Profile of uncommon primary adult hepatic malignancies at a tertiary care center

Hepatopathology; Liver cancer; Non-hepatocellular liver malignancy; Background: Hepatocellular carcinoma has been the most common primary malignancy of the liver in adults, followed by cholangiocarcinoma. The less common malignancies are those arising from the vascular endothelial cells, neuroendocrine cells, hematolymphoid tissues, and mesenchymal tissues. Imaging studies alone may pose a diagnostic challenge, due to the variable appearances. Histological review of the tissue specimen along with immunohistochemical stains are imperative for diagnosis. However, a multidisciplinary approach is necessary to make an accurate diagnosis and help in management.