European Polymer Journal最新文献_第5页

Eco-friendly synthesis of highly stable Au and Ag nanostructures, using a novel poly(p-arsobetaine), and the cytotoxic study in different cell lines

IF 5.8 2区化学

European Polymer Journal Pub Date : 2025-01-30 DOI: 10.1016/j.eurpolymj.2025.113765

Fernando D. Mercado-Pizaño , Ana M. Herrera-González , J. García-Serrano , Sandra Cecilia Esparza-González , A. Lobo Guerrero

{"title":"Eco-friendly synthesis of highly stable Au and Ag nanostructures, using a novel poly(p-arsobetaine), and the cytotoxic study in different cell lines","authors":"Fernando D. Mercado-Pizaño , Ana M. Herrera-González , J. García-Serrano , Sandra Cecilia Esparza-González , A. Lobo Guerrero","doi":"10.1016/j.eurpolymj.2025.113765","DOIUrl":"10.1016/j.eurpolymj.2025.113765","url":null,"abstract":"<div><div>Polyzwitterions have attracted significant interest owing to a surge in research dedicated to the development of new nanotechnologies and applications at the biological level. Polyzwitterion contains ionic groups of opposite sign, commonly on the same pendant groups and generally, most macromolecules with this characteristic are soluble in water, endowing them with unique properties stemming from the electrostatic interactions present. This study presents the design and characterization of a novel poly(<em>p</em>-arsobetaine) as both a reducing agent for Au<sup>+3</sup> and Ag<sup>+1</sup> ions and a stabilizing agent for Au and Ag nanoparticles. Poly(<em>p</em>-arsobetaine) was synthesized through chemical modification, and the precursor products, as well as poly(<em>p-</em>arsobetaine), were characterized using <sup>1</sup>H NMR, FTIR, and TGA techniques. Due to the presence of both amine and arsonic acid groups within the same pendant group, poly(<em>p</em>-arsobetaine) qualifies as a new polyzwitterion. Highlighting, Au and Ag nanoparticles stabilized with poly(<em>p</em>-arsobetaine) in colloidal solution demonstrate non-toxic properties, likely attributed to the green synthesis approach that employs only water and poly(<em>p-</em>arsobetaine), excluding toxic reducing agents and organic solvents during the synthesis of Au and Ag nanoparticles. This finding is significant, as neither the Au and Ag nanoparticles nor poly(<em>p</em>-arsobetaine) exhibit toxicity to healthy HEK293 cells. Nevertheless, Au and Ag nanoparticles stabilized with poly(<em>p-</em>arsobetaine) selectively induce cell death through the apoptosis mechanisms in MCF-7 breast cancer cells.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"227 ","pages":"Article 113765"},"PeriodicalIF":5.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fully biobased epoxy vitrimer from resorcinol diglyceryl ether, vanillin, and 1,10-diaminodecane

IF 5.8 2区化学

European Polymer Journal Pub Date : 2025-01-29 DOI: 10.1016/j.eurpolymj.2025.113749

Long-Yang Zhan, Ping Li, Yi-Dong Li, Yin Ran, Jian-Bing Zeng

{"title":"Fully biobased epoxy vitrimer from resorcinol diglyceryl ether, vanillin, and 1,10-diaminodecane","authors":"Long-Yang Zhan, Ping Li, Yi-Dong Li, Yin Ran, Jian-Bing Zeng","doi":"10.1016/j.eurpolymj.2025.113749","DOIUrl":"10.1016/j.eurpolymj.2025.113749","url":null,"abstract":"<div><div>Biobased epoxy vitrimers (BEVs) offer a promising solution to the recyclability and resource challenges associated with traditional epoxy thermosets. However, numerous existing BEVs suffer from inadequate properties or complex fabrication processes. Herein, we present a fully biobased, high-performance epoxy vitrimer synthesized from renewable and commercially available feedstocks: resorcinol diglyceryl ether (DGER), vanillin (VAN), and 1,10-diaminodecane (DDA). A dynamic imine crosslinker (DIC) was synthesized from VAN and DDA, which then underwent solvent-free and catalyst-free melt curing with DGER to form the BEV. Detailed studies of the curing kinetics of DGER-DIC and the properties of the resulting BEV were conducted, with comparisons to a control fossil-based epoxy vitrimer made from bisphenol A diglycidyl ether (DGEBA) and DIC. The DGER-DIC system showed a curing activation energy of 62.43 ± 3.73 kJ·mol<sup>–1</sup>, slightly lower than DGEBA-DIC’s 67.71 ± 2.38 kJ·mol<sup>–1</sup>. The BEV exhibited excellent mechanical properties, featuring a tensile strength amounting to 69.23 MPa and a Young’s modulus at 1.91 GPa, along with high thermal stability. The imine bonds provided fast stress relaxation, self-healing performance, and excellent reprocessability, with tensile strength recovering over 90 % after multiple processing cycles. These properties rival those of the DGEBA derived epoxy vitrimers, highlighting the potential of DGER as a sustainable alternative for creating recyclable epoxy thermosets.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"227 ","pages":"Article 113749"},"PeriodicalIF":5.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printed biomaterials: From fabrication techniques to clinical applications: A systematic review

IF 5.8 2区化学

European Polymer Journal Pub Date : 2025-01-29 DOI: 10.1016/j.eurpolymj.2024.113606

Amandeep Kaur , Sandeep Singh , Niraj Bala , Sushil Kumar Kansal

{"title":"3D printed biomaterials: From fabrication techniques to clinical applications: A systematic review","authors":"Amandeep Kaur , Sandeep Singh , Niraj Bala , Sushil Kumar Kansal","doi":"10.1016/j.eurpolymj.2024.113606","DOIUrl":"10.1016/j.eurpolymj.2024.113606","url":null,"abstract":"<div><div>The type of biomaterial employed in the manufacturing of an implant determines its success. The material for implants should be easily adaptable, inert biocompatible, and mechanically robust. But the ideal properties may vary depending on the specific application and patient needs. In the pharmaceutical and medical industries, 3D printing technology has revolutionised the capacity to create customised implants for patients that are integrated with bioactive medications, cells, and proteins. Currently, a wide range of biomaterials such as ceramics, polymers, metals, hydrogels and composites are employed in medical 3D printing. Various applications of 3D printing such as manufacture of personalised implants, prostheses, drug delivery systems and 3D scaffolds for biological tissue engineering and regenerative medicine have grown quickly as a result of ongoing research and advancements in the biomaterials used in 3D printing. In this study, novel biomaterials utilised in medical 3D printing techniques are the main subject of interest. Furthermore, the present review sheds light on the most widely used medical 3D printing technologies, including fused deposition modelling, extrusion-based bioprinting, polyjet printing, and inkjet methods, as well as their clinical applications, different biomaterials that are presently under investigation by researchers, and important challenges.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"227 ","pages":"Article 113606"},"PeriodicalIF":5.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shear thinning and self-healing behavior of an IPN nanocomposite based on gelatin methacryloyl/alginate/nano-clay for cartilage tissue engineering application

IF 5.8 2区化学

European Polymer Journal Pub Date : 2025-01-27 DOI: 10.1016/j.eurpolymj.2025.113761

Mahshid Hafezi , Saied Nouri Khorasani , Shahla Khalili , Mehdi Sattari-Najafabadi , Mahsa Najarzadegan , Rasoul Esmaeely Neisiany

{"title":"Shear thinning and self-healing behavior of an IPN nanocomposite based on gelatin methacryloyl/alginate/nano-clay for cartilage tissue engineering application","authors":"Mahshid Hafezi , Saied Nouri Khorasani , Shahla Khalili , Mehdi Sattari-Najafabadi , Mahsa Najarzadegan , Rasoul Esmaeely Neisiany","doi":"10.1016/j.eurpolymj.2025.113761","DOIUrl":"10.1016/j.eurpolymj.2025.113761","url":null,"abstract":"<div><div>Advanced self-healing and shear-thinning hydrogels have garnered significant attention in tissue engineering (TE), especially cartilage TE, due to their tunable and recoverable properties. However, their inadequate mechanical strength negatively affects their application and there is still a lively interest in developing these hydrogels. In this study, we present an innovative interpenetrating polymer network (IPN) nanocomposite hydrogel composed of gelatin methacryloyl (GM), sodium alginate (SA), and nano-clay (NC) with a two-step cross-linking process. The effects of varying NC concentrations on the self-healing, shear-thinning, and rheological properties of the hydrogels were investigated. The GM/SA/NC hydrogels demonstrated remarkable self-healing capabilities, achieving recovery ratios between 93.5% and 95.6% within 120 s of strain application. Notably, these hydrogels recovered 86% to 94% of their original storage modulus immediately upon shear stress removal, highlighting their superior mechanical resilience compared to prior hydrogels. The shear-thinning index (STI) decreased from 1.71 to 1.26, enhancing the material’s processability for TE applications. Additionally, the hydrogels exhibited a robust capacity to withstand cyclic fatigue and recover from damage, solidifying their potential as promising candidates for a variety of TE applications. The resulting IPN nanocomposite hydrogel had desirable characteristics, making it a promising candidate for various TE applications.</div><div>−.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"226 ","pages":"Article 113761"},"PeriodicalIF":5.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of gas barrier properties of chitosan-based composite coatings under humid conditions through palmitic acid grafting

IF 5.8 2区化学

European Polymer Journal Pub Date : 2025-01-26 DOI: 10.1016/j.eurpolymj.2025.113769

Fatima Essabti, Alain Guinault, Sébastien Roland, Matthieu Gervais

引用次数: 0

Organosilicone-based clustered phosphinic acid endows outstanding synergistic flame retardancy of epoxy resins

IF 5.8 2区化学

European Polymer Journal Pub Date : 2025-01-26 DOI: 10.1016/j.eurpolymj.2025.113771

Yize Wang , Lijie Qu , Lijun Qian , Wang Xi , Jingyu Wang , Yong Qiu

{"title":"Organosilicone-based clustered phosphinic acid endows outstanding synergistic flame retardancy of epoxy resins","authors":"Yize Wang , Lijie Qu , Lijun Qian , Wang Xi , Jingyu Wang , Yong Qiu","doi":"10.1016/j.eurpolymj.2025.113771","DOIUrl":"10.1016/j.eurpolymj.2025.113771","url":null,"abstract":"<div><div>In this study, an organosilicone-based clustered phosphinic acid (MVCP) was successfully synthesized by an addition reaction with 2,4,6,8-tetra-methyl-2,4,6,8-tetra-vinyl-<em>cyclo</em>-tetrasiloxane (MVC) and hypophosphorous acid (HPA). MVCP was applied to biscitraconimide-reinforced epoxy resin (BCIEP) systems separately or along with TAD, a 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derivative flame retardant. MVCP/TAD modified BCIEP were investigated systematically concerning on the flame retardancy and mechanism. When the flame retardants containing reached 3 wt%, the limiting oxygen index (LOI) of 3(MVCP/TAD)/BCIEP was increased to 31.2%, while UL 94 reached V-0 level. The peak heat release rate (pk-HRR) of 3(MVCP/TAD)/BCIEP was reduced by 37.3% and the charring residual rate was increased by 7.3% in the cone calorimetry test results, compared to those of BCIEP. Upon combustion, the clustered MVCP formed an aerogel-like residual carbon structure on the surface of the blends through the characteristics of its own silica aggregation, indicating that MVCP was an excellent condensed phase flame retardant. Meanwhile, MVCP reduced the damage of TAD to the mechanical properties of the matrix, showing a broad application prospect.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"227 ","pages":"Article 113771"},"PeriodicalIF":5.8,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

H2O2-responsive mPEG-2-mercapto-1-methylimidazole prodrug nanosystem for enhanced therapeutic efficacy against hyperthyroidism

IF 5.8 2区化学

European Polymer Journal Pub Date : 2025-01-25 DOI: 10.1016/j.eurpolymj.2025.113767

Yue Dai , Dian Zheng , Yanan Zhao , Wenying Wei , Xiaopei Wu , Honglian Dai

{"title":"H2O2-responsive mPEG-2-mercapto-1-methylimidazole prodrug nanosystem for enhanced therapeutic efficacy against hyperthyroidism","authors":"Yue Dai , Dian Zheng , Yanan Zhao , Wenying Wei , Xiaopei Wu , Honglian Dai","doi":"10.1016/j.eurpolymj.2025.113767","DOIUrl":"10.1016/j.eurpolymj.2025.113767","url":null,"abstract":"<div><div>Methimazole (MMI) is a widely used anti-hyperthyroidism drug. To improve the therapeutic effect of MMI and reduce its side effects on thyroid and liver, a new hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) responsive prodrug nanosystem for the therapy of hyperthyroidism was constructed via thiol-Michael addition between MMI and propiolic acid and followed by esterification with polyethylene glycol monomethyl ether (mPEG) and then ultrasonic dispersion. The α, β-unsaturated C = C double bond (−SCH = CHCOO–) in the prodrug could be cleaved by high concentrations of H<sub>2</sub>O<sub>2</sub> (0.3 mM or above) to release MMI, which was verified by <sup>1</sup>H nuclear magnetic resonance (<sup>1</sup>H NMR) and electrospray ionization mass spectrometry (ESI MS). Esterase and weakly acidic pH stimulation could also enhance the drug release. The cell experiment demonstrated that the nanoparticles (NPs) could significantly elevate diseased cell-selective drug release and the released amount could be adjusted according to the level of H<sub>2</sub>O<sub>2</sub> in the diseased cells. In addition, due to the synergy of H<sub>2</sub>O<sub>2</sub>-stimulated drug release and H<sub>2</sub>O<sub>2</sub>-deprivation, the NPs showed a more noticeable inhibition effect on lactoperoxidase (LPO) and were more effective in hyperthyroidism treatment than MMI. More importantly, in vitro cell culture studies and in vivo evaluations demonstrated that the system had markedly reduced thyroid toxicity and hepatotoxicity compared with MMI. It also possessed a prolonged circulating half-life, and could significantly reduce the oxidative damage of thyroid and liver tissues caused by hyperthyroidism. Thus, this nanosystem provides a novel strategy for improving the therapeutic efficacy of MMI against hyperthyroidism.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"228 ","pages":"Article 113767"},"PeriodicalIF":5.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waste tire based thermoreversible elastomeric networks

IF 5.8 2区化学

European Polymer Journal Pub Date : 2025-01-25 DOI: 10.1016/j.eurpolymj.2025.113770

Boumekla Yougourthen , Chataigner Isabelle , Dez Isabelle

引用次数: 0

Glutathione-integrated waterborne polyurethanes: aqueous dispersible, redox-responsive biomaterials for cancer drug delivery

IF 5.8 2区化学

European Polymer Journal Pub Date : 2025-01-23 DOI: 10.1016/j.eurpolymj.2025.113759

Francesco Cancilla , Annalisa Martorana , Calogero Fiorica , Giovanna Pitarresi , Gaetano Giammona , Fabio S. Palumbo

{"title":"Glutathione-integrated waterborne polyurethanes: aqueous dispersible, redox-responsive biomaterials for cancer drug delivery","authors":"Francesco Cancilla , Annalisa Martorana , Calogero Fiorica , Giovanna Pitarresi , Gaetano Giammona , Fabio S. Palumbo","doi":"10.1016/j.eurpolymj.2025.113759","DOIUrl":"10.1016/j.eurpolymj.2025.113759","url":null,"abstract":"<div><div>Waterborne polyurethanes (WPUs) are increasingly recognized for their eco-friendly characteristics and mechanical versatility, offering a sustainable alternative to solvent-based polyurethanes. In this study, redox-responsive glutathione-extended WPUs were developed to enable targeted drug release in the reductive tumour microenvironment. Three WPUs with increasing hydrophilic character were synthesized using a PCL-PEG-PCL triblock copolymer, isophorone diisocyanate and 2,2-bis(hydroxymethyl)propionic acid (DMPA) as an emulsifier, allowing efficient water dispersion of hydrophobic polyurethane segments. A purification process was developed to replace triethylammonium counterions with sodium ions, resulting in a dried polymer easily redispersible in water through autoclaving. Membranes produced from WPU dispersions demonstrated excellent hydrolytic stability and high hydrophilicity. Effective paclitaxel (PTX) loading (40 μg/mg) was achieved during autoclaving and controlled drug release was observed, with increased release rates under reductive conditions. Under homeostatic conditions, less than 20 % of the loaded PTX was released over 16 days, while in a reductive tumour-like environment, the release rate increased to 40 %, indicating strong redox responsiveness. Enhanced cytotoxicity was also observed in HCT-116 cells under simulated reductive conditions. This redox-triggered drug release, responsive to high glutathione levels of tumours, highlights the potential of WPUs for localized cancer therapies. These biomaterials offer a promising platform for developing injectable or implantable WPU-based systems for peritumoral or intratumoral delivery of anticancer drugs, reducing off-target effects and improving treatment efficacy.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"226 ","pages":"Article 113759"},"PeriodicalIF":5.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photopolymerization initiated by aggregation-induced emission (AIE) dyes: Towards design of fluorescent photocatalysts with hybridized excited state

IF 5.8 2区化学

European Polymer Journal Pub Date : 2025-01-22 DOI: 10.1016/j.eurpolymj.2025.113750

Ke Sun , Wenlong Tang , Mingyang Wu , Yuchen Yang , Yizhi Shao , Tao Gong , Yangyang Xu , Hongwei Ma , Jianyong Jin

{"title":"Photopolymerization initiated by aggregation-induced emission (AIE) dyes: Towards design of fluorescent photocatalysts with hybridized excited state","authors":"Ke Sun , Wenlong Tang , Mingyang Wu , Yuchen Yang , Yizhi Shao , Tao Gong , Yangyang Xu , Hongwei Ma , Jianyong Jin","doi":"10.1016/j.eurpolymj.2025.113750","DOIUrl":"10.1016/j.eurpolymj.2025.113750","url":null,"abstract":"<div><div>Despite the truth that organic chromophores were deeply investigated as light-harvesting photocatalysts (PCs) or photoinitiators (PIs), innovative designs on the photoredox catalysts with specific photophysical/chemical characteristics, for instance, chromophores with clear hybridized excited state or aggregation-induced emission (AIE) are rarely reported to conduct visible-light induced polymerization. Here, we newly designed four chromophores as PCs in photopolymerization, with Donor-Acceptor structure and hybrid local and charge-transfer (HLCT) states, in order to provide diradicals with moderate concentrations while inducing the photopolymerization of acrylate monomers under separate light sources with different wavelengths. As results, moderate spin–orbit coupling (SOC) coefficients may assist to depress the retardation or inhibition of photopolymerization processes, which enables to efficiently induce free radical photopolymerization of acrylate monomer upon light irradiation. What’s more, two of them are recognized as typical AIE dyes, direct laser write experiments were thus performed on AIE dye-induced photopolymerization, especially for the water-soluble resin, poly(ethylene glycol) diacrylate (PEGDA), which seems to expand their applications in bio and medical fields as perspective.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"226 ","pages":"Article 113750"},"PeriodicalIF":5.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0