Journal of Pathology of Nepal最新文献_第4页

Mucinous lesions of the appendix: a histopathological study 阑尾粘液病变:组织病理学研究

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.39338

O. Shrestha, R. Baral

{"title":"Mucinous lesions of the appendix: a histopathological study","authors":"O. Shrestha, R. Baral","doi":"10.3126/jpn.v12i1.39338","DOIUrl":"https://doi.org/10.3126/jpn.v12i1.39338","url":null,"abstract":"Background: Mucinous lesions of the appendix are frequently misinterpreted in histopathological examination due to their relative rarity. Our study focuses on interpreting the histopathological spectrum of such lesions and understanding the disease burden of appendiceal mucinous lesions in a tertiary centre.\u0000Materials and Methods: This was a retrospective cross-sectional study conducted in the Department of Pathology. Gross and microscopic findings of appendicectomy specimens with mucinous lesions were analysed and classified according to the latest WHO 2019 recommendation.\u0000Results: Seven hundred and forty appendicectomy specimens were received during the study period out of which nine appendix (1.2%) had mucinous lesions. Five (55.6%) of these lesions had a mucinous neoplasm while four of them (44.4%) were non-neoplastic. The most common lesion was low-grade appendiceal mucinous neoplasm (n=4; 44.4%). Two cases (22.2%) were retention cysts and there was one case each of mucinous adenocarcinoma, appendiceal diverticulosis, and endometriosis-associated mucinous metaplasia of the appendix. The mucinous neoplasms were significantly more common in females (80%). High-grade appendiceal mucinous neoplasms and serrated lesions or polyps weren’t seen in our study.\u0000Conclusions: Mucinous lesions of the appendix are often incidental findings in patients operated for symptoms of acute appendicitis. Low-grade appendiceal mucinous neoplasms are the most common among them. Thorough knowledge of the neoplastic mimics and careful gross, as well as microscopic examination, is a must for proper diagnosis and staging since it has a significant impact on further patient management and prognostication.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86063894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study of serum calcium, phosphorous and magnesium level in hypothyroid cases 甲状腺功能减退患者血清钙、磷、镁水平的研究

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.40422

A. Dhungana, N. Shreevastva, Subash Pant, Baburam Pokharel

{"title":"A study of serum calcium, phosphorous and magnesium level in hypothyroid cases","authors":"A. Dhungana, N. Shreevastva, Subash Pant, Baburam Pokharel","doi":"10.3126/jpn.v12i1.40422","DOIUrl":"https://doi.org/10.3126/jpn.v12i1.40422","url":null,"abstract":"Background: Hypothyroidism is an endocrine disorder occurred either due to its impaired activity or hormonal deficiency. Trace elements are required as a cofactor for many enzymes in various metabolic pathways which are regulated by thyroid hormone. Hence, thyroid disorders are linked with disturbances in various metabolisms. So, the purpose of this study is to evaluate whether serum calcium, magnesium, and phosphorus level are deranged or not in hypothyroid cases.\u0000Materials and Methods: A prospective study was carried out in a total of 112 cases of hypothyroid and euthyroid subjects aged 20-50 years involving both male and female individuals. Thyroid function test, serum calcium, phosphorous and magnesium activities were measured in both the study population.\u0000Results: Serum calcium was significantly lower while serum phosphorous and magnesium levels were significantly higher in hypothyroidism (p<0.001). There was a significant negative correlation between Thyroid Stimulating Hormone (TSH) and calcium (r-value -0.282, p0.035) while, there was a significant positive correlation between TSH and serum phosphorous and magnesium (r-value 0.593, p<0.001) and (r-value 0.513, p<0.001) respectively.\u0000Conclusions: Our study, suggests that there was a significant change in the levels of serum calcium, phosphorous, and magnesium in thyroid dysfunction. Assessing the level of serum calcium and phosphorous can be fairly used as an index of bone resorption. So, preventive measures like supplementation of minerals can be initiated early in those who are at risk of rapid bone loss and to prevent osteoporotic fractures.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78835493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perimenopausal invasive complete hydatidiform mole: a rare encounter 围绝经期侵袭性完全葡萄胎:罕见病例

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.33932

Aasiya Rajbhandari, Karishma Malla Vaidya, Bibhuti Dahal

引用次数: 0

Utility of reporting urine cytology samples as per the Paris system 根据巴黎系统报告尿液细胞学样本的效用

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.41443

R. Dhakhwa, Ozone Shrestha, R. Thapa, S. Pradhan

{"title":"Utility of reporting urine cytology samples as per the Paris system","authors":"R. Dhakhwa, Ozone Shrestha, R. Thapa, S. Pradhan","doi":"10.3126/jpn.v12i1.41443","DOIUrl":"https://doi.org/10.3126/jpn.v12i1.41443","url":null,"abstract":"Background: Urinary tract cytology is an accurate test for the detection of urothelial malignancy especially high-grade urothelial carcinoma. The Paris System for Reporting Urinary Cytology was introduced to standardize urinary tract cytology reporting. We aim to evaluate the utility of reporting urinary cytology as per this system and correlate with histopathology.\u0000Materials and Methods: This is a descriptive cross-sectional prospective study conducted on urine samples submitted for cytological examination at Kathmandu Medical College Teaching Hospital, Sinamangal, Nepal between 1st November 2020 to 31st July 2021. Ethical consent was taken from the Institutional Review Committee. Urine cytology was reported as per The Paris System for Reporting Urinary Cytology and correlated with the histopathologic diagnosis. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for the high-grade and low-grade urothelial lesion.\u0000Results: A total of 104 urine samples were evaluated. Biopsy specimens were available for 38 cases. Urine cytology consisted of 1.92% non-diagnostic cases, 69.23% negative for high-grade urothelial carcinoma, 5.76% atypical urothelial cells, 5.76% suspicious for high-grade urothelial carcinoma, 13.46% high-grade urothelial carcinoma, and 3.84% low-grade urothelial neoplasm respectively. Sensitivity, specificity, negative predictive value and positive predictive value were 90.48%, 82.35%, 86.37% and 87.5% respectively for high grade urothelial carcinoma and 40%, 93.9%,50% and 91.17% respectively for low grade urothelial lesions.\u0000Conclusions: Our study shows that reporting urine cytology as per The Paris System for Reporting Urinary Cytology provides high sensitivity for the detection of high-grade urothelial lesions.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"440 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84486680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multiple bone fractures with a hidden aetiology-A case report 病因不明的多发骨折1例

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.30547

P. Jayalakshmy, Sreelekshmi K. Thunoli, Asiq N. Siddeeque

引用次数: 0

Usefulness of prostate specific antigen density in detecting prostate carcinoma: A hospital-based study in patients with prostate biopsies 前列腺特异性抗原密度检测前列腺癌的有效性:一项基于医院的前列腺活检患者的研究

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.41841

R. Shrestha, Shova Kunwar, Suman Gurung, A. Pokharel

{"title":"Usefulness of prostate specific antigen density in detecting prostate carcinoma: A hospital-based study in patients with prostate biopsies","authors":"R. Shrestha, Shova Kunwar, Suman Gurung, A. Pokharel","doi":"10.3126/jpn.v12i1.41841","DOIUrl":"https://doi.org/10.3126/jpn.v12i1.41841","url":null,"abstract":"Background: Prostate-specific antigen density has been suggested to enhance the diagnostic efficacy of serum prostate-specific antigen alone in detecting prostate cancer, thereby reducing unnecessary biopsies and associated morbidities. This study aimed to assess the diagnostic performance of prostate-specific antigen density in detecting prostate cancer.\u0000Materials and methods: A retrospective analysis of histologically proven benign and malignant prostate diseases, submitted in the histopathology department was performed from April 2019 to March 2020. The diagnostic performance of prostate-specific antigen density was assessed and its optimum cut-off value was determined using the receiver operating characteristic curves. The diagnostic efficacy of prostate-specific antigen density was also compared with prostate-specific antigen in detecting prostate cancer.\u0000Results: The AUC to predict prostate cancer was 0.89 (95% CI 0.79-0.98. p <0.001) for prostate-specific antigen density. The diagnostic performance of prostate-specific antigen density at cut-off 0.18 ng/ml/cc was better than prostate-specific antigen alone (AUC, 0.838 vs 0.662). Sensitivity was 80% for both prostate-specific antigen density at cut-off 0.18 ng/ml/cc and prostate-specific antigen. But, prostate-specific antigen density had a higher specificity of 87.7 % than prostate-specific antigen (52.3%)and thus it could better distinguish benign diseases from prostate cancer. It would have reduced unnecessary biopsy by 35%.\u0000Conclusions: The diagnostic efficacy of prostate-specific antigen density was good and it was found to be a better predictor of prostate cancer at the cut-off value of 0.18ng/ml/cc when compared to prostate-specific antigen alone.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73861133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of skin cancer based on skin biopsies in Bir hospital, Nepal 尼泊尔Bir医院基于皮肤活检的皮肤癌患病率

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.43033

S. Tiwari, P. Koirala, S. Shrestha, N. Parajuli

{"title":"Prevalence of skin cancer based on skin biopsies in Bir hospital, Nepal","authors":"S. Tiwari, P. Koirala, S. Shrestha, N. Parajuli","doi":"10.3126/jpn.v12i1.43033","DOIUrl":"https://doi.org/10.3126/jpn.v12i1.43033","url":null,"abstract":"Background: Cancer, one of the most dreaded non-communicable diseases has become an important contributor to the global burden of diseases. The incidence of skin cancer is rising. Clinical history, physical examination, laboratory investigations including biopsy are different modalities for the diagnosis of the disease. This study aimed to find the prevalence of skin cancer among patients visiting Bir hospital.\u0000Materials and Methods: This was a retrospective study carried out in the National Academy of Medical Science, Bir Hospital from Baishakh 1st 2071 to 30th Poush 2075. It included all the skin malignancies and pre-invasive lesions received and diagnosed in the Department of Pathology.\u0000Results: A total number of 1555 skin biopsies were obtained in the past five years where we diagnosed a total of 165 (10 %) cases as malignant which included the premalignant cases too. The most affected age group was 66 to 75 years (29 %) with 55% male and 45%females. Our data showed head and neck was the most common site occupying 67% of the total case followed by lower limbs 15%. Our study also revealed that 40% of malignant cases were basal cell carcinoma which was followed by squamous cell carcinoma comprised 36% and malignant melanoma(15%).\u0000Conclusions: In this study, basal cell carcinoma was the most common malignancy followed by squamous cell carcinoma and malignant melanoma. Head and neck was the most common site.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72822618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathological pattern of adult renal tumours in a tertiary cancer center 某三级肿瘤中心成人肾肿瘤的组织病理学模式

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.41857

R. Bhatta, G. Pandey, N. Jha, S. Bastakoti, I. Dhungana, Suraj Upreti

{"title":"Histopathological pattern of adult renal tumours in a tertiary cancer center","authors":"R. Bhatta, G. Pandey, N. Jha, S. Bastakoti, I. Dhungana, Suraj Upreti","doi":"10.3126/jpn.v12i1.41857","DOIUrl":"https://doi.org/10.3126/jpn.v12i1.41857","url":null,"abstract":"Background: Renal tumours are 16th most common malignancies in the world accounting for 2.2% of all new malignancies and 1.8% of all cancer deaths. Histopathological classification of renal tumours along with tumour grade and stage is proven to have prognostic value.\u0000Material and Methods: This was a retrospective study conducted in Department of Pathology at B.P. Koirala Memorial Cancer Hospital Bharatpur from January 2017 to December 2019 including cases of partial and radical nephrectomies of patients more than sixteen years of age.\u0000Results: Total 78 nephrectomy specimens were received out of which 70 (89.7% consisted of malignant tumour and 8 (10.3%) were benign lesions. Clear cell type renal cell carcinoma was the most common malignant tumour consisting of 57 (81.4%) cases of renal cell carcinoma, followed by papillary type 9(12.9%), Cchromophobe (4.3%) and one case (1.3%) of multiloculated cystic renal neoplasm was noted. Renal cell carcinoma was seen in age range of 26 to 80 years with majority of patients more than 50 years of age, while a small peak (14.3%) was noted in female patients of 31 to 40 years of age.\u0000Conclusions: This study found increased incidence of renal cell carcinoma among female patients of 31 to 40 years of age in contrast to studies done in the Western population.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75411044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dedifferentiated chordoma, a case report 去分化脊索瘤1例

Journal of Pathology of Nepal Pub Date : 2022-03-31 DOI: 10.3126/jpn.v12i1.42213

Girishma Shrestha, P. Roy, I. Arun, A. Chatterjee, Gautam Biswas

引用次数: 0

Clinicopathological study of cutaneous adnexal cyst with some unusual presentation 有特殊表现的皮肤附件囊肿的临床病理研究

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.34396

P. Singh, H. Dahiya

{"title":"Clinicopathological study of cutaneous adnexal cyst with some unusual presentation","authors":"P. Singh, H. Dahiya","doi":"10.3126/jpn.v11i2.34396","DOIUrl":"https://doi.org/10.3126/jpn.v11i2.34396","url":null,"abstract":"Background: Cutaneous cysts are slow-growing benign intradermal or subcutaneous tumors that occur commonly in the hair-bearing areas of the body. Sometimes they occur in non-hair-bearing areas due to traumatic implantation of the epidermis. The present study was conducted to determine the prevalence of various cutaneous cysts in our hospital set up, to record an unusual presentation and clinico-histopathological correlation.\u0000Material and methods: This is a hospital-based retrospective analysis of cutaneous cysts conducted for 6 months. All skin biopsies diagnosed under the category of the cutaneous cyst were included in the study. Histopathology slides stained with Hematoxylin and eosin were analyzed.\u0000Results: A total of 185 cases of cutaneous cysts were included in the study. The most frequent cutaneous cyst was an epidermal cyst (75.13%) followed by a dermoid cyst (18.38%). Epidermal cysts occurred at unusual locations of the palm, lower extremity, and breast. Unusual locations of the dermoid cyst were the floor of the mouth, gluteal region, scalp, and back. Two cases of scrotal epidermal cysts were associated with idiopathic calcinosis of the scrotum. In one case each proliferating trichilemmal cyst and apocrine hidrocystoma occurred over the unusual location of the back while cysticercosis occurred at an unusual location of the scalp. Inflammatory changes were found in 27 cases (14.59%) of cutaneous cysts. An overall clinicopathological correlation was seen in 91.89% (170/185) cases of cutaneous cysts\u0000Conclusions: Unusual clinical presentation of cutaneous cysts can pose a diagnostic dilemma. Definitive diagnosis in such cases is possible by histopathological analysis.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78528993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2