Journal of Pathology of Nepal最新文献

Platelet count and platelet indices in patients of pregnancy-induced hypertension at a rural tertiary care hospital in western India 在印度西部农村三级医院妊娠高血压患者的血小板计数和血小板指数

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.48484

Nagare Mangala, A. Shaikh, Harsha M Dangare

{"title":"Platelet count and platelet indices in patients of pregnancy-induced hypertension at a rural tertiary care hospital in western India","authors":"Nagare Mangala, A. Shaikh, Harsha M Dangare","doi":"10.3126/jpn.v13i1.48484","DOIUrl":"https://doi.org/10.3126/jpn.v13i1.48484","url":null,"abstract":"Background: Pregnancy-induced hypertension is a serious complication during pregnancy causing maternal and fetal morbidity and mortality. Pregnancy-induced hypertension associated with thrombocytopenia can help in predicting the severity of the disease. The study aimed to study the platelet count, and platelet indices in Pregnancy induced hypertension patients and compare them with normotensive pregnant women. \u0000Materials and methods: This was a case control study, conducted on patients visiting antenatal care (ANC) at a Tertiary care rural hospital in western India. Study population included a total of 82 patients, which were divided into 2 groups with 41 patients in each control (healthy pregnant women) and study groups (pregnant women with PIH). Patients with chronic hypertension and known case of thrombocytopenia were excluded from the study. The blood samples collected were processed on fully automated cell counter for estimation of platelet count and indices.\u0000Results: The platelet count in the study group ranged from 186434.1±81086.9 whereas in the control group it was 268659±72206.9, showing that the platelet count was significantly lower in women with Pregnancy induced hypertension than in the control group. The MPV, PDW, systolic BP, diastolic BP was found to be significantly elevated in the study group as compared to the control group.\u0000Conclusions: The present study concludes that blood parameter such as platelets count and platelet indices can be considered as an early, economical and easily available parameter for assessment of severity of PIH cases.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80323280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Esthesioneuroblastoma: an institutional based descriptive study of a rare tumor 感觉神经母细胞瘤:一种罕见肿瘤的制度性描述性研究

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.42524

G. Vasudevan, Srilatha Parampalli Srinivas, P. Jaiprakash, K. Pujary

{"title":"Esthesioneuroblastoma: an institutional based descriptive study of a rare tumor","authors":"G. Vasudevan, Srilatha Parampalli Srinivas, P. Jaiprakash, K. Pujary","doi":"10.3126/jpn.v13i1.42524","DOIUrl":"https://doi.org/10.3126/jpn.v13i1.42524","url":null,"abstract":"Background: Esthesioneuroblastoma is a slow-growing rare malignant neuroectodermal tumor arising from the olfactory epithelium. It has a bimodal incidence with peaks in the second and third decades of life and the sixth and seventh decades of life with equal incidence among men and women. Prognostic factors include the Hyams grade and modified Kadish stage. This study analyzed the clinicopathological features of esthesioneuroblastoma.\u0000Materials and methods- Retrospective study of patients who were diagnosed with esthesioneuroblastoma at a tertiary care hospital between January 2012 and May 2019 was conducted. The research was performed according to the World Medical Association Declaration of Helsinki. Institutional research committee approval (IEC: 473/2019) was obtained.\u0000Results: Clinicopathological profiles of 8 patients who were diagnosed with esthesioneuroblastoma during the period were included. Among the eight patients, five were female and three were male. Common presenting complaints were nasal obstruction, difficulty in breathing, epistaxis, local pain, and anosmia. The average age of presentation was 52 years, ranging from 14 to 73 years. Anterior rhinoscopic examination in these cases showed a polypoid mass located in the nasal cavity. According to the Hyams grading system, three of the eight cases were grade-2 and the remaining five cases were grade-3 Hyams histological grade. Three cases exhibited foci of ganglioneuroblastic transformation. Three patients had metastases to cervical lymph nodes and three patients had recurrence.\u0000Conclusions: Esthesioneuroblastoma is a rare aggressive malignant tumor. It can exhibit divergent epithelial or ganglionic differentiation. A proper diagnosis should be made, graded and staged before proceeding to treatment.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90672990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of expression of Cyclin D1 and E-cadherin with gleason grade, serum prostate specific antigen levels and prostatic volume in prostatic carcinoma 前列腺癌中Cyclin D1和E-cadherin表达与gleason分级、血清前列腺特异性抗原水平和前列腺体积的相关性

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.42969

C. Aatirah, J. Bhatia, J. Sandhu, Ravjot Singh Bhatia

{"title":"Correlation of expression of Cyclin D1 and E-cadherin with gleason grade, serum prostate specific antigen levels and prostatic volume in prostatic carcinoma","authors":"C. Aatirah, J. Bhatia, J. Sandhu, Ravjot Singh Bhatia","doi":"10.3126/jpn.v13i1.42969","DOIUrl":"https://doi.org/10.3126/jpn.v13i1.42969","url":null,"abstract":"Background: Prostate cancer is increasingly being diagnosed early due to easy access and availability of better diagnostic modalities. Gleason scoring is important for prognosis and is used to determine the management protocol. As the behavior of these tumors is unpredictable, many markers are being investigated. Cyclin D1 and E-Cadherin have been linked to the development, progression, and aggressiveness in some studies. We studied the expression of E cadherin and cyclin D1 in various grades to understand their relationship with clinicopathologic features, PSA, and prostatic volume.\u0000Material & methods: 52 patients diagnosed with prostatic adenocarcinoma on core biopsy after ethical clearance in our tertiary care center were included in the study and their records were retrieved. Hematoxylin and Eosin stained sections were used for Gleason scoring as well as Gleason grade group as per existing protocols. Immunohistochemistry using antibodies against Cyclin D1 and E-Cadherin along with appropriate controls was performed. Studied parameters were correlated with E-Cadherin and cyclin D1. We used a statistical software package (version 22, IBM, US).\u0000Results: Cyclin D1 showed increasing immunoexpression with an increase in Gleason score and Gleason grade group emphasizing a significant correlation between these parameters (p= 0.001). There was a significant negative association between E-cadherin score, Gleason score, and Gleason grade group (p=0.001). No correlation was obtained with serum PSA or prostatic volume.\u0000Conclusions: E-cadherin and Cyclin D1 dysregulation could be used as prognostic and predictive markers in prostatic carcinoma.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86059985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental Inguinal Tubercular Lymphadenitis in a female of Androgen Insensivity Syndrome- A rarest of rare presentation 偶发腹股沟结核性淋巴结炎的女性雄激素不敏感综合征-罕见的罕见的表现

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.51477

Paridhi, S. Bahadur, Madhuvan Gupta, Shalini Shukla, S. Kalhan, D. Goel, Deeksha Singh, Vivek Gupta

引用次数: 0

A clinicopathological study of sinonasal lesions-5 years study in a rural hospital setup 鼻窦病变的临床病理研究——农村医院5年研究

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.53143

Savita Dongapure, Anand Anantharao Shankar, R. Parthibhan

{"title":"A clinicopathological study of sinonasal lesions-5 years study in a rural hospital setup","authors":"Savita Dongapure, Anand Anantharao Shankar, R. Parthibhan","doi":"10.3126/jpn.v13i1.53143","DOIUrl":"https://doi.org/10.3126/jpn.v13i1.53143","url":null,"abstract":"Background: Sinonasal lesions of both non-neoplastic and neoplastic variants are frequently observed by clinicians in the nasal cavity and paranasal sinuses. Sinonasal lesions are important due to divergence in their behavior and prognosis. Hence, a careful histological workup remains the mainstay of a final definitive diagnosis and timely intervention.\u0000Materials and methods: A prospective analysis was done on 151 patients of Sinonasal masses who presented to the Department of Otorhinolaryngology, MVJ Medical College and Hospital, from 2014 to 2019. Their biodata, clinical profile, and histopathological diagnosis were analyzed.\u0000Results: Non-neoplastic lesions (135 cases, 89.4%) were more frequent than neoplastic lesions (16 cases, 10.59%), and showed male predominance with an M: F ratio of 1.7:1. Nasal polyp (119 cases, 88%) was the most common lesion. Nasal obstruction (89 cases 89.45%) was the most common presenting feature. Among the neoplastic lesions, lobular capillary hemangioma was the most common benign lesion (2 cases,50%), and squamous cell carcinoma 2 cases (18.1%), was the most common malignant lesion.\u0000Conclusions: Sinonasal masses can present with overlapping clinical features, hence, it is important to categorize them into non-neoplastic and neoplastic lesions for further management. Histopathology remains the gold standard for establishing the diagnosis in such cases.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83286173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cavernous hemangioma in adult parotid gland encroaching on the parapharyngeal space: A case report 成人腮腺海绵状血管瘤侵犯咽旁间隙1例

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.54473

Manish Regmi, Prabesh Adhikari, Rojin Thapa, Rohit Khadgi

引用次数: 0

Assessment of thyroid lesions using fine-needle aspiration cytology in accordance with The Bethesda System and its histopathological correlation - A prospective study. 根据Bethesda系统使用细针穿刺细胞学评估甲状腺病变及其组织病理学相关性-一项前瞻性研究。

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.50879

Himachal Mishra, Manika Alexander, B. Bommanahalli

{"title":"Assessment of thyroid lesions using fine-needle aspiration cytology in accordance with The Bethesda System and its histopathological correlation - A prospective study.","authors":"Himachal Mishra, Manika Alexander, B. Bommanahalli","doi":"10.3126/jpn.v13i1.50879","DOIUrl":"https://doi.org/10.3126/jpn.v13i1.50879","url":null,"abstract":"Background: Fine Needle Aspiration Cytology is a first-line diagnostic technique that provides an accurate and precise diagnosis for assessing thyroid abnormalities. This study was conducted to analyze the cytology smears of thyroid lesions using The Bethesda system of reporting thyroid cytology and to correlate the cytological findings with histopathology diagnosis to determine the diagnostic accuracy of FNAC.\u0000Materials and methods: A prospective cross-sectional study was carried out. FNAC of thyroid lesions of 203 patients were examined and reported as per the Bethesda system for reporting thyroid cytopathology. Of these, 33 patients underwent surgery, whose histopathological findings were compared and correlated with respective cytopathological diagnoses. The IBM SPSS (Statistical Package for the Social Sciences) software version 27 was used for data analysis.\u0000Results: Among 203 cases evaluated, there were 11 Non-diagnostic (Category I) cases, 171 benign (Category II) cases, 4 cases of atypia of undetermined significance (Category III), 7 were suspicious for Follicular Neoplasm (Category IV), 2 were suspicious for malignancy (Category V) and 8 were malignant (Category VI). Out of 203 patients, only 33 patients underwent surgery, of whom 26 (78.79%) were benign and 7 (21.21%) were malignant on histopathology. The corresponding values for sensitivity, specificity, and diagnostic precision of FNAC were 71.42%, 100%, and 93.93% respectively, while positive and negative predictive values were determined as 100% and 92.85% respectively.\u0000Conclusions: The study shows that thyroid tumors can be successfully categorized and reported cytologically as per The Bethesda system.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83668475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACTH more than 2000 pg/ml; is it immunoassay interference or another matter? ACTH > 2000 pg/ml;是免疫分析干扰还是其他问题?

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.54455

Vivek Pant, S. Pradhan

引用次数: 0

ISO 15189:2022; what’s new in new? ISO 15189:2022;新事物中的新事物是什么?

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.52487

S. Pradhan, K. Gautam, Vivek Pant

引用次数: 0

Histomorphological patterns of skin adnexal tumours with an insight into molecular updates - A single institutional study 皮肤附件肿瘤的组织形态学模式与洞察分子更新-一个单一的机构研究

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.43167

S. Kandasamy, R. Murugan, G. Vasugi, Kumudhini Priya Gunasekaran

引用次数: 0