{"title":"Synthetic Approaches to Organic Nanoparticles","authors":"S. Köstler, V. Ribitsch","doi":"10.1002/9783527610419.NTLS0251","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0251","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000Types of Organic Particle and Scope of This Chapter \u0000Characteristics of Organic Nanoparticles \u0000 \u0000 \u0000Methods of Organic Nanoparticle Preparation \u0000Top-Down Approaches to Organic Nanoparticles \u0000Reduction of Particle Size by Mechanical Forces \u0000Lithographic Methods \u0000 \u0000 \u0000Bottom-Up Approaches to Organic Nanoparticles \u0000Solution-Based Bottom-Up Methods \u0000 \u0000 \u0000Vapor Condensation-Based Methods \u0000 \u0000 \u0000Application of Organic Nanoparticles \u0000Summary and Future Perspectives \u0000 \u0000 \u0000Keywords: \u0000 \u0000nanoparticle; \u0000colloid; \u0000polymer; \u0000organic crystal; \u0000emulsion; \u0000polyelectrolyte; \u0000microfluidics; \u0000drug","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"2008 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125625472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biological and Biomimetic Synthesis of Metal Nanomaterials","authors":"Jianping Xie, Y. Tan, J. Lee","doi":"10.1002/9783527610419.NTLS0209","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0209","url":null,"abstract":"In recent years, an increasing emphasis has been placed on the development of cleaner methods to prepare nanomaterials in the pursuit of nanotechnology. The synthesis of nanoparticles by organisms or biomolecules is ideal from the point of a reduced environmental footprint. It is also particularly suitable for end uses in medicine and related fields, where biocompatibility is a major requirement. In this chapter, the current progress in biological and biomimetic synthesis of metal nanoparticles is summarized (using nanogold and nanosilver as examples). In particular, the differences between biological/biomimetic syntheses and conventional chemical syntheses are highlighted, and the fundamental principles involved are discussed. \u0000 \u0000 \u0000Keywords: \u0000 \u0000noble metals; \u0000nanomaterials; \u0000biosynthesis; \u0000biomimetic synthesis; \u0000green chemistry; \u0000microorganisms; \u0000proteins; \u0000peptides","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"283 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122953991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of Carbon Nanotubes to Brain Tumor Therapy","authors":"Dongchang Zhao, B. Badie","doi":"10.1002/9783527610419.NTLS0242","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0242","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000The Current Challenge of Brain Tumor Therapy \u0000Current Status of Clinical Practice in Brain Tumor Therapy \u0000The Progress of Investigational Therapies for Brain Tumors \u0000Targeted Molecular Therapy \u0000Anti-Angiogenic Therapy \u0000Immunotherapy \u0000Gene Therapy \u0000 \u0000 \u0000 \u0000 \u0000The Characteristics of CNTs for Biological Applications \u0000Single-Walled and Multi-Walled Carbon Nanotubes \u0000Functionalization of CNTs \u0000Covalent Surface Modification \u0000Noncovalent Surface Modification \u0000 \u0000 \u0000CNT Delivery System \u0000Delivery of Antibodies and Peptides \u0000Delivery of siRNA \u0000Delivery of DNA Molecules \u0000Delivery of CpG \u0000Delivery of Vaccines \u0000Delivery of Chemical Drugs \u0000 \u0000 \u0000 \u0000 \u0000Strategies of Application of CNTs to Brain Tumor Therapy \u0000CNTs Targeting Brain Tumor-Macrophages \u0000Internalization of CNTs by BV2 Microglia Cells In Vitro \u0000Preferential Uptake of CNTs by Macrophages in a Glioma Model \u0000Phosphatidylserine-Coated CNTs Targeting Microglia/Macrophages \u0000 \u0000 \u0000CNTs Targeting Tumor Cells and Preliminary Efforts Towards In Vivo Cancer Therapy \u0000CNTs Actively Targeting Tumor Cells \u0000CNTs Passively Targeting Tumor Cells \u0000CNTs Thermal Effects on Tumor Cells \u0000 \u0000 \u0000 \u0000 \u0000Toxicity Issues of CNTs in Brain Tumor Therapy \u0000Conclusions and Future Directions \u0000Acknowledgments \u0000 \u0000 \u0000Keywords: \u0000 \u0000carbon nanotubes; \u0000drug-delivery system; \u0000nanomedicine; \u0000brain tumor; \u0000immunotherapy; \u0000tumor-associated macrophage; \u0000siRNA; \u0000CpG oligodeoxynucleotides","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125158056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Carbon Nanotubes for Cancer Therapy","authors":"W. Gmeiner","doi":"10.1002/9783527610419.NTLS0239","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0239","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000Limitations of Current Therapy Options \u0000Developing Nanomaterials for Cancer Treatment \u0000CNTs: Physical Properties, Manufacture, and Chemical Modifications \u0000 \u0000 \u0000Hyperthermia for Cancer Treatment \u0000Current Ablative Technologies \u0000Use of CNTs for Hyperthermia Treatment \u0000 \u0000 \u0000CNTs for Drug Delivery \u0000Localization of CNTs to Malignant Tissues \u0000Drug Delivery Using CNTs \u0000 \u0000 \u0000Imaging Using CNTs \u0000CNT-Related Toxicity \u0000Summary and Future Perspective \u0000Acknowledgments \u0000 \u0000 \u0000Keywords: \u0000 \u0000carbon nanotube; \u0000thermal ablation; \u0000drug delivery; \u0000cancer therapy; \u0000hyperthermia; \u0000cancer imaging","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124362054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nanocomposites for Drug Delivery","authors":"S. Shen, Yuancai Dong, W. Ng, L. Chia, R. Tan","doi":"10.1002/9783527610419.NTLS0225","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0225","url":null,"abstract":"The sections in this article areIntroductionNanoparticle Composites for Drug DeliveryPolymeric Nanoparticle CompositesPLGA Nanoparticle CompositesChitosan Nanoparticle CompositesLiposomesSolid Lipid Nanoparticle CompositesMicellesIron Oxide Nanoparticle Composites for Drug DeliverySilica Nanoparticle CompositesNanofiber Composites for Drug DeliveryDelivery of AntibioticsDelivery of Anticancer Drugs“Smart” Nanofiber Drug CarriersMultifunctional NanofibersTwo-Dimensional Mesoporous Material-Incorporated NanocompositesInorganic 2-D Nanoporous CompositesOxide-Modified Nanoporous CompositesMesoporous Bioactive GlassesMagnetic Functionalized Mesoporous CompositesLuminescent Mesoporous CompositesPolymer–Silica NanocompositesStimuli-Responsive NanocompositesThree-Dimensional Nanostructured NanocompositesHydrogel Nanocomposite Drug CarriersSummary and OutlookKeywords:nanocomposites;drug delivery;nanofibers;nanoparticles;mesoporous materials;3-D nanostructures;hydrogel;controlled release","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132978296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Blasi, A. Schoubben, S. Giovagnoli, C. Róssi, M. Ricci
{"title":"Solid Lipid Nanoparticles to Improve Brain Drug Delivery","authors":"P. Blasi, A. Schoubben, S. Giovagnoli, C. Róssi, M. Ricci","doi":"10.1002/9783527610419.NTLS0257","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0257","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000The General Problem of Brain Drug Delivery \u0000Basic Brain Physiology \u0000Brain Drug-Delivery Strategies \u0000 \u0000 \u0000Solid Lipid Nanoparticles for Brain Drug Delivery \u0000General Information \u0000Physico-Chemical Aspects of Lipid Packing and SLN Structure \u0000Surfactants and SLNs for Brain Targeting \u0000Evidence of Brain Drug Accumulation \u0000SLN Potentiality in Brain Imaging \u0000Toxicity Issues \u0000 \u0000 \u0000Concluding Remarks \u0000 \u0000 \u0000Keywords: \u0000 \u0000solid lipid nanoparticles; \u0000colloids; \u0000drug targeting; \u0000brain delivery; \u0000blood–brain barrier; \u0000neurovascular unit; \u0000polysorbate-coated nanoparticles","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"7 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116793770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sulbha K. Sharma, Ying-ying Huang, P. Mróz, T. Wharton, L. Chiang, Michael R Hamblin
{"title":"Fullerenes in Photodynamic Therapy","authors":"Sulbha K. Sharma, Ying-ying Huang, P. Mróz, T. Wharton, L. Chiang, Michael R Hamblin","doi":"10.1002/9783527610419.NTLS0244","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0244","url":null,"abstract":"The sections in this article areIntroductionPhotodynamic TherapyTraditional PhotosensitizersPhotophysics and Photochemistry in PDTAnticancer Mechanism of PDTCellular EffectsIn Vivo EffectsAntimicrobial Mechanism of PDTFullerenes as PhotosensitizersPhotophysics of FullerenesPhotochemistry of FullerenesInteractions of Fullerenes with DNADrug-Delivery Strategies for FullerenesStrategies to Overcome the Unfavorable Spectral Absorption of FullerenesCovalent Attachment of Light-Harvesting Antennae to FullerenesTwo-Photon PDTAnticancer Effects of FullerenesIn Vitro PDT with FullerenesIn Vivo PDT with FullerenesFullerenes for Antimicrobial PhotoinactivationPhotoinactivation of VirusesPhotoinactivation of Bacteria and Other PathogensSummary and Future PerspectivesAcknowledgmentsKeywords:fullerenes;photodynamic therapy;reactive oxygen species;singlet oxygen;superoxide;photochemical mechanism;phototoxicity;two-photon absorption","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126751486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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