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Journal of Pathology of Nepal最新文献

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Serum anti-thyroid peroxidase antibody in infertile Nepalese women: a hospital-based study 尼泊尔不孕妇女血清抗甲状腺过氧化物酶抗体:一项基于医院的研究
Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.27267
E. Tuladhar, S. Manandhar, M. Raut, A. Bhattarai, V. Sharma, B. Yadav
{"title":"Serum anti-thyroid peroxidase antibody in infertile Nepalese women: a hospital-based study","authors":"E. Tuladhar, S. Manandhar, M. Raut, A. Bhattarai, V. Sharma, B. Yadav","doi":"10.3126/jpn.v10i2.27267","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.27267","url":null,"abstract":"Anti-thyroid peroxidase; Autoimmune; Infertility; Thyroid disease; Background: Infertility is a critical component of reproductive health that can precipitate agony for a couple. Antibodies against thyroid peroxidase can lead to not only autoimmune thyroiditis which is highly prevalent in women, but may also represent a generalized autoimmune milieu in our body that can be associated with infertility. This study aims to assess anti-thyroid peroxidase antibodies in female patients with infertility.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"17 1","pages":"1742-1745"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89536924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Blood transfusion practices in a tertiary care hospital in Nepal 尼泊尔一家三级保健医院的输血实践
Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.30424
A. Shrestha, B. Aryal, A. Poudel, Shraddha Poudel, S. Shrestha, A. Adhikari, Prakrit Chhetri
{"title":"Blood transfusion practices in a tertiary care hospital in Nepal","authors":"A. Shrestha, B. Aryal, A. Poudel, Shraddha Poudel, S. Shrestha, A. Adhikari, Prakrit Chhetri","doi":"10.3126/jpn.v10i2.30424","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.30424","url":null,"abstract":"Blood transfusion; Cross match; Transfusion index; Utilization; Background: Blood transfusion is an integral part of patient management. Good transfusion practice guided by standard protocols is considered ideal for optimal use of resources and manpower. Cross-match requests disproportionate to the actual requirement causes overestimation of blood usage and potential wastage. This study aims to determine the crossmatch, transfusion, and utilization rates for blood using transfusion index, and cross-match to transfusion ratio in the various departments of the hospital for the evaluation of transfusion practices.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"35 1","pages":"1728-1732"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88681233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Hematological and biochemical profile of person with macrocytic anemia in a tertiary health care centre of Nepal 尼泊尔三级保健中心大细胞性贫血患者的血液学和生化特征
Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.30225
R. Pathak, S. Pudasaini, Sushmita Ghimire, Anil Singh Basnyat, Anuj Kc
{"title":"Hematological and biochemical profile of person with macrocytic anemia in a tertiary health care centre of Nepal","authors":"R. Pathak, S. Pudasaini, Sushmita Ghimire, Anil Singh Basnyat, Anuj Kc","doi":"10.3126/jpn.v10i2.30225","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.30225","url":null,"abstract":"Anemia; Folic acid; Macrocytic; Red blood cell indices; Vitamin B12; Background: Anemia is a nutritional problem worldwide with an increased risk of morbidity and mortality in all age groups. Macrocytic anemia often originates from abnormalities that impair the erythroid precursor maturation in the bone marrow. Since the clinical manifestations of different types of anemias are similar, hematological parameters including hemoglobin, Red blood cell indices, and Peripheral Blood Smear examination are useful in the diagnosis of anemia.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"14 1","pages":"1722-1727"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86138957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mixed adenoneuroendocrine carcinoma of proximal stomach; a rare but sinister pathology 胃近端混合性腺神经内分泌癌;一种罕见但邪恶的病理
Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.29050
Deepshikha Gaire, Daisy Maharjan, Nitasha Sharma
{"title":"Mixed adenoneuroendocrine carcinoma of proximal stomach; a rare but sinister pathology","authors":"Deepshikha Gaire, Daisy Maharjan, Nitasha Sharma","doi":"10.3126/jpn.v10i2.29050","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.29050","url":null,"abstract":"Mixed adeno-neuroendocrine carcinoma is a rare tumor of the gastrointestinal tract comprising of both epithelial and neuroendocrine components, each representing at least 30% of the tumor. Diagnosis is based on clinical evaluation, radiological findings, histopathological features in conjunction with immunostaining with specific neuroendocrine markers such as chromogranin, synaptophysin, CD56, and markers of epithelial differentiation such as cytokeratin, CDX2, and carcinoembryonic antigen. A 50-year-old female presented with a history of dysphagia, chest pain, anorexia, and significant weight loss with normal physical findings and baseline investigations. Upper Gastrointestinal endoscopy showed growth at the gastroesophageal junction involving cardia of the stomach. Histopathological examination of the resected mass showed both adenocarcinoma and neuroendocrine carcinomatous components each involving more than 30% of total mass examined. Identifying adenocarcinoma component admixed with a high-grade neuroendocrine component is significant as the prognosis and survival of patients differ from pure adenocarcinoma.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86371313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traumatic ulcerative granuloma with stromal eosinophilia: a series of four cases with review of literature 外伤性溃疡性肉芽肿伴间质嗜酸性粒细胞增多:附4例文献复习
Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.24596
S. Mehta, Rajeshwari K Muthusamy
{"title":"Traumatic ulcerative granuloma with stromal eosinophilia: a series of four cases with review of literature","authors":"S. Mehta, Rajeshwari K Muthusamy","doi":"10.3126/jpn.v10i2.24596","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.24596","url":null,"abstract":"A series of four cases of Traumatic Ulcerative Granuloma with Stromal Eosinophilia in the lateral borders of the tongue were analyzed regarding oral hygiene, sharp tooth, clinical presentation, histology, and follow-up. The lesion manifests as a small solitary ulcer with induration in the oral mucosa mimicking malignancy. Histology revealed ulcers with exudate and granulation tissue with dense polymorphous infiltrate rich in eosinophils. Infiltrate extends down in between the skeletal muscle fibers and salivary gland lobules. A sharp tooth was found to be the inciting factor in a proportion of cases. Histopathological examination is mandatory to confirm the diagnosis and to exclude malignancy and other eosinophil rich disorders. ABSTRACT Sangita Sharma Mehta1, Rajeshwari K Muthusamy1","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"49 1","pages":"1779-1782"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83239975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profile of uncommon primary adult hepatic malignancies at a tertiary care center 在三级保健中心罕见的原发性成人肝脏恶性肿瘤的概况
Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.29933
E. Thomas, A. Venkatasubramanian
{"title":"Profile of uncommon primary adult hepatic malignancies at a tertiary care center","authors":"E. Thomas, A. Venkatasubramanian","doi":"10.3126/jpn.v10i2.29933","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.29933","url":null,"abstract":"Hepatopathology; Liver cancer; Non-hepatocellular liver malignancy; Background: Hepatocellular carcinoma has been the most common primary malignancy of the liver in adults, followed by cholangiocarcinoma. The less common malignancies are those arising from the vascular endothelial cells, neuroendocrine cells, hematolymphoid tissues, and mesenchymal tissues. Imaging studies alone may pose a diagnostic challenge, due to the variable appearances. Histological review of the tissue specimen along with immunohistochemical stains are imperative for diagnosis. However, a multidisciplinary approach is necessary to make an accurate diagnosis and help in management.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"21 1","pages":"1718-1721"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78966771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A brief overview of homologous recombination deficiency testing in cancers for the ‘Next-Generation’ Pathologist 对“下一代”病理学家在癌症中同源重组缺陷检测的简要概述
Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.29862
P. Vijayan, L. Bonilla
{"title":"A brief overview of homologous recombination deficiency testing in cancers for the ‘Next-Generation’ Pathologist","authors":"P. Vijayan, L. Bonilla","doi":"10.3126/jpn.v10i2.29862","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.29862","url":null,"abstract":"Cancer genomics; Genomic scar assay; Homologous recombination deficiency; Homologous recombination repair genes; HRD status of tumors; Mutational signatures; PARPi responsive; Genomic instability is one of the hallmarks of cancer, having a crucial role in cancer pathogenesis as well as tumor proliferation. This essential feature is secondary to dysregulation of DNA damage repair pathways. Homologous repair represents the most reliable double-strand break repair mechanism. Homologous recombination deficiency is responsible for generating and perpetuating DNA damage in cancer, posing an opportunity for targeting treatment with poly(ADP-ribose) polymerase inhibitors through ‘synthetic lethality’, as well as platinum-based agents. Comprehensive genomic analysis has made it possible to discover molecular biomarkers that assist in the identification of Homologous recombination deficient tumors, allowing for the expansion of such treatment strategies to various other malignancies. Leveraging the improvement of genomic analysis methods to be more efficient in identifying Homologous recombination deficiency is crucial in the advancement of cancer care. The current review highlights the current strategies for Homologous recombination deficiency detection, clinical implications, limitations, and applicability. ABSTRACT Poornima Vijayan1, Luisa Bonilla1,2","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"63 1","pages":"1760-1765"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75969274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Handling and processing of pathology samples of suspected or confirmed COVID-19 patient COVID-19疑似或确诊患者病理标本的处理和处理
Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.29792
D. Karki, P. Upadhyaya, Purbesh Adhikari, M. Dahal, J. Yadav
{"title":"Handling and processing of pathology samples of suspected or confirmed COVID-19 patient","authors":"D. Karki, P. Upadhyaya, Purbesh Adhikari, M. Dahal, J. Yadav","doi":"10.3126/jpn.v10i2.29792","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.29792","url":null,"abstract":"COVID-19; Laboratory; SARS-CoV-2; The SARS-CoV-2 has emerged as a major public health concern. Human to human transmission has been confirmed via droplets, contaminated surfaces, and hands. All the staffs and personnel working in the laboratory are also at risk of contracting this infection, especially during the handling and processing of samples from suspected or confirmed patients of COVID-19. With no definite treatment and vaccine in sight, the way forward is to break the chain of transmission by eliminating the risk of exposure to laboratory staffs by proper handling and processing of all the samples in an appropriate containment level laboratory, proper use of PPE with special attention on disposal and decontamination of work surfaces. ABSTRACT Diksha Karki1, Paricha Upadhyaya1, Purbesh Adhikari1, Mona Dahal1, Jitendra Kumar Yadav1 1Department of Pathology, BP Koirala Institute of Health Sciences, Dharan, Nepal","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"431 1","pages":"1766-1771"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78806895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of tumour infiltrating lymphocytes in core needle biopsies and resected specimens of breast carcinoma 乳腺癌穿刺活检及切除标本中肿瘤浸润淋巴细胞的评价
Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.30227
P. Sangam, Priyanka Parmesh
{"title":"Evaluation of tumour infiltrating lymphocytes in core needle biopsies and resected specimens of breast carcinoma","authors":"P. Sangam, Priyanka Parmesh","doi":"10.3126/jpn.v10i2.30227","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.30227","url":null,"abstract":"Results: The mean value of tumor-infiltrating lymphocytes in 34 cases was 27.03% in core needle biopsies and 34.6% in surgically resected specimens. High tumor-infiltrating lymphocytes score was seen in 8 (23.6%) and 11 (32.4%) cases and low to intermediate score was seen in 26 (76.4%) cases and 23 (67.6%) in core needle biopsies and surgically resected specimens respectively. Intermediate and high tumor-infiltrating lymphocytes categories in core needle biopsies accounted for good agreement with surgically resected specimens (60%-intermediate, 87.5 %-high). More than three cores had a better agreement.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"26 1","pages":"1711-1717"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82347850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunophenotyping in incidental gastrointestinal neuroendocrine tumors: study at tertiary care centre 偶发性胃肠道神经内分泌肿瘤的免疫分型:三级保健中心的研究
Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.29754
Rachana Lakhe, R. Swami, Purva Kulkarni, P. Doshi, N. Mani
{"title":"Immunophenotyping in incidental gastrointestinal neuroendocrine tumors: study at tertiary care centre","authors":"Rachana Lakhe, R. Swami, Purva Kulkarni, P. Doshi, N. Mani","doi":"10.3126/jpn.v10i2.29754","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.29754","url":null,"abstract":"Chromogranin; Incidental; Ki67 index; Neuroendocrine; Synaptophysin; Background: Gastrointestinal neuroendocrine tumors are rare slow-growing tumors with distinct histological, biological, and clinical characteristics that have increased in incidence and prevalence in the last few decades. This study is aimed to find out the incidence of neuroendocrine tumors among the gastrointestinal tumors and to grade gastrointestinal neuroendocrine tumors.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"180 1","pages":"1751-1755"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81993143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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