Journal of Pathology of Nepal最新文献_第7页

Histomorphological Mimickers of benign prostatic lesions with prostatic adenocarcinoma 良性前列腺病变伴前列腺腺癌的组织形态学模拟物

Journal of Pathology of Nepal Pub Date : 2021-03-20 DOI: 10.3126/jpn.v10i2.29009

Priyanka S Murgod, P. Doshi, A. Nisal, R. Nimbargi

{"title":"Histomorphological Mimickers of benign prostatic lesions with prostatic adenocarcinoma","authors":"Priyanka S Murgod, P. Doshi, A. Nisal, R. Nimbargi","doi":"10.3126/jpn.v10i2.29009","DOIUrl":"https://doi.org/10.3126/jpn.v10i2.29009","url":null,"abstract":"Background: The prostate is a walnut-sized organ that surrounds the urethra. More than 99% of prostate cancers are prostatic adenocarcinoma. It is the second most commonly occurring cancer in men and the fourth most commonly occurring cancer in India and all over the world. Numerous lesion of the prostate are very similar to prostate cancer, hence awareness is very important. This study aimed to determine the histopathological features of prostate adenocarcinoma and its common mimickers.Materials and Methods: A retrospective study of histopathological features of radical prostatectomy and transurethral resection of the prostate specimens, sent to the department of pathology for a period of one year. A brief clinical history and serum prostate-specific antigen levels were noted.Results: The surgical specimens of 303 cases of prostatic diseases were studied. Benign prostatic hyperplasia was the most frequent diagnosis in 192 patients followed by Prostate adenocarcinoma seen in 80 patients. Prostatic intraepithelial neoplasia formed the predominant mimicker (5.9%), followed by basal cell hyperplasia (3.0%). Serum prostate-specific antigen was seen in the range of 1.73 - 100 ng/ml in the cases of adenocarcinoma. In the mimics, prostate-specific antigen was in the range of 1.2- 18ng/ml.Conclusions: Biopsy remains a gold standard for the diagnosis of adenocarcinoma and its mimickers. The lesions in this study were diagnosed on hematoxylin and eosin staining.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91192240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemogram components and platelets count variation in anemic patients attending Birat Medical College and Teaching Hospital, Morang, Nepal 尼泊尔莫朗比拉特医学院及教学医院贫血患者血谱成分及血小板计数变化

Journal of Pathology of Nepal Pub Date : 2021-03-20 DOI: 10.3126/jpn.v11i1.30385

S. Upadhyaya Kafle, Mrinalini Singh, N. Kafle, A. Sinha

{"title":"Hemogram components and platelets count variation in anemic patients attending Birat Medical College and Teaching Hospital, Morang, Nepal","authors":"S. Upadhyaya Kafle, Mrinalini Singh, N. Kafle, A. Sinha","doi":"10.3126/jpn.v11i1.30385","DOIUrl":"https://doi.org/10.3126/jpn.v11i1.30385","url":null,"abstract":"Background: Anemia being the expression of the underlying disease is a global public health problemaffecting both developing as well as developed countries. The RBC indices and platelet count variationamong anemic patients are important to know their association for clinical implications.Materials and Methods: A hospital-based cross-sectional study among anemic patients with hemoglobin<10 gm%, attending Birat Medical College Teaching Hospital, Nepal from 15 May to 15 July 2020 wereanalyzed for RBC indices and platelet count variation. Demographic data, RBC indices, platelet countvariation, and types of anemia were evaluated. Pearson’s correlation coefficient was used for correlatingthe platelet count with RBC indices. A Chi-square test was used to know about the association betweenthe types of anemia and platelet count variation.Results: Out of 150 anemic patients, the female to male ratio was 1.5:1, with the most common agegroup between 40-49 years. There exist high differences between minimum and maximum individualRBC indices (Hb, MCV, MCH, MCH) and platelet count values. The platelet count variation with RBCvalues and MCV had a statistically significant positive and negative correlation respectively. However,the correlation between platelet count variation with hemoglobin concentration level and type of anemiawas positive but statistically not significant.Conclusion: Findings suggest that platelet count variation with RBC indices and types of anemiacorrelated well among anemic patients. Such association will enable the clinicians for diagnosing andtreatment purposes. \u0000 ","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88778957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inherited bone marrow failure syndromes. An overview 遗传性骨髓衰竭综合征。概述

Journal of Pathology of Nepal Pub Date : 2021-01-01 DOI: 10.3126/jpn.v11i1.31635

S. Karki

{"title":"Inherited bone marrow failure syndromes. An overview","authors":"S. Karki","doi":"10.3126/jpn.v11i1.31635","DOIUrl":"https://doi.org/10.3126/jpn.v11i1.31635","url":null,"abstract":"Inherited bone marrow failure syndromes are a diverse set of genetic disorders characterized by insufficient blood cell production leading to cytopenias/pancytopenia. Bone marrow failure can be restricted to one or two blood cell lineages, with symptoms specific to the particular cell lineage or it can affect all cell lineages, causing clinical symptoms similar to aplastic anemia. Inherited bone marrow failure syndromes are genetically heterogeneous diseases resulting from germline mutations that affect key cellular pathways namely ribosomal biogenesis, telomerase biology, DNA repair, and structural proteins. Common Inherited bone marrow failure syndromes are Diamond-Blackfan anemia, Fanconi anemia, Dyskeratosis Congenita, and Shwachman-Diamond syndrome. These different syndromes have variable prognoses and risks of developing hematological or solid malignancies. Thus the accurate diagnosis of these diseases differentiating it from other Inherited bone marrow failure syndromes and other causes of bone marrow failure is of utmost importance for management and surveillance of long-term squeal of the disease. Other causes of BMF can be acquired. The most common forms of Bone marrow failure can occur from chemicals, radiation, drugs, viral infections, immune disorders, myelodysplastic syndrome, paroxysmal nocturnal hemoglobinuria, or large granular lymphocytic leukemia. Moreover, these Inherited bone marrow failure syndromes are often heritable, affecting other family members, thus requiring insightful genetic counseling. This review discusses the frequent Inherited bone marrow failure syndromes along with their differential diagnosis.","PeriodicalId":31517,"journal":{"name":"Journal of Pathology of Nepal","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83963905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analogous feature of cemento-ossifying fibroma and bone pathology: a clinico-pathological correlation 骨水泥骨化纤维瘤与骨病理的相似特征:临床-病理相关性

Journal of Pathology of Nepal Pub Date : 2020-12-28 DOI: 10.3126/jpn.v10i2.31217

T. Raut, S. Keshwar, A. Pradhan, A. Shrestha

引用次数: 0

Digital education amidst global pandemic: A virtual reality for an academic Pathologist! 全球流行病中的数字教育:学术病理学家的虚拟现实!

Journal of Pathology of Nepal Pub Date : 2020-11-23 DOI: 10.3126/jpn.v10i2.33026

P. Sherpa

引用次数: 0

Small cell neuroendocrine carcinoma coexisting with adenocarcinoma of the uterine cervix - a rare entity 小细胞神经内分泌癌与子宫颈腺癌共存是一种罕见的病例

Journal of Pathology of Nepal Pub Date : 2020-11-22 DOI: 10.3126/jpn.v10i2.28736

Mukta Meel, A. Jindal, Mukesh Kumar, A. Mittal

引用次数: 1

Utility of fine needle aspiration cytology in head and neck lesions and its correlation with histopathology- a study in tertiary care hospital 细针抽吸细胞学在头颈部病变中的应用及其与组织病理学的相关性——三级医院的研究

Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.30255

S. Thapa, Arnab Ghosh, Dilasma Ghartmagar, S. Regmi, O. Talwar

引用次数: 0

Use of immunohistochemistry for detection of Epidermal growth factor receptor mutation status in lung adenocarcinoma 应用免疫组织化学检测肺腺癌中表皮生长因子受体突变状态

Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.30170

N. Shah, H. Popper, S. Karki, D. R. Mishra

引用次数: 0

Primary synovial sarcoma thyroid: an unusual presentation 原发性甲状腺滑膜肉瘤:一种不寻常的表现

Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.28358

P. Srivastava, N. Anand, N. Husain

引用次数: 1

Role of training session in improving the knowledge of blood transfusion practices among undergraduates- a hospital based study. 培训课程在提高大学生输血实践知识中的作用——一项基于医院的研究。

Journal of Pathology of Nepal Pub Date : 2020-09-30 DOI: 10.3126/jpn.v10i2.29827

P. Vasavi, M. Usha, Anurag Yadav

引用次数: 1