Journal of Pathology of Nepal最新文献_第3页

Utility of D-dimer and other biomarkers in COVID-19 patients - A prospective study in a tertiary care center d -二聚体和其他生物标志物在COVID-19患者中的应用——三级医疗中心的一项前瞻性研究

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.37752

I. A, J. K, Shridevi Sh, Bharat C

{"title":"Utility of D-dimer and other biomarkers in COVID-19 patients - A prospective study in a tertiary care center","authors":"I. A, J. K, Shridevi Sh, Bharat C","doi":"10.3126/jpn.v12i2.37752","DOIUrl":"https://doi.org/10.3126/jpn.v12i2.37752","url":null,"abstract":"Background: Clinical status and concurrent comorbidities of COVID-19 patients largely determine the need for their admittance to ICUs, similarly, several laboratory parameters like D-dimer, LDH, serum ferritin, CRP, and IL-6 may facilitate the assessment of disease severity and rational triaging. Therefore, their role in the management of COVID-19 patients has to be assessed.\u0000Materials and methods: Prospective study was done on patients who were tested positive for COVID-19 infection and admitted to various centers under the Vijayanagara Institute of Medical Sciences, India. Patients were divided into mild, moderate, and severe cases. Demographic data and serum levels of biomarkers like D-dimer, LDH, ferritin, CRP, and IL-6 were collected in these patients, and data were statistically analyzed.\u0000Results: A total of 164 cases were included in this study, of which, 62 were mild, 47 moderate, and 55 were severely infected COVID-19 patients. There was male predominance in patients infected with COVID-19. The median age of presentation was 53, 60, and 57 years in mild, moderate, and severe cases respectively. Median was also derived for D-dimer, LDH, serum ferritin, CRP, and IL-6 in mild, moderate, and severe cases. Changes in D-dimer, LDH, and serum ferritin levels in mild, moderate, and severe cases showed statistical significance(p<0.05).\u0000Conclusions: D-dimer helps in the early identification of mild, moderate, and severe cases and can be used for the vigilant monitoring of patients. LDH and serum ferritin helps in the identification of oxygen-dependent and oxygen-independent patients. The role of CRP and IL-6 in the management of COVID-19 patients has to be further investigated.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91067310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A digital fibromyxoid tumor: a case report 指纤维黏液样瘤1例

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.45260

Krishnanand Jha, S. Shrestha, S. Kafle

引用次数: 0

Role of image guided fine needle aspiration cytology of lung lesions in patients visiting Gandaki Medical College 影像引导下细针穿刺细胞学检查在甘达基医学院患者肺部病变中的作用

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.51747

S. Ranabhat, S. Poudel, G. Pun, Anita Awale

{"title":"Role of image guided fine needle aspiration cytology of lung lesions in patients visiting Gandaki Medical College","authors":"S. Ranabhat, S. Poudel, G. Pun, Anita Awale","doi":"10.3126/jpn.v12i2.51747","DOIUrl":"https://doi.org/10.3126/jpn.v12i2.51747","url":null,"abstract":"Background: Computed Tomography guided Fine needle aspiration cytology of lung mass is an effective modality to diagnose lung cancer. Its use has been extended in differentiating lung tumors into various cytomorphological types so that it becomes easier for further treatment. The study is aimed to study the morphological features of various types of lung lesions, correlate with histopathology wherever possible and evaluate the sensitivity, specificity, and accuracy of fine needle aspiration cytology procedure.\u0000Materials and Methods: It is an observational cross-sectional study conducted in the Department of Pathology of Gandaki Medical College and Teaching Hospital from April 2018 to December 2020 and 109 cases were included.\u0000Results: In the study, 109 cases were included, female were 61(56%) while males were 48(44%) with an M: F ratio is 1:1.2. The maximum number of cases was seen in the age >70 years (45.9%), mean age being 68.4years. Smoking was seen in 66(60.6%) cases. Squamous cell carcinoma (SCC) 32( 29.4%) was the most common cytological finding followed by adenocarcinoma 20(18.3%). Similarly, SCC was the most common histopathological finding which comprised 30( 53.5%) followed by adenocarcinoma 14(25%). Fine needle aspiration cytology and histopathological diagnosis are significantly associated with a p-value <0.001. The sensitivity, specificity, and accuracy of fine needle aspiration cytology were 76%,80%, and 76.6% respectively.\u0000Conclusions: Computes tomography-guided fine needle aspiration cytology is a relatively safe, inexpensive, and accurate procedure in the diagnosis of different lung lesions for early diagnosis and appropriate treatment.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"9 30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82008359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increment in hemoglobin and hematocrit levels after blood transfusion in a tertiary care hospital 三级医院输血后血红蛋白和红细胞压积水平的升高

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.52822

Prakriti Shah, M. Shrestha, Aasiya Rajbhandari, Rohit Khadgi, Prayash Chand

{"title":"Increment in hemoglobin and hematocrit levels after blood transfusion in a tertiary care hospital","authors":"Prakriti Shah, M. Shrestha, Aasiya Rajbhandari, Rohit Khadgi, Prayash Chand","doi":"10.3126/jpn.v12i2.52822","DOIUrl":"https://doi.org/10.3126/jpn.v12i2.52822","url":null,"abstract":"Background: Blood transfusion is considered to be the first line of therapy for all types of anemia. One unit of blood transfusion is known to increase the hemoglobin level by 1g/dl and hematocrit by 3%. This study aims to analyze the mean increment in hemoglobin and hematocrit levels after 1-unit of blood transfusion in a tertiary care hospital.\u0000Materials and Methods: A retrospective study was done. 133 patients with 1-unit of blood transfusion (whole blood or packed red blood cells)having pre and post-transfusion hemoglobin and hematocrit values were enrolled in the study.\u0000Results: Patients of all diagnoses, who received blood transfusion were enrolled, with the highest proportion (27.1%) in the age group 18-35 years. Male predominance was seen (57.1%) and a majority of the patients were on hemodialysis (57.9%). The most common blood group was B positive (30%) and 90.9% were Rh positive. 48 patients were transfused with whole blood and 85 were transfused with packed red blood cells. The mean increment in hemoglobin and hematocrit levels were 0.75 ± 2.21 and 2.47 ± 6.84 respectively. A significant increment in post-transfusion parameters was seen compared with pre-transfusion parameters (p <0.001).\u0000Conclusions: A mean increment in hemoglobin and hematocrit level was seen in patients after transfusion. However, the value of the increment is low in our study as compared to the literature. This may be due to varied reasons, ranging from a history of chronic disease, acute bleeding, the volume of other fluids administered, and the characteristics of the donor.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85237280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of tumor infiltrating lymphocytes in breast carcinomas 乳腺癌肿瘤浸润淋巴细胞的评价

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.47200

S. Karki, S. B. Tiwari, A. Basnet

{"title":"Evaluation of tumor infiltrating lymphocytes in breast carcinomas","authors":"S. Karki, S. B. Tiwari, A. Basnet","doi":"10.3126/jpn.v12i2.47200","DOIUrl":"https://doi.org/10.3126/jpn.v12i2.47200","url":null,"abstract":"Background: Among the parameters that have a prognostic and/or predictive significance to therapeutic response, in the case of breast carcinoma, the study of tumor-infiltrating lymphocytes in breast carcinomas is emerging. The present study aimed to access the clinicopathological profiles of tumor-infiltrating lymphocytes in patients with primary breast carcinoma.\u0000Materials and Methods: Information was collected from the archive of the Department of Pathology, about invasive breast cancers diagnosed between April 2019 –March 2020. Hormone receptor status and Ki-67 index were assessed. For tumor-infiltrating lymphocytes, hematoxylin and eosin sections were evaluated following the guidelines of the “International Working Group for tumor-infiltrating lymphocytes in Breast Cancer—2014”.\u0000Results: High tumor-infiltrating lymphocytes were seen in 64.2% and 43.8% in ages < 50 and > 50 respectively. All cases of invasive lobular carcinoma had low tumor-infiltrating lymphocytes. 62.5% of T1 tumors were associated with low TILs whereas 80% of low tumor-infiltrating lymphocytes were T3. 71.4% of lymph node-positive tumors had low tumor-infiltrating lymphocytes. All breast cancers showed lymphocytic infiltrate. 40% of the tumors showed intermediate to high tumor-infiltrating lymphocytes. Lymphocyte-predominant breast cancers were 30%. Among the LPBC, 55.5% were triple-negative breast cancers, 33.3% were HR+, and 11.2% were HER2 positive.\u0000Conclusions: Low tumor-infiltrating lymphocytes presented at an advanced stage of the disease at the time of diagnosis. tumor-infiltrating lymphocytes in breasts decreased with increasing age. LPBCs were predominantly TNBCs. All breast cancers were immunogenic, stating the necessity to report tumor-infiltrating lymphocytes in all breast carcinomas.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90848827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scope of mean neutrophil volume as an indicator of neonatal sepsis 平均中性粒细胞体积作为新生儿败血症指标的范围

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.43997

Chaitra B E, R. Parthiban, Shilpa G, I. Krishnappa, Impana Gowda

{"title":"Scope of mean neutrophil volume as an indicator of neonatal sepsis","authors":"Chaitra B E, R. Parthiban, Shilpa G, I. Krishnappa, Impana Gowda","doi":"10.3126/jpn.v12i2.43997","DOIUrl":"https://doi.org/10.3126/jpn.v12i2.43997","url":null,"abstract":"Background: Neonatal sepsis is one of the leading causes of mortality in developing countries because of its non-specific presentation. Blood culture is the gold standard for diagnosing sepsis, but culture results take 48 – 72 hours. Therefore, there is a need for an indicator that could be used as a simple parameter to indicate the possibility of evolving sepsis to the clinician. The efficacy of mean neutrophil volume as an indicator must be evaluated.\u0000Materials and methods: The study aims to evaluate the utility of the mean neutrophil volume in the early diagnosis of neonatal sepsis. Following ethical clearance, the study involved analyzing mean neutrophil volume from peripheral smears of 50 newborns clinically diagnosed with neonatal sepsis. The control group included mean neutrophil volume findings from peripheral smears of normal newborns. Maternal or fetal factors like pregnancy-induced hypertension and birth asphyxia that could cause changes in neutrophils were excluded. The mean neutrophil value was calculated after establishing the mean diameter of 100 neutrophils per case using the National Institutes of Health Image J software.\u0000Results: The average mean neutrophil volume was found to be significantly increased in the sepsis group (181x104fl) than in the control group (739x103fl). A statistically significant difference (p= < 0.0001) in the mean neutrophil volume was observed.\u0000Conclusions: Mean neutrophil volume is a potential indicator to distinguish neonates with and without sepsis and help clinicians in the early diagnosis and management of sepsis.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84269954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Filarial granuloma presenting as a fibroadenoma 丝状肉芽肿表现为纤维腺瘤

Journal of Pathology of Nepal Pub Date : 2022-09-30 DOI: 10.3126/jpn.v12i2.36124

Agya Shrestha, S. Karki

引用次数: 0

Histopathological study of round cell tumors of the head and neck region in a tertiary care hospital: A retrospective study 三级医院头颈部圆细胞瘤的组织病理学研究:回顾性研究

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.35056

Zhuvi Zhuvithsii, A. Sarma, Shiraj Ahmed, L. Kakoti, J. Sharma, T. Pathak, Sawmik Das, A. Kataki

{"title":"Histopathological study of round cell tumors of the head and neck region in a tertiary care hospital: A retrospective study","authors":"Zhuvi Zhuvithsii, A. Sarma, Shiraj Ahmed, L. Kakoti, J. Sharma, T. Pathak, Sawmik Das, A. Kataki","doi":"10.3126/jpn.v12i1.35056","DOIUrl":"https://doi.org/10.3126/jpn.v12i1.35056","url":null,"abstract":"Background: Small round cell tumors are heterogeneous, highly aggressive malignant tumors occuring in unusual sites with overlapping clinical and radiographic features. Their diagnosis is challenging using conventional histopathologic approaches because of indistinct features in small biopsy samples and hence immunohistochemistry is a must. This study was undertaken to evaluate the pattern, common types, age, sex distribution of round cell tumors of the head and neck region and to obtain morphological immunohistochemistry correlation.\u0000Material and Methods: It is a retrospective study of 99 cases which fulfilled the inclusion criteria. Paraffin blocks were retrieved and were reviewed by two independent expert observers and immunohistochemistry was repeated whenever necessary.\u0000Results: Final diagnosis was given based on the immunohistochemistry pattern and our study showed 8 spectrums of round cell tumours. Lymphoma was the most common followed by neuroendocrine carcinoma. Most B-cell Non Hodgkin Lymphoma, undifferentiated carcinomas and Neuroendocrine carcinomas were observed in older group whereas, Ewing sarcoma /Primitive Neuro Ectodermal Tumour and T cell NHL were seen more in younger group. According to sex wise distribution, 70 (70.7%) cases were male and 29 (29.3%) females with male to female ratio of 2.4:1.\u0000Conclusions: Round cell tumors can occur at any sites of the head and neck region. There are certain morphologic features for each tumor which may help the surgical pathologist to come to a probable diagnosis in addition to careful search of the detailed history, location of tumor, presentation, radiological findings and ultimately correlating with immunohistochemistry.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76983218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lupus anticoagulant: a clinical and laboratory diagnostic dilemma 狼疮抗凝血剂:临床和实验室诊断的困境

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.37703

Shalini Trivedi, P. Jain, Nutan Dixit, Manoj Arun, Udita Singhal

引用次数: 0

Correlation of cytomorphology with flowcytometric immunophenotyping in patients of acute leukemia in tertiary care hospital 三级医院急性白血病患者细胞形态学与流式细胞免疫分型的相关性研究

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.34365

G. Pandey, Rahsmi Nichlani, Farah Jalaly, Naila Durrani, M. Ali

{"title":"Correlation of cytomorphology with flowcytometric immunophenotyping in patients of acute leukemia in tertiary care hospital","authors":"G. Pandey, Rahsmi Nichlani, Farah Jalaly, Naila Durrani, M. Ali","doi":"10.3126/jpn.v12i1.34365","DOIUrl":"https://doi.org/10.3126/jpn.v12i1.34365","url":null,"abstract":"Background: Morphological diagnosis of leukemias may sometimes not correlate with flow cytometry diagnosis. Classification of hematological neoplasm by the World Health Organization gives priority to cytogenetic, molecular biology, and even patient history, in an attempt to classify patients primarily regarding prognosis. Cytomorphology and immunophenotyping complement each other. Morphology is burdened by a high degree of subjectivity. That is why correlation of information provided by the two techniques is still absolutely necessary. The aim of our study was to correlate between cytomorphological findings and immunophenotyping results on a group of patients investigated for acute leukemia.\u0000Materials and Methods: Study was conducted in department of pathology in Chirayu Medical College and Hospital, Bhopal from December 2018 to September 2019. Cases were diagnosed as acute leukemia based on complete blood count and bone marrow aspirate/peripheral smear.These cases were sent to flowcytometry for immunophenotyping for further confirmation.\u0000Results: Total 74 cases of acute leukemias were diagnosed, out of which 30 were Acute myeloid leukemia and 44 were Acute lymphoblastic leukemia. There was 95.95% correlation between diagnosis on cytomorphology and flowcytometry. Two cases remain unclassified on cytomorphology which turn out to be Acute myeloid leukemia on flowcytometry. One case of Acute myeloid leukemia on cytomorphology was diagnosed as Acute lymphoblastic leukemia on flowcytometry.\u0000Conclusions: Inclusion of flowcytometry in routine diagnostic workup of acute leukemia ensures proper characterization as well as management. Major challenges for the near future are the standardization of technical procedures, data interpretation, and reporting.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84053741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0