Journal of Pathology of Nepal最新文献_第5页

Histopathological findings on endometrial biopsy in a tertiary care center of Nepal: a retrospective cross-sectional study 尼泊尔三级保健中心子宫内膜活检的组织病理学结果:一项回顾性横断面研究

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.38595

A. Shrestha, B. Aryal, A. Adhikari, A. Poudel, Ramhari Rouniyar, Bidur Khatiwada

{"title":"Histopathological findings on endometrial biopsy in a tertiary care center of Nepal: a retrospective cross-sectional study","authors":"A. Shrestha, B. Aryal, A. Adhikari, A. Poudel, Ramhari Rouniyar, Bidur Khatiwada","doi":"10.3126/jpn.v11i2.38595","DOIUrl":"https://doi.org/10.3126/jpn.v11i2.38595","url":null,"abstract":"Introduction: Abnormal uterine bleeding is the most common presentation in endometrial pathology and endometrial biopsy is the investigation of choice. This study aimed to describe the histological findings of patients who underwent endometrial biopsy to estimate the most common endometrial diseases in Nepali women.\u0000Materials and methods: This retrospective cross-sectional study was conducted using hospital records, and included females who underwent endometrial biopsy at a tertiary level hospital from 1 April 2018 to 31 March 2020. Histopathological findings were categorized into eight groups, and patients were divided into three age groups to obtain the relative occurrence of each type of disease at different ages\u0000Results:342 female patients were included in the study, among which 97 were pregnancy-related and 245 were non-pregnancy-related. The mean age of the patients was 41.63 years (± 11.45 years). In 28 cases (8.2%) of the 342 total cases, the endometrial biopsy sample was deemed inadequate. Among the non-pregnancy-related cases, normal physiological changes were the most common reported finding (n=93, 38.0%), followed by abnormal physiologic changes (n=68, 27.8%). Premalignant conditions (n=15, 6.1%) and malignancy (n=5, 2.0%) were less common.\u0000Conclusions: Normal physiological changes and disordered proliferative endometrium are the most common findings in an endometrial biopsy. Endometrial hyperplasia and malignancy are less common, and usually found in women more than 40 years in age.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81317255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical mimickers of epidermoid cyst in scalp: a retrospective histopathological study 头皮表皮样囊肿的临床模拟物:回顾性组织病理学研究

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.30678

K. Kshitija, R. Nagpal, Seethamsetty Saitha, V. Sreedhar

{"title":"Clinical mimickers of epidermoid cyst in scalp: a retrospective histopathological study","authors":"K. Kshitija, R. Nagpal, Seethamsetty Saitha, V. Sreedhar","doi":"10.3126/jpn.v11i2.30678","DOIUrl":"https://doi.org/10.3126/jpn.v11i2.30678","url":null,"abstract":"Background: Cystic lesions of the scalp with a clinical diagnosis of an epidermoid cyst are encountered in clinical practice. However, these lesions had a different diagnostic interpretation on histopathology examination. Therefore our study focused on the lesions clinically resembling the presentation of epidermoid cyst in the scalp region.\u0000Materials and Methods: Forty-one cases of scalp lesions with a clinical diagnosis of epidermoid cyst over 2 years were reviewed. Details of the patients such as clinical diagnosis, age, gender, duration, gross findings, and histopathology diagnosis were obtained from the medical and histopathology records.\u0000Results: Epidermoid cysts diagnosed both clinically and on histopathology examination accounted for 29.26% whereas the clinical mimickers constituted 70.73%. The mean age of the patient was 35-years with an equal sex ratio. The commonest location was the parietal region (41.37%). Benign and malignant lesions consisted of 97.56% and 2.4% respectively. A trichilemmal cyst was the most common clinical mimicker diagnosed.\u0000Conclusions: Clinicians should be aware of wide differential diagnosis of epidermoid cyst in the scalp region as the management and outcome vary with each lesion. Histopathology examination proved to be a diagnostic tool in differentiating these lesions.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89120665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benign multicystic peritoneal mesothelioma: a case report 良性腹膜多囊间皮瘤1例

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.29114

Rashmi Sharma, S. Verma, D. Desai, R. Malhotra, Ranjana Desai

引用次数: 0

Tumor-infiltrating lymphocytes in colorectal carcinoma 结直肠癌的肿瘤浸润淋巴细胞

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.38227

S. Karki, Sanjib Pariyar

{"title":"Tumor-infiltrating lymphocytes in colorectal carcinoma","authors":"S. Karki, Sanjib Pariyar","doi":"10.3126/jpn.v11i2.38227","DOIUrl":"https://doi.org/10.3126/jpn.v11i2.38227","url":null,"abstract":"Background: Immunotherapy has become an important modality of treatment for CRC. The cells contributing to an effective immune response are CD8+ T cells of tumor-infiltrating lymphocytes. The present study aimed to assess the tumor-infiltrating lymphocytes on colorectal cancer and correlate them with other prognostic parameters.\u0000Material and methods: Cases of colectomy from April 2019 -Sept 2020 with a diagnosis of colorectal carcinoma were included in the study. Parameters i.e age, sex, size, location of the tumor, lymphovascular invasion, perineural invasion, T stage, N status, histological tumor type, and grade, resected margins were retrieved from the database of the department. The intensity of overall inflammatory cell reaction at the invasive tumor front was evaluated in H and E stained sections.\u0000Results: 56 cases of colorectal cancers were reported during the study period with M: F ratio of 1.15:1. The age ranged from 23-79years with a mean age of 54.3years. The tumors were predominant in the colon (50 cases) than the rectum. Colonic carcinomas had high-grade tumor-infiltrating lymphocytes as compared to rectal carcinomas. The grade of tumor-infiltrating lymphocytes was statistically significantly associated with T, N status, and grade of tumors.\u0000Conclusions: Inflammatory reactions at the invasive tumor front can be easily analyzed in resection specimens of colorectal cancers without additional costs. Low-grade tumor-infiltrating lymphocytes are indicative of high-stage tumors with a poor prognosis. Hence, the inclusion of tumor-infiltrating lymphocytes in pathological reports for risk stratification of the patient is mandatory.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74257805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chronic myeloid leukemia in childhood: a case report 儿童慢性髓性白血病1例报告

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.35291

U. Bhatta, D. Regmi

引用次数: 0

Immunophenotyping pattern of mixed phenotypic acute leukemia: historical review and diagnostic pitfalls 混合表型急性白血病的免疫表型模式:历史回顾和诊断缺陷

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.34001

Monika Gupta, P. Dhamija, N. Marwah, Sujata Prasad, R. Sen

{"title":"Immunophenotyping pattern of mixed phenotypic acute leukemia: historical review and diagnostic pitfalls","authors":"Monika Gupta, P. Dhamija, N. Marwah, Sujata Prasad, R. Sen","doi":"10.3126/jpn.v11i2.34001","DOIUrl":"https://doi.org/10.3126/jpn.v11i2.34001","url":null,"abstract":"Introduction: Multiparametric approaches are used for the diagnosis and classification of acute leukemia. Even after extensive immunophenotyping, a rare and heterogeneous subgroup that cannot be readily classified as Mixed Phenotypic Acute leukemia in which the blasts exhibit the antigens of more than one lineage. This study aimed to analyze the incidence of Mixed Phenotypic Acute Leukemia and correlate the clinicopathological and immunophenotypic characteristics.\u0000Materials and methods: This study was done in a tertiary health institute. Complete clinical details of patients were taken followed by morphological evaluation including peripheral blood, bone marrow aspiration, and biopsy was done. Immunophenotyping was performed on the FACS Canto II Flow cytometer. The diagnosis of Mixed Phenotypic Acute Leukemiawas based on the World Health Organization 2008 classification.\u0000Results: We analyzed 7 cases, which include 57.14%of B/Mixed Phenotypic Acute Leukemia and 42.86% of T/Mixed Phenotypic Acute Leukemia. The male to female ratio was 0.4:1. Hematological parameters including hemoglobin, total leucocyte count, platelets count, and blasts percentage were correlated. On flow cytometry, all cases were positive for cMPO while B/Myeloid cases were positive for CD19 and at least one B cell marker. T/Myeloid cases were positive for cCD3 and CD7 in all cases besides other myeloid and T cell markers.\u0000Conclusions: The frequency of Mixed Phenotypic Acute Leukemia in our study was found to be 2.7%, in concordance with published data (2.2-2.6%). Strict diagnostic criteria should be followed in the diagnosis because it originates from primitive multipotent progenitors which are resistant to treatment and lineage plasticity.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83839841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhinosporidiosis presenting as an orbital mass 鼻孢子虫病表现为眼眶肿块

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.33390

Sujan Sharma

引用次数: 0

Analysis of frozen section compared to permanent section: a 2 year study in a single teritiary care hospital 冷冻切片与永久切片的对比分析:在一家三级医院进行的为期2年的研究

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.37681

S. Ayyagari, Anusha Potnuru, Sk. Aamer Saleem, Pavani Marapaka

引用次数: 0

Clinico-haematological profile in COVID-19 patients: an observational study at tertiary care center COVID-19患者的临床血液学特征:三级保健中心的观察性研究

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.35080

Jayalaxmi Yadav Kallur, Indira Priyadarshini Anubrolu, Shridevi S H, B. C

{"title":"Clinico-haematological profile in COVID-19 patients: an observational study at tertiary care center","authors":"Jayalaxmi Yadav Kallur, Indira Priyadarshini Anubrolu, Shridevi S H, B. C","doi":"10.3126/jpn.v11i2.35080","DOIUrl":"https://doi.org/10.3126/jpn.v11i2.35080","url":null,"abstract":"Background: It is known as in other viral infections, severe acute respiratory syndrome coronavirus 2 infections, can be associated with haematological changes and often has the potential to optimize the monitoring of the infectious process and their severity. Hence, we took up this study to analyze clinico-haematological profiles in coronavirus disease-2019 patients and to compare haematological changes between mild, moderate, and severe cases.\u0000Materials and methods: The study included the patients who were tested positive for coronavirus disease-2019 infection and the patients were classified into mild, moderate and severe cases. The demographic data and the laboratory haematological parameters were collected and statistically analysed. The median values were compared between mild, moderate, and severe cases using non-parametric tests, Kruskal-Wallis test with posthoc Mann-Whitney, and the p-value was calculated using Chi-square test for statistical significance.\u0000Results: Data was collected for 276 patients, of which 167 patients were mild cases, 50 were moderate and 59 were severe. The median was derived for all the haematological parameters in mild, moderate, and severe groups which showed an increasing trend in total leucocyte count, absolute neutrophil count, neutrophil to lymphocyte ratio, and a decreasing trend in absolute lymphocyte count and statistically significant with p-value <0.05.\u0000Conclusions: Coronavirus disease-2019 infection is associated with changes in haematological parameters, as the severity of the disease progresses total leucocyte count, absolute neutrophil count, and neutrophil to lymphocyte ratio increase but absolute lymphocyte count decreased. High neutrophil to lymphocyte ratio and lymphopenia are valuable early risk stratification parameters.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82194416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on glycogen content of endometrial glands in infertile women 不孕妇女子宫内膜腺糖原含量的研究

Journal of Pathology of Nepal Pub Date : 2021-09-30 DOI: 10.3126/jpn.v11i2.35150

Karthik Lr, Raja Parthiban S R, S. D., S. N. Shetageri

{"title":"A study on glycogen content of endometrial glands in infertile women","authors":"Karthik Lr, Raja Parthiban S R, S. D., S. N. Shetageri","doi":"10.3126/jpn.v11i2.35150","DOIUrl":"https://doi.org/10.3126/jpn.v11i2.35150","url":null,"abstract":"Background: Infertility is a public health problem worldwide. One of the important factors involved in infertility is the poor quality of endometrium which leads to death of the ovum before and after implantation. Glycogen is known to be a direct source of nutrients for the early conceptus and its depletion may result in inadequate preparation of endometrium around the time of implantation and leading to infertility. \u0000Materials and methods: This is a prospective study conducted at a tertiary care hospital for 2 years. The study included 75 cases of infertility (primary and secondary). Relevant data were collected from all the 75 biopsied infertile cases during the study period. Periodic acid Schiff stain was performed on all cases to detect the amount of glycogen in the endometrium. The findings were compiled, analyzed, and compared with other studies.\u0000Results: Primary infertility accounted for 77.3%and Secondary infertility 22.7% of the 75 cases. On histology, anovulatory cycles accounted for 52% of cases. In the remaining cases, 38.7% showed secretory phase, 4%cases each showed luteal phase defect and hyperplasia, and 1.3% tubercular endometritis. Glycogen content of the endometrium was (1+) in 54.6%, (2+) in 9.3%, (3+) in 9.3% and (4+) in 26.8% in the infertility patients.Glycopenia was seen in 12% of the 75 cases studied.\u0000Conclusions: Endometrial factors are important causes of infertility and depletion of glycogen, that can be corrected by hormonal therapy to improve the fertility potential needs to be evaluated in all cases of infertility.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78784001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0