tailor the mechanical and electrical conductivity of gelatin hydrogels by combining genipin crosslinking with the modulation of aggregation states of gelatin chains through Hofmeister effect. The obtained conductive gelatin hydrogels exhibit high tensile strength (5.48 MPa) and compressive stress at 80 % strain (5.66 MPa), excellent stretchability (&gt;500 %), remarkable freezing-resistant performance, and good strain sensitivity. By virtue of these outstanding properties, the hydrogels were used as strain sensors for human motion detection, demonstrating a gauge factor of 0.6 at 110–200 % tensile strain. Additionally, the hydrogel sensors demonstrate a rapid response time (&lt;0.32 s) and can withstand cyclic tensile/compressive loads at both room temperature and −20 °C, owing to their compact and stable network structure formed by the synergistic action of Hofmeister effect and chemical crosslinking. The strain sensors based on gelatin hydrogels can detect and track human movements, indicating promising applications in the field of wearable technology.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"222 ","pages":"Article 113583"},"PeriodicalIF":5.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4D printing of pH-responsive bilayer with programmable shape-shifting behaviour","authors":"Smruti Parimita ,&nbsp;Amit Kumar ,&nbsp;Hariharan Krishnaswamy ,&nbsp;Pijush Ghosh","doi":"10.1016/j.eurpolymj.2024.113581","DOIUrl":"10.1016/j.eurpolymj.2024.113581","url":null,"abstract":"<div><div>4D printing of smart materials has seen remarkable advancements in the domain of biomedical devices, with a particular focus on developing responsive and adaptive programmable structures. In this work, we report the 4D printing of two solvent-responsive hydrogels forming a bilayer that undergoes bidirectional actuation depending on the pH of the solvent. A strong interlayer adhesion between the hydrogels is formed without subjecting either of their surfaces to any chemical modification. These hydrogels have an interfacial toughness of 71.8 J/m² and undergoes no delamination during actuation inside a solvent. Conventionally, pH-responsive actuators are only limited to simple 2D films prepared by solvent casting. However, our work focuses on the design and fabrication of complex bilayer and patterned structures using Direct-Ink Writing (DIW) approach. These printed structures actuate upon immersion in a solvent medium, and the actuation is reversible in nature. The influence of programmable variables on the morphed structure was studied systematically by modifying the rheological properties (in the range of <span><math><mrow><mn>1</mn><msup><mrow><mn>0</mn></mrow><mrow><mn>2</mn></mrow></msup></mrow></math></span>–<span><math><mrow><mn>1</mn><msup><mrow><mn>0</mn></mrow><mrow><mn>5</mn></mrow></msup></mrow></math></span> Pa s) and printing parameters (optimized at a printing speed of 5 mm/sec, with the extrusion pressure of 5–6 bar and nozzle diameter of 0.5 mm) of the 3D printed bilayer structure. The physicochemical properties of the printable hydrogel ink were tuned such that the same structure can respond to both acidic and basic pH (with non-morphing point at pH 7), by altering the directionality of actuation. We have demonstrated the applications of these pH-responsive actuators in smart valves.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"222 ","pages":"Article 113581"},"PeriodicalIF":5.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous gradient copolymers of N-vinylsuccinimide/N-vinylsuccinamic acid with O-cholesteryl (meth)acrylate via RAFT polymerization as potential drug delivery systems","authors":"Mariia L. Levit ,&nbsp;Evgenii V. Sivtsov ,&nbsp;Ekaterina S. Sinitsyna ,&nbsp;Irina O. Bagaeva ,&nbsp;Anatolii V. Dobrodumov ,&nbsp;Alexandra L. Nikolaeva ,&nbsp;Natalia V. Zakharova ,&nbsp;Alexey I. Gostev ,&nbsp;Sergey A. Silonov ,&nbsp;Iosif V. Gofman ,&nbsp;Evgenia G. Korzhikova-Vlakh","doi":"10.1016/j.eurpolymj.2024.113586","DOIUrl":"10.1016/j.eurpolymj.2024.113586","url":null,"abstract":"<div><div>Today, biocompatible and bioinspired well-defined copolymers with the ability to form nanoparticles are of great interest as potential drug delivery systems. In this study, we report the synthesis of novel biocompatible copolymers from monomers with different activity and capable of forming gradient copolymers by RAFT polymerization. In particular, the copolymerization of <em>N</em>-vinylsuccinimide (VSI) and <em>O</em>-cholesteryl (meth)acrylate (Ch(M)A) mediated by <em>S,S’</em>-dibenzyl trithiocarbonate (DBTTC) has been thoroughly studied by varying the monomer ratio and the ratio of monomer to RAFT agent. Important dependencies such as molecular weight and monomer conversion versus time, and molar fraction of monomer units as a function of monomer conversion were investigated. The obtained copolymers were thoroughly characterized using a number of physicochemical methods such as ¹H NMR, ¹H–¹³C HSQC and ATR-IR-spectroscopy, size-exclusion chromatography, static and dynamic light-scattering, as well as thermogravimetric analysis. In addition, the reactivity ratios of VSI and ChMA were determined and the dyad and triad compositions of the copolymers were calculated from the obtained values. The synthesized P(VSI-<em>co</em>-Ch(M)A) were subjected to selective hydrolysis of succinimide ring to convert it into succinamic acid. This approach yields a set of bioinspired amphiphilic copolymers based on <em>N</em>-vinylsuccinamic acid (VSAA) and Ch(M)A. The synthesized series of P(VSI-<em>co-</em>Ch(M)A) and P(VSAA-<em>co</em>-Ch(M)A) were used to obtain nanoparticles by nanoprecipitation or self-assembly <em>via</em> direct dissolution in aqueous medium. In addition, the method of surface hydrolysis of VSI units in pre-formed P(VSI-<em>co-</em>Ch(M)A) nanoparticles was applied to produce nanoparticles with hydrophilic negatively charged surface and enhanced stability. All techniques were optimized to prepare nanoparticles with characteristics suitable for systems considered for drug delivery. Successful loading of the antitumor drug irinotecan into nanoparticles was achieved with high encapsulation efficacies. The storage stability of empty and irinotecan loaded nanoparticles were studied in various media (water, saline solution, serum containing cell culture medium) under room and refrigerator conditions. The developed empty nanoparticles exhibited low rate of uptake by macrophages and low cytotoxicity to irinotecan-sensitive colon cancer cells (Caco-2). In turn, the irinotecan-loaded nanoparticles demonstrated inhibitory activity against Caco-2 cells comparable to the free drug.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"222 ","pages":"Article 113586"},"PeriodicalIF":5.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanically strong, reprocessable and chemically recyclable furan-based poly(acylhydrazone)s materials with hydrogen-bonding networks","authors":"Xiaowei Li ,&nbsp;Chilong Liu ,&nbsp;Xiaoru Quan,&nbsp;Yanxin Zhang,&nbsp;Su Wang,&nbsp;Shuangfei Zhao,&nbsp;Jiming Yang,&nbsp;Yirong Feng,&nbsp;Wei He,&nbsp;Kai Guo","doi":"10.1016/j.eurpolymj.2024.113584","DOIUrl":"10.1016/j.eurpolymj.2024.113584","url":null,"abstract":"<div><div>Acylhydrazone linkages are attractive in designing reconfigurable and chemically recyclable polymer due to their reversible characteristics and ease of preparation. We fabricate mechanically strong, thermally stable and chemically recyclable poly(acylhydrazone)s (pDFF-IPDH) using biobased 2,5-diformylfuran (DFF) and dihydrazide compounds as monomers. The linear chains are physically cross-linked via hydrogen bonding between the acylhydrazone moieties. The pDFF-IPDH sample exhibits good mechanical properties, offering both high strength and toughness. The linear and reversible acylhydrazone backbones endow polymers with attractive temperature-dependent dynamic natures, which enables the topological network to rearrange, giving the poly(acylhydrazone)s excellent reprocessability. Moreover, the feasibility of formaldehyde-promoted depolymerization presents an effective recycling pathway, offering promising opportunities in addressing the challenge between recyclability and service performance.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"221 ","pages":"Article 113584"},"PeriodicalIF":5.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in synthesis and applications of Polyaniline-Coated Nanocomposites: A comprehensive review","authors":"Priya Kaushik ,&nbsp;Ruchi Bharti ,&nbsp;Renu Sharma ,&nbsp;Monika Verma ,&nbsp;Richard T. Olsson ,&nbsp;Annu Pandey","doi":"10.1016/j.eurpolymj.2024.113574","DOIUrl":"10.1016/j.eurpolymj.2024.113574","url":null,"abstract":"<div><div>This review explores the synthesis, characterization, and diverse applications of polyaniline (PANI)-based nanocomposites. PANI, known for its tunable electrical conductivity, eco-stability, and cost-effectiveness, has gained significant attention in advanced materials. This study focused on various preparation techniques, such as chemical oxidative polymerization, electrochemical polymerization, and vapor phase polymerization, highlighting their unique characteristics and impacts on nanocomposite performance. Critical applications of PANI nanocomposites are examined, including their roles in supercapacitors, sensors, solar cells, anticorrosion devices, water purification, and catalysis. Integrating PANI with metals, metal oxides, graphene, and carbon nanostructures enhances its functionality, making it a versatile candidate for innovative technological solutions. This review also addresses the challenges in commercializing PANI nanocomposites and proposes future research directions to overcome these obstacles.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"221 ","pages":"Article 113574"},"PeriodicalIF":5.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of organosoluble, quaternized and naproxen sodium- loaded poly(vinyl alcohol)-based electrospun nanofibers","authors":"Gokhan Acik ,&nbsp;Neslihan Turhan Cakir ,&nbsp;Cagatay Altinkok","doi":"10.1016/j.eurpolymj.2024.113565","DOIUrl":"10.1016/j.eurpolymj.2024.113565","url":null,"abstract":"<div><div>Electrospinning is an effective and common method utilized to produce fibers from sub-micrometer to nanoscale. Although poly(vinyl alcohol) (PVA) can be easily electrospun in water, its widespread usage limited in electrospinning applications due to its poor solubility in organic solvents. In this regard, this study concentrated on partially modifying of PVA via chemical transformation by treating with dichloroacetic acid (DCAA) (poly(VA-<em>co</em>-VDCAc)) and triethyl amine (TEA) (poly(VA-<em>co</em>-VDCAc-<em>co</em>-QVAc)), respectively to increase organosolubility as well as provide antibacterial activity. Additionally, the modal drug, namely naproxen sodium (NAP), was incorporated into the modified polymer matrixes by simple blending. Electrospinning method was applied to fabricate the organosoluble, quaternized and NAP-loaded PVA-based nanofibers as potential drug carriers in controlled drug release. The chemical structure, morphology, wettability as well as the thermal features of the obtained nanofibers and their precursors at various stages were investigated using Fourier-transform infrared (FT-IR), proton nuclear magnetic resonance (¹H NMR) spectroscopies, scanning electron microscopy (SEM), water contact angle (WCA) measurements, thermogravimetric and differential scanning calorimetry (TGA and DSC) analyses, respectively. SEM images proved that the nanofibers had noticeably smooth, cylindrical, uniform, and continuous and the modification reactions were affected the mean diameter of the samples. The utilization of modified electrospun PVA-based nanofibers as carrier for delivery of naproxen sodium (NAP) was elucidated. Release behaviors of the electrospun fibers were determined at pH 7.4, and the release of the NAP was faster for non-quaternized sample. Antibacterial activity of electrospun nanofibers against <em>Escherichia coli</em> <!-->(<em>E. coli</em>) and<!--> <em>Staphylococcus aureus</em> (<em>S. aureus</em>) bacteria was evaluated in vitro, and poly(VA-<em>co</em>-VDCAc-<em>co</em>-QVAc)s electrospun nanofibers have better potential in killing bacteria. Overall, this research provides useful guidance for tailoring electrospinning processes for drug delivery of PVA-based materials.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"221 ","pages":"Article 113565"},"PeriodicalIF":5.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Versatile organosilicone porous materials for the detection of nitroaromatics and the visualization of fingerprints","authors":"Yafang Zhang ,&nbsp;Pengfei Hua ,&nbsp;Yanfu Chai ,&nbsp;Yujing Zuo","doi":"10.1016/j.eurpolymj.2024.113576","DOIUrl":"10.1016/j.eurpolymj.2024.113576","url":null,"abstract":"<div><div>Achieving explosive detection and fingerprints visualization at the same time is of great significance. Towards this end, based on the cage structure and multiple reaction sites of octavinyl polyhedral oligomeric silsesquioxane (OVS), a series of multifunctional silicone porous materials <strong>OVSBs</strong> and <strong>OVSTs</strong> were designed and synthesized with 1,3,5-triphenylbenzene and 2,4,6-triphenyl-1,3,5-triazine. These porous materials have narrow pore size distribution, high specific surface area and pony-sized that smaller than 5 nm. The micropore volume ratio of porous materials can be changed by regulating the molar ratio of OVS to functional compounds. <strong>OVSB-2</strong> shows excellent adsorption capacity for fluorescent dyes due to its highest specific surface area and high micropore volume ratio. <strong>OVSB-2</strong> also has superior fluorescence characteristic, which can quickly detect nitroaromatic compounds within 20 s. This work provided a new method for expanding the application of silicone mesoporous materials in explosive detection and fingerprints visualization simultaneously.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"221 ","pages":"Article 113576"},"PeriodicalIF":5.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of free radical/cationic hybrid UV-cured silicone materials with reducing oxygen inhibition via silyl radicals","authors":"Xiaoquan Li ,&nbsp;Fuping Bian ,&nbsp;Rui Huang ,&nbsp;Jiyan Wei ,&nbsp;Xuefeng Gui ,&nbsp;Jiwen Hu ,&nbsp;Shudong Lin","doi":"10.1016/j.eurpolymj.2024.113582","DOIUrl":"10.1016/j.eurpolymj.2024.113582","url":null,"abstract":"<div><div>UV-curing technology is a new, green technology with the advantages of being efficient, energy-saving, and environmentally friendly; however, there is a general oxygen-inhibition problem during the UV-curing process, especially when silicone acrylates are applied to the UV-curing treatment. Herein, epoxy-based silicone prepolymers (ESP) containing Si-H bonds were prepared through the hydrosilylation reaction of poly(dimethylsiloxane-co-methylhydrosiloxane) (PDMS-PHMS) and allyl glycidyl ether (AGE) to graft epoxy groups onto silicone segments while retaining part of the Si-H bond. The epoxy groups in the prepolymers are capable of cationic photopolymerization, and the retained Si-H bonds in the prepolymers can generate highly reactive silyl radicals for initiating free-radical photopolymerization. The anti-oxygen inhibition ability of silicone acrylates was enhanced with the addition of ESPs. Through experimental investigation, it was found that ESP-3 grafted with 0.30% epoxy groups had the best effect on reducing oxygen inhibition, and the silicone acrylates were able to undergo UV curing in air without sticky surfaces when the added amounts of ESP-3 were at 20 wt%. The addition of ESP-3 has no major impact on the transparency and thermal performance of the UV-cured coatings and further enhances their hydrophobic properties. The free radical/cationic hybrid UV-cured silicone materials reduce the problem of oxygen inhibition, and the UV-cured silicone materials have great potential as hydrophobic and self-cleaning materials.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"221 ","pages":"Article 113582"},"PeriodicalIF":5.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D bioprinting of thick core–shell vascularized scaffolds for potential tissue engineering applications","authors":"Zineb Ajji ,&nbsp;Arman Jafari ,&nbsp;Ali Mousavi ,&nbsp;Abdellah Ajji ,&nbsp;Marie-Claude Heuzey ,&nbsp;Houman Savoji","doi":"10.1016/j.eurpolymj.2024.113564","DOIUrl":"10.1016/j.eurpolymj.2024.113564","url":null,"abstract":"<div><div>The promise of tissue engineering in developing functional, living, 3D<!--> <!-->thick structures has been limited due to the constraints of nutrient and oxygen delivery through diffusion. Although<!--> <!-->advancements in additive manufacturing approaches have enhanced the fidelity and complexity of 3D (bio)printed constructs, the vascularization of such scaffolds is less investigated. Here, we have leveraged extrusion-based 3D bioprnting of core/shell constructs to develop millimeter-thick scaffolds with embedded microvasculature for potential soft tissue repair. Composites of methacrylated gelatin (GelMA) and gelatin have been used for this purpose. A systematic approach was used to investigate the effect of<!--> <!-->parameters, such as material and<!--> <!-->photoinitiator concentrations, and photocuring time, on the properties of constructs. Results have shown<!--> <!-->the structures have Young’s modulus close to the soft tissues.<!--> <!-->3D bioprinting parameters were optimized so that the printing and photo crosslinking procedures did not negatively affect the cell viability. It was also observed that a continuous hollow inner core could be successfully printed within the scaffolds, which upon incorporation of endothelial cells during the 3D bioprinting process, could form micro-vessels embedded in the constructs. Together, our results demonstrate the significant potential of the proposed approach for developing thick vascularized tissue-engineered scaffolds suitable for soft tissue engineering.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"222 ","pages":"Article 113564"},"PeriodicalIF":5.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}