Fabrication of pH-responsive smart films from P(3HB-co-4HB) and acetal-modified dextran for controlled drug release

IF 6.3 2区化学 Q1 POLYMER SCIENCE

European Polymer Journal Pub Date : 2025-10-02 DOI:10.1016/j.eurpolymj.2025.114327

Vinod Kumar Kannaujiya , Wilson Ling , Chun Hui Wang , Jin Zhang , Cyrille Boyer

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Abstract

Leveraging the biodegradability and biocompatibility of polyhydroxybutyrate (PHB), this study develops pH-responsive drug delivery films by blending P(3HB-co-4HB) copolymer with acetal-modified dextran (AcDex) via solvent casting. AcDex reduces the crystallinity of P(3HB-co-4HB), increasing stiffness while reducing ductility. The film’s mechanical properties exhibit distinct pH-dependent behaviour: under acidic conditions (pH 5.0), AcDex hydrolysis induces pore formation and reduces mechanical strength, while minimal changes occur at neutral pH (7.4). Exploiting the film’s pH-triggered hydrolysis characteristic, Rhodamine B (RhB) was encapsulated as a model drug to assess release kinetics and understand how significantly it is influenced by film thickness, AcDex content, acetalation degree, and acyclic-to-cyclic acetal ratio. Under acidic conditions, the films demonstrate up to a 6.0-fold increase in RhB release within 24 h compared to neutral pH. These results highlight the potential of AcDex/P(3HB-co-4HB) films as pH-responsive drug delivery systems.

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P（3HB-co-4HB）和缩醛修饰右旋糖酐制备ph响应型药物控释智能膜

利用聚羟基丁酸酯（PHB）的生物可降解性和生物相容性，本研究通过溶剂铸造将P（3HB-co-4HB）共聚物与缩醛修饰的葡聚糖（AcDex）共混，制备ph响应型药物传递膜。AcDex降低了P（3HB-co-4HB）的结晶度，增加了刚度，同时降低了延展性。薄膜的机械性能表现出明显的pH依赖行为：在酸性条件下（pH 5.0）， AcDex水解诱导孔隙形成并降低机械强度，而在中性pH（7.4）下变化最小。利用膜的ph触发水解特性，罗丹明B （Rhodamine B, RhB）被封装为模型药物，以评估其释放动力学，并了解膜厚度、AcDex含量、缩醛化程度和无环缩醛比对其的显著影响。在酸性条件下，与中性ph相比，AcDex/P（3HB-co-4HB）膜在24小时内释放的RhB增加了6.0倍。这些结果突出了AcDex/P（3HB-co-4HB）膜作为ph响应性药物递送系统的潜力。

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来源期刊

European Polymer Journal 化学-高分子科学

CiteScore

9.90

自引率

10.00%

发文量

691

审稿时长

23 days

期刊介绍： European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas: Polymer synthesis and functionalization • Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers. Stimuli-responsive polymers • Including shape memory and self-healing polymers. Supramolecular polymers and self-assembly • Molecular recognition and higher order polymer structures. Renewable and sustainable polymers • Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites. Polymers at interfaces and surfaces • Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications. Biomedical applications and nanomedicine • Polymers for regenerative medicine, drug delivery molecular release and gene therapy The scope of European Polymer Journal no longer includes Polymer Physics.