金属、金属氧化物和类金属纳米颗粒对抗癌细胞和细菌病原体的效率:不同的作用机制

Mehran Alavi, M. Rai, Fleming Martínez, D. Kahrizi, Haroon Khan, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José G. M. Costa
{"title":"金属、金属氧化物和类金属纳米颗粒对抗癌细胞和细菌病原体的效率:不同的作用机制","authors":"Mehran Alavi, M. Rai, Fleming Martínez, D. Kahrizi, Haroon Khan, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José G. M. Costa","doi":"10.55705/cmbr.2022.147090.1023","DOIUrl":null,"url":null,"abstract":"various practical their unique properties compared with bulk materials, of for several a combination of physicochemical properties of nanoparticles based on metalloid, metal, and metal oxides such as selenium, silver, gold, titanium dioxide, zinc oxide, copper oxide, platinum, and magnesium oxide, have been well known and referred to as anticancer and antimicrobial agents or carriers. The inactivation and eradication of Gram-positive and Gram-negative bacteria may be mainly resulted from the oxidative damages in the bacterial medium. Overall, metalloid, metal and metal oxide NPs can be functionalized by other antibacterial or anticancer agents and biocompatible stabilizers to increase their efficiency in physiological conditions. However, the undesirable cytotoxicity of these nanoparticles in physiological conditions is the major hindrance to their application in the pharmaceutical industry and therapeutics. Nevertheless, it is expected that these problems will be solved in the near future. is to an of the recent signs of in increasing anticancer and antibacterial mechanisms of metal and metal-based nanoparticles.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"57 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"45","resultStr":"{\"title\":\"The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action\",\"authors\":\"Mehran Alavi, M. Rai, Fleming Martínez, D. Kahrizi, Haroon Khan, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José G. M. Costa\",\"doi\":\"10.55705/cmbr.2022.147090.1023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"various practical their unique properties compared with bulk materials, of for several a combination of physicochemical properties of nanoparticles based on metalloid, metal, and metal oxides such as selenium, silver, gold, titanium dioxide, zinc oxide, copper oxide, platinum, and magnesium oxide, have been well known and referred to as anticancer and antimicrobial agents or carriers. The inactivation and eradication of Gram-positive and Gram-negative bacteria may be mainly resulted from the oxidative damages in the bacterial medium. Overall, metalloid, metal and metal oxide NPs can be functionalized by other antibacterial or anticancer agents and biocompatible stabilizers to increase their efficiency in physiological conditions. However, the undesirable cytotoxicity of these nanoparticles in physiological conditions is the major hindrance to their application in the pharmaceutical industry and therapeutics. Nevertheless, it is expected that these problems will be solved in the near future. is to an of the recent signs of in increasing anticancer and antibacterial mechanisms of metal and metal-based nanoparticles.\",\"PeriodicalId\":304796,\"journal\":{\"name\":\"Cellular, Molecular and Biomedical Reports\",\"volume\":\"57 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"45\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cellular, Molecular and Biomedical Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55705/cmbr.2022.147090.1023\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellular, Molecular and Biomedical Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55705/cmbr.2022.147090.1023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 45

摘要

与块状材料相比,各种实用的纳米粒子的独特性能,以及基于类金属、金属和金属氧化物(如硒、银、金、二氧化钛、氧化锌、氧化铜、铂和氧化镁)的几种物理化学性能的组合,已经众所周知,并被称为抗癌和抗菌剂或载体。革兰氏阳性菌和革兰氏阴性菌的灭活和根除可能主要是由于细菌培养基中的氧化损伤。总的来说,类金属、金属和金属氧化物NPs可以被其他抗菌或抗癌剂和生物相容性稳定剂功能化,以提高其在生理条件下的效率。然而,这些纳米颗粒在生理条件下的不良细胞毒性是其在制药工业和治疗学应用的主要障碍。然而,预计这些问题将在不久的将来得到解决。金属和金属基纳米颗粒的抗癌和抗菌机制的最新迹象之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action
various practical their unique properties compared with bulk materials, of for several a combination of physicochemical properties of nanoparticles based on metalloid, metal, and metal oxides such as selenium, silver, gold, titanium dioxide, zinc oxide, copper oxide, platinum, and magnesium oxide, have been well known and referred to as anticancer and antimicrobial agents or carriers. The inactivation and eradication of Gram-positive and Gram-negative bacteria may be mainly resulted from the oxidative damages in the bacterial medium. Overall, metalloid, metal and metal oxide NPs can be functionalized by other antibacterial or anticancer agents and biocompatible stabilizers to increase their efficiency in physiological conditions. However, the undesirable cytotoxicity of these nanoparticles in physiological conditions is the major hindrance to their application in the pharmaceutical industry and therapeutics. Nevertheless, it is expected that these problems will be solved in the near future. is to an of the recent signs of in increasing anticancer and antibacterial mechanisms of metal and metal-based nanoparticles.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信