Environmental Research最新文献

{"title":"Ecological partitioning and functional specialization of Thermoproteota across multiple trench sediments.","authors":"Yue Zhang, Hongbin Liu, Pudi Wang, Hao Liu, Hongmei Jing","doi":"10.1016/j.envres.2026.125897","DOIUrl":"https://doi.org/10.1016/j.envres.2026.125897","url":null,"abstract":"<p><p>Thermoproteota (formerly referred to as Thaumarchaeota) are phylogenetically divided into ammonia-oxidizing archaea (AOA) affiliated with Nitrososphaeria and basal non-ammonia-oxidizing archaea (non-AOA). While both groups co-existed in the hadal trenches, their differentiations across multiple trenches remain poorly understood. Here, 25 medium- and high-quality metagenome-assembled genomes (MAGs), including 18 AOA and 7 non-AOA representatives, were generated from metagenomics of Diamantina, Kermadec, Mariana-Yap trench sediments. AOA MAGs of Nitrosopumilales encompassing CSP1-1, DRGT01 and Nitrosopumilus exhibited chemoautotrophic potential with broader niche widths and higher diversity across trenches. Potential nitrification rates (PNR) were predominantly associated with AOA activity and exhibited clear depth-/trench-dependent patterns, driven by NH₄⁺ availability. In contrast, the non-AOA lineage diverged approximately earlier (∼2.66 Ga), whereas the divergence between B1T1B5 and JAPUIC01 was estimated at ∼1.91 Ga during the Paleoproterozoic. B1T1B5 harbored auto/mixotrophic traits, whereas JAPUIC01 exhibited a metabolically flexible, heterotrophic strategy potentially suited to anaerobic niches. The pronounced niche partitioning and functional specialization of AOA and non-AOA Thermoproteota across geographically isolated trenches were based on their genomic traits, likely an integrated consequence of microbial ecological adaptation and strong purifying selection of the local environmental condition. The findings provide a unified ecological and evolutionary framework for understanding Thermoproteota diversification in the deep ocean and reveals how functional specialization and genomic adaptive evolution shape nitrogen cycling in Earth's deepest ecosystems.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"125897"},"PeriodicalIF":8.2,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Design of Glutamic Acid-Functionalized Polyacrylonitrile Fiber: Advanced Phosphate Capture via Intermolecular Weak Interactions.","authors":"Yehang Wu, Jing Yuan, Fanglin He, Chaohai Wei, Jinshan Wei, Moses Basitere, Guanglei Qiu","doi":"10.1016/j.envres.2026.125920","DOIUrl":"https://doi.org/10.1016/j.envres.2026.125920","url":null,"abstract":"<p><p>Excessive phosphorus discharge is a primary driver of aquatic eutrophication, highlighting the need for efficient and sustainable phosphate removal technologies. In phosphate-binding protein PstS, amino acid residues construct multiple hydrogen-bonding networks with phosphate ions, facilitating high-affinity phosphate sequestration. Inspired by this mechanism, glutamic acid was employed as a functional monomer and introduced onto polyacrylonitrile fiber to mimic the intermolecular weak interaction environment of the active site of PstS, generating the glutamic acid-functionalized polyacrylonitrile fiber (PANF-Glu). It exhibits desirable adsorption performance (maximized at 123.69 mg P/g) over a wide pH range (3-11). It also showed outstanding regeneration performance. >91% adsorption capacity was retained after 5 adsorption-desorption cycles. Characterization and theoretical calculations indicate that abundant carboxyl and amine groups on the surface of PANF-Glu allowed the formation of a stable hydrogen-bonding network with phosphate ions. The enhanced hydrophilicity of the adsorption interface further facilitates the diffusion and mass transfer of phosphate ions towards the adsorbent surface. Electrostatic attractions from protonated amine groups and van der Waals forces rendered an enhanced phosphate capture. By establishing a synergy between hydrogen bonding and electrostatic attraction, this material achieves efficient phosphate adsorption and regeneration, offering a valuable practice for the development of phosphate adsorbents based on multiple intermolecular weak interactions. Furthermore, this biomimetic design involves no metal, avoiding the risk of secondary pollution caused by potential metal leaching. Consequently, PANF-Glu holds theoretical and practical promise for advanced phosphate removal from water and wastewater, which may have important implications for the development of advanced phosphate adsorption materials.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"125920"},"PeriodicalIF":8.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Ce-O_v-Mn and Cu-O_v-Mn asymmetric centers in CeCu-MnO₂ for efficient toluene oxidation by facilitating key oxygen species cycling.","authors":"Wei Liu, Xu Zhang, Hongyu Yu, Zhongxian Song, Xuejun Zhang, Xi Chen, Juan Wang","doi":"10.1016/j.envres.2026.125896","DOIUrl":"https://doi.org/10.1016/j.envres.2026.125896","url":null,"abstract":"<p><p>MnO₂-based materials have been extensively investigated for the elimination of aromatic volatile organic compounds (VOCs). Nevertheless, their practical performance is limited by sluggish activation-consumption-replenishment kinetics of key oxygen species. Here, we have successfully engineered Cu-O-Mn and Ce-O-Mn asymmetric centers within MnO₂. Their successful construction not only gives rise to Cu-O_v-Mn and Ce-O_v-Mn defect sites but also refines the electron transfer efficiency between metal and oxygen species in CeCu-MnO₂. The Cu-O_v-Mn or Ce-O_v-Mn defect sites promote the adsorption of gaseous oxygen onto the CeCu-MnO₂ surface while simultaneously facilitating the migration of lattice oxygen, thereby substantially accelerating the activation-consumption-replenishment cycle of reactive oxygen species. Consequently, CeCu-MnO₂ exhibits catalytic activity markedly superior to that of Ce-MnO₂ and Cu-MnO₂. Its T₉₀ is lowered by 25 °C and 33 °C relative to Cu-MnO₂ and Ce-MnO₂, respectively, and its low-temperature reaction rate is nearly twice as high as that of the latter two. Moreover, CeCu-MnO₂ demonstrates excellent catalytic stability and water resistance, confirming its immense potential for industrial application.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"125896"},"PeriodicalIF":8.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transgenerational Effects of Paternal in Utero Arsenic Exposure on MASLD-like Phenotypes.","authors":"Qing-Hua Qian, Qian-Qun Yang, Ya-Ping Song, Tao Wang, An-Kang Liu, Yu-Ting Kong, Zhu Ge, Qiang-Sheng Li, Yán Wāng, De-Xiang Xu","doi":"10.1016/j.envres.2026.125905","DOIUrl":"https://doi.org/10.1016/j.envres.2026.125905","url":null,"abstract":"<p><p>Previous study indicated that early-life arsenic (As) exposure caused adulthood metabolic dysfunction-associated steatotic liver disease (MASLD)-like phenotypes. This study aimed to investigate the impacts of paternal in utero As exposure on MASLD-like phenotypes in offspring. Pregnant dams received NaAsO₂ (15 mg/L) through drinking water. In utero As-exposed male pups were designated as F0 mice and mated with untreated females to produce F1 offspring. F1 males were subsequently mated with untreated females to generate F2 offspring, both without further As exposure. MASLD-like phenotypes were evaluated in F1 and F2 offspring. On PNW28, As-exposed F1 offspring exhibited hepatic steatosis, glucose intolerance, insulin resistance, and obesity, accompanied by altered metabolic hormones, such as GLP-1, GIP, insulin, and ADPN. The core MASLD-like phenotypes, including hepatic steatosis, glucose intolerance and insulin resistance, exhibited transgenerational transmission from F1 to F2 generations. In F2 offspring, these metabolic abnormalities were detected at PNW45 but not at PNW28, predominantly in male offspring. In contrast, As-induced obesity and metabolic hormone alterations exhibited transgenerational attenuation. F2 offspring retained only adipocyte hypertrophy, with no significant changes in white or brown adipose tissue weight. Furthermore, hormonal alterations in F2 mice were limited to reduced GLP-1 and elevated ADPN levels, while other altered hormones normalized. This study is the first to confirm that paternal in utero As exposure causes MASLD-like phenotypes in F1 offspring and transgenerational transmission to F2 generation.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"125905"},"PeriodicalIF":8.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical Responses of Mytilus galloprovincialis to Individual and Binary Exposures to PFDoA, Bisphenol A and Tricresyl Phosphate: Exposure and Post-exposure Dynamics.","authors":"Duarte Alves, Marta Cunha, Amadeu Soares, Rosa Freitas","doi":"10.1016/j.envres.2026.125889","DOIUrl":"https://doi.org/10.1016/j.envres.2026.125889","url":null,"abstract":"<p><p>This study investigated the biochemical responses of the mussel Mytilus galloprovincialis both immediately after exposure (14 days) and following a subsequent recovery period (14 days) in uncontaminated conditions. Mussels were exposed to bisphenol A (BPA), perfluorododecanoic acid (PFDoA), and tricresyl phosphate (TCP), either individually at a nominal concentration of 20 ng/L or in binary mixtures containing 20 ng/L of each compound (40 ng/L total nominal concentration). Biomarkers of aerobic metabolism, energy reserves, antioxidant defences, esterase-mediated biotransformation, oxidative damage, and cholinergic function were assessed at the end of both periods. At the end of exposure, BPA was associated mainly with reduced electron transport system activity, PFDoA with modulation of antioxidant responses, and TCP with increased lipid peroxidation and altered acetylcholinesterase activity. After transfer to clean seawater, some responses approached period-specific control values, whereas others persisted or became more evident. BPA-exposed mussels retained lower aerobic metabolic capacity; PFDoA-exposed mussels showed continued modulation of glutathione peroxidase and total antioxidant capacity; TCP-exposed mussels retained elevated lipid peroxidation and incomplete restoration of acetylcholinesterase activity; and the TCP/PFDoA treatment showed increased metabolic, carboxylesterase and antioxidant responses. Binary exposures modified the biochemical profiles in an endpoint-dependent manner, but the design does not permit formal classification as additive, synergistic, or antagonistic. Because exposure concentrations and tissue burdens were not analytically verified, the mechanistic interpretation of persistence and recovery is limited. Overall, post-exposure responses were only partially reversible and differed among endpoints, supporting the inclusion of post-exposure periods and period-specific controls in ecotoxicological assessments.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"125889"},"PeriodicalIF":8.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular toxicity and apoptosis-related responses to individual and combined exposure to microplastics and perfluorooctane sulfonic acid (PFOS) in Hediste diversicolor coelomocytes","authors":"Ahlem Sahnoun,&nbsp;Siwar Abouda,&nbsp;Sirine Alaya,&nbsp;Mohamed Rida Abelouah,&nbsp;Sara Gaida,&nbsp;Yossra Missaoui,&nbsp;Hana Najahi,&nbsp;Paola Rapisarda,&nbsp;Carmen Sica,&nbsp;Alfina Grasso,&nbsp;Gea Oliveri Conti,&nbsp;Margherita Ferrante,&nbsp;Mohamed Banni","doi":"10.1016/j.envres.2026.125818","DOIUrl":"10.1016/j.envres.2026.125818","url":null,"abstract":"<div><div>Microplastics (MPs) are emerging contaminants of increasing concern in marine ecosystems due to their widespread occurrence and ability to adsorb and transport hazardous chemicals such as perfluorooctane sulfonic acid (PFOS). PFOS is a persistent per- and polyfluoroalkyl substance (PFAS) with high environmental stability, bioaccumulative potential, and well-documented toxicity to aquatic organisms. However, the combined effects of MPs and PFOS on marine invertebrates remain poorly understood. This study evaluated the individual and combined effects of environmentally relevant concentrations of MPs (50 mg kg^-1 sediment) and PFOS (0.1, 0.5, and 1 μg kg^-1 sediment) on the coelomic fluid of the benthic polychaete <em>Hediste diversicolor</em> after 7 days of sediment exposure. The MPs consisted of particles &lt;30 μm composed of PVC, PET, PS, HDPE, LDPE, and PE with heterogeneous morphologies. PFOS accumulated in the coelomic fluid in a dose-dependent manner, with higher concentrations observed under co-exposure, suggesting that the presence of MPs may influence PFOS bioavailability and uptake. This increased accumulation was accompanied by pronounced cytotoxic and genotoxic effects, including lysosomal membrane destabilization, increased micronucleus frequency, and DNA fragmentation. Co-exposure also upregulated the pro-apoptotic genes <em>p53</em>, <em>Bax</em>, and <em>Casp-3</em>, while downregulating the anti-apoptotic gene <em>Bcl-2</em>, indicating activation of apoptotic pathways. Overall, the effects of combined exposure varied according to the endpoint and PFOS concentration, with co-exposure producing greater responses for some endpoints but not consistently across all treatments. These findings highlight the increased hazard posed by the co-occurrence of MPs and PFOS and emphasize the need to consider contaminant mixtures in marine environmental risk assessment.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"310 ","pages":"Article 125818"},"PeriodicalIF":8.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ mechanochemical carbonation enables carbon-negative detoxification and upcycling of municipal solid waste incineration fly ash.","authors":"Junwei Liu, Xinyue Wang, Xiaoqing Lin, Jie Chen, Jingwei Li, Lin Liu, Jianyang Wang, Zhiliang Chen","doi":"10.1016/j.envres.2026.125899","DOIUrl":"https://doi.org/10.1016/j.envres.2026.125899","url":null,"abstract":"<p><p>Municipal solid waste incineration fly ash (MSWI FA) as a hazardous waste in many countries is characterized by strong alkalinity, enrichment of multiple heavy metals, and high chloride content, making its detoxification and utilization a major global challenge. Herein, we propose an in situ mechanochemical carbonation (MC) that simultaneously couples ball milling with wet carbonation, thereby accelerating CO₂ absorption and enabling rapid detoxification (under the evaluated leaching conditions) and resource-oriented upcycling of FA. Additive-free MC substantially enhanced FA reactivity, likely through increased exposure of reactive surfaces and enhanced access to unreacted reactive phases during milling, achieving a CO₂ absorption of 124 g/kg-FA in 40 min (twice that of conventional wet carbonation) and 83% of theoretical CO₂ absorption potential. Net CO₂ balance assessment considering energy- and reagent-related carbon emissions within the defined process boundary indicated the carbon-negative potential of MC treatment (e.g., -95.6 kg CO₂/t-FA after 40 min treatment). MC-induced deep carbonation reduced Cl content in FA by ∼67% compared with conventional carbonation, yielding a final Cl content of 0.223%. Introduction of additives (NaOH, NaH₂PO₄, and/or trimercapto-s-triazine trisodium salt) into MC treatment further increased CO₂ absorption by up to 68% and simultaneously decreased the short-term leaching concentration of multiple heavy metals (i.e., Pb, Cd, Cu, Cr, Zn, Ni) by >94%, with the immobilization effects attributable to pH regulation and additive-induced mineral formation and complexation.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"125899"},"PeriodicalIF":8.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatio-Temporal Trends in Wildfire Smoke Exposures at Schools and Childcare Centers in the United States and Implications for Child and Adolescent Health.","authors":"Stephanie A Foster, Molly L Kile, Andrew Larkin, Megan MacDonald, Megan McClelland, Parichehr Salimifard, Perry Hystad","doi":"10.1016/j.envres.2026.125883","DOIUrl":"https://doi.org/10.1016/j.envres.2026.125883","url":null,"abstract":"<p><strong>Background: </strong>Wildfires are on the rise in the Unites States. Epidemiological evidence demonstrates that wildfire smoke exposure is harmful to health, especially for children and adolescents. We quantified temporal and regional trends in wildfire smoke exposure at United States public schools and childcare centers to inform risk assessment, mitigation strategies, and policy.</p><p><strong>Methods: </strong>We derived annual smoke days (binary indicator of wildfire \"smoke day\" versus \"non-smoke day\" determined using smoke plume identification from satellite imagery and simulated air trajectories from fire locations), and student-smoke-days for public schools (n=115,612) and childcare centers (n=131,372) across the United States from 2006-2023 using national daily wildfire PM_2.5 products. Indoor/outdoor PM₂.₅ mass concentration ratios were derived for West Coast facilities (n=71) with nearby PurpleAir monitors.</p><p><strong>Results: </strong>Mean annual smoke days increased from 6.8 to 54.4 at schools (during the academic year) and from 9.4 to 112.2 at childcare centers (year-round) between 2006 and 2023, totaling 2.64 and 1.02 billion student-smoke-days in 2023, respectively. Smoke-day counts were highest in the South and Midwest, while the West experienced the most severe days. Median (IQR) indoor/outdoor PM₂.₅ ratios for schools across working-hours was 0.86 (0.54, 1.39), indicating substantial but variable building protection.</p><p><strong>Conclusions: </strong>Exposure to wildfire smoke days at youth educational facilities increased rapidly over time, especially between 2019 and 2023, with substantial regional differences in magnitude and severity. Schools and childcare centers can play a pivotal role in wildfire smoke preparedness through implementation of clean-air strategies and exposure mitigation plans to protect child and adolescent health.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"125883"},"PeriodicalIF":8.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-life exposure to environmental pollutants and endocrine disruptors: emerging risks and mechanistic insights in maternal, fetal, and child health.","authors":"B Nishanthini, A Yazhini, Pramilaa Kumar, Panchamoorthy Saravanan, R Rajeshkannan, M Rajasimman, S Venkat Kumar","doi":"10.1016/j.envres.2026.125878","DOIUrl":"10.1016/j.envres.2026.125878","url":null,"abstract":"<p><p>Exposure to environmental pollutants and endocrine-disrupting chemicals (EDCs) in early life is a critical public health issue because it can alter developmental programming that impacts susceptibility to disease throughout life. The prenatal and early postnatal periods are times of vulnerability when exposure to environmental stressors may impact endocrine signalling, placental function, epigenetic regulation, and metabolic homeostasis. There is increasing evidence that exposure to bisphenols, phthalates, per- and polyfluoroalkyl substances (PFAS), pesticides, heavy metals, and air pollutants has been associated with pregnancy outcomes, neurodevelopmental disorders, metabolic dysfunction, endocrine abnormalities and reproductive impairments. Exposomics, high-resolution mass spectrometry, biomonitoring, and passive sampling technologies have made crucial advances in characterising complex environmental exposures. At the same time, novel methods such as multi-omics, single-cell sequencing, spatial biology and microbiome studies have yielded more detailed mechanistic understanding of how environmental factors can impact developmental processes via epigenetic, inflammatory, oxidative stress, and endocrine pathways. The placenta has emerged as a valuable biomarker matrix for assessing fetal exposure and developmental programming. Exposure routes, biomonitoring methods, placental processes, molecular and epigenetic modifications, and the impacts of early-life environmental exposures on neurodevelopment, metabolism, endocrine function, and reproduction are all summarised in this review. It also emphasises current advancements in exposure assessment, preventive measures, and policy frameworks, highlighting the importance of life-course perspectives and environmental justice. To identify important windows of susceptibility, improve risk assessment, and develop strategies to safeguard maternal and child health, exposomics in conjunction with systems biology and longitudinal epidemiological approaches will be essential.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"125878"},"PeriodicalIF":8.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bromophenols, pentachlorophenol, and chlorinated benzenes in pooled human serum samples from Australia.","authors":"Sina Schweizer, Julia Orr, Sandra Nilsson, Katharina Rund, Theresa Zwickel, Alexander Schächtele, Peter Hobson, Jochen Mueller, Walter Vetter","doi":"10.1016/j.envres.2026.125898","DOIUrl":"https://doi.org/10.1016/j.envres.2026.125898","url":null,"abstract":"<p><p>Through various routes humans are constantly exposed to polyhalogenated compounds which are ubiquitous in the environment. Evidence of their harmful environmental and toxic properties led to many of them being classified and regulated as persistent organic pollutants (POPs) under the Stockholm Convention. The analysis of human serum samples enables the assessment of human exposure to these compounds. However, such biomonitoring should not only cover POPs but also halogenated natural products (HNPs) which have very similar structures, and can also be present in humans. The marine environment of Australia is known for its high abundance of HNPs including bromophenols. To consider and compare both classes of polyhalogenated compounds, human serum samples from three general areas in Australia were purposefully pooled using de-identified surplus pathology samples as well as pooled de-identified samples from an occupational cohort (typically 25 donors), i.e. urban areas, coastal areas as well as islands. Overall, 26 serum pools were analyzed for three bromophenols as well as chlorinated phenols, penta- (PeCB) and hexachlorobenzene (HCB). Pentachlorophenol (PCP) showed the highest levels in all serum pools. One serum sample with donors from a remote island showed exceptionally high levels of PCP (10,500 pg/mL serum) and 2,6-dibromophenol (2,6-DBP, 1,500 pg/mL serum). Typically, 2,4,6-tribromophenol was the 2^nd most abundant analyte (up to 140 pg/mL serum). However, the determined wide ranges of concentrations in the pools from the three general areas were overlapping. Significant differences between urban-dominated regions and islands as well as the coast were only found for 2,4-DBP, 2,6-DBP and HCB.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"125898"},"PeriodicalIF":8.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}