质子泵抑制剂的使用和缺铁性贫血的风险:系统回顾和荟萃分析。

IF 1.3 Q4 PHARMACOLOGY & PHARMACY
Mohammad Daud Ali
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引用次数: 2

摘要

目的:在过去十年中进行了各种研究,关于铁死性贫血(IDA)与-à-vis使用质子泵抑制剂(PPIs)的危险的发现不一致。因此,最近进行了系统回顾和荟萃分析,以评估与质子泵抑制剂使用有关的ida相关危险。方法:从研究开始到2021年2月28日,检索EBSCOhost、PubMed®和Cochrane Central的数据库,以确定所有目标与本研究调查一致的研究。采用纽卡斯尔-渥太华量表(NOS)对研究调查标准进行评价。该研究的主要(1º)目标是评估质子泵抑制剂(PPI)使用者的IDA风险。数据处理采用RevMan (Review Manager) 5.4版本。结果:本系统综述和荟萃分析共采用了14项调查研究。9项研究的综合相对风险显示质子泵抑制剂的使用与IDA风险之间存在数值上的相关关系(RR 2.56 [95% CI 1.43-4.61], p < 0.00001)。当代的系统回顾和荟萃分析表明,质子泵抑制剂使用者比非ppi使用者更容易患IDA。结论:根据我的研究结果,开处方的医生在给长期服用PPIs的人开处方时应该谨慎,以避免IDA的危险。此外,他们的血清铁水平应检查,以确保质子泵抑制剂是安全的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Proton Pump Inhibitors' Use and Risk of Iron Deficiency Anaemia: A Systematic Review and Meta-analysis.

Aim: Various research was conducted during the last decade, with inconsistent findings regarding iron death anaemia (IDA) perils vis-à-vis utilization of proton-pump inhibitors (PPIs). Consequently, recent systematic review and meta-analysis were implemented to evaluate IDA-related perils concerning the utilization of proton-pump inhibitors.

Methods: The databases of EBSCOhost, PubMed® and Cochrane Central were searched from the research outset until February 28, 2021 purposely to identify all research with objectives that align with the present research investigation. The Newcastle-Ottawa Scale (NOS) was utilized for the evaluation of the research investigation standard. The prime (1º) goal of the research was to gauge IDA peril among users of proton-pump inhibitors (PPI). For data processing, RevMan (Review Manager) version 5.4 was employed.

Results: In total, fourteen investigations research was employed in this systematic review and metaanalysis. The combined relative risk of nine research exhibited a numerically consequential interrelation betwixt the utilization of proton-pump inhibitors and IDA peril (RR 2.56 [95% CI 1.43-4.61], p < 0.00001). Contemporary systematic review and meta-analysis examination posit that proton-pump inhibitor consumers are prone to greater peril of coming down with IDA in comparison to non-PPI users.

Conclusion: In keeping with the findings of my research, prescriber physicians should exercise caution when prescribing PPIs to individuals taking it for a long time to avoid the peril of IDA. Additionally, their serum iron level should be checked to ensure that proton-pump inhibitors are safe.

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来源期刊
CiteScore
4.80
自引率
9.10%
发文量
55
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