Mehran Alavi, M. Rai, Fleming Martínez, D. Kahrizi, Haroon Khan, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José G. M. Costa
{"title":"金属、金属氧化物和类金属纳米颗粒对抗癌细胞和细菌病原体的效率:不同的作用机制","authors":"Mehran Alavi, M. Rai, Fleming Martínez, D. Kahrizi, Haroon Khan, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José G. M. Costa","doi":"10.55705/cmbr.2022.147090.1023","DOIUrl":null,"url":null,"abstract":"various practical their unique properties compared with bulk materials, of for several a combination of physicochemical properties of nanoparticles based on metalloid, metal, and metal oxides such as selenium, silver, gold, titanium dioxide, zinc oxide, copper oxide, platinum, and magnesium oxide, have been well known and referred to as anticancer and antimicrobial agents or carriers. The inactivation and eradication of Gram-positive and Gram-negative bacteria may be mainly resulted from the oxidative damages in the bacterial medium. Overall, metalloid, metal and metal oxide NPs can be functionalized by other antibacterial or anticancer agents and biocompatible stabilizers to increase their efficiency in physiological conditions. However, the undesirable cytotoxicity of these nanoparticles in physiological conditions is the major hindrance to their application in the pharmaceutical industry and therapeutics. Nevertheless, it is expected that these problems will be solved in the near future. is to an of the recent signs of in increasing anticancer and antibacterial mechanisms of metal and metal-based nanoparticles.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"57 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"45","resultStr":"{\"title\":\"The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action\",\"authors\":\"Mehran Alavi, M. Rai, Fleming Martínez, D. Kahrizi, Haroon Khan, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José G. M. Costa\",\"doi\":\"10.55705/cmbr.2022.147090.1023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"various practical their unique properties compared with bulk materials, of for several a combination of physicochemical properties of nanoparticles based on metalloid, metal, and metal oxides such as selenium, silver, gold, titanium dioxide, zinc oxide, copper oxide, platinum, and magnesium oxide, have been well known and referred to as anticancer and antimicrobial agents or carriers. The inactivation and eradication of Gram-positive and Gram-negative bacteria may be mainly resulted from the oxidative damages in the bacterial medium. Overall, metalloid, metal and metal oxide NPs can be functionalized by other antibacterial or anticancer agents and biocompatible stabilizers to increase their efficiency in physiological conditions. However, the undesirable cytotoxicity of these nanoparticles in physiological conditions is the major hindrance to their application in the pharmaceutical industry and therapeutics. Nevertheless, it is expected that these problems will be solved in the near future. is to an of the recent signs of in increasing anticancer and antibacterial mechanisms of metal and metal-based nanoparticles.\",\"PeriodicalId\":304796,\"journal\":{\"name\":\"Cellular, Molecular and Biomedical Reports\",\"volume\":\"57 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"45\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cellular, Molecular and Biomedical Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55705/cmbr.2022.147090.1023\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellular, Molecular and Biomedical Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55705/cmbr.2022.147090.1023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action
various practical their unique properties compared with bulk materials, of for several a combination of physicochemical properties of nanoparticles based on metalloid, metal, and metal oxides such as selenium, silver, gold, titanium dioxide, zinc oxide, copper oxide, platinum, and magnesium oxide, have been well known and referred to as anticancer and antimicrobial agents or carriers. The inactivation and eradication of Gram-positive and Gram-negative bacteria may be mainly resulted from the oxidative damages in the bacterial medium. Overall, metalloid, metal and metal oxide NPs can be functionalized by other antibacterial or anticancer agents and biocompatible stabilizers to increase their efficiency in physiological conditions. However, the undesirable cytotoxicity of these nanoparticles in physiological conditions is the major hindrance to their application in the pharmaceutical industry and therapeutics. Nevertheless, it is expected that these problems will be solved in the near future. is to an of the recent signs of in increasing anticancer and antibacterial mechanisms of metal and metal-based nanoparticles.