ACS Measurement Science Au最新文献_第10页

Electrochemical Impedance Spectroscopy─A Tutorial 电化学阻抗谱──教程

ACS Measurement Science Au Pub Date : 2023-03-08 DOI: 10.1021/acsmeasuresciau.2c00070

Alexandros Ch. Lazanas, and , Mamas I. Prodromidis*,

{"title":"Electrochemical Impedance Spectroscopy─A Tutorial","authors":"Alexandros Ch. Lazanas,  and , Mamas I. Prodromidis*, ","doi":"10.1021/acsmeasuresciau.2c00070","DOIUrl":"10.1021/acsmeasuresciau.2c00070","url":null,"abstract":"This tutorial provides the theoretical background, the principles, and applications of Electrochemical Impedance Spectroscopy (EIS) in various research and technological sectors. The text has been organized in 17 sections starting with basic knowledge on sinusoidal signals, complex numbers, phasor notation, and transfer functions, continuing with the definition of impedance in electrical circuits, the principles of EIS, the validation of the experimental data, their simulation to equivalent electrical circuits, and ending with practical considerations and selected examples on the utility of EIS to corrosion, energy related applications, and biosensing. A user interactive excel file showing the Nyquist and Bode plots of some model circuits is provided in the Supporting Information. This tutorial aspires to provide the essential background to graduate students working on EIS, as well as to endow the knowledge of senior researchers on various fields where EIS is involved. We also believe that the content of this tutorial will be a useful educational tool for EIS instructors.","PeriodicalId":29800,"journal":{"name":"ACS Measurement Science Au","volume":"3 3","pages":"162–193"},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/b6/tg2c00070.PMC10288619.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10091856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

Modeling and Analysis of the Capillary Force for Interactions of Different Tip/Substrate in AFM Based on the Energy Method 基于能量法的AFM中不同针尖/基板相互作用毛细力建模与分析

ACS Measurement Science Au Pub Date : 2023-03-07 DOI: 10.1021/acsmeasuresciau.3c00001

Amir Farokh Payam*,

引用次数: 3

Potential Avenues for Exosomal Isolation and Detection Methods to Enhance Small-Cell Lung Cancer Analysis 增强小细胞肺癌分析的外泌体分离和检测方法的潜在途径

ACS Measurement Science Au Pub Date : 2023-02-14 DOI: 10.1021/acsmeasuresciau.2c00068

Waqar Ahmed Afridi, Simon Strachan, Surasak Kasetsirikul, Amandeep Singh Pannu, Narshone Soda, Daniel Gough, Nam-Trung Nguyen and Muhammad J. A. Shiddiky*,

{"title":"Potential Avenues for Exosomal Isolation and Detection Methods to Enhance Small-Cell Lung Cancer Analysis","authors":"Waqar Ahmed Afridi, Simon Strachan, Surasak Kasetsirikul, Amandeep Singh Pannu, Narshone Soda, Daniel Gough, Nam-Trung Nguyen and Muhammad J. A. Shiddiky*, ","doi":"10.1021/acsmeasuresciau.2c00068","DOIUrl":"10.1021/acsmeasuresciau.2c00068","url":null,"abstract":"Around the world, lung cancer has long been the main factor in cancer-related deaths, with small-cell lung cancer (SCLC) being the deadliest form of lung cancer. Cancer cell-derived exosomes and exosomal miRNAs are considered promising biomarkers for diagnosing and prognosis of various diseases, including SCLC. Due to the rapidity of SCLC metastasis, early detection and diagnosis can offer better diagnosis and prognosis and therefore increase the patient’s chances of survival. Over the past several years, many methodologies have been developed for analyzing non-SCLC-derived exosomes. However, minimal advances have been made in SCLC-derived exosome analysis methodologies. This Review discusses the epidemiology and prominent biomarkers of SCLC. Followed by a discussion about the effective strategies for isolating and detecting SCLC-derived exosomes and exosomal miRNA, highlighting the critical challenges and limitations of current methodologies. Finally, an overview is provided detailing future perspectives for exosome-based SCLC research.","PeriodicalId":29800,"journal":{"name":"ACS Measurement Science Au","volume":"3 3","pages":"143–161"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/c0/tg2c00068.PMC10288614.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10091859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Analysis and Identity Confirmation of Anthocyanins in Brassica oleracea Extracts by Direct Injection Ion Mobility-Mass Spectrometry 直接注射离子迁移-质谱法分析甘蓝提取物中花青素的结构及鉴定

ACS Measurement Science Au Pub Date : 2023-02-09 DOI: 10.1021/acsmeasuresciau.2c00058

River J. Pachulicz, Long Yu, Blagojce Jovcevski, Vincent Bulone and Tara L. Pukala*,

{"title":"Structural Analysis and Identity Confirmation of Anthocyanins in Brassica oleracea Extracts by Direct Injection Ion Mobility-Mass Spectrometry","authors":"River J. Pachulicz, Long Yu, Blagojce Jovcevski, Vincent Bulone and Tara L. Pukala*, ","doi":"10.1021/acsmeasuresciau.2c00058","DOIUrl":"https://doi.org/10.1021/acsmeasuresciau.2c00058","url":null,"abstract":"Anthocyanins are a subclass of plant-derived flavonoids that demonstrate immense structural heterogeneity which is challenging to capture in complex extracts by traditional liquid chromatography–mass spectrometry (MS)-based approaches. Here, we investigate direct injection ion mobility-MS as a rapid analytical tool to characterize anthocyanin structural features in red cabbage (Brassica oleracea) extracts. Within a 1.5 min sample run time, we observe localization of structurally similar anthocyanins and their isobars into discrete drift time regions based upon their degree of chemical modifications. Furthermore, drift time-aligned fragmentation enables simultaneous collection of MS, MS/MS, and collisional cross-section data for individual anthocyanin species down to a low picomole scale to generate structural identifiers for rapid identity confirmation. We finally identify anthocyanins in three other Brassica oleracea extracts based on red cabbage anthocyanin identifiers to demonstrate our high-throughput approach. Direct injection ion mobility-MS therefore provides wholistic structural information on structurally similar, and even isobaric, anthocyanins in complex plant extracts, which can inform the nutritional value of a plant and bolster drug discovery pipelines.","PeriodicalId":29800,"journal":{"name":"ACS Measurement Science Au","volume":"3 3","pages":"200–207"},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmeasuresciau.2c00058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49767745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroanalytical Overview: The Determination of Levodopa (L-DOPA) 电分析综述:左旋多巴(L-DOPA)的测定

ACS Measurement Science Au Pub Date : 2023-02-03 DOI: 10.1021/acsmeasuresciau.2c00071

Robert D. Crapnell, and , Craig E. Banks*,

引用次数: 4

Measurement of Surface Diffusion at the Electrochemical Interface by In Situ Linear Optical Diffraction 原位线性光学衍射法测量电化学界面表面扩散

ACS Measurement Science Au Pub Date : 2023-01-26 DOI: 10.1021/acsmeasuresciau.2c00066

Lasse Kattwinkel, and , Olaf M. Magnussen*,

引用次数: 1

In Situ Confocal Raman Microscopy of Redox Polymer Films on Bulk Electrode Supports 体电极支架上氧化还原聚合物薄膜的原位共聚焦拉曼显微镜研究

ACS Measurement Science Au Pub Date : 2023-01-13 DOI: 10.1021/acsmeasuresciau.2c00064

Jiahe Xu, Miharu Koh, Shelley D. Minteer and Carol Korzeniewski*,

{"title":"In Situ Confocal Raman Microscopy of Redox Polymer Films on Bulk Electrode Supports","authors":"Jiahe Xu, Miharu Koh, Shelley D. Minteer and Carol Korzeniewski*, ","doi":"10.1021/acsmeasuresciau.2c00064","DOIUrl":"10.1021/acsmeasuresciau.2c00064","url":null,"abstract":"A spectroelectrochemical cell is described that enables confocal Raman microscopy studies of electrode-supported films. The confocal probe volume (∼1 μm3) was treated as a fixed-volume reservoir for the observation of potential-induced changes in chemical composition at microscopic locations within an ∼20 μm thickness layer of a redox polymer cast onto a 3 mm diameter carbon disk electrode. Using a Raman system with high collection efficiency and wavelength reproducibility, spectral subtraction achieved excellent rejection of background interferences, opening opportunities for measuring within micrometer-scale thickness redox films on widely available, low-cost, and conventional carbon disk electrodes. The cell performance and spectral difference technique are demonstrated in experiments that detect transformations of redox-active molecules exchanged into electrode-supported ionomer membranes. The in situ measurements were sensitive to changes in the film oxidation state and swelling/deswelling of the polymer framework in response to the uptake and discharge of charge-compensating electrolyte ions. The studies lay a foundation for confocal Raman microscopy as a quantitative in situ probe of processes within electrode-immobilized redox polymers under development for a range of applications, including electrosynthesis, energy conversion, and chemical sensing.","PeriodicalId":29800,"journal":{"name":"ACS Measurement Science Au","volume":"3 2","pages":"127–133"},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c0/19/tg2c00064.PMC10120033.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9756166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Novel Experimental and Analysis Strategies for Fast Voltammetry: 2. A Troubleshoot-Free Flow Cell for FSCV Calibrations 新型快速伏安法实验与分析策略:2。用于FSCV校准的无故障流动电池

ACS Measurement Science Au Pub Date : 2023-01-11 DOI: 10.1021/acsmeasuresciau.2c00059

Melissa Hexter, Joseph van Batenburg-Sherwood and Parastoo Hashemi*,

引用次数: 1

Real-Time Reaction Monitoring of Azide–Alkyne Cycloadditions Using Benchtop NMR-Based Signal Amplification by Reversible Exchange (SABRE) 基于可逆交换(SABRE)的台式核磁共振信号放大技术实时监测叠氮-炔环加成反应

ACS Measurement Science Au Pub Date : 2023-01-10 DOI: 10.1021/acsmeasuresciau.2c00065

Hye Jin Jeong, Sein Min, Juhee Baek, Jisu Kim, Jean Chung and Keunhong Jeong*,

{"title":"Real-Time Reaction Monitoring of Azide–Alkyne Cycloadditions Using Benchtop NMR-Based Signal Amplification by Reversible Exchange (SABRE)","authors":"Hye Jin Jeong, Sein Min, Juhee Baek, Jisu Kim, Jean Chung and Keunhong Jeong*, ","doi":"10.1021/acsmeasuresciau.2c00065","DOIUrl":"10.1021/acsmeasuresciau.2c00065","url":null,"abstract":"Rufinamide, possessing a triazole ring, is a new antiepileptic drug (AED) relatively well-absorbed in the lower dose range (10 mg/kg per day) and is currently being used in antiepileptic medications. Triazole derivatives can interact with various enzymes and receptors in biological systems via diverse non-covalent interactions, thus inducing versatile biological effects. Strain-promoted azide–alkyne cycloaddition (SPAAC) is a significant method for obtaining triazoles, even under physiological conditions, in the absence of a copper catalyst. To confirm the progress of chemical reactions under biological conditions, research on reaction monitoring at low concentrations is essential. This promising strategy is gaining acceptance for applications in fields such as drug development and nanoscience. We investigated the optimum Ir catalyst and magnetic field for achieving maximum proton hyperpolarization transfer in triazole derivatives. These reactions were analyzed using signal amplification by reversible exchange (SABRE) to overcome the limitations of low sensitivity in nuclear magnetic resonance spectroscopy, when monitoring copper-free click reactions in real time. Finally, a more versatile copper-catalyzed click reaction was monitored in real time, using a 60 MHz benchtop NMR system, in order to analyze the reaction mechanism.","PeriodicalId":29800,"journal":{"name":"ACS Measurement Science Au","volume":"3 2","pages":"134–142"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/3e/tg2c00065.PMC10120034.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9756167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reach for the Stars─Inspiring Latin American Women in STEM 摘星─激励拉丁美洲女性投身STEM

ACS Measurement Science Au Pub Date : 2022-12-21 DOI: 10.1021/acsmeasuresciau.2c00060

Mariana D. Avila-Huerta*, and , Diana L. Mancera-Zapata*,

引用次数: 0