Current Reviews in Clinical and Experimental Pharmacology最新文献_第8页

The Effects of Probiotics and Prebiotics on Gastrointestinal and Behavioural Symptoms in Autism Spectrum Disorder. 益生菌和益生元对自闭症谱系障碍胃肠道和行为症状的影响。

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Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2022-01-01 DOI: 10.2174/2772432816666210805141257

José Guevara-Gonzaléz, José Guevara-Campos, Lucía González, Omar Cauli

{"title":"The Effects of Probiotics and Prebiotics on Gastrointestinal and Behavioural Symptoms in Autism Spectrum Disorder.","authors":"José Guevara-Gonzaléz, José Guevara-Campos, Lucía González, Omar Cauli","doi":"10.2174/2772432816666210805141257","DOIUrl":"https://doi.org/10.2174/2772432816666210805141257","url":null,"abstract":"Background: Autism Spectrum Disorders (ASDs) are a group of prevalent neuropsychiatric disorders. They present a complex and unknown etiology, which in most cases includes significant peripheral alterations outside the brain such as in the composition of gut microbiota. Because the gut microbiota is involved in modulating the gut-brain axis, several studies have suggested that the microbiome in the gut can modify metabolites which are able to cross the blood-brain barrier and modulate brain function.Methods: We reviewed the current evidence regarding microbiota alterations in patients with ASD and the effects of the administration of probiotics and prebiotics in these patients, both in terms of gastrointestinal and behavioural symptoms.Results: Administration of a probiotic formulation containing different strains of Lactobacillus (L. acidophilus, L. rhamnosus, and others) and Bifidobacteria had beneficial effects upon these aforementioned symptoms and their use is recommended in a subgroup of ASD patients that present gastrointestinal disturbances. Nonetheless, the types of gastrointestinal disturbances that most benefit from such interventions remain to be elucidated in order to personalize the medical approaches.Conclusion: Recent clinical studies have shown that probiotic treatments can regulate the gut microbiota and may result in improvements in some behavioral abnormalities associated with ASD. Trials using prebiotic fibers or synbiotics preparations are still lacking and necessary in order to deep in such therapeutic strategies in ASD with comorbid gastrointestinal disrturbances.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":"17 3","pages":"166-173"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39379594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Meet the Section Editor 见栏目编辑

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Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2021-10-01 DOI: 10.2174/277243281604211015122308

Ya-yun Wang

引用次数: 0

Meet the Associate Editorial Board Member 会见副编辑委员会成员

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Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2021-09-22 DOI: 10.2174/277243281603210802093312

M. Spanakis

引用次数: 0

Notice of Withdrawal 撤回通知

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Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2021-08-31 DOI: 10.2174/2772432816666210901105513

Gaetano Gorgone, Massimiliano Plastino, Antonio Vaccaro, Antonietta Fava, Domenico Bosco

引用次数: 0

Meet The Associate Editorial Board Member 会见副编委

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Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2021-08-03 DOI: 10.2174/277243281602210610114054

Sherif Hassan

引用次数: 0

Berberine Nanoencapsulation Attenuates Hallmarks of Scoplomine Induced Alzheimer's-Like Disease in Rats 小檗碱纳米胶囊化可减弱莨菪碱诱导的大鼠阿尔茨海默病的特征

IF 1.1

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2021-05-01 DOI: 10.2174/2772432mta3rnzqm0

Samar R. Saleh

引用次数: 3

Effects of ADJUVANT Ketamine on Induction of Anesthesia for the Cesarean Section ADJUVANT氯胺酮对剖宫产麻醉诱导的影响

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Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2021-05-01 DOI: 10.2174/2772432mta1emtedw

Mahmoudreza Moradkhani

引用次数: 0

Role of Brain Imaging in Drug Development for Psychiatry. 脑成像在精神病学药物开发中的作用。

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Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2021-03-22 DOI: 10.2174/1574884716666210322143458

J. D. den Boer, E. D. de Vries, R. Borra, A. Waarde, A. Lammertsma, R. Dierckx

{"title":"Role of Brain Imaging in Drug Development for Psychiatry.","authors":"J. D. den Boer, E. D. de Vries, R. Borra, A. Waarde, A. Lammertsma, R. Dierckx","doi":"10.2174/1574884716666210322143458","DOIUrl":"https://doi.org/10.2174/1574884716666210322143458","url":null,"abstract":"BACKGROUND\u0000Over the last decades, many brain imaging studies have contributed to new insights in the pathogenesis of psychiatric disease. However, in spite of these developments, progress in the development of novel therapeutic drugs for prevalent psychiatric health conditions has been limited.\u0000\u0000\u0000OBJECTIVE\u0000In this review, we discuss translational, diagnostic and methodological issues that have hampered drug development in CNS disorders with a particular focus on psychiatry. The role of preclinical models is critically reviewed and opportunities for brain imaging in early stages of drug development using PET and fMRI are discussed. The role of PET and fMRI in drug development is reviewed emphasizing the need to engage in collaborations between industry, academia and phase I units.\u0000\u0000\u0000RESULTS\u0000Brain imaging technology has revolutionized the study of psychiatric illnesses, and during the last decade, neuroimaging has provided valuable insights at different levels of analysis and brain organization, such as effective connectivity (anatomical), functional connectivity patterns and neurochemical information that may support both preclinical and clinical drug development.\u0000\u0000\u0000CONCLUSION\u0000Since there is no unifying pathophysiological theory of individual psychiatric syndromes and since many symptoms cut across diagnostic boundaries, a new theoretical framework has been proposed that may help in defining new targets for treatment and thus enhance drug development in CNS diseases. In addition, it is argued that new proposals for data-mining and mathematical modelling as well as freely available databanks for neural network and neurochemical models of rodents combined with revised psychiatric classification will lead to new validated targets for drug development.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":"17 1 1","pages":"46-71"},"PeriodicalIF":1.1,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43931177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiotensin-Receptor Blockers and the Risk of AlzheimerÂ´s Disease: A Meta-analysis 血管紧张素受体阻滞剂与AlzheimerÂ疾病风险的meta分析

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Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2021-02-01 DOI: 10.2174/2772432mta0imtmcx

T. Oscanoa

引用次数: 4

In Silico Model for Predicting CYP2D6-Mediated Drug-Drug Interactions. 预测cyp2d6介导的药物-药物相互作用的计算机模型。

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Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2021-01-01 DOI: 10.2174/1574884715666200507130824

Roberto Lozano, Alberto Frutos, Alejandro Martinez

{"title":"In Silico Model for Predicting CYP2D6-Mediated Drug-Drug Interactions.","authors":"Roberto Lozano, Alberto Frutos, Alejandro Martinez","doi":"10.2174/1574884715666200507130824","DOIUrl":"https://doi.org/10.2174/1574884715666200507130824","url":null,"abstract":"Background: Successful integration of in vitro into in vivo data on Drug-Drug Interaction (DDI) is dependent on the inhibitory concentration used. Obtaining plasma concentration of a drug is only readily available for a small number of drugs in clinical practice. We propose the use of a therapeutic range as a substitute for inhibitory concentration.Objective: Because of this, we aimed to construct a linear-regression model based on the areaunder- curve of the victim drugs and the therapeutic range for a set of known inhibitors of the CYP2D6 of interest.Methods: Correlation analysis of linear log-log regression of two main variables: The Area-Under- Curve ratio (AUCr) of the victim drugs and the therapeutic range-to-inhibition constant ratio, with data obtained from literature.Results: Data were fitted to linear log-log regression, between the average of AUCr values and mean value of therapeutic range-to-inhibition constant ratio (TRm-to-Ki), of the inhibitory drugs.Conclusion: According to our results, knowledge of the inhibition constant and therapeutic range (or its plasma levels if disponible) of the inhibitor would be sufficient to determine the intensity and clinical relevance of a CYP2D6-mediated DDI.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":"16 2","pages":"124-127"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37911559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1