Current Reviews in Clinical and Experimental Pharmacology最新文献

The Use of Different Local Anesthetics in Pregnant Women in Dentistry: A Systematic Review. 不同局麻药在牙科孕妇中的应用：系统综述。

IF 1.3

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2025-04-21 DOI: 10.2174/0127724328349965250407082245

Yasmin Gabrielly Miranda da Cunha, Eloiza Ferreira da Silva, Gabriela M Oliveira, Carlos F Santos, Adriana M Calvo

{"title":"The Use of Different Local Anesthetics in Pregnant Women in Dentistry: A Systematic Review.","authors":"Yasmin Gabrielly Miranda da Cunha, Eloiza Ferreira da Silva, Gabriela M Oliveira, Carlos F Santos, Adriana M Calvo","doi":"10.2174/0127724328349965250407082245","DOIUrl":"https://doi.org/10.2174/0127724328349965250407082245","url":null,"abstract":"Background: Despite the potential side effects of local anesthetics, they are indispensable for relieving pain and, consequently, reducing the patient's stress.Objective: The objective of the present research was to evaluate, through a systematic review, the different types of local anesthetics available for use in dental procedures in pregnant patients.Methods: Electronic bibliographic searches were conducted to retrieve studies published from 2000 to 2024 concerning the use of local anesthetics in pregnant women in dentistry. Five studies were included in this review (2 case series, 2 cohort studies, and 1 randomized clinical trial).Results: The studies involved a total of 1,954 patients. The primary local anesthetic used was lidocaine with epinephrine/adrenaline. There were no significant differences in pregnant women who received local anesthesia regarding gestational age at delivery, birth weight of the baby, induction of labor pain, preterm birth delivery, spontaneous abortions, stillbirths, fetal anomalies, risk of experiencing serious medical adverse events or adverse pregnancy outcomes. A limited number of studies were identified, and the information was restricted.Conclusion: Both the present review and previous studies support the lack of grounds to avoid providing dental care and using local anesthetics during pregnancy.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic Effects and Complications of Berberine on Cardiac Arrhythmias: A Systematic Review. 小檗碱治疗心律失常的机制及并发症：系统综述。

IF 1.3

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2025-04-17 DOI: 10.2174/0127724328346501250404175826

Shahab Masoumi, Mohammadreza Moetazedian, Samira Jafari, Saeid Heidari-Soureshjani, Catherine Mt Sherwin

{"title":"Mechanistic Effects and Complications of Berberine on Cardiac Arrhythmias: A Systematic Review.","authors":"Shahab Masoumi, Mohammadreza Moetazedian, Samira Jafari, Saeid Heidari-Soureshjani, Catherine Mt Sherwin","doi":"10.2174/0127724328346501250404175826","DOIUrl":"https://doi.org/10.2174/0127724328346501250404175826","url":null,"abstract":"Background: Arrhythmia is an abnormal sinus rhythm of the heartbeat, and in addition to threatening the patient's health, it may also cause fatal complications.Objectives: The present review study was investigated the effects of berberine (BBR) on cardiac arrhythmias and its possible complications.Methods: A systematic search was conducted on electronic databases such as PubMed/MEDLINE, Web of Science, Scopus, Embase, and Cochrane Library to identify relevant studies published before June 10, 2024. Inclusion criteria were defined based on the study's aim. Two reviewers performed data extraction independently to ensure accuracy and minimize bias. The data were finally extracted and analyzed.Results: Finally, 22 studies were included. BBR revealed antiarrhythmic effects through antioxidant, anti-inflammatory, and anti-apoptotic activity and improved mitochondrial function. Moreover, BBR modulated ion channels and improved electrical remodeling trough inhibited Potassium current (IK), IK1, IKr, IKs, ICa, INa, KATP channels and human ether-a-go-go related gene (hERG) and improved expression of inwardly rectifying potassium (Kir)6.2 and Kir2.1. It also increased action potential duration (APD), prolonged the effective refractory period (ERP), and reduced the frequency and complexity of ventricular premature complexes (VPC). However, it causes some cardiovascular side effects, including prolonged QT interval, bradycardia, and hypotensive effects. BBR may also lead to gastrointestinal complications, immunosuppressive effects, and interaction with concomitant drugs.Conclusion: Although BBR's cardioprotective properties have satisfactory effects on cardiac arrhythmia, it causes prolonged QT interval, bradycardia, hypotension, and cardiotoxicity. However, more clinical studies are needed to obtain more reliable results.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fisetin, a Promising Anti-Cancer Flavonoid: A Brief Review of Its Biological Effects and Molecular Mechanisms in Lung Cancer Prevention and Therapy. 鱼腥草素--一种前景看好的抗癌类黄酮：简评其在肺癌预防和治疗中的生物效应和分子机制

IF 1.3

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2025-04-04 DOI: 10.2174/0127724328344902250324062309

Ali Jahanban-Esfahlan, Parina Asgharian, Samin Mohammadi, Hadi Ghanbari, Solmaz Asnaashari

{"title":"Fisetin, a Promising Anti-Cancer Flavonoid: A Brief Review of Its Biological Effects and Molecular Mechanisms in Lung Cancer Prevention and Therapy.","authors":"Ali Jahanban-Esfahlan, Parina Asgharian, Samin Mohammadi, Hadi Ghanbari, Solmaz Asnaashari","doi":"10.2174/0127724328344902250324062309","DOIUrl":"https://doi.org/10.2174/0127724328344902250324062309","url":null,"abstract":"Introduction: Experimental evidence has demonstrated that compounds of natural origin possess adjuvant anti-cancer properties, and their combination with anti-cancer drugs has the potential to reduce drug resistance in cancer treatment exhibiting chemoprotective effects.Method: Fisetin (FIS), a flavonoid-structured polyphenolic compound found in various vegetables and fruits, is used as a yellow/ochre coloring agent and shows diverse pharmacological and biological effects. FIS can modulate various signaling pathways in relation to oxidative stress, inflammation, cell proliferation, metastasis, and angiogenesis. Thus, FIS is proposed to be a beneficial agent for preventing and treating numerous human malignancies. Awareness of natural compound action mechanisms paves the way for scientific communities, healthcare organizations, and the pharmaceutical industry to develop and introduce new drugs to treat diseases. In this paper, the general properties of FIS were highlighted first, and later, using the Scopus database, all related scientific literature regarding the studies that investigated the effects of FIS on lung cancer was collected.Results: The critical points were extracted from the research works, and possible effects and molecular mechanisms of FIS on cancer cells were reviewed, and a comprehensive discussion about the roles of this phytochemical on different signaling pathways that were very crucial in lung cancer cells was provided.Conclusion: Finally, the current challenges and future perspectives of lung cancer prevention and therapy approaches using FIS were addressed.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Determinants of Statin-induced Myopathy: A Network Metaanalysis of Observational Studies. 他汀类药物诱导肌病的遗传决定因素：观察性研究的网络荟萃分析。

IF 1.3

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2025-03-28 DOI: 10.2174/0127724328356429250315163111

Kannan Sridharan, Gowri Sivaramakrishnan

{"title":"Genetic Determinants of Statin-induced Myopathy: A Network Metaanalysis of Observational Studies.","authors":"Kannan Sridharan, Gowri Sivaramakrishnan","doi":"10.2174/0127724328356429250315163111","DOIUrl":"https://doi.org/10.2174/0127724328356429250315163111","url":null,"abstract":"Introduction: Statin-induced myopathy (SIM) is a prevalent adverse event impacting treatment adherence. Despite extensive exploration of genotypes, conflicting evidence obscures their role in SIM incidence, prompting this network meta-analysis.Methods: Observational studies meeting eligibility criteria (patients on any statin with reported SNPs and SIM details) were systematically reviewed. Severe SIM was defined as creatine kinase elevations exceeding 10 times the upper limit of normal. Mixed treatment comparison pooled estimates were generated from direct and indirect pooled estimates, represented by odds ratios (OR) with 95% confidence intervals (CI), and validated via bootstrap analysis.Results: Thirty-four studies (26,152 participants) examining genotypes spanning drug transporters, metabolizing enzymes, reactive oxygen species production, and myopathy-related genes were analyzed. Significant associations were observed with drug transporters (OR: 1.4; 95% CI: 1.04, 1.5). Notably, solute carrier organic anion transporter 1B1 (SLCO1B1) (rs4149056) exhibited a moderate association with SIM (OR: 2.1; 95% CI: 1.7, 2.6), validated by bootstrap analysis (OR: 2.1; 95% CI: 1.7, 2.8). Similar associations were found for severe SIM with SLCO1B1 (rs4149056) (OR: 3.8; 95% CI: 1.4, 10.4) and ATP Binding Cassette Subfamily B Member 1 (ABCB1) (rs2373588) (OR: 2.8; 95% CI: 1.4, 5.4). Intraclass differences in genetic predictor risks were noted among statins.Conclusion: Our meta-analysis underscores the significant association of SLCO1B1 with SIM, supporting its clinical utility. Further research is warranted to clarify additional genetic predictors. These findings endorse current guidelines advocating for SLCO1B1 genotyping in statin therapy decisions.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobiological Mechanisms of Ketamine Use, its Addiction, and Withdrawal: A Mini Review. 氯胺酮使用、成瘾和戒断的神经生物学机制综述。

IF 1.3

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2025-03-03 DOI: 10.2174/0127724328362434250224105609

Sin Hui Ng, Yu Zhao Lee, Ming Ye Hong, Audrey Siew Foong Kow, Annette d'Arqom, Chau Ling Tham, Yu-Cheng Ho, MIng Tatt Lee

{"title":"Neurobiological Mechanisms of Ketamine Use, its Addiction, and Withdrawal: A Mini Review.","authors":"Sin Hui Ng, Yu Zhao Lee, Ming Ye Hong, Audrey Siew Foong Kow, Annette d'Arqom, Chau Ling Tham, Yu-Cheng Ho, MIng Tatt Lee","doi":"10.2174/0127724328362434250224105609","DOIUrl":"https://doi.org/10.2174/0127724328362434250224105609","url":null,"abstract":"Ketamine, a substance used for anesthesia and known for inducing dissociation, can lead to addiction and the development of severe withdrawal symptoms. Ketamine alters brain networks before affecting somesthetic sensation. Ketamine abuse was especially prevalent in East and Southeast Asia, and its popularity has continued to expand globally in recent decades. Ketamine is gaining popularity in the public and private sectors as a cheaper off-label depression treatment. Unfortunately, ketamine may cause side effects, such as heart and blood vessel instability, respiratory depression, liver injury, hallucinations, etc. The pain-relieving and mental effects of ketamine might induce reliance; thus, it should be used cautiously. This review highlights the neurobiological processes underpinnings of ketamine's addictive potential, withdrawal, and its effects on brain networks like the prefrontal cortex, hippocampus, and mesolimbic pathway, which play vital roles in decision-making, memory, and reward processing. In addition, the involvement of neurotransmitter systems, specifically glutamate and dopamine, in mediating the addictive properties of ketamine and the neuroadaptive changes that occurred during withdrawal are also discussed. It also explains that low-dose ketamine can alter the secretion of stress hormone cortisol and hypothalamic-pituitary-adrenal (HPA) axis dysregulation, possibly attributed to the current repurposing study of ketamine as a fast-acting antidepressant. Understanding these pathways is essential for developing effective ketamine addiction treatments, managing withdrawal symptoms, and possibly reversing brain changes for the betterment of human health and psychological well- being.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Gut Connection: A Narrative Review on the In-depth Analysis of Gut Microbiota and Metabolites in Depression. 肠道联系：抑郁症患者肠道微生物群和代谢物深度分析的叙述性综述。

IF 1.3

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2025-01-31 DOI: 10.2174/0127724328332998250118182255

Ayesha Sultana, Md Sadique Hussain, Mudasir Maqbool, Mohit Agrawal, Ajay Singh Bisht, Navneet Khurrana, Gurvinder Singh, Rajesh Kumar

{"title":"The Gut Connection: A Narrative Review on the In-depth Analysis of Gut Microbiota and Metabolites in Depression.","authors":"Ayesha Sultana, Md Sadique Hussain, Mudasir Maqbool, Mohit Agrawal, Ajay Singh Bisht, Navneet Khurrana, Gurvinder Singh, Rajesh Kumar","doi":"10.2174/0127724328332998250118182255","DOIUrl":"https://doi.org/10.2174/0127724328332998250118182255","url":null,"abstract":"Depression is a prevalent mood disorder with significant public health implications. Despite extensive research, its precise causes remain inadequately understood. Recently, interest has surged in the role of the gut microbiome and its metabolites in the pathophysiology of depression. This review aims to provide a comprehensive overview of the relationship between gut microbiota, its metabolites, and depression while exploring potential mechanisms influencing the efficacy of antidepressant medications. A narrative review methodology was employed, synthesizing recent studies utilizing a multi-omics approach. We examined alterations in gut microbiome composition and metabolite production in individuals diagnosed with depression, discussing the technical tools and methods commonly applied in this research area. The findings indicate that individuals with depression show significant alterations in gut microbiome composition, notably an imbalance in Firmicutes, Bacteroidetes, and Actinobacteria. Changes in metabolite production, including short-chain fatty acids, tryptophan, and bile acids, were also observed. Moreover, the review highlights that antidepressant medications may exert their therapeutic effects by modulating gut microbiota and its metabolites. This review emphasizes the intricate interplay between gut microbiota, its metabolites, and depression, revealing critical insights into the mechanisms underlying antidepressant efficacy. We recommend that future research focus on elucidating these interactions to develop innovative therapeutic strategies, potentially transforming the management of depression through microbiota-targeted approaches.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking the Mold: Advances and Hurdles in Antifungal Resistance Management for Dermatophytes. 打破霉菌：皮肤植物抗真菌耐药性管理的进展和障碍。

IF 1.3

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2025-01-30 DOI: 10.2174/0127724328328331241217194034

Zaid Ra'ed Alnsour, Mouiad Ra'ed Alnsour, Ayham Ra'ed Alnsour, Majd Majed Massadeh, Karem Hassan Alzoubi, Majed Mohammad Masadeh

{"title":"Breaking the Mold: Advances and Hurdles in Antifungal Resistance Management for Dermatophytes.","authors":"Zaid Ra'ed Alnsour, Mouiad Ra'ed Alnsour, Ayham Ra'ed Alnsour, Majd Majed Massadeh, Karem Hassan Alzoubi, Majed Mohammad Masadeh","doi":"10.2174/0127724328328331241217194034","DOIUrl":"https://doi.org/10.2174/0127724328328331241217194034","url":null,"abstract":"Examining antifungal resistance in dermatophytes is crucial in infectious diseases, dermatology, and clinical microbiology. The increasing occurrence of resistant infections and their influence on the effectiveness of therapy seem overwhelming. This study examines the present condition of antifungal resistance in dermatophytes, highlighting the need for ongoing and up-to-date research. Fungal diseases constantly change, and fungi have developed new resistance mechanisms. Here, we analyze the historical context of research on antifungal resistance, examining the variables that contribute to the development of resistance, such as the growing use of antifungals in clinical and agricultural contexts. We also explore the consequences of resistance to antifungal agents in clinical practice and public health. The review emphasizes the significance of new diagnostic technologies, like next-generation sequencing, in comprehending resistance mechanisms. It also underscores the crucial role of international collaboration in tackling this worldwide health concern. In conclusion, the paper emphasizes the need for continuous research to adjust to the evolving epidemiology of dermatophyte infections, create efficient treatment approaches, and guide public health interventions. This will ensure that the management of antifungal resistance is grounded in the most up-to-date scientific knowledge and optimal methods.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Role of Indian Spices in the Management of Diabetic Complication: A Pre-Clinical and Clinical Review. 印度香料在糖尿病并发症管理中的潜在作用：临床前和临床回顾。

IF 1.3

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2025-01-01 DOI: 10.2174/0127724328331153240918093157

Swarnalata Mohapatra, Santosh Ranjit, Gurudutta Pattnaik, Patitapabana Parida, Sonali Dutta, Goutam Ghosh, Goutam Rath, Biswakanth Kar

{"title":"Potential Role of Indian Spices in the Management of Diabetic Complication: A Pre-Clinical and Clinical Review.","authors":"Swarnalata Mohapatra, Santosh Ranjit, Gurudutta Pattnaik, Patitapabana Parida, Sonali Dutta, Goutam Ghosh, Goutam Rath, Biswakanth Kar","doi":"10.2174/0127724328331153240918093157","DOIUrl":"https://doi.org/10.2174/0127724328331153240918093157","url":null,"abstract":"Diabetic is a metabolic disorder that is concerning for people worldwide, caused by a lack of insulin or ineffective production of insulin in the pancreas. Diabetic retinopathy, nephropathy, and neuropathy are significant microvascular complications of diabetes mellitus, contributing to substantial morbidity and mortality worldwide. Several synthetic medications have been developed. However, none of the compounds provides complete recovery. Long-term use of some synthetic medications might have serious negative effects, thus, there is a need for safe, affordable, and effective medications. Throughout human history, traditional ailments have been much respected as a source of treatment. Their widespread usage across the globe suggests that herbs/ spices are becoming an increasingly important component of cutting-edge, contemporary medications. Therefore, the objective of this review is mainly based on the beneficial effect of Indian spices in managing diabetes. We review the current primary and clinical evidence about the potential of Indian spices, including curcumin, ginger, coriander, cumin seed, garlic, clove, cinnamon, curry leaves, and fenugreek seed with mainly their hypoglycemic and antioxidant properties, for treating diabetes mellitus, also managing diabetic-associated complications, such as neuropathy, retinopathy, and nephropathy. Here, we present the pre-clinical and clinical studies demonstrating how these spices can improve glucose metabolism, enhance insulin secretion, and mitigate oxidative stress, potentially alleviating diabetic complications.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":"20 2","pages":"140-157"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the Pathogenesis and Treatment of Chemotherapy-Induced Neuropathy: A Focus on Oxidative Stress and Neuroinflammation. 化疗诱发神经病变的发病机理和治疗方法透视：关注氧化应激和神经炎症。

IF 1.3

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2025-01-01 DOI: 10.2174/0127724328314214240829181006

Jiaqi Yu, Yuanfeng Fu, Weifeng Xu, Ren-Bo Ding, Jiaolin Bao

{"title":"Insights into the Pathogenesis and Treatment of Chemotherapy-Induced Neuropathy: A Focus on Oxidative Stress and Neuroinflammation.","authors":"Jiaqi Yu, Yuanfeng Fu, Weifeng Xu, Ren-Bo Ding, Jiaolin Bao","doi":"10.2174/0127724328314214240829181006","DOIUrl":"10.2174/0127724328314214240829181006","url":null,"abstract":"Cancer is a high-morbidity disease prevalent worldwide. Chemotherapy is the primarily used regimen for cancer treatment; however, it also brings severe side effects. Chemotherapy-induced Peripheral Neuropathy (CIPN) and Chemotherapy-induced Cognitive Impairment (CICI) are two main complications occurring in chemotherapy. They are both associated with nervous system injury and are therefore collectively referred to as Chemotherapy-induced Neuropathy (CIN). CIPN induces neuralgia and numbness in limbs, while CICI causes amnesia and cognitive dysfunction. Currently, there are no effective therapeutics to prevent or cure CIN, so research into new drugs to alleviate CIN becomes urgent. Oxidative stress and neuroinflammation are the common pathogenic mechanisms of CIPN and CICI. Excessive Reactive Oxygen Species (ROS) and pro-inflammatory cytokines cause peripheral nervous system damage and hence CIPN. Peripheral ROS and cytokines also change the permeability of the blood-brain barrier, thereby increasing oxidative stress and neuroinflammation in the central nervous system, ultimately leading to CICI. Several antidepressants have been used to treat CIN and exhibited good clinical effects. Their potential pharmacological mechanism has been reported to ameliorate oxidative stress and neuroinflammation, guiding a new feasible way for effective therapeutic development against CIN. This mini-review has summarized the latest advances in the research on CIN with respect to clinical status, pathogenesis, and treatment. It has also discussed the potential of repurposing antidepressants for CIN treatment and prospected the strategy of developing therapeutics by targeting oxidative stress and neuroinflammation against CIN.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":" ","pages":"98-102"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translational Approach using Advanced Therapy Medicinal Products for Huntington's Disease. 利用先进疗法药物产品治疗亨廷顿氏症的转化方法。

IF 1.3

Current Reviews in Clinical and Experimental Pharmacology Pub Date : 2025-01-01 DOI: 10.2174/0127724328300166240510071548

Maryam Alsadat Mousavi, Maliheh Rezaei, Mahsa Pourhamzeh, Mehri Salari, Nikoo Hossein-Khannazer, Anastasia Shpichka, Seyed Massood Nabavi, Peter Timashev, Massoud Vosough

{"title":"Translational Approach using Advanced Therapy Medicinal Products for Huntington's Disease.","authors":"Maryam Alsadat Mousavi, Maliheh Rezaei, Mahsa Pourhamzeh, Mehri Salari, Nikoo Hossein-Khannazer, Anastasia Shpichka, Seyed Massood Nabavi, Peter Timashev, Massoud Vosough","doi":"10.2174/0127724328300166240510071548","DOIUrl":"10.2174/0127724328300166240510071548","url":null,"abstract":"Current therapeutic approaches for Huntington's disease (HD) focus on symptomatic treatment. Therefore, the unavailability of efficient disease-modifying medicines is a significant challenge. Regarding the molecular etiology, targeting the mutant gene or advanced translational steps could be considered promising strategies. The evidence in gene therapy suggests various molecular techniques, including knocking down mHTT expression using antisense oligonucleotides and small interfering RNAs and gene editing with zinc finger proteins and CRISPR-Cas9-based techniques. Several post-transcriptional and post-translational modifications have also been proposed. However, the efficacy and long-term side effects of these modalities have yet to be verified. Currently, cell therapy can be employed in combination with conventional treatment and could be used for HD in which the structural and functional restoration of degenerated neurons can occur. Several animal models have been established recently to develop cell-based therapies using renewable cell sources such as embryonic stem cells, induced pluripotent stem cells, mesenchymal stromal cells, and neural stem cells. These models face numerous challenges in translation into clinics. Nevertheless, investigations in Advanced Therapy Medicinal Products (ATMPs) open a promising window for HD research and their clinical application. In this study, the ATMPs entry pathway in HD management was highlighted, and their advantages and disadvantages were discussed.","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":" ","pages":"14-31"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0