Cellular, Molecular and Biomedical Reports最新文献

{"title":"When Successive Viral Mutations Prevent Definitive Treatment of COVID-19","authors":"M. Mohammadi, Hoda Sabati","doi":"10.55705/cmbr.2022.339012.1040","DOIUrl":"https://doi.org/10.55705/cmbr.2022.339012.1040","url":null,"abstract":"SARS-CoV-2 In this at new mutations in COVID-19 as well as the adverse effects of the virus on the and gastrointestinal tract. The discovery of these novel SARS-CoV-2 variations threatens to the substantial success made so far in restricting the spread of this viral disease, despite the extraordinary speed with which vaccines against COVID-19 have been developed and vigorous worldwide mass immunization efforts. Through mechanisms involving the dysregulated ACE 2 receptor and TMPRSS2, the SARS-CoV-2 virus has the potential to induce significant systemic disease in the GI tract, liver, biliary tract, and pancreas. Due to the observation of new and daily mutations of this dangerous virus, the definitive treatment of this disease is becoming more and more difficult and facing major challenges that it requires many clinical trials and researches.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127625630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of Seabuckthorn (Hippophae rhamnoides L.) in medical sciences","authors":"H. Ahani, Soroush Attaran","doi":"10.55705/cmbr.2022.330326.1020","DOIUrl":"https://doi.org/10.55705/cmbr.2022.330326.1020","url":null,"abstract":"Seabuckthorn has multiple-use properties. This review explores the medicinal applications of Hippophae rhamnoides in healing ailments. The plant is being used in different parts of the world for its nutritional and medicinal properties. Sea buckthorn-based preparations have been extensively exploited in folklore treatment of slow digestion, stomach malfunctioning, cardiovascular problems, liver injury, tendon and ligament injuries, skin diseases and ulcers. In recent years, the medicinal and pharmacological activities of Seabuckthorn have been well investigated using limited clinical trials. Homeopathy is a well-respected modality to assist wellness. Traditional and modern medicinal experts have been applied this plant to treat various diseases. Seabuckthorn is an important plant because of its immense medicinal and therapeutic potential. However, several knowledge gaps identified in this paper would give impetus to new academic and R&D activities, especially for the development of Sea buckthorn-based herbal medicine and nutraceuticals. Its full application in dermatology may be attributed to the presence of a variety of flavonoids, vitamins, and unsaturated fatty acids. Great use of the plant in the traditional system for dermatological aspects, demands further comprehensive phytochemical work based on its actual use by the traditional population. Anti-inflammation is the most important applicable ingredient of this miracle berry. Article info Received: 18 Oct 2021 Revised: 29 Dec 2021 Accepted: 30 Jan 2022 Use your device to scan and read the article online","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127274516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action","authors":"Mehran Alavi, M. Rai, Fleming Martínez, D. Kahrizi, Haroon Khan, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José G. M. Costa","doi":"10.55705/cmbr.2022.147090.1023","DOIUrl":"https://doi.org/10.55705/cmbr.2022.147090.1023","url":null,"abstract":"various practical their unique properties compared with bulk materials, of for several a combination of physicochemical properties of nanoparticles based on metalloid, metal, and metal oxides such as selenium, silver, gold, titanium dioxide, zinc oxide, copper oxide, platinum, and magnesium oxide, have been well known and referred to as anticancer and antimicrobial agents or carriers. The inactivation and eradication of Gram-positive and Gram-negative bacteria may be mainly resulted from the oxidative damages in the bacterial medium. Overall, metalloid, metal and metal oxide NPs can be functionalized by other antibacterial or anticancer agents and biocompatible stabilizers to increase their efficiency in physiological conditions. However, the undesirable cytotoxicity of these nanoparticles in physiological conditions is the major hindrance to their application in the pharmaceutical industry and therapeutics. Nevertheless, it is expected that these problems will be solved in the near future. is to an of the recent signs of in increasing anticancer and antibacterial mechanisms of metal and metal-based nanoparticles.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132265545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Active Pulmonary Tuberculosis Among Women With Diabetes","authors":"R. Behzadmehr, Khadije Rezaie-Keikhaie","doi":"10.55705/cmbr.2022.336572.1036","DOIUrl":"https://doi.org/10.55705/cmbr.2022.336572.1036","url":null,"abstract":"Diabetes is one of the most common non-contagious diseases in the world. This disease is the fourth or fifth cause of death in most developed countries. The relationship between tuberculosis and diabetes had been introduced years ago and diabetes is considered a threatening factor in tuberculosis in the research history. Not only tuberculosis is prevalent among diabetic persons, but also diabetes can affect the appearance of imaging of tuberculosis. This is a kind of analytic study, a case-control study, which was carried out between the years 2014 and 2015 in Zabol City. In this study, the radiographic findings from the patients suffering from pulmonary tuberculosis in diabetic patients and not diabetic patients are compared. These radiographic were handed to a radiologist and the radiologic findings of these graphs from the anatomic location (upper and lower half of the right and left bellows), Presence or absence of cavities, nodules, density and pleural involvement were recorded and compared with the diabetic and non-diabetic group. After gathering of the data using SPSS software, descriptive statistics were presented in the form of (frequency, percent) graphs and a chi-square test (p<0.05) was used to analyze and comparing of the results of diabetic and un-diabetic patients. The population of the study consisted of Chest radiographs for 124 TB patients which 61 %) were suffering from diabetics. In this study, 45 (71.43%) non-diabetic and 42 (65.85%) diabetic patients were women (p=0.7). There were 12 diabetic TB patients (19.67%) and 3 non-diabetic- TB patients (4.76%) with the consolidation of middle part of left lung (p=0.01) and 8 (13.11%) diabetic TB and 1 (1.59%) non-diabetic TB with reticulonodular infiltration of lower part of left lung (p=0.02). There was no significant difference in the rest of the radiographic results. The findings of this study indicate that reticulonodular infiltration and consolidation of lower &middle parts of the lung in TB diabetic patients is more than in TB non-diabetic patients and diabetes can affect the findings of pulmonary tuberculosis radiography.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125869740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular structure and molecular functions of plants, animals, bacteria, and viruses","authors":"H. Kheyrodin, Raheba Jami, F. Rehman","doi":"10.55705/cmbr.2022.330941.1021","DOIUrl":"https://doi.org/10.55705/cmbr.2022.330941.1021","url":null,"abstract":"support, and protection to the cell and its organelles. However, this cellular component is present exclusively in eukaryotic plants, fungi, and a few prokaryotic organisms. Compounds found in plant cells are absent in animal cells, and DNA base sequences reflect this. Moreover, plant DNA is often larger than animal DNA. In this review, we concluded that the differences between plant and animal DNA defendant on the sequence of bases in the helix.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"203 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134064363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular analysis of Bio-makers of Chloroquine resistance in Plasmodium falciparum Isolate from Gombe Local Government Area, Gombe State, Nigeria","authors":"I. Muhammad, Pukuma Sale, M. Salisu, Tanko Muhammad, B. Abubakar, Augustine Maidala, Enock Nuwanyada","doi":"10.55705/cmbr.2022.335753.1033","DOIUrl":"https://doi.org/10.55705/cmbr.2022.335753.1033","url":null,"abstract":"most cheapest and effective chemotherapeutic drugs for Plasmodium falciparum -malaria, but for a long, the drug has been officially withdrawn in almost all malaria-endemic countries including Nigeria, due to the development of resistance by the parasite. Withdrawal of the drug may make the drug regains its efficacy. Therefore, this study aimed to determine the presence of Biomarkers associated with chloroquine resistance from Gombe Local Government Area, Gombe State, Nigeria after its withdrawal in 2005. Twenty hundred blood samples were collected from consented study subjects and analysed using Microscopy, RDT and PCR. DNA was extracted using Quick-DNA™ Miniprep (No. D4069), Purity and Concentration of the DNA were determined using Nanodrop Spectrophotometer. 57 true positive samples were selected for molecular analysis. Nested PCR was used to amplify the required codon (C72S, M74I, K76T and N75E) position of PCRT the gene of P. falciparum . Both Primary and Secondary PCR was carried out. The PCR products were subjected to electrophoresis in 2% agarose and stained with ethidium bromide. The amplicons were purified and sequenced, after which the sequenced products were subjected to BLAST software. Single Nucleotide Polymorphism was recorded from C72S and K76T with a prevalence of 05(8.80%) and 46(80.70%) respectively. Confirmed biomarkers of Chloroquine resistance are still present in P. falciparum isolate from Gombe L.G.A.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133219333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitric oxide signaling pathway in medicinal plants","authors":"Ali Salehi-Sardoei, Halimeh Khalili","doi":"10.55705/cmbr.2022.330292.1019","DOIUrl":"https://doi.org/10.55705/cmbr.2022.330292.1019","url":null,"abstract":"Nitrogen monoxide or nitric oxide is a biological active growth regulator that a wide of shown that it acts as a growth regulator (signaling molecule) in plants. As soon as Nitric Oxide (NO) known as a new biological agent in plants and animals, biological branches of sciences like medicine, biochemistry, and have paid special attention to it. NO is a very reactive gas shape free radical which has attracted much attention during recent years. This compound is produced by the plant and it has increased the shelf life of some fruits, vegetables and cut flowers in low concentrations. NO is mostly synthesized from enzymatic and non-enzymatic pathways whose enzymatic biosynthesis pathway is done by reductase nitrate biosynthesis pathway through the cytosol, also it is known as an important and very reactive signaling molecule with short life which is produced by a group of enzymes known as synthesize NO which transforms L-arginine to L-citrulline and NO. It has been revealed that plants use NO as a growth regulator which regulates and modifies antimicrobial defensive responses. Recently, it has been approved that this material plays a vital role in regulating the normal physiological activities of plants such as pores closing, aging, increasing the vase life of cut flowers after harvesting, respiration and photosynthesis, antioxidant enzymes activities and growth.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131349726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hepatitis B in HIV-positive patients in Zabol","authors":"Leli Rezaie-Kahkhaie, Khadijeh Saravani, Khadije Rezaie-Keikhaie, Seyed Esmaeil Azimi-Khatibani, Abdul Hafiz Daman-Sooz, Mehdi Afshari, A. Kamali","doi":"10.55705/cmbr.2021.356667.1058","DOIUrl":"https://doi.org/10.55705/cmbr.2021.356667.1058","url":null,"abstract":"Today, due to the increase in life expectancy in HIV-infected patients","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126376232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of virulence factors among Staphylococcus aureus strains isolated from patients with urinary tract infection in Al-Najaf Al-Ashraf teaching hospital","authors":"Qassim hassan Aubais aljelehawy, Layth Hussein Hadi Alshaibah, Zahraa Khudhair Abbas Al- Khafaji","doi":"10.55705/cmbr.2021.144995.1017","DOIUrl":"https://doi.org/10.55705/cmbr.2021.144995.1017","url":null,"abstract":"Staphylococcus aureus contains numerous surface proteins called microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) that mediate binding to host tissues and initiate colonization leading to infection. Virulence genes such as enzymes, toxins, adhesin proteins, cell surface proteins play an important role in the pathogenicity of S. aureus strains. The distribution and prevalence of virulence genes vary among S. aureus strains in different regions. However, the highest frequency of virulence genes among S. aureus strains is related to toxin genes. There are many PCR methods for detecting these microorganisms such as conventional PCR, multiplex PCR, reverse transcription PCR (RT-PCR), and quantitative PCR (qPCR). Therefore, this study aimed to investigate the presence of virulence genes among methicillin-resistant S. aureus (MRSA) strains. In this study, multiplex PCR technique was applied to determine the presence of virulence genes among MRSA strains. Results showed the frequency of virulence genes among bacterial strains isolated from Al-Najaf Al-Ashraf teaching hospital. In addition, among the strains, hla gene with 91% frequency, exhibited the highest prevalence among pathogenic genes. Sea, mecA, clfB, femA, fnbB, tsst, hlb genes with 88%, 65%, 54%, 45%, 39%, 27% and 13% were in the next ranks, respectively. This investigation showed mecA is a gene found in bacterial cells that allows them to be resistant to antibiotics such as methicillin and other penicillin-like antibiotics.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130002384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Sugar Changes in Patients with Acute Drug Poisoning","authors":"Khadijeh Saravani, M. Afshari, A. Aminisefat, Omid Bameri","doi":"10.55705/cmbr.2021.146061.1022","DOIUrl":"https://doi.org/10.55705/cmbr.2021.146061.1022","url":null,"abstract":"Changes in blood sugar in poisoning can be one of the most important determinants of the outcome of patients with poisoning. Since poisoning is one of the most common and increasing causes of death worldwide and one of the most critical medical emergencies, this study aimed to investigate changes in blood sugar in patients with acute poisoning and how patients' blood sugar can predict the severity and outcome of the disease. The present study was performed on 200 patients with acute drug poisoning referred to the emergency department of Amir Al-Momenin Hospital in Zabol from March 2018 to March 2020. Blood glucose levels of all patients were recorded at the time of admission and every hour to the first 5 hours after admission, and the results were entered in the information form of each patient. Finally, the data were entered into SPSS V22 software and statistically analyzed. The mean age of participants was 23.21 ± 12.80 years, and the minimum and maximum age of patients were 1 year and 77 years, respectively, and only 9.8% of them had a history of diabetes. In this study, the highest rate of intoxication with opioids such as methadone and tramadol was (38%), followed by benzodiazepines (20.5%), NSAIDs (19.5%), and SSRIs (7%) were the most commonly used drugs. The prevalence of hypoglycemia in this study was 3% (6 patients), while no cases of hyperglycemia were reported. In this study, most changes in blood sugar were caused by alcohol poisoning. Also, neuroleptics, NSAIDs, and chemicals had the least changes in blood sugar. However, patients' blood sugar at the beginning of poisoning did not affect patients' prognosis. The present study results showed that changes in blood sugar during treatment during drug intoxication, alcohol, medications(sulfonylurea, glibenclamide), and NSAID are very important, so regular monitoring of blood glucose in intoxication with these cases is essential.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130841361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}