富勒烯在光动力疗法中的应用

Nanotechnologies for the Life Sciences Pub Date : 2012-02-15 DOI:10.1002/9783527610419.NTLS0244

Sulbha K. Sharma, Ying-ying Huang, P. Mróz, T. Wharton, L. Chiang, Michael R Hamblin

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引用次数: 2

摘要

本文的部分内容包括:光动力疗法、传统光敏剂、pdt的光物理和光化学、pdt的肿瘤机制、pdt细胞效应、体内效应、pdt富勒烯作为光敏剂的微生物机制、富勒烯的光物理、富勒烯的光化学、富勒烯与dna的相互作用、富勒烯的药物递送策略、克服富勒烯不利光谱吸收的策略、捕光天线的共价附着关键词:富勒烯;光动力治疗;活性氧;单线态氧;超氧化物;光化学机制;光毒性;双光子吸收

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Fullerenes in Photodynamic Therapy

The sections in this article are Introduction Photodynamic Therapy Traditional Photosensitizers Photophysics and Photochemistry in PDT Anticancer Mechanism of PDT Cellular Effects In Vivo Effects Antimicrobial Mechanism of PDT Fullerenes as Photosensitizers Photophysics of Fullerenes Photochemistry of Fullerenes Interactions of Fullerenes with DNA Drug-Delivery Strategies for Fullerenes Strategies to Overcome the Unfavorable Spectral Absorption of Fullerenes Covalent Attachment of Light-Harvesting Antennae to Fullerenes Two-Photon PDT Anticancer Effects of Fullerenes In Vitro PDT with Fullerenes In Vivo PDT with Fullerenes Fullerenes for Antimicrobial Photoinactivation Photoinactivation of Viruses Photoinactivation of Bacteria and Other Pathogens Summary and Future Perspectives Acknowledgments Keywords: fullerenes; photodynamic therapy; reactive oxygen species; singlet oxygen; superoxide; photochemical mechanism; phototoxicity; two-photon absorption

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Nanotechnologies for the Life Sciences

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