Environmental Research最新文献

{"title":"Preparation of iron−rich belite−sulfoaluminate cement utilizing iron tailings and fluorogypsum","authors":"Rui Li ,&nbsp;Lutao Xue ,&nbsp;Wenqiang Yu ,&nbsp;Ruan Chi ,&nbsp;Yubiao Li","doi":"10.1016/j.envres.2025.122778","DOIUrl":"10.1016/j.envres.2025.122778","url":null,"abstract":"<div><div>In order to promote the development and application of low−carbon cement varieties and the recycling of industrial solid waste, this study used iron tailings and fluorogypsum to prepare iron−rich belite−sulfoaluminate cement (I−BCSA). The suitable conditions for the preparation of I−BCSA in this system were with an excessive addition of 6 wt% of SO₃ in the raw meal, at a calcination temperature of 1250 °C for 1.5 h, and an added−gypsum content of 15 wt%. Under this suitable preparation condition, the contents of ye'elimite, dicalcium silicate (C₂S) and tetracalcium aluminoferrite (C₄AF) in I−BCSA clinker were 29.17 %, 50.23 % and 16.71 %, respectively. In addition, the impurity ions (Mg, S and F ions) hindered the transformation of α′_H−C₂S into α′_L−C₂S during the cooling process of clinker by causing the distortion and the inside porosity decrease of α′_H−C₂S crystal (phase transition energy barrier: 254 eV → 553 eV). This resulted in 20.49 % of the C₂S in the I−BCSA clinker existing in the α′_H crystal form. The presence of C₄AF and α′_H−C₂S in clinker significantly improved the strength development of the product before 28 days. At a water/cement ratio of 0.35, the 3−day, 7−day, and 28−day compressive strengths of I−BCSA paste reached 43 MPa, 51 MPa, and 66 MPa, respectively, basically surpassed the strength development of commercial cement (including 42.5−grade of R–type OPC and CSA) exhibiting good early strength, under the same conditions. Moreover, the hydration products of I–BCSA were mainly ettringite, C–S–H gel, Fe(OH)₃ gel, Al(OH)₃ gel, C₃(A, F)·6H₂O and CaCO₃, with relative proportions of 50.13 %, 36.06 %, 4.57 %, 4.21 %, 2.54 % and 2.49 %, respectively. From the perspective of hydration products, the synergistic support of ettringite and C–S–H gel was more conducive to the strength development of paste than the support of ettringite or C–S–H gel alone. Finally, the long–term (after 28 days) performance of I–BCSA still needs to be further studied in the future to promote the practical application of I–BCSA.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"286 ","pages":"Article 122778"},"PeriodicalIF":7.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoengineered Scheelite-Structured SrWO₄ Decorated on MXene Sheets: A Novel Platform for Electrochemical Sensing of the Anti-Cancer Drug Nilutamide with DFT Insights.","authors":"Akash Ashokrao Jagtap, Vaibhav Kanke, Rajalakshmi Sakthivel, Amar S Katkar, Lu-Yin Lin, Yu-Chien Lin, Xinke Liu, Cihun-Siyong Gong, Ching-Wei Tung, Ren-Jei Chung","doi":"10.1016/j.envres.2025.122776","DOIUrl":"https://doi.org/10.1016/j.envres.2025.122776","url":null,"abstract":"<p><p>The persistent presence of the pharmaceutical pollutant nilutamide (NLT) in environmental and biological systems poses a serious threat to ecosystems and human health, necessitating efficient and sustainable detection strategies. In this study, we present a nanoengineered SrWO₄@MXene electrocatalyst as a high-performance platform for electrochemical sensing. The hybrid material seamlessly integrates the catalytic activity and electrochemical stability of SrWO₄ with the exceptional conductivity and tunable surface chemistry of MXenes, resulting in a synergistic architecture optimized for rapid and selective NLT detection. Detailed structural and spectroscopic characterizations confirmed the successful fabrication of the electrocatalyst, while electrochemical studies demonstrated an ultra-low detection limit of 0.07 μM, a linear range of 5-115 μM, and a high sensitivity of 5.66 μA μM^-1 cm^-2. Moreover, density functional theory calculations provided insights into the energy level and electron active site of NLT during the electrochemical process. Real-world applications in pond water and human serum demonstrated the electrocatalyst's robustness, selectivity, and real-world applicability. This study establishes SrWO₄@MXene as an innovative, scalable, and environmentally sustainable electrocatalyst for pharmaceutical pollutant monitoring, offering significant advancements in electrochemical sensing for environmental and clinical applications.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"122776"},"PeriodicalIF":7.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The temporal change in heat-related mortality in relation to the Heat Health Action Plans in the five major cities of Australia","authors":"Nguyen Thi Tuong Vy ,&nbsp;Nu Quy Linh Tran ,&nbsp;Yohani Dalugoda ,&nbsp;Nguyen Minh Quoc ,&nbsp;Nguyen Ngoc Nhat Thanh ,&nbsp;Stacey Pizzino ,&nbsp;Dung Phung","doi":"10.1016/j.envres.2025.122764","DOIUrl":"10.1016/j.envres.2025.122764","url":null,"abstract":"<div><div>Heat-Health Action Plans (HHAPs) are essential public health interventions to reduce heat-related mortality and morbidity, yet how heat-related health risks have changed following their implementation remains scarce. This study aimed to examine the temporal changes in heat-related mortality in relation to the implementation of the HHAPs across five major cities of Australia, including Melbourne, Sydney, Brisbane, Adelaide, and Perth. Daily mortality and temperature data from 1999 to 2019 were analysed using distributed lag non-linear models to compare the heat-related mortality attributable fractions (AF%) between pre- and post-HHAP periods. The results showed an overall reduction in heat-related mortality after HHAP implementation, with a notable 0.12 % (95 % CI: −0.28 - 0.04) decrease in mortality attributable to extreme heat across five cities. The reduction was more evident in individuals aged 75 and older (−0.18 %, 95 % CI: −0.35 - 0.01), while the 0–74 age group saw slight increases (+0.13 %, 95 % CI: −0.13 - 0.39). Heatwave-related mortality showed general reductions or slight increases across cities, with AF differences in period 2 and 1 ranging from −0.20 % to +0.01 %. Brisbane, Perth, Sydney, and Adelaide witnessed notable AF decreases or minimal increases in period 2 across different definitions of heatwaves (−1.38 % to −0.01 % in Brisbane, −2.01 % to +0.05 % in Perth, −0.19 %–0.00 % in Sydney, and −0.71 %–0.17 % in Adelaide). In Melbourne, AF increased notably in period 2 for low-intensity heatwaves (≥2 days + 90th/92th percentile) by +0.25 % and +0.38 %, primarily due to the increase among those aged 0–74. Meanwhile, Sydney showed AF increases by +0.08 % to +0.43 % among the elderly during low-intensity heatwaves despite overall AF reductions. These findings suggest that HHAPs have reduced heat-related mortality in Australia's major cities, particularly during extreme heat days. However, extreme heat continues to pose significant health risks, highlighting the need for enhanced heat-health strategies.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"286 ","pages":"Article 122764"},"PeriodicalIF":7.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal blood metal levels during pregnancy and body mass index z-score, overweight, and obesity among children: Findings of the Japan Environment and Children's Study","authors":"Limin Yang ,&nbsp;Miori Sato ,&nbsp;Mayako Saito-Abe ,&nbsp;Yumiko Miyaji ,&nbsp;Daisuke Harama ,&nbsp;Kei Sakamoto ,&nbsp;Minaho Nishizato ,&nbsp;Natsuhiko Kumasaka ,&nbsp;Hidetoshi Mezawa ,&nbsp;Kiwako Yamamoto-Hanada ,&nbsp;Yukihiro Ohya ,&nbsp;Maki Fukami ,&nbsp;Japan Environment and Children's Study (JECS) Group","doi":"10.1016/j.envres.2025.122755","DOIUrl":"10.1016/j.envres.2025.122755","url":null,"abstract":"<div><div>This study explored the association between maternal blood lead, cadmium, mercury, and manganese concentrations during pregnancy and body mass index z-scores (zBMI), overweight, and obesity among children aged 0–4 years based on data from the Japan Environment and Children's Study (JECS). After data selection, 93,782 mother–child pairs were selected for analysis. Associations between prenatal metal exposure and obesity in children were explored using the generalized estimating equation (GEE), latent class growth analysis (LCGA), and quantile g-computation models. After adjusting for confounders, mercury (Hg) showed a very weak opposite association with zBMI, overweight, and obesity according to the GEE model. A one-unit increase in the log₂(Hg) was associated with an approximately 3 % reduction in the odds of obesity. Similarly, lead and cadmium were associated with a slight reduction in zBMI. Results from the LCGA model showed that increased mercury exposure was associated with reduced odds of belonging to the late-onset or persistent obesity trajectory groups. The mixture effect from the quantile g-computation model indicated the same direction of association. A one-quartile simultaneous increase in the lead, cadmium, mercury, and manganese concentrations was associated with a 0.024 reduction in zBMI and the risk of overweight and obesity (approximately 4.6 % and 6.4 %, respectively). Extremely weak negative associations were observed between prenatal metal exposure and zBMI, overweight, and obesity during early childhood. However, given the weak effect size, we acknowledge that prenatal metal exposure does not significantly influence childhood obesity from a public health and clinical perspective.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"286 ","pages":"Article 122755"},"PeriodicalIF":7.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discontinuation of glacial meltwater input reshapes the diversity and stability of eukaryotic planktonic microbial communities in glacial lakes","authors":"Xiaodong Li ,&nbsp;Qianggong Zhang ,&nbsp;Peng Zhang ,&nbsp;Qing Yang ,&nbsp;Zijian Lu ,&nbsp;Yanan Zhou ,&nbsp;Meiqi Huang ,&nbsp;Guangli Mu ,&nbsp;Zhao Xue ,&nbsp;Linyuan Lu ,&nbsp;Yindong Tong","doi":"10.1016/j.envres.2025.122785","DOIUrl":"10.1016/j.envres.2025.122785","url":null,"abstract":"<div><div>Glacial lakes play a vital role as indicators of global climate change and regional environmental responses. Eukaryotic planktonic microorganisms, pivotal in driving biogeochemical cycling of nutrients within these ecosystems, are crucial for preserving stability and ecological function of glacial lake environments. Nevertheless, the spatial and temporal dynamics, along with the mechanisms responsible for sustaining eukaryotic planktonic microbial communities in glacial lakes, especially during the glacier retreat and lake formation, are still largely uncharted. In this study, we investigate the diversity and stability of eukaryotic planktonic microbial communities in the glacial lakes at different developmental stages on the Qinghai-Tibet Plateau (QTP) through 18S rDNA gene amplification sequencing. Our results indicated that both the diversity and stability of the eukaryotic communities initially increased and then declined as the glacial lakes matured, with the species showing increasing environmental adaptability. Following cessations of glacial meltwater inputs, both diversity and stability had decreased, resulting in a more uniform species composition. The key environmental factors determining community diversities and stability include turbidity, pH, nitrate, and phosphate. The formation of eukaryotic planktonic microbial communities was predominantly influenced by the stochastic process, with dispersal limitation playing a key role. These discoveries could deepen our comprehension regarding the biogeographic distribution of microbial communities in emerging glacial lakes on the QTP and provide valuable insights into studying microbial ecological adaptations in the extreme environments and their response to climate change.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"286 ","pages":"Article 122785"},"PeriodicalIF":7.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-component tree biomass approach to estimate litterfall Hg deposition in a warm-temperate coniferous forest in southern Europe","authors":"A. Parente-Sendín ,&nbsp;M. Méndez-López ,&nbsp;N. Calvo-Portela ,&nbsp;L. Acemel-Míguez ,&nbsp;F. Alonso-Vega ,&nbsp;J.C. Nóvoa-Muñoz","doi":"10.1016/j.envres.2025.122767","DOIUrl":"10.1016/j.envres.2025.122767","url":null,"abstract":"<div><div>Terrestrial ecosystems are a key component in the biogeochemical cycle of Hg. About 50 % of atmospheric Hg is captured in the system because of the ability of vegetation to retain and subsequently transfer it to the soil surface through litterfall. In a stand dominated by Scots pine (<em>Pinus sylvestris</em>), the widest spatially distributed tree species in the northern hemisphere and the second worldwide, this two-year study evaluated monthly the litterfall Hg deposition fluxes (FHg_Ta) through all litterfall fractions involved (needles, twigs, bark, miscellaneous, and male inflorescences). The range of annual fluxes of litterfall (LF_Ta) was 504–512 g m⁻², although needles were the dominant fraction (275–315 g m⁻²), the non-foliar tissues contribution reached 41 % of LF_Ta. Average of total Hg concentrations in litterfall fractions were branches (60–61 μg kg⁻¹) &gt; miscellaneous (52-49 μg kg⁻¹) ≈ needles (51-49 μg kg⁻¹) &gt; bark (45-43 μg kg⁻¹) &gt; male inflorescences (24-20 μg kg⁻¹). Annual fluxes of litterfall Hg deposition (FHg_Ta) accounted for 25.4 and 23.1 μg m⁻², and needles, being the largest contributor (59–67 %), especially during the growing season (from the end of spring to early autumn). Nevertheless, during the dormant season, non-foliar tissues ruled the Hg deposition, indicating mechanisms of atmospheric Hg retention other than foliar uptake are also involved, as the notable influence of litterfall biomass (LF_Ta) on FHg_Ta also indicated. The monthly sampling monitoring strategy and the Hg determination in individual litterfall fractions served as an accurate annual record of FHg_Ta that allows for anticipating high Hg deposition periods that could threaten soil biota and freshwater ecosystems.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"286 ","pages":"Article 122767"},"PeriodicalIF":7.7,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimetallic FeNi-ZSM-5-catalyzed pyrolysis of photovoltaic waste: Selective and high-yield aromatic valorization for circular resource recovery","authors":"Xin Chen ,&nbsp;Jingyong Liu ,&nbsp;Ziting Lin ,&nbsp;Yan Chen ,&nbsp;Leyao Tao ,&nbsp;Fatih Evrendilek ,&nbsp;Liangzhong Li ,&nbsp;Shubin Wang ,&nbsp;Jianli Huang ,&nbsp;Yao He ,&nbsp;Wuming Xie","doi":"10.1016/j.envres.2025.122753","DOIUrl":"10.1016/j.envres.2025.122753","url":null,"abstract":"<div><div>Catalytic pyrolysis, an efficient thermochemical process, offers a promising pathway to valorize thermoset photovoltaic backsheets (TPV) into high-value chemicals. This study investigates the ex situ catalytic pyrolysis of TPV using two acidic catalysts, ZSM-5 and FeNi-ZSM-5, under varied operational conditions, with a focus on product distribution and process efficiency. The catalytic intervention significantly enhanced pyrolysis performance. Both catalysts enhanced pyrolysis oil deoxygenation, reducing acidic compounds and increasing hydrocarbon yields. Temperature elevation further intensified this trend: hydrocarbon content surged from 4.60 % to 96.29 %, while acidic compounds decreased sharply from 94.64 % to trace levels. This shift transformed primary products from benzoic acid derivatives to high-value polycyclic aromatic hydrocarbons. High temperatures (≥600 °C) reduced hazardous compounds during fast pyrolysis. During slow pyrolysis, FeNi-ZSM-5 achieved 68.30 % benzene selectivity at 485 °C, enriching aromatic content in the gas phase. Joint optimization of five predictive models identified 603 °C with TPV + FeNi-ZSM-5 as optimal or minimal residual mass. These results underscore the dual role of the catalysts in improving conversion efficiency and refining product selectivity. By enabling tailored control over pyrolysis pathways, ZSM-5 and FeNi-ZSM-5 present a scalable strategy for transforming PV waste into value-added chemicals, aligning with circular economy objectives while mitigating environmental hazards.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"286 ","pages":"Article 122753"},"PeriodicalIF":7.7,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics and endocrine-disrupting byproducts (bisphenol A & phthalate esters) in popular infant formula brands in Iran; qualification, quantification and risk assessment","authors":"Maryam Ahmadi ,&nbsp;Hooshyar Hossini ,&nbsp;Meghdad Pirsaheb","doi":"10.1016/j.envres.2025.122713","DOIUrl":"10.1016/j.envres.2025.122713","url":null,"abstract":"<div><div>Concerns regarding the health implications of microplastics (MPs) pollution and their byproducts, such as bisphenol A (BPA) and phthalate esters (PAEs), have escalated, particularly for vulnerable populations like infants. Since infants are primarily nourished by breast milk or infant formula, their heightened exposure risk to these contaminants warrants investigation. This study assessed the presence, morphological characteristics, and associated byproducts (BPA and PAEs) of MPs in commercially available infant formulas sold in the Iranian market. In this descriptive-analytical, cross-sectional study, 27 infant formula samples were analyzed from three high-consumption brands in Iran, with each brand represented by products for the &lt;6, 6–12, and &gt;12 months age groups. Imaging techniques and chemical analysis were employed to characterize MPs, while an advanced analytical chemistry technique was used to quantify BPA and phthalates. The average number of MP particles per 400-g formula container was 585.2 ± 187.2 (ranging from 66.7 to 1000). These particles were predominantly polypropylene (PP) fibers with black or blue coloration. Exposure to MPs was lowest in newborns and highest in infants aged three months. Both BPA and phthalate esters were detected in all samples. While phthalate exposure levels remained below established hazardous thresholds, BPA exposure exceeded permissible limits. These findings raise significant public health concerns, as chronic exposure to MPs and hormone-disrupting chemicals could pose serious risks to development and long-term health. These results suggest that manufacturers optimize production and packaging processes to minimize contamination risks.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"286 ","pages":"Article 122713"},"PeriodicalIF":7.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C/N-Driven Synergies: Earthworms optimize CO2/N2O mitigation and soil quality in floral waste recycling","authors":"Hongyang Li ,&nbsp;Guijun Wu ,&nbsp;Mei Li ,&nbsp;Changqun Duan ,&nbsp;Chang-e Liu","doi":"10.1016/j.envres.2025.122712","DOIUrl":"10.1016/j.envres.2025.122712","url":null,"abstract":"<div><div>The expansion of floriculture has increased the need for sustainable floral waste management to support agricultural carbon neutrality. This study assessed the impact of carnation, lily, and rose straw amendments (with varying C/N ratios, lignin, and cellulose) on GHG emissions and soil quality with earthworm (<em>Eisenia fetida</em>). Controlled microcosm experiments were conducted to examine the effects of straw types and earthworms on CO₂ and N₂O fluxes, as well as soil properties, enzyme activities, and microbial functions. The results revealed that Earthworms enhanced straw mineralization, increasing cumulative CO₂ emissions by 1.09–1.50-fold compared to controls (<em>P</em> &lt; 0.05). N₂O emissions varied by C/N ratio: earthworms reduced N₂O emissions by 42.7 % (carnation) and 20.3 % (lily), but increased it by 56.4 % (rose). Optimal GHG mitigation was achieved in low-C/N systems (carnation + earthworms) which reduced N₂O emissions by 42.7 % with a moderate CO₂ increase (9.1 %), highlighting the risks of high lignin content and microbial N limitation. Soil quality, measured through the Soil Quality Index (SQI), was significantly improved by earthworm-straw interactions in all treatments (TDS-SQI: 0.61–0.68) compared to straw-alone controls (TDS-SQI: 0.53–0.60) (<em>P</em> &lt; 0.05). The TDS-SQI revealed that Earthworm-straw combinations, especially those with low C/N ratios, optimized both soil quality and GHG mitigation. This study highlights earthworms' potential to modulate carbon-nitrogen cycling, offering a feasible strategy for sustainable floral waste recycling that supports carbon neutrality goals. Prioritizing this approach in floral waste recycling programs is recommended for sustainable agriculture.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"286 ","pages":"Article 122712"},"PeriodicalIF":7.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organophosphate Flame Retardants Disrupt Autism-Relevant Gene Networks Across Development: A Cross-Species Multi-Omics Study","authors":"Yi-Hui Zhou,&nbsp;George Sun","doi":"10.1016/j.envres.2025.122734","DOIUrl":"10.1016/j.envres.2025.122734","url":null,"abstract":"<div><div>Organophosphate flame retardants (OPFRs) are widely used environmental contaminants with suspected developmental neurotoxicity, yet their stage-specific molecular impacts and potential relevance to autism spectrum disorder (ASD) remain poorly defined. We integrated transcriptomic and lipidomic analyses from two rat models to investigate OPFR-induced disruption across early neurodevelopment. In dataset GSE148266, fetal forebrain and placenta were analyzed following in utero OPFR exposure; in dataset GSE211430, neonatal cortical RNA-seq and lipidomics were profiled after postnatal exposure to triphenyl phosphate and isopropylated triaryl phosphate (1000 μg/day; n = 10/sex/group). Differential expression (DESeq2; FDR &lt;0.05), pathway enrichment (GSEA), and multi-omics integration (DIABLO; |r| &gt; 0.9) were performed. Fetal exposure altered 191 genes (144 mapped to human orthologues), including ASD-relevant genes such as <em>ADNP</em>, <em>BRAF</em>, and <em>MAPK3</em>, with enrichment in spliceosome (NES = 2.39), cell-cycle regulation (NES = 2.26), and suppressed Toll-like/NOD-like immune signaling (NES = −2.06). Postnatal exposure disrupted 34 genes and 12 lipids, notably PC(15:0_16:0) and TG(18:1_20:1_20:1), which correlated with synaptic and immune-related genes. Eighteen neonatal DEGs overlapped with human ASD cortical transcriptomes, and integrated analysis revealed shared neurotransmission networks across developmental stages.</div><div>These findings demonstrate that OPFRs disrupt conserved neurodevelopmental gene networks in a stage-specific manner. The convergence of transcriptomic and lipidomic signals with ASD-relevant features supports further investigation of OPFRs as candidate environmental risk factors and highlights molecular pathways for future biomarker and toxicity studies.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"286 ","pages":"Article 122734"},"PeriodicalIF":7.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}