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Journal of Pathology of Nepal最新文献

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Prevalence of subtypes of gastric intestinal metaplasia and its relationship with Helicobacter pylori infection 胃肠化生亚型的流行及其与幽门螺杆菌感染的关系
Journal of Pathology of Nepal Pub Date : 2020-05-13 DOI: 10.3126/jpn.v10i1.28541
S. Chalise, R. Ghimire, S. Pradhan
{"title":"Prevalence of subtypes of gastric intestinal metaplasia and its relationship with Helicobacter pylori infection","authors":"S. Chalise, R. Ghimire, S. Pradhan","doi":"10.3126/jpn.v10i1.28541","DOIUrl":"https://doi.org/10.3126/jpn.v10i1.28541","url":null,"abstract":"Materials and Methods: This was a cross sectional study done at Kathmandu Medical College teaching Hospital in Pathology department from December 2018 to August 2019. The endoscopic biopsies were evaluated for intestinal metaplasia and Helicobacter pylori with the help of Hematoxylin and Eosin stains as well as Giemsa stain. Subtypes of intestinal metaplasia were classified with the help of periodic acidSchiff/Alcian Blue stain combination and High Iron DiamineAlcian Blue stain at pH 2.5. The relationship between Helicobacter pylori and subtypes of intestinal metaplasia were compared. Fisher’s exact test was used for statistical evaluation. A p value of ˂ 0.05 was considered as statistically significant.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"3 1","pages":"1650-1653"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74807135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cervical cytochemistry: a potential adjunct to cytomorphology for detection of abnormal cells in cervical cancer screening 宫颈细胞化学:一个潜在的辅助细胞形态学检测异常细胞宫颈癌筛查
Journal of Pathology of Nepal Pub Date : 2020-05-13 DOI: 10.3126/jpn.v10i1.27880
I. Krishnappa, R. Kalyani, R. Parthiban, A. Agrawal
{"title":"Cervical cytochemistry: a potential adjunct to cytomorphology for detection of abnormal cells in cervical cancer screening","authors":"I. Krishnappa, R. Kalyani, R. Parthiban, A. Agrawal","doi":"10.3126/jpn.v10i1.27880","DOIUrl":"https://doi.org/10.3126/jpn.v10i1.27880","url":null,"abstract":"CAP-Pap stain; Cervical cancer; Pap stain; Background: Pap smear examination has been universally used as an effective screening tool for early detection of cervical carcinoma. The aim of this study was to assess the utility of Cervical Acid Phosphatase staining as an adjunct to routine Pap smear testing to improvethe sensitivity and specificity of routine Pap smear examination for cervical cancer detection.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"79 1","pages":"1639-1644"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78728939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spectrum of hemoglobinopathies in a tertiary care centre 三级保健中心的血红蛋白病谱
Journal of Pathology of Nepal Pub Date : 2020-05-13 DOI: 10.3126/jpn.v10i1.27369
N. Sharma, A. Pant, U. Manandhar
{"title":"Spectrum of hemoglobinopathies in a tertiary care centre","authors":"N. Sharma, A. Pant, U. Manandhar","doi":"10.3126/jpn.v10i1.27369","DOIUrl":"https://doi.org/10.3126/jpn.v10i1.27369","url":null,"abstract":"HbD/HbE hemoglobinopathies; Hemoglobin electrophoresis; Hemoglobinopathies; Sickle cell disorders; Thalassemia; Background: Thalassemia and other structural hemoglobinopathies are the most common single gene disorders throughout the world with the highest frequency in the tropics, subtropics, Mediterranean basin and Southeast Asia. This study aims to provide a better assessment on the spectrum of hemoglobinopathies in our context.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"15 1","pages":"1645-1649"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81122039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A radical shift in the diagnostic approach to diffuse gliomas 弥漫性胶质瘤诊断方法的根本转变
Journal of Pathology of Nepal Pub Date : 2020-05-13 DOI: 10.3126/jpn.v10i1.28947
R. Panth
{"title":"A radical shift in the diagnostic approach to diffuse gliomas","authors":"R. Panth","doi":"10.3126/jpn.v10i1.28947","DOIUrl":"https://doi.org/10.3126/jpn.v10i1.28947","url":null,"abstract":"Gliomas; IDH; 1p/19q-codeletion; Astrocytic tumours comprise the majority of central nervous system tumours and they have been traditionally graded as recommended by World Health Organization on the basis of atypia, mitoses, microvascular proliferation and necrosis. The 2016 WHO classification of diffuse gliomas incorporates both molecular and histological criteria to categorize these tumours to better predict behavior. A layered diagnostic format is now the recommended approach with the WHO grade being assigned on histological criteria to be supplemented by molecular characterization once the result of isocitrate dehydrogenase is available. The presence of 1p/19q-codeletion has now been included in the definition of oligodendrogliomas. Oligoastrocytomas have now almost vanished as an entity because they are classified as either astrocytomas or oligodendrogliomas after molecular testing. Tests have to be modified in resource limited settings to reach a molecular diagnosis based on new scientific literature and research. ABSTRACT Rajesh Panth1","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"124 1","pages":"1663-1674"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87872916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of clinician’s input in surgical pathology process in a developing country 发展中国家临床医生在外科病理过程中的投入评估
Journal of Pathology of Nepal Pub Date : 2020-05-12 DOI: 10.3126/jpn.v10i1.25929
O. Uchendu
{"title":"Evaluation of clinician’s input in surgical pathology process in a developing country","authors":"O. Uchendu","doi":"10.3126/jpn.v10i1.25929","DOIUrl":"https://doi.org/10.3126/jpn.v10i1.25929","url":null,"abstract":"Materials and Methods: This is a three-year (2016-2018) study of all (1262) routines surgical pathology specimens (SPS) received at the histopathology department of Delta State University Teaching Hospital Oghara. Parameters analyzed include the quality of the containers and fixatives used during specimen submission and the information supplied by the clinician (Specimen nature, patients’ age, gender, address, , hospital number, phone number and clinical information. The information was analyzed using Microsoft Excel 2017 and the result presented in tables.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"33 1","pages":"1608-1612"},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84943540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometrial assessment by transvaginal ultrasonography and correlation with histopathology among post menopausal women 绝经后妇女经阴道超声检查子宫内膜及其与组织病理学的关系
Journal of Pathology of Nepal Pub Date : 2020-05-12 DOI: 10.3126/jpn.v10i1.26936
H. K. Shrestha, R. Adhikari, K. Shrestha
{"title":"Endometrial assessment by transvaginal ultrasonography and correlation with histopathology among post menopausal women","authors":"H. K. Shrestha, R. Adhikari, K. Shrestha","doi":"10.3126/jpn.v10i1.26936","DOIUrl":"https://doi.org/10.3126/jpn.v10i1.26936","url":null,"abstract":"Copyright: This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Transvaginal ultrasonography has increased the reliability of imaging diagnosis of women with endometrial pathologies and this technique has become widely used to evaluate endometrial thickness in women with postmenopausal bleeding.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"146 1","pages":"1613-1617"},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88646053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Polypoidal lesions of the gastrointestinal tract 胃肠道息肉样病变
Journal of Pathology of Nepal Pub Date : 2020-05-12 DOI: 10.3126/jpn.v10i1.27743
P. Sherpa, A. Jha, S. Koirala, Rojan Ghimire
{"title":"Polypoidal lesions of the gastrointestinal tract","authors":"P. Sherpa, A. Jha, S. Koirala, Rojan Ghimire","doi":"10.3126/jpn.v10i1.27743","DOIUrl":"https://doi.org/10.3126/jpn.v10i1.27743","url":null,"abstract":"Background: With increasing usage of endoscopic procedures, gastrointestinal polypoidal lesions are commonly encountered specimens. Histopathological examination is crucial as biological behavior is dependent on its pathological nature. \u0000Materials and Methods: A retrospective descriptive study performed in Pathology department, Om Hospital and Research Centre from January 2017 to June 2019. The study included lesions received as polyp or polypoidal lesions of gastrointestinal tract for histopathological examination. Data was analysed using SPSS version 17.0. Gender, number and site were analysed using Chi square test to evaluate its association with neoplastic nature. Correlation with age and size was tested with Pearson’s correlation coefficient. \u0000Results: Among 150 cases of gastrointestinal tract polypoidal lesions, 58% were seen in male and 42% in female. Hyperplastic polyp and conventional adenoma were the commonest non-neoplastic and neoplastic lesions respectively. The age of patients ranged from 7 to 84 years with a mean age of 50 years. Rectosigmoid region was the commonest site. 134 patients had single and 16 had multiple polypoidal lesions. Most polypoidal lesion had size <1 cm. Gender, age, number and size showed no correlation with neoplastic nature. A significant association was found with site with notably higher number of neoplastic lesions in large intestine. \u0000Conclusion: A spectrum of histological types of polypoidal lesions were found in Gastrointestinal tract, most frequently in colorectal region. Hyperplastic polyp and adenomatous polyp were the commonest non-neoplastic and neoplastic lesions respectively. A notably higher number of polypoidal lesions in the large intestine were found to be neoplastic in nature.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77043865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Assessment of plasma insulin, c-peptide, and blood pressure parameters of type 1 and type 2 diabetes mellitus and diabetic complications 1型和2型糖尿病及其并发症患者血浆胰岛素、c肽和血压参数的评估
Journal of Pathology of Nepal Pub Date : 2020-05-12 DOI: 10.3126/jpn.v10i1.27324
Friday K. Iweka, G. A. Okogun, Ebenezer O. Dic-Ijiewere, Lawrence F Dada, I. K. Akhuemokhan, B. N. Obodo, Omotejohwo A Onoyovwi, Omoruyi Egherevba
{"title":"Assessment of plasma insulin, c-peptide, and blood pressure parameters of type 1 and type 2 diabetes mellitus and diabetic complications","authors":"Friday K. Iweka, G. A. Okogun, Ebenezer O. Dic-Ijiewere, Lawrence F Dada, I. K. Akhuemokhan, B. N. Obodo, Omotejohwo A Onoyovwi, Omoruyi Egherevba","doi":"10.3126/jpn.v10i1.27324","DOIUrl":"https://doi.org/10.3126/jpn.v10i1.27324","url":null,"abstract":"Results: The biochemical results showed that the mean plasma glucose of Type 1 diabetes (213.65±20.35) and Type 2 diabetes (218.78+7.85) were significantly (P<0.05) higher than that of non-diabetic control (81.88±17.22) mg/dl; the mean plasma glucose and the systolic reading of the Diabetes Mellitus with Nephropathy, hypertension, coronary artery disease, neuropathy, and retinopathy patients were significantly (p<0.05) higher than the control subjects. Among diabetic hypertensive patients mean insulin and c-peptide levels were significantly (p<0.05) lower, while the mean insulin level was insignificantly (p>0.05) lower in diabetic patients with neuropathy or coronary artery disease. No significant (p>0.05) differences was observed in the mean plasma c-peptide level, and diastolic reading of diabetic patient with neuropathy. There were no significant (p>0.05) differences in the mean plasma c-peptide level, systolic and diastolic readings of Diabetic patients with coronary heart disease or retinopathy.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"11 1","pages":"1635-1638"},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74407208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison between direct assay and popular equations for Low Density Lipoprotein-cholesterol estimation in Nepalese Population 尼泊尔人口低密度脂蛋白-胆固醇直接测定法与流行方程的比较
Journal of Pathology of Nepal Pub Date : 2020-05-12 DOI: 10.3126/jpn.v10i1.27163
S. Thapa, P. Gyawali, R. Bhatta, P. Risal
{"title":"Comparison between direct assay and popular equations for Low Density Lipoprotein-cholesterol estimation in Nepalese Population","authors":"S. Thapa, P. Gyawali, R. Bhatta, P. Risal","doi":"10.3126/jpn.v10i1.27163","DOIUrl":"https://doi.org/10.3126/jpn.v10i1.27163","url":null,"abstract":"Copyright: This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: The aim of this study was to compare LDL-C estimations using various equations with directly measured LDL-C and to find the most accurate and reliable equation for measuring serum LDL-C at different triglycerides level.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"94 1","pages":"1618-1624"},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91326871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating intraoperative cytology with histopathology diagnosis and its importance in ovarian tumors 评估术中细胞学与组织病理学诊断在卵巢肿瘤中的重要性
Journal of Pathology of Nepal Pub Date : 2020-05-12 DOI: 10.3126/jpn.v10i1.27551
K. M. Vaidya, B. Shrestha, Runa Jha, Binit Shrestha, Aasiya Rajbhandari, Rizuta Joshi, Kirtipal Subedi
{"title":"Evaluating intraoperative cytology with histopathology diagnosis and its importance in ovarian tumors","authors":"K. M. Vaidya, B. Shrestha, Runa Jha, Binit Shrestha, Aasiya Rajbhandari, Rizuta Joshi, Kirtipal Subedi","doi":"10.3126/jpn.v10i1.27551","DOIUrl":"https://doi.org/10.3126/jpn.v10i1.27551","url":null,"abstract":"Results: Both touch / imprint cytology were able to diagnose benign and malignant ovarian neoplasm. Out of 103 cases, in cytology showed 89.1% patients were negative and 10.9% patients were positive. Histopathology shows 84.2% of benign ovarian neoplasm, 3.9% borderline neoplasm and 11.9% of malignant. Diagnostic accuracy of touch/ imprint was 99% with sensitivity 100% and specificity was 91.67%. Positive predictive value was 98.89% and negative predictive value was 100%.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"300 1","pages":"1630-1634"},"PeriodicalIF":0.0,"publicationDate":"2020-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89035970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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