Solid Lipid Nanoparticles to Improve Brain Drug Delivery

Abstract

The sections in this article are Introduction The General Problem of Brain Drug Delivery Basic Brain Physiology Brain Drug-Delivery Strategies Solid Lipid Nanoparticles for Brain Drug Delivery General Information Physico-Chemical Aspects of Lipid Packing and SLN Structure Surfactants and SLNs for Brain Targeting Evidence of Brain Drug Accumulation SLN Potentiality in Brain Imaging Toxicity Issues Concluding Remarks Keywords: solid lipid nanoparticles; colloids; drug targeting; brain delivery; blood–brain barrier; neurovascular unit; polysorbate-coated nanoparticles