固体脂质纳米颗粒改善大脑药物输送

Nanotechnologies for the Life Sciences Pub Date : 2012-02-15 DOI:10.1002/9783527610419.NTLS0257

P. Blasi, A. Schoubben, S. Giovagnoli, C. Róssi, M. Ricci

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引用次数: 5

摘要

本文的主要内容包括:脑药物传递的一般问题脑基本生理学脑药物传递策略脑药物传递的固体脂质纳米颗粒脑药物传递的一般信息脂质包装和SLN结构的物理化学方面的一般信息脑靶向表面活性剂和SLN脑药物积累的证据脑成像SLN电位毒性问题结束语关键词:固体脂质纳米颗粒;胶体;药物的目标;大脑交付;血脑屏障;神经与血管的单位;polysorbate-coated纳米颗粒

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Solid Lipid Nanoparticles to Improve Brain Drug Delivery

The sections in this article are Introduction The General Problem of Brain Drug Delivery Basic Brain Physiology Brain Drug-Delivery Strategies Solid Lipid Nanoparticles for Brain Drug Delivery General Information Physico-Chemical Aspects of Lipid Packing and SLN Structure Surfactants and SLNs for Brain Targeting Evidence of Brain Drug Accumulation SLN Potentiality in Brain Imaging Toxicity Issues Concluding Remarks Keywords: solid lipid nanoparticles; colloids; drug targeting; brain delivery; blood–brain barrier; neurovascular unit; polysorbate-coated nanoparticles

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Nanotechnologies for the Life Sciences

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