Cellular, Molecular and Biomedical Reports最新文献_第3页

Bioinformatics analysis of microtubule-associated protein-1 light chain 3 (MAP1LC3A) and (BECN1) genes in autophagy 微管相关蛋白-1轻链3 (MAP1LC3A)和BECN1基因在自噬中的生物信息学分析

Cellular, Molecular and Biomedical Reports Pub Date : 2022-09-01 DOI: 10.55705/cmbr.2022.345001.1046

A. Mirzaei, F. Fazeli

{"title":"Bioinformatics analysis of microtubule-associated protein-1 light chain 3 (MAP1LC3A) and (BECN1) genes in autophagy","authors":"A. Mirzaei, F. Fazeli","doi":"10.55705/cmbr.2022.345001.1046","DOIUrl":"https://doi.org/10.55705/cmbr.2022.345001.1046","url":null,"abstract":"Autophagy is an effective regulatory process for eliminating tumors and worn-out intracellular components. Different groups of enzymes and regulatory elements are involved in the autophagy process. MAP1LC3A and BECN1 genes are the most important gene groups in autophagy. These genes, through the production of beclin1 autophagosomes. In general, both MAP1LC3A and BECN1 genes are active in cellular responses and the biological process. The aim of this study was bioinformatics analysis at the level of genome and proteome and to evaluate and compare the expression of MAP1LC3A and BECN1 genes in different human body tissues. The results of this study showed that the expression level of the BECN1 gene was relatively higher than the MAP1LC3A gene in different mammals. Cell analysis of MAP1LC3A and BECN1 genes by antibodies that bind to proteins of target genes showed that the protein encoded by the BECN1 gene is more present in the cytosol and the proteins encoded by MAP1LC3A gene are locally present in vesicles. It was also found that the protein encoded by the MAP1LC3A gene had a higher expression in brain tissues than in other tissues, while the beclin-1 protein in cardiac tissue showed higher expression than in other tissues. Finally, by using this information, it is possible to provide the ground for targeted therapies.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131996048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Current trends and new methods of detection of SARS-CoV-2 infection SARS-CoV-2感染检测现状及新方法

Cellular, Molecular and Biomedical Reports Pub Date : 2022-09-01 DOI: 10.55705/cmbr.2022.345025.1047

M. Mohammadi, A. Omidi, Hoda Sabati

引用次数: 5

Medical and medicinal importance of Rheum spp. collected from different altitudes of the Kashmir Himalayan range 从克什米尔喜马拉雅山脉不同海拔采集的大黄属植物的医学和药用价值

Cellular, Molecular and Biomedical Reports Pub Date : 2022-09-01 DOI: 10.55705/cmbr.2022.349901.1050

S. Tabin, Raghubir P. Gupta, A. Kamili, J. Parray

引用次数: 5

Global perspective of phosphate solubilizing microbes and phosphatase for improvement of soil, food and human health 溶磷微生物和磷酸酶在改善土壤、食物和人类健康方面的全球前景

Cellular, Molecular and Biomedical Reports Pub Date : 2022-09-01 DOI: 10.55705/cmbr.2022.347523.1048

U. Dhuldhaj, N. Malik

引用次数: 13

GC-MS Analysis of the Active Compound in Ethanol Extracts of White Pepper (Piper nigrum L.) and Pharmacological Effects 白胡椒乙醇提取物中有效成分的GC-MS分析及药理作用

Cellular, Molecular and Biomedical Reports Pub Date : 2022-07-29 DOI: 10.55705/cmbr.2022.351720.1051

I. N. Arsana, N. Juliasih, A. A. Ayu Sauca Sunia Widyantari, N. Suriani, Agus Manto

引用次数: 5

Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products 用于血液制品细菌净化的二氧化硅纳米颗粒表面改性

Cellular, Molecular and Biomedical Reports Pub Date : 2022-06-01 DOI: 10.55705/cmbr.2022.338888.1039

Mehran Alavi, M. Hamblin, M. Mozafari, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho

{"title":"Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products","authors":"Mehran Alavi, M. Hamblin, M. Mozafari, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho","doi":"10.55705/cmbr.2022.338888.1039","DOIUrl":"https://doi.org/10.55705/cmbr.2022.338888.1039","url":null,"abstract":"Bacterial infections can be caused by contamination of labile blood products with specific bacteria, such as Staphylococcus aureus and Staphylococcus epidermidis . Hospital equipment, bio-protective equipment, delivery systems, and medical devices can be easily contaminated by microorganisms. Multidrug-resistant bacteria can survive on various organic or inorganic polymeric materials for more than 90 days. Inhibiting the growth and eradicating these microorganisms is vital in blood transfusion processes. Blood bags and other related medical devices can be improved by the incorporation of organic or inorganic nanomaterials, particularly silicon dioxide (SiO 2 ) nanoparticles. The addition of solid organic or inorganic nanoparticles to synthetic polymers or biopolymers can provide new properties in addition to antimicrobial activity. Among these NPs, formulations composed of SiO 2 nanoparticles and polymers have been shown to improve the mechanical and antimicrobial properties of catheters, prosthetic inserts, blood bags, and other medical devices SiO 2 nanoparticles possess several advantages, including large-scale synthetic availability, simple one-pot synthesis methods, porous structure for loading antibacterial agents, good biocompatibility, and thermal stability. Plasticized polyvinyl chloride is the main polymer, which has been functionalized by these nanoparticles. In this review, we discuss the recent advances and challenges regarding the functionalization of polyvinyl chloride by SiO 2 nanoparticles to hinder bacterial contaminations in blood products.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127044539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Genetic resistance to human malaria 对人类疟疾的基因抗性

Cellular, Molecular and Biomedical Reports Pub Date : 2022-06-01 DOI: 10.55705/cmbr.2022.342533.1043

Ismail Muhammad, B. Abubakar, Tanko Muhammad

引用次数: 3

Bioinformatics analysis and pharmacological effect of Stevia rebaudiana in the prevention of type-2 diabetes 甜菊糖预防2型糖尿病的生物信息学分析及药理作用

Cellular, Molecular and Biomedical Reports Pub Date : 2022-06-01 DOI: 10.55705/cmbr.2022.336232.1035

A. Mirzaei, Vida Shakoory-moghadam

引用次数: 15

Effect of unripe fruit extract of Momordica charantia on total cholesterol, total triglyceride and blood lipoproteins in the blood of rats with hyperlipidemia 苦瓜生果提取物对高脂血症大鼠血液中总胆固醇、总甘油三酯和脂蛋白的影响

Cellular, Molecular and Biomedical Reports Pub Date : 2022-06-01 DOI: 10.55705/cmbr.2022.338806.1038

Mehdi Doosti-Moghaddam, H. Miri, A. Ghahghaei, M. Hajinezhad, H. Saboori

{"title":"Effect of unripe fruit extract of Momordica charantia on total cholesterol, total triglyceride and blood lipoproteins in the blood of rats with hyperlipidemia","authors":"Mehdi Doosti-Moghaddam, H. Miri, A. Ghahghaei, M. Hajinezhad, H. Saboori","doi":"10.55705/cmbr.2022.338806.1038","DOIUrl":"https://doi.org/10.55705/cmbr.2022.338806.1038","url":null,"abstract":"Hyperlipidemia is a major risk factor for the development of cardiovascular disease. In this study, the effects of an unripe fruit extract of Momordica charantia on total cholesterol, total triglyceride and lipoproteins in the blood of mice with hyperlipidemia were investigated. In this study, 28 adult male Wistar rats weighing 210 to 250 g were selected and randomly divided into four groups of seven. One group was on a normal diet and the other groups were fed a high-fat diet for 8 weeks to develop hyperlipidemia. Experimental groups in this study were included group 1: control, oral administration of normal food without any drugs or extracts. Group 2: hyperlipidemia mice, feeding with normal food. Group 3: hyperlipidemia mice with a diet containing 4%. Group 4: hyperlipidemia mice with a diet containing 8%. The animals were fed by gavage at a dose of 4% and 8% of M. charantia powder solution for 15 days. Blood samples were taken and the level of total cholesterol, total triglyceride, and high-density lipoproteins (HDL) were measured enzymatically. The amount of low-density lipoproteins was calculated by Friedewald's formula. Data were analyzed using the analysis of variance. Experimental results showed that immature fruit powder of M. charantia quarantine significantly reduced serum triglycerides in group 8% mice fed rats fed a high-fat diet. Moreover, immature fruit powder of M. charantia increased the level of high-density lipoproteins. There was a statistically significant difference between the level of cholesterol and the level of low-density proteins (LDL). The highest reduction belonged to the group receiving immature powder. The results of the experiment showed that the unripe fruit extract of M. charantia has strong antilipidemic effects on rats fed with a high-fat diet.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124728583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Antibacterial and antifungal activities of medicinal plant species and endophytes 药用植物和内生菌的抗菌和抗真菌活性

Cellular, Molecular and Biomedical Reports Pub Date : 2022-06-01 DOI: 10.55705/cmbr.2022.340532.1042

Shirin Ahmadi

{"title":"Antibacterial and antifungal activities of medicinal plant species and endophytes","authors":"Shirin Ahmadi","doi":"10.55705/cmbr.2022.340532.1042","DOIUrl":"https://doi.org/10.55705/cmbr.2022.340532.1042","url":null,"abstract":"Systemic bacterial and fungal infections in recent years due to the increasing number of debilitating diseases immune system such as AIDS, blood malignancies, overdose, corticosteroid drugs, and broad-spectrum antibiotics has been raised. There is a prevalence of acute and subsequent candida infections with drug-resistance properties such as fluconazole. Due to the prevalence and spread of fungal and bacterial diseases, the effort to find treatments has increased more than before. The use of plant compounds for the therapy of fungal and bacterial diseases is effective due to their unique biocompatible and bioavailable. The trend toward new antifungal and antibacterial agents being introduced to the market remains small, while resistance to many antibiotics is emerging, especially in patients receiving long-term treatment. Considering the enormous antimicrobial potentials of natural compounds isolated from plants and endophytes and screening of new antibiotics for various pharmaceutical applications as an alternative source remains largely unknown. Endophytes and medicinal plant species have main primary and secondary metabolites suitable to hindrance or inactivation of pathogens. Recently, various studies about the antibacterial and antifungal activities of these metabolites have been reported. For this purpose, in this review, antibacterial and antifungal activities of endophytes of Pestalotiopsis genus and medicinal plant species of Zingiber and Hydnora genera have been discussed according to recent studies.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121448101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15