Journal of Pathology of Nepal最新文献_第2页

Study of blood group and platelet counts in ER and ENT patients with epistaxis 急诊及耳鼻喉科出血患者血型及血小板计数的研究

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.54149

B. Pradhan, Raunak Bista, B. Bhattarai, Ashaya Luitel, Sujan Pandey, S. Pradhan

{"title":"Study of blood group and platelet counts in ER and ENT patients with epistaxis","authors":"B. Pradhan, Raunak Bista, B. Bhattarai, Ashaya Luitel, Sujan Pandey, S. Pradhan","doi":"10.3126/jpn.v13i1.54149","DOIUrl":"https://doi.org/10.3126/jpn.v13i1.54149","url":null,"abstract":"Background: Epistaxis is one of the most common emergencies and a very difficult problem to tackle especially in Primary Health Centers or Health Posts in rural areas of Nepal. The objective of the study was to identify blood group and platelet count with the occurrence of nasal bleeding.\u0000Materials and Methods: A prospective study was carried out among 96 patients visiting Kathmandu Medical College and Teaching Hospital in Emergency Department and ENT Department with epistaxis from October 2021 to October 2022. Ethical clearance was obtained from IRC Kathmandu Medical College Teaching Hospital (reference no: 0609202105). A blood sample was sent for blood groups and platelet count. Convenience sampling was used. Data were entered in Microsoft Excel 2016 and analyzed in Statistical Package for Social Sciences version.\u0000Results: The age group of 20-29 years was found to be the commonest age group presented with epistaxis. The commonest blood group with epistaxis was found to be O+ve and platelet count was found to be within the normal range in the majority of the cases.\u0000Conclusions: Epistaxis was found to be more common among patients with O+ve than non ‘O’ blood groups. Patients with Blood group O+ve need to be investigated further for coagulation profile before any kind of procedure.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84132966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on the usage and wastage of blood components in blood bank of B.P. Koirala Institute of Health Sciences, Dharan 柯伊拉腊卫生科学研究所血库血液成分使用及浪费的研究

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.30588

Moushami Singh, A. Pradhan, Punam Poudyal

{"title":"A study on the usage and wastage of blood components in blood bank of B.P. Koirala Institute of Health Sciences, Dharan","authors":"Moushami Singh, A. Pradhan, Punam Poudyal","doi":"10.3126/jpn.v13i1.30588","DOIUrl":"https://doi.org/10.3126/jpn.v13i1.30588","url":null,"abstract":"Background: Human blood till date has no substitute. Transfusion of blood and its components is a lifesaving procedure. Hence, optimum utilization and minimum wastage of blood and its components should be strictly monitored.\u0000 Materials and Methods: This is a prospective study conducted on data collected from the blood bank of B.P. Koirala Institute of Health Sciences, Dharan, Nepal for a duration of 1 year from year 2015 to 2016. The sample size was calculated by using systematic random sampling with every third sampling interval sample collection method. The study included usage and wastage of packed red blood cells, platelet concentrate, fresh frozen plasma, and cryoprecipitate including data on the supply of blood components to different departments, age distribution, gender distribution, and distribution of blood components based on blood groups.\u0000 Results: A total of 1641 units of blood component were included in the study. A total of 92.9% (1524 units) were used and 7.13% (117 units) were wasted. The renal disorder was the most common cause of blood component utilization. The medicine department utilized the majority of the blood components. The expiry was the most common cause of wastage. Among the wasted blood components, platelet concentrate was the maximum. \u0000Conclusion: Blood components are a life-saving resource. It should be evaluated and analyzed properly for utilization in a justifiable manner. The hospital should act in accordance so that maximum blood components are utilized in a safe manner and waste is minimized to the least.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88146074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study to determine between HbA1C and C-reactive protein in Diabetes mellitus 糖尿病患者HbA1C与c反应蛋白的相关性研究

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.55583

D. Gautam, S. Adhikari, Rojin Thapa, Larisha Kharel

{"title":"Study to determine between HbA1C and C-reactive protein in Diabetes mellitus","authors":"D. Gautam, S. Adhikari, Rojin Thapa, Larisha Kharel","doi":"10.3126/jpn.v13i1.55583","DOIUrl":"https://doi.org/10.3126/jpn.v13i1.55583","url":null,"abstract":"Background: Studies have shown that C-reactive protein, as an inflammatory marker, is an important risk factor for insulin resistance and type 2 DM. Measurement of inflammatory markers like CRP will improve the prediction of the risk of these events. The aim of this study was to investigate the relationship between hemoglobin A1c, one of the indicators of diabetes, and the highly sensitive C-reactive protein, one of the indicators of inflammation.\u0000Materials and Methods: This prospective observational study was carried out in the Department of Pathology, Patan Hospital. This study included each 154 subjects of Type 2 diabetic patients and healthy control. Statistical analysis was done using Pearson’s correlation test and data was expressed as mean ±SD for each parameter. A p-value of < 0.05 was considered to be significant.\u0000Results: Most (57.7%) of the patients were between 40 to 60 years with a female preponderance of (0.5:1). The HbA1c and CRP values were high in the case group compared to the control group and analysis shows statistical significance. There was a statistically significant association between CRP level in the diabetic group (patient with HbA1C greater than 5.7%) than in the control group (patient with HbA1C equal to or less than 5.7%) (p- Value=0.005).\u0000Conclusions: Higher HbA1c levels are associated with increased CRP, demonstrating that poorly controlled diabetes mellitus is associated with increased systemic inflammation. Timely screening and early detection of elevated CRP in diabetes mellitus patients can prevent further complications and consequences.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89569757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathologic study of endometrium in cases of abnormal uterine bleeding 子宫异常出血的子宫内膜组织病理学研究

Journal of Pathology of Nepal Pub Date : 2023-07-12 DOI: 10.3126/jpn.v13i1.40891

J. Bindhuja

{"title":"Histopathologic study of endometrium in cases of abnormal uterine bleeding","authors":"J. Bindhuja","doi":"10.3126/jpn.v13i1.40891","DOIUrl":"https://doi.org/10.3126/jpn.v13i1.40891","url":null,"abstract":"Background: Abnormal uterine bleeding is one of the most common presenting symptoms among women visiting the gynecology outpatient department. Sonography and endometrial biopsy are the usual methods of evaluation; rarely, invasive procedures like hysteroscopy may be needed. Endometrial sampling can be used as a first step in the evaluation. This study was done to analyze the histopathology of the endometrium and to evaluate the causes of abnormal uterine bleeding.\u0000Materials and Methods: Endometrial samples were obtained using dilation and curettage from 50 women presenting to the gynaecology outpatient department with abnormal uterine bleeding symptoms in a medical college hospital.\u0000Results: Among the 50 cases, 21 were found to have endometrial hyperplasia (72.4%); 24 were diagnosed to have an organic lesion (48%). The endometrium was found to be in the proliferative phase in the majority of the cases (40%). The most common age group was 31-40 years and simple cystic hyperplasia was the commonest endometrial pattern. Single-parity women were most commonly affected and they showed a secretory endometrium under microscopy.\u0000Conclusions: Endometrial sampling should be carried out in every patient with abnormal uterine bleeding to study the histopathology of the endometrium and to evaluate the causes of the disease.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86406146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histomorphological pattern of lesions of cystoscopic bladder biopsies in a tertiary center in Nepal- A retrospective descriptive study 在尼泊尔三级中心膀胱镜活检病变的组织形态学模式-回顾性描述性研究

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.46081

A. Shrestha, A. Regmi, Abilasha Rana, Sony Ghimire, Prakat Karki, Sajina Thapa, Amit Shrestha, Rewant Singh

{"title":"Histomorphological pattern of lesions of cystoscopic bladder biopsies in a tertiary center in Nepal- A retrospective descriptive study","authors":"A. Shrestha, A. Regmi, Abilasha Rana, Sony Ghimire, Prakat Karki, Sajina Thapa, Amit Shrestha, Rewant Singh","doi":"10.3126/jpn.v12i2.46081","DOIUrl":"https://doi.org/10.3126/jpn.v12i2.46081","url":null,"abstract":"Background: Bladder cancer accounts for 3% of all cancer diagnoses and is one of the most common cancers worldwide. Bladder tumors have different subtypes and behavioral patterns. This study is performed in the pathology department of Shree Birendra Hospital. It is a data review done on cystoscopic bladder biopsy results for the past 5 years to study the histomorphological patterns of various bladder lesions.\u0000Materials and Methods: This is a descriptive cross-sectional study done on cystoscopic bladder biopsy results. A hospital register-based retrospective study was conducted on the data of five years duration. The epidemiological parameters were calculated using Microsoft Excel.\u0000Results: A total of 56 cystoscopic biopsies were performed during the study period of 5 years. Among them, 45(80.36%) were male and 11(19.64%) were female. The peak incidence was seen in the age group 70-79 years (26.78%). The majority of the patients had neoplastic lesions (83.92%). The peak incidence of neoplastic lesions also belonged to the age group 70-79 years (31.19%). The most common malignant lesion was papillary urothelial carcinoma i.e. 45 cases (95.74 % among the neoplastic lesions and 80.36% among all the total bladder lesions)\u0000Conclusions: Among the bladder lesions that have undergone cystoscopic biopsies, urothelial carcinoma is the most common with male predominance. The early and definitive diagnosis with accurate grading and staging of bladder tumors can be done by histopathology. Early identification of bladder tumors has an impact on the therapeutic approach as well.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84117519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histological study of endoscopic biopsies from the lower gastrointestinal tract 下消化道内镜活检的组织学研究

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.45248

L. Banstola, Suresh Thapa, Suresh Raj Poudel, Bhoj Raj Gautam

引用次数: 0

Tumor-associated tissue eosinophilia in preinvasive and invasive squamous cell carcinoma of cervix 侵袭前和侵袭性宫颈鳞状细胞癌的肿瘤相关组织嗜酸性粒细胞增多

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.40313

Radhika C Sasturkar, Ramesh Bh, Sunita Nyamagoudar, Sateesh S Jigjini

{"title":"Tumor-associated tissue eosinophilia in preinvasive and invasive squamous cell carcinoma of cervix","authors":"Radhika C Sasturkar, Ramesh Bh, Sunita Nyamagoudar, Sateesh S Jigjini","doi":"10.3126/jpn.v12i2.40313","DOIUrl":"https://doi.org/10.3126/jpn.v12i2.40313","url":null,"abstract":"Background: Differentiating between preinvasive and invasive squamous neoplasms of the cervix can be a challenge in small, superficial fragments of cervical biopsy, particularly when inflammatory infiltrates obscure the epithelial stroma interface and due to tangential sectioning of the acanthotic squamous epithelium. This study evaluates whether thresholds of eosinophils in stroma serve as a morphological marker for the presence of tumor invasion in squamous neoplasms of the cervix.\u0000Material and methods: Sixty-five cases of invasive squamous cell carcinoma and preinvasive squamous neoplasia were evaluated. In each case, the number of eosinophils per HPF and per 10 HPF in the tissue adjacent to the neoplastic epithelium was counted. For statistical purposes, the elevated eosinophils were categorized as > 3 eosinophils/HPF, > 5 eosinophils/HPF, and >10/10 HPF.\u0000Results: Stromal eosinophils were present in 1/5 cases of LSIL, 3/8 HSIL cases, 15/16 cases of microinvasive squamous cell carcinoma, and 34/36 cases of invasive squamous cell carcinoma, signifying an increase in eosinophil count from a spectrum of preinvasive to invasive carcinoma. Greater than 5 eosinophils/HPF and >10 eosinophils/10 HPF had sensitivity, specificity, and positive predictive values of 55%, 100%, 100%, and 75%, 100%and 100%, respectively. The difference of >5eosinophils/HPF and >10eosinophils/10 HPF between SIL and SCC was statistically significant.\u0000Conclusions: Our study suggests that the presence of increased eosinophils in squamous neoplasia of the cervix can be associated with tumor invasion and should prompt a thorough evaluation when evidence of invasion is absent.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82587661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematologic parameters in thrombocytopenic patients with dengue fever 登革热伴血小板减少患者的血液学参数

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.52485

Aasiya Rajbhandari, M. Shrestha, Prakriti Shah, S. Adhikari

{"title":"Hematologic parameters in thrombocytopenic patients with dengue fever","authors":"Aasiya Rajbhandari, M. Shrestha, Prakriti Shah, S. Adhikari","doi":"10.3126/jpn.v12i2.52485","DOIUrl":"https://doi.org/10.3126/jpn.v12i2.52485","url":null,"abstract":"Background: Dengue fever is an endemic disease in Nepal that has shown increasing incidence each passing year. Dengue has a wide range of clinical presentations and laboratory findings. Thrombocytopenia is a common finding in dengue-infected patients along with other findings like leukopenia, lymphocytosis, raised hematocrit, and elevated liver enzymes. Thrombocytopenia is an indicator of disease severity and can lead to severe bleeding manifestations. This study aims to find the association of thrombocytopenia with other hematologic parameters.\u0000Materials and methods: This retrospective study enrolled 651 dengue patients tested at Patan Academy of Health Sciences who also underwent complete blood count at presentation.\u0000Results: Dengue-infected patients of all age groups with a slight male predominance. Thrombocytopenia was noted in 48.69% of cases. Thrombocytopenia showed a significant association with age (p=0.009), total leukocyte count(p=0.00), and hemoglobin levels (p= 0.015).\u0000Conclusions: Thrombocytopenia in dengue patients is frequently encountered. Increasing age, leukopenia, and anemia are factors significantly associated with thrombocytopenia at presentation.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78474752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete blood counts parameters and neonatal sepsis 全血细胞计数参数与新生儿败血症

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.53167

Shiva Raj K.C., Purnima Gyawali, A. Dhakal, Geetika K C, D. Shrestha

{"title":"Complete blood counts parameters and neonatal sepsis","authors":"Shiva Raj K.C., Purnima Gyawali, A. Dhakal, Geetika K C, D. Shrestha","doi":"10.3126/jpn.v12i2.53167","DOIUrl":"https://doi.org/10.3126/jpn.v12i2.53167","url":null,"abstract":"Background: Neonatal sepsis is one of the common causes of neonatal mortality. Blood culture is the gold standard procedure to confirm sepsis. However, the rapid rate of disease progression makes its timely diagnosis and prompt management very crucial before the availability of culture. The study aimed to determine the significance of complete blood count parameters including platelet indices in diagnosing neonatal sepsis.\u0000Materials and Methods: This study included 129 suspected cases of neonatal sepsis admitted to KIST Medical College Teaching Hospital from 15th April 2018 to 14th April 2019. Complete blood count, platelet indices, micro erythrocyte sedimentation rate, C-reactive protein, and blood culture were performed and analyzed.\u0000Results: Of 129 suspected neonatal sepsis, abnormal leukocyte count was encountered in 31 (24.0%) patients. Culture-proven sepsis was seen in 25 (19.1%) patients. The sensitivity and specificity of Neonatal Sepsis Screening Criteria were 10.0% and 80.0% respectively.\u0000Among platelet-derived indices, PDW (full form) had a sensitivity of 80% and specificity of 56% with a cut of 17.02 CV. MPV (full form), with a cut-off value of 9.78 fL had a sensitivity of 88 % with a specificity of 59%. Both MPV and PDW had low positive predictive values (33.3%) but a high negative predictive value (95.2%).\u0000Conclusions: Along with total leukocyte count, platelet indices have shown their significance in determining neonatal sepsis with significant negative predictive value. The addition of MPV and PDW to the Neonatal Sepsis Screening Criteria might help the treating physician to rule in or rule out neonatal sepsis and manage it accordingly.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77069853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Histopathological spectrum of intrathoracic lesions 胸内病变的组织病理学谱

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.31815

M. Kamath, P. Shetty

引用次数: 0