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Do epigenetic aging biomarkers mediate the association between exposure and health outcomes? A scoping review of mediation analysis. 表观遗传老化生物标志物介导暴露与健康结果之间的关联吗?中介分析的范围审查。
IF 7.7 2区 环境科学与生态学
Environmental Research Pub Date : 2026-05-01 DOI: 10.1016/j.envres.2026.124600
Ryosuke Fujii, Yoshiki Tsuboi, Andres Cardenas, Sakurako S Okuzono, Linda Valeri, Hiroya Yamada, Mirai Yamazaki, Hiroshi Okumiyama, Kazuma Murakami, Riku Umematsu, Koji Suzuki
{"title":"Do epigenetic aging biomarkers mediate the association between exposure and health outcomes? A scoping review of mediation analysis.","authors":"Ryosuke Fujii, Yoshiki Tsuboi, Andres Cardenas, Sakurako S Okuzono, Linda Valeri, Hiroya Yamada, Mirai Yamazaki, Hiroshi Okumiyama, Kazuma Murakami, Riku Umematsu, Koji Suzuki","doi":"10.1016/j.envres.2026.124600","DOIUrl":"https://doi.org/10.1016/j.envres.2026.124600","url":null,"abstract":"<p><p>Epigenetic aging biomarkers are promising novel biological age indicators derived from algorithms based on DNA methylation patterns. Since epigenetic age was first described over a decade ago, it has been used as an exposure or an outcome in biomedical research to address the fundamental question of \"aging\". Yet, a critical question remains unresolved: how epigenetic age mediates the effects of exposures on health outcomes. Mediation analysis provides a rigorous statistical framework for decomposing total effects into direct and indirect pathways, thereby testing the extent to which epigenetic age deviation explains exposure-outcome relationships. Meanwhile, the reporting quality using mediation analysis varied across studies. This scoping review provides a methodological primer on causal mediation analysis and a literature review using epigenetic age as a mediator with quality assessment. We conducted an initial literature search through four online databases (PubMed, Embase, MEDLINE, and CINAHL) at the beginning of September 2025. We identified 22 studies (published since 2022) examining epigenetic aging as a mediator between environmental/lifestyle exposures and health outcomes. Most studies used blood-based DNA methylation and applied causal mediation frameworks. GrimAge, PhenoAge, and DunedinPACE were more frequently used. Outcomes primarily included mortality and cardiovascular disease, while exposures covered smoking, diet, socioeconomic factors, clinical biomarkers, and environmental pollutants. Although causal mediation analysis suggested that epigenetic aging could be a possible mechanistic mediator linking exposures to disease risk, many studies lacked methodological rigor. To enhance epigenetic evaluation in broad settings, further work should apply causal mediation analysis to epigenetic aging markers with a rigorous methodology.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"124600"},"PeriodicalIF":7.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Anammox Start-Up for Moderate- to Low-Strength Ammonium Wastewater: Adaptation of Mature Anammox Sludge to High- and Low-Loading Strategies. 提高中低强度氨氮废水厌氧氨氧化启动:成熟厌氧氨氧化污泥对高、低负荷策略的适应。
IF 7.7 2区 环境科学与生态学
Environmental Research Pub Date : 2026-04-25 DOI: 10.1016/j.envres.2026.124603
Yuerong Ding, Qian Zhang, Xiaoqian Dong, Bin Zhang, Yong Huang, Daosen Wu, Haonan Shen, Zhiyao Huang, Meng Li, Hongyu Wang
{"title":"Enhancing Anammox Start-Up for Moderate- to Low-Strength Ammonium Wastewater: Adaptation of Mature Anammox Sludge to High- and Low-Loading Strategies.","authors":"Yuerong Ding, Qian Zhang, Xiaoqian Dong, Bin Zhang, Yong Huang, Daosen Wu, Haonan Shen, Zhiyao Huang, Meng Li, Hongyu Wang","doi":"10.1016/j.envres.2026.124603","DOIUrl":"https://doi.org/10.1016/j.envres.2026.124603","url":null,"abstract":"<p><p>Municipal and industrial wastewaters entering biological treatment often exhibit low C/N ratios and moderate-to-low ammonium strength. While suitable for such streams, the anaerobic ammonium oxidation (Anammox) process suffers from slow start-up and unstable performance under substrate-limited conditions. This study compared start-up strategies via high-nitrogen-loading gradient adaptation versus low-nitrogen-loading environmental acclimation in integrated fixed-film activated sludge - up-flow anaerobic sludge blanket (IFAS-UASB) reactors inoculated with mature Anammox sludge, evaluating their effects on system performance and microbial communities. High-loading start-up markedly enhanced process activation, stimulated extracellular polymeric substance (EPS) secretion, and achieved a maximum total-nitrogen removal efficiency of 80.0%. Performance remained stable at approximately 65% even after stepwise reduction of the influent nitrogen concentration, exceeding the approximately 40% efficiency under low-loading conditions. Microbial analyses further indicated that high loading enriched anammox bacteria (AnAOB) (e.g., Candidatus Brocadia and Candidatus Jettenia) and fostered positive interactions with associated taxa, forming a cooperative metabolic network. In contrast, low-loading systems were dominated by denitrifiers, with AnAOB declining sharply due to competitive exclusion. Carrier type showed limited influence. These findings demonstrate that high-loading start-up, by optimizing community assembly and enhancing functional-bacteria enrichment, offers an effective strategy for the rapid start-up and efficient, stable operation of Anammox systems treating moderate- to low-strength ammonium wastewater.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"124603"},"PeriodicalIF":7.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total Effect of Heat on Mortality Considering Heat-Mediated Air Pollution and Interaction Effect under Demographic, Mitigation, and Adaptation Scenarios. 人口、减缓和适应情景下考虑热介导空气污染和相互作用效应的热对死亡率的总影响。
IF 7.7 2区 环境科学与生态学
Environmental Research Pub Date : 2026-04-25 DOI: 10.1016/j.envres.2026.124593
Honghyok Kim, Garam Byun, Yongsoo Choi, Sera Kim, Hyomi Kim
{"title":"Total Effect of Heat on Mortality Considering Heat-Mediated Air Pollution and Interaction Effect under Demographic, Mitigation, and Adaptation Scenarios.","authors":"Honghyok Kim, Garam Byun, Yongsoo Choi, Sera Kim, Hyomi Kim","doi":"10.1016/j.envres.2026.124593","DOIUrl":"10.1016/j.envres.2026.124593","url":null,"abstract":"<p><p>Health impact assessments of high ambient temperature (HAT)-related mortality has typically been assessed through direct thermal effects alone, overlooking critical pathways. Here, we conceptualize HAT impacts as a multifaceted process that includes both direct effects and indirect effects mediated through HAT-induced increases in ambient air pollution, notably ozone, and their interactions. We developed a unified epidemiologic framework of mediation, interaction, and exposure measurement error, and estimated the total effect (TE) of HAT on mortality. Using national mortality and environmental data from South Korea, we projected HAT-related mortality from 2025 to 2100 under demographic and mitigation/adaptation scenarios, which includes the direct effect of HAT and indirect effect of HAT (through HAT-mediated ozone) and the interaction between HAT and HAT-mediated ozone. Across all scenarios, the interaction between HAT and HAT-mediated ozone contributed to a substantial fraction of HAT-related mortality. Under low mitigation/adaptation scenario, SSP5-RCP8.5, HAT is projected to cause 855,202 deaths (95% CI: 518,447-1,224,610), of which 481,214 deaths (126,493-884,528) are attributable to the interaction between HAT and HAT-mediated ozone, while 335,363 deaths (186,224-522,933) are attributable to the direct effect of HAT alone. The total deaths could be reduced to 389,446 deaths (229,335-563,693) under high mitigation/adaptation scenario, SSP1-RCP2.6, of which 221,025 deaths (58,078-406,881) are attributable to the interaction, while 163,744 deaths (85,012-241,821) are attributable to the direct effect of HAT. Our findings imply that heat-related mortality may be higher than previously reported in the literature, highlighting the need for effective mitigation and adaptation strategies to reduce the TE of HAT.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"124593"},"PeriodicalIF":7.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antagonistic interactions between polyethylene microplastics and oxytetracycline mitigate toxicity of the anammox process and the proliferation of ARGs. 聚乙烯微塑料和土霉素之间的拮抗相互作用减轻了厌氧氨氧化过程的毒性和ARGs的增殖。
IF 7.7 2区 环境科学与生态学
Environmental Research Pub Date : 2026-04-24 DOI: 10.1016/j.envres.2026.124584
Tongzhan Xue, Xinlei Yang, Weihua Li, Houyun Yang, Jiajia Xu, Li Yu, Bo Dong, Lidong Chen, Xinyu Chen
{"title":"Antagonistic interactions between polyethylene microplastics and oxytetracycline mitigate toxicity of the anammox process and the proliferation of ARGs.","authors":"Tongzhan Xue, Xinlei Yang, Weihua Li, Houyun Yang, Jiajia Xu, Li Yu, Bo Dong, Lidong Chen, Xinyu Chen","doi":"10.1016/j.envres.2026.124584","DOIUrl":"https://doi.org/10.1016/j.envres.2026.124584","url":null,"abstract":"<p><p>Emerging pollutants such as microplastics and antibiotics pose potentially serious risks to the metabolism and ecology of microorganisms. To explore the short-term stress mechanism of polyethylene microplastics (PE MPs) and oxytetracycline (OTC) on the anaerobic ammonia oxidation (anammox) process, single and combined stress experiments of with 5 mg/L PE MPs and 5 mg/L OTC on anammox were conducted based on the gradient experiments. The results showed that OTC had a more significant impact on the nitrogen removal performance of anammox process compared to PE MPs alone and that of the combined stress, and the combined stress exhibited an antagonistic effect. OTC stress can alter the secretion and structural composition of extracellular polymeric substances (EPS) of anammox bacteria, reduce the size of anammox granular sludge (AnGS), and decrease the stability of AnGS. However, PE MPs had a positive effect on the EPS of anammox bacteria. The relative abundance of Planctomycetes decreased in all stress groups, with the greatest decrease observed in the OTC group. The relative abundances of OTC resistance genes, tetG and tetX, decreased in the PE MPs group, while they increased in the OTC group and the combined stress group. PE MPs had an inhibitory effect on the spread of antibiotic resistance genes (ARGs), and the combined stress of PE MPs and OTC may mainly affect the amplification of the efflux pump gene tetG.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"124584"},"PeriodicalIF":7.7,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First report on the maternal transfer of total and intracellular metals and metalloids in the Critically Endangered Spiny butterfly ray, Gymnura altavela. 极危刺蝶总金属和细胞内金属及类金属的母体转移首次报道。
IF 7.7 2区 环境科学与生态学
Environmental Research Pub Date : 2026-04-21 DOI: 10.1016/j.envres.2026.124525
Amanda Pontes Lopes, Mateus Brandão Marques, Clara Velloso Teixeira-Leite, Marcelo Vianna, Tatiana Dillenburg Saint'Pierre, Rachel Ann Hauser Davis
{"title":"First report on the maternal transfer of total and intracellular metals and metalloids in the Critically Endangered Spiny butterfly ray, Gymnura altavela.","authors":"Amanda Pontes Lopes, Mateus Brandão Marques, Clara Velloso Teixeira-Leite, Marcelo Vianna, Tatiana Dillenburg Saint'Pierre, Rachel Ann Hauser Davis","doi":"10.1016/j.envres.2026.124525","DOIUrl":"https://doi.org/10.1016/j.envres.2026.124525","url":null,"abstract":"<p><p>Increasing risks from metal and metalloid contamination, mainly due to human activities, have become of particular concern for endangered species that already face multiple pressures. These contaminants can bioaccumulate in exposed organisms and induce oxidative stress, cellular damage, reproductive impairments, and embryonic alterations. In viviparous species like the critically endangered Spiny butterfly ray (Gymnura altavela), maternal transfer is a relevant but still underexplored contaminant exposure pathway during early development. This study provides the first evidence of maternal transfer of several elements in G. altavela through integrated maternal and embryo tissue and reproductive fluid analyses. Samples were obtained from artisanal fisheries in Rio de Janeiro, southeastern Brazil, elemental determinations were performed employing inductively coupled plasma mass spectrometry (ICP-MS) and oxidative stress biomarkers were investigated by spectrophotometry. Maternal offloading was verified for most determined elements, with accumulation observed in various embryo tissues. Several metals and metalloids were also observed as capable of traversing the blood-brain barrier, suggesting neurotoxicity potential, as well as accumulating in the rectal gland, possibly resulting in osmoregulation alterations. Higher contaminant levels were noted in the left side of the reproductive system, potentially due to ovarian asymmetry and greater embryonic loads in this side. Reproductive and yolk-associated tissues exhibited higher metal and metalloid concentrations when compared to other batoid species, suggesting high local contamination. These findings highlight maternal transfer as a critical exposure route and suggest that pregnant females and their embryos may be significantly affected in contaminated areas. This supports conservation actions, such as incorporating contaminant monitoring into management plans and prioritizing pollution mitigation in identified G. altavela nursery and fishing grounds.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"124525"},"PeriodicalIF":7.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances and future perspectives in ceramic-based nanofiltration membranes: Material innovations, applications, and sustainability challenges 陶瓷基纳滤膜的最新进展和未来展望:材料创新、应用和可持续性挑战。
IF 7.7 2区 环境科学与生态学
Environmental Research Pub Date : 2026-03-15 Epub Date: 2026-01-11 DOI: 10.1016/j.envres.2026.123754
Sungwon Choi , Deokhwan Kim , Jonghun Lee , Chanhyuk Park , Myungchan Kim , Byung-Moon Jun , Hojung Rho
{"title":"Recent advances and future perspectives in ceramic-based nanofiltration membranes: Material innovations, applications, and sustainability challenges","authors":"Sungwon Choi ,&nbsp;Deokhwan Kim ,&nbsp;Jonghun Lee ,&nbsp;Chanhyuk Park ,&nbsp;Myungchan Kim ,&nbsp;Byung-Moon Jun ,&nbsp;Hojung Rho","doi":"10.1016/j.envres.2026.123754","DOIUrl":"10.1016/j.envres.2026.123754","url":null,"abstract":"<div><div>The demand for advanced water treatment technologies has increased with the expansion of industrial activities and the tightening of environmental regulations. Nanofiltration (NF) membranes have garnered considerable attention because of their selective separation performance and energy efficiency. The need for ceramic NF membranes has emerged as they provide the high chemical stability and precise selectivity required to remove recalcitrant pollutants, such as low-molecular-weight compounds discharged from the semiconductor and pharmaceutical industries. However, research on ceramic NF membranes remains limited, and reviews that comprehensively examine their technological developments are rare. This review systematically analyzes the studies on ceramic NF membranes published over the past 5 y, focusing on fabrication strategies, structural properties, surface modification, separation performance, and long-term operational stability. Special attention is paid to enhancing selectivity and permeability through pore structure and surface charge control, antifouling strategies, and changes in membrane performance under various operating conditions. Applications in water treatment and resource recovery were evaluated to assess their practical applicability. Lastly, key challenges toward industrial implementation, including the enhancement of manufacturing feasibility, the advancement of antifouling strategies, and the integration of multifunctional properties, have been identified through this review. These insights suggest future research directions for advancing industrial applicability of ceramic NF membranes.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"293 ","pages":"Article 123754"},"PeriodicalIF":7.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to “Follow up of the prostate cancer treatment based on a novel sensing method for anti-prostate cancer drug (flutamide)” [Environ. Res. 238 (2023) 117261] 《基于新型抗前列腺癌药物(氟他胺)传感方法的前列腺癌治疗随访》的撤稿通知[环境]。Res. 238 (2023) 117261]
IF 7.7 2区 环境科学与生态学
Environmental Research Pub Date : 2026-03-15 Epub Date: 2026-01-13 DOI: 10.1016/j.envres.2026.123765
Xinyu Tan , Melika Namadchian , Mehdi Baghayeri
{"title":"Retraction notice to “Follow up of the prostate cancer treatment based on a novel sensing method for anti-prostate cancer drug (flutamide)” [Environ. Res. 238 (2023) 117261]","authors":"Xinyu Tan ,&nbsp;Melika Namadchian ,&nbsp;Mehdi Baghayeri","doi":"10.1016/j.envres.2026.123765","DOIUrl":"10.1016/j.envres.2026.123765","url":null,"abstract":"","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"293 ","pages":"Article 123765"},"PeriodicalIF":7.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Independent impacts of co-formulants contained in anthelmintic formulations on seed germination of grassland species 驱虫药配方中共制剂对草地物种种子萌发的独立影响
IF 7.7 2区 环境科学与生态学
Environmental Research Pub Date : 2026-03-15 Epub Date: 2026-01-12 DOI: 10.1016/j.envres.2026.123762
Carsten Eichberg , Lars Laber , Scarlett Jaß , Andrés García , Tobias W. Donath
{"title":"Independent impacts of co-formulants contained in anthelmintic formulations on seed germination of grassland species","authors":"Carsten Eichberg ,&nbsp;Lars Laber ,&nbsp;Scarlett Jaß ,&nbsp;Andrés García ,&nbsp;Tobias W. Donath","doi":"10.1016/j.envres.2026.123762","DOIUrl":"10.1016/j.envres.2026.123762","url":null,"abstract":"<div><div>Agrochemicals have been shown to affect non-target organisms and are often applied as mixtures of active ingredient and co-formulants. Although there is evidence that co-formulants play a role in these effects, their contribution has hardly been studied.</div><div>Therefore, we studied effects of co-formulants on seed germination (percentage, time, synchrony) using a common anthelmintic formulation. The seeds of four species of temperate grasslands (<em>Achillea ptarmica</em>, <em>Agrostis capillaris</em>, <em>Dianthus deltoides</em>, <em>Plantago lanceolata</em>) were exposed to a commercial moxidectin formulation at a concentration of 10 mg l<sup>−1</sup> as well as three of its co-formulants: benzyl alcohol (BA), butylated hydroxytoluene (BHT) and disodium ethylenediamine tetraacetic acid (EDTA-Na<sub>2</sub>).</div><div>Results showed that the tested anthelmintic formulation as a whole and two of its co-formulants (BA, BHT) as individual substances significantly impacted germination behaviour of the test species. Formulation, BA and BHT significantly reduced germination percentage in all species compared to the control, with BA exerting the strongest effect (reduction up to 99 %). The same three treatments significantly increased mean germination time in all species by a factor of two to four. Germination synchrony showed a weaker response and was only affected in two species (<em>A. capillaris</em>, <em>D. deltoides</em>) and only by BHT (reduction of 49 % and 60 %, respectively).</div><div>The strong effects of BA and BHT on seed germination suggest that their contribution to effects of anthelmintic formulations is at least partly due to an independent impact. Therefore, co-formulants should be given greater consideration both in the design of ecotoxicological experiments and in environmental risk assessments.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"293 ","pages":"Article 123762"},"PeriodicalIF":7.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical exercise mitigates the adverse effects of PM2.5 constituents on lung function: New evidence for inflammatory pathways from a crossover study 体育锻炼减轻PM2.5成分对肺功能的不利影响:来自交叉研究的炎症途径的新证据
IF 7.7 2区 环境科学与生态学
Environmental Research Pub Date : 2026-03-15 Epub Date: 2026-01-09 DOI: 10.1016/j.envres.2026.123743
Pengpeng Wu , Qian Guo , Ling Qi , Yuchen Zhao , Mengyao Bian , Chen Wang , Bin Han , Junfeng (Jim) Zhang , Xiaoli Duan
{"title":"Physical exercise mitigates the adverse effects of PM2.5 constituents on lung function: New evidence for inflammatory pathways from a crossover study","authors":"Pengpeng Wu ,&nbsp;Qian Guo ,&nbsp;Ling Qi ,&nbsp;Yuchen Zhao ,&nbsp;Mengyao Bian ,&nbsp;Chen Wang ,&nbsp;Bin Han ,&nbsp;Junfeng (Jim) Zhang ,&nbsp;Xiaoli Duan","doi":"10.1016/j.envres.2026.123743","DOIUrl":"10.1016/j.envres.2026.123743","url":null,"abstract":"<div><div>Physical exercise in polluted air involves a significant trade-off. However, the interaction effects and underlying mechanisms between PM<sub>2.5</sub> constituents and physical exercise on lung function remain poorly understood. This crossover study was conducted among 74 adults who completed a session of outdoor physical exercise and a session of no exercise in random order. We analyzed the chemical constituents of PM<sub>2.5</sub> that the subjects were exposed to during each session, measured lung function, and assessed 10 biomarkers of systemic inflammation both before and after each session. We used linear mixed-effect models to assess the independent and interactive effects of PM<sub>2.5</sub> constituents and physical exercise on lung function and biomarkers. We also conducted a moderated mediation analysis to examine the role of inflammatory factors that mediated the effects of PM<sub>2.5</sub> constituents and physical exercise on lung function. We found that traffic emissions and resuspended dust may be major contributors to the adverse effects of PM<sub>2.5</sub> on lung function, and that physical exercise significantly attenuated these detrimental impacts. We also identified heat shock protein 70 (HSP70), granulocyte-macrophage colony stimulating factor, toll-like receptor 4 protein (TLR-4), Clara cell protein 16, and interleukin-8 as the mediators in the association. Our results support the hypothesis that PM<sub>2.5</sub> constituents and physical exercise interact to affect lung function through the HSP70-mediated regulation of the TLR4/NF-κB inflammatory pathway. These findings are expected to inform future control strategies targeting source-specific PM<sub>2.5</sub> constituents and public health decisions on exercise on air pollution days.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"293 ","pages":"Article 123743"},"PeriodicalIF":7.7,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine learning-driven water quality index prediction in the Dau Tieng reservoir, southern Vietnam, with interpretability via SHapley additive exPlanations: A vision for water quality management strategies 越南南部Dau Tieng水库的机器学习驱动的水质指数预测,通过SHapley加法解释的可解释性:水质管理策略的愿景。
IF 7.7 2区 环境科学与生态学
Environmental Research Pub Date : 2026-03-15 Epub Date: 2026-01-08 DOI: 10.1016/j.envres.2026.123714
Thanh Tung Nguyen , Trung Hieu Nguyen , Thuy Vy Tran , Nguyen Tuan Anh , Minh-Ky Nguyen , Thai Van Anh , Wen-Pei Tsai , Hoang Huy Huynh
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